Dmitri V Zaykin

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Contrasting linkage-disequilibrium patterns between cases and controls as a novel association-mapping method
    Dmitri V Zaykin
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Am J Hum Genet 78:737-46. 2006
  2. pmc Optimally weighted Z-test is a powerful method for combining probabilities in meta-analysis
    D V Zaykin
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    J Evol Biol 24:1836-41. 2011
  3. pmc P-value based analysis for shared controls design in genome-wide association studies
    Dmitri V Zaykin
    Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, North Carolina, USA
    Genet Epidemiol 34:725-38. 2010
  4. pmc Correlation-based inference for linkage disequilibrium with multiple alleles
    Dmitri V Zaykin
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Genetics 180:533-45. 2008
  5. pmc Combining p-values in large-scale genomics experiments
    Dmitri V Zaykin
    National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Pharm Stat 6:217-26. 2007
  6. pmc Ranks of genuine associations in whole-genome scans
    Dmitri V Zaykin
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Genetics 171:813-23. 2005
  7. pmc Haplotype associations with quantitative traits in the presence of complex multilocus and heterogeneous effects
    Kyoko Shibata
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Genet Epidemiol 33:63-78. 2009
  8. pmc Expansion of the human mu-opioid receptor gene architecture: novel functional variants
    Svetlana A Shabalina
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Hum Mol Genet 18:1037-51. 2009
  9. ncbi request reprint Bounds and normalization of the composite linkage disequilibrium coefficient
    Dmitri V Zaykin
    Genetic Data Sciences, GlaxoSmithKline Inc, Research Triangle Park, North Carolina 27709, USA
    Genet Epidemiol 27:252-7. 2004
  10. pmc Facial pain with localized and widespread manifestations: separate pathways of vulnerability
    Gary D Slade
    Regional Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Electronic address
    Pain 154:2335-43. 2013

Collaborators

Detail Information

Publications19

  1. pmc Contrasting linkage-disequilibrium patterns between cases and controls as a novel association-mapping method
    Dmitri V Zaykin
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Am J Hum Genet 78:737-46. 2006
    ....
  2. pmc Optimally weighted Z-test is a powerful method for combining probabilities in meta-analysis
    D V Zaykin
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    J Evol Biol 24:1836-41. 2011
    ..Although there is no single approach that is the best in every situation, the weighted Z-test enjoys certain properties that make it an appealing choice as a combination method for meta-analysis...
  3. pmc P-value based analysis for shared controls design in genome-wide association studies
    Dmitri V Zaykin
    Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, North Carolina, USA
    Genet Epidemiol 34:725-38. 2010
    ..P-value based combined tests for association are flexible and essentially as powerful as the approach based on aggregating the individual subject data...
  4. pmc Correlation-based inference for linkage disequilibrium with multiple alleles
    Dmitri V Zaykin
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Genetics 180:533-45. 2008
    ..Calculation of the new multiallele test statistic and its P-value is very simple and utilizes the approximate distribution of R2. We provide a computer program that evaluates approximate as well as "exact" permutational P-values...
  5. pmc Combining p-values in large-scale genomics experiments
    Dmitri V Zaykin
    National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Pharm Stat 6:217-26. 2007
    ..GM gives somewhat higher power than TPM, RTP, Fisher, and Simes methods across a range of simulations...
  6. pmc Ranks of genuine associations in whole-genome scans
    Dmitri V Zaykin
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Genetics 171:813-23. 2005
    ..Effects of multilocus (e.g., haplotype association) tests and impact of linkage disequilibrium on the distribution of ranks associated with TAs are evaluated and can be taken into account...
  7. pmc Haplotype associations with quantitative traits in the presence of complex multilocus and heterogeneous effects
    Kyoko Shibata
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Genet Epidemiol 33:63-78. 2009
    ..An illustrative example of usefulness of the method is discussed, utilizing analysis of multilocus effects within the catechol-O-methyltransferase gene...
  8. pmc Expansion of the human mu-opioid receptor gene architecture: novel functional variants
    Svetlana A Shabalina
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Hum Mol Genet 18:1037-51. 2009
    ..Our results provide evidence for an essential role for MOR-1K isoforms in nociceptive signaling and suggest that genetic variations in alternative OPRM1 isoforms may contribute to individual differences in opiate responses...
  9. ncbi request reprint Bounds and normalization of the composite linkage disequilibrium coefficient
    Dmitri V Zaykin
    Genetic Data Sciences, GlaxoSmithKline Inc, Research Triangle Park, North Carolina 27709, USA
    Genet Epidemiol 27:252-7. 2004
    ..They provide standardized measures of composite linkage disequilibrium, defined as the proportion of its maximum attainable value, given observed allele or genotype frequencies...
  10. pmc Facial pain with localized and widespread manifestations: separate pathways of vulnerability
    Gary D Slade
    Regional Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Electronic address
    Pain 154:2335-43. 2013
    ..9 E-08), although the result was not significant in the replication cohort. These findings illustrate potential for clinical classification of chronic pain based on distinct molecular profiles and genetic background. ..
  11. pmc Large recursive partitioning analysis of complex disease pharmacogenetic studies. II. Statistical considerations
    Dmitri V Zaykin
    GlaxoSmithKline, Inc, Genetic Data Sciences, Research Triangle Park, NC 27709, USA
    Pharmacogenomics 6:77-89. 2005
    ..RP is a straightforward way to create realistic subgroups, and prediction intervals for the within-subgroup disease incidence are easily obtained...
  12. ncbi request reprint Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals
    Dmitri V Zaykin
    GlaxoSmithKline Inc, Discovery Genetics, Research Triangle Park, NC 27709, USA
    Hum Hered 53:79-91. 2002
    ..The method appears to be successful in relating data from multiple, correlated markers to response...
  13. pmc Novel rank-based approaches for discovery and replication in genome-wide association studies
    Chia Ling Kuo
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Genetics 189:329-40. 2011
    ..Further, we relate ranking probabilities to the proportion of false discoveries among top u SNPs. A study-specific proportion can be estimated from P-values, and its expected value can be predicted for study design applications...
  14. pmc Effect of two- and three-locus linkage disequilibrium on the power to detect marker/phenotype associations
    Dahlia M Nielsen
    Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695 7566, USA
    Genetics 168:1029-40. 2004
    ..Single-marker tests tend to prevail when pairwise LD is high. For moderate pairwise values and weak multilocus LD, either testing strategy may come out ahead, although it is also quite likely that neither has much power...
  15. pmc Interval estimation of genetic susceptibility for retrospective case-control studies
    Dmitri V Zaykin
    Department of Population Genetics, GlaxoSmithKline Inc, Research Triangle Park NC 27709, USA
    BMC Genet 5:9. 2004
    ..This article describes classical and Bayesian interval estimation of genetic susceptibility based on random samples with pre-specified numbers of unrelated cases and controls...
  16. pmc Selection of genetic markers for association analyses, using linkage disequilibrium and haplotypes
    Zhaoling Meng
    Bioinformatics Research Center, Campus Box 7566, North Carolina State University, Raleigh, NC 27695 7566, USA
    Am J Hum Genet 73:115-30. 2003
    ..We also show that haplotype-association results that Hosking et al. obtained near CYP2D6 were almost identical before and after marker selection...
  17. ncbi request reprint Effectiveness of computational methods in haplotype prediction
    Chun Fang Xu
    Discovery Genetics, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
    Hum Genet 110:148-56. 2002
    ..However, none of the methods was accurate in predicting individual haplotype phases. The EM and the PHASE methods provided better estimates for overall haplotype frequencies than the subtraction method for both genomic regions...
  18. ncbi request reprint Multiple tests for genetic effects in association studies
    Peter H Westfall
    Texas Tech University, Lubbock, TX, USA
    Methods Mol Biol 184:143-68. 2002
  19. pmc Genetic flip-flop without an accompanying change in linkage disequilibrium
    Dmitri V Zaykin
    Am J Hum Genet 82:794-6; author reply 796-7. 2008