Giovanna Zappala

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Tumor dormancy and the neuroendocrine system: an undisclosed connection?
    Giovanna Zappala
    Basic Biobehavioral and Psychological Sciences Branch, Clinical Research Directorate CMRP, SAIC Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
    Cancer Metastasis Rev 32:189-200. 2013
  2. pmc IGFBP-3, hypoxia and TNF-alpha inhibit adiponectin transcription
    Giovanna Zappala
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 382:785-9. 2009
  3. pmc Induction of apoptosis in human prostate cancer cells by insulin-like growth factor binding protein-3 does not require binding to retinoid X receptor-alpha
    Giovanna Zappala
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Endocrinology 149:1802-12. 2008
  4. ncbi request reprint Nonsecreted insulin-like growth factor binding protein-3 (IGFBP-3) can induce apoptosis in human prostate cancer cells by IGF-independent mechanisms without being concentrated in the nucleus
    Nisan Bhattacharyya
    Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:24588-601. 2006

Collaborators

  • Nisan Bhattacharyya
  • Malgorzata Wiench
  • Jiang Hong
  • Hanief Shahjee
  • Cem Elbi
  • Bruce Raaka
  • Klaus Pechhold
  • Matthew M Rechler

Detail Information

Publications4

  1. doi request reprint Tumor dormancy and the neuroendocrine system: an undisclosed connection?
    Giovanna Zappala
    Basic Biobehavioral and Psychological Sciences Branch, Clinical Research Directorate CMRP, SAIC Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
    Cancer Metastasis Rev 32:189-200. 2013
    ..We review experimental and clinical evidence and propose that neuroendocrine dynamics of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis might contribute to the loss of tumor dormancy...
  2. pmc IGFBP-3, hypoxia and TNF-alpha inhibit adiponectin transcription
    Giovanna Zappala
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 382:785-9. 2009
    ..These results suggest that IGFBP-3 may mediate the inhibition of adiponectin transcription by hypoxia and TNF-alpha, and that IGFBP-3 binding to RXR-alpha may be required for the observed inhibition...
  3. pmc Induction of apoptosis in human prostate cancer cells by insulin-like growth factor binding protein-3 does not require binding to retinoid X receptor-alpha
    Giovanna Zappala
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Endocrinology 149:1802-12. 2008
    ..We conclude that in PC-3 cells, RXR-alpha is not required for the nuclear translocation of IGFBP-3 and that IGFBP-3 can induce apoptosis in human prostate cancer cells without binding RXR-alpha...
  4. ncbi request reprint Nonsecreted insulin-like growth factor binding protein-3 (IGFBP-3) can induce apoptosis in human prostate cancer cells by IGF-independent mechanisms without being concentrated in the nucleus
    Nisan Bhattacharyya
    Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:24588-601. 2006
    ..These results indicate that IGFBP-3 can induce apoptosis in an IGF-independent manner without being secreted or concentrated in the nucleus...