Affiliation: National Institutes of Health
- Tumor dormancy and the neuroendocrine system: an undisclosed connection?Giovanna Zappala
Basic Biobehavioral and Psychological Sciences Branch, Clinical Research Directorate CMRP, SAIC Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
Cancer Metastasis Rev 32:189-200. 2013..We review experimental and clinical evidence and propose that neuroendocrine dynamics of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis might contribute to the loss of tumor dormancy...
- IGFBP-3, hypoxia and TNF-alpha inhibit adiponectin transcriptionGiovanna Zappala
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA
Biochem Biophys Res Commun 382:785-9. 2009..These results suggest that IGFBP-3 may mediate the inhibition of adiponectin transcription by hypoxia and TNF-alpha, and that IGFBP-3 binding to RXR-alpha may be required for the observed inhibition...
- Induction of apoptosis in human prostate cancer cells by insulin-like growth factor binding protein-3 does not require binding to retinoid X receptor-alphaGiovanna Zappala
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Endocrinology 149:1802-12. 2008..We conclude that in PC-3 cells, RXR-alpha is not required for the nuclear translocation of IGFBP-3 and that IGFBP-3 can induce apoptosis in human prostate cancer cells without binding RXR-alpha...
- Nonsecreted insulin-like growth factor binding protein-3 (IGFBP-3) can induce apoptosis in human prostate cancer cells by IGF-independent mechanisms without being concentrated in the nucleusNisan Bhattacharyya
Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 281:24588-601. 2006..These results indicate that IGFBP-3 can induce apoptosis in an IGF-independent manner without being secreted or concentrated in the nucleus...