Kai Yu

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Genetic admixture and population substructure in Guanacaste Costa Rica
    Zhaoming Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America
    PLoS ONE 5:e13336. 2010
  2. pmc A flexible Bayesian model for studying gene-environment interaction
    Kai Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    PLoS Genet 8:e1002482. 2012
  3. pmc Robust joint analysis allowing for model uncertainty in two-stage genetic association studies
    Dongdong Pan
    Department of Statistics, Yunnan University, Kunming 650091, PR China
    BMC Bioinformatics 12:9. 2011
  4. ncbi request reprint Two-sample comparison based on prediction error, with applications to candidate gene association studies
    K Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Ann Hum Genet 71:107-18. 2007
  5. pmc Population substructure and control selection in genome-wide association studies
    Kai Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America
    PLoS ONE 3:e2551. 2008
  6. pmc Efficient p-value evaluation for resampling-based tests
    Kai Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
    Biostatistics 12:582-93. 2011
  7. pmc Flexible design for following up positive findings
    Kai Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Am J Hum Genet 81:540-51. 2007
  8. pmc Pathway analysis by adaptive combination of P-values
    Kai Yu
    Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland 20892, USA
    Genet Epidemiol 33:700-9. 2009
  9. pmc A partially linear tree-based regression model for multivariate outcomes
    Kai Yu
    Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland 20892, USA
    Biometrics 66:89-96. 2010
  10. pmc A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma
    Maria Teresa Landi
    Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Hum Genet 85:679-91. 2009

Collaborators

Detail Information

Publications96

  1. pmc Genetic admixture and population substructure in Guanacaste Costa Rica
    Zhaoming Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America
    PLoS ONE 5:e13336. 2010
    ..However, we further demonstrate that existing PS adjustment approaches can reduce the inflation to an acceptable level for gene discovery...
  2. pmc A flexible Bayesian model for studying gene-environment interaction
    Kai Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    PLoS Genet 8:e1002482. 2012
    ....
  3. pmc Robust joint analysis allowing for model uncertainty in two-stage genetic association studies
    Dongdong Pan
    Department of Statistics, Yunnan University, Kunming 650091, PR China
    BMC Bioinformatics 12:9. 2011
    ..However, existing joint analyses are based on test statistics derived under an assumed genetic model, and thus might not have robust performance when the assumed genetic model is not appropriate...
  4. ncbi request reprint Two-sample comparison based on prediction error, with applications to candidate gene association studies
    K Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Ann Hum Genet 71:107-18. 2007
    ..To illustrate the application of the proposed method in population-based association studies, we use the procedure to study the association between non-Hodgkin lymphoma and the IL10 gene...
  5. pmc Population substructure and control selection in genome-wide association studies
    Kai Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America
    PLoS ONE 3:e2551. 2008
    ..A study using suboptimal controls can have acceptable type I error when an effective strategy for the correction of PS is employed...
  6. pmc Efficient p-value evaluation for resampling-based tests
    Kai Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
    Biostatistics 12:582-93. 2011
    ..We demonstrate the application of the new method by applying it to a large-scale genetic association study of prostate cancer...
  7. pmc Flexible design for following up positive findings
    Kai Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Am J Hum Genet 81:540-51. 2007
    ..We also find that, in the context of flexible design, the joint analysis is generally more powerful than the replication analysis...
  8. pmc Pathway analysis by adaptive combination of P-values
    Kai Yu
    Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland 20892, USA
    Genet Epidemiol 33:700-9. 2009
    ..We also illustrate the advantage of the proposed methods using a study of the association between the nicotinic receptor pathway and cigarette smoking behaviors...
  9. pmc A partially linear tree-based regression model for multivariate outcomes
    Kai Yu
    Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland 20892, USA
    Biometrics 66:89-96. 2010
    ..The proposed method is general enough to be used for the assessment of the joint effect of a set of multiple risk factors on a multivariate outcome in other biomedical research settings...
  10. pmc A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma
    Maria Teresa Landi
    Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Hum Genet 85:679-91. 2009
    ..In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma...
  11. pmc Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men
    Jacqueline M Major
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
    J Nutr 142:866-71. 2012
    ..g., α-tocopherol) under supplementation conditions improves our understanding of the biological determinants of these nutritional exposures and their associations with cancer etiology...
  12. pmc Genetic background comparison using distance-based regression, with applications in population stratification evaluation and adjustment
    Qizhai Li
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Genet Epidemiol 33:432-41. 2009
    ....
  13. pmc Genetic variants in epidermal growth factor receptor pathway genes and risk of esophageal squamous cell carcinoma and gastric cancer in a Chinese population
    Wen Qing Li
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 8:e68999. 2013
    ..05). Our data suggest an association between specific genes in the EGFR signaling pathway and risk of GC and ESCC. Further studies are warranted to validate these associations and to investigate underlying mechanisms. ..
  14. pmc The association between inflammation-related genes and serum androgen levels in men: the prostate, lung, colorectal, and ovarian study
    Tamra E Meyer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA
    Prostate 72:65-71. 2012
    ..Androgens and inflammation have been implicated in the etiology of several cancers, including prostate cancer. Serum androgens have been shown to correlate with markers of inflammation and expression of inflammation-related genes...
  15. doi request reprint TNF polymorphisms and prostate cancer risk
    Kim N Danforth
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20852, USA
    Prostate 68:400-7. 2008
    ..Inflammation has been hypothesized to increase prostate cancer risk. Tumor necrosis factor (TNF) is an important mediator of the inflammatory process, but the relationship between TNF variants and prostate cancer remains unclear...
  16. pmc Large-scale fine mapping of the HNF1B locus and prostate cancer risk
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Hum Mol Genet 20:3322-9. 2011
    ..This study demonstrates a complex relationship between variants in the HNF1B region and prostate cancer risk. Further studies are needed to investigate the biological basis of the association of variants in 17q12 with prostate cancer...
  17. pmc A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 41:579-84. 2009
    ..1 (rs999737; P = 1.74 x 10(-7)) localizes to RAD51L1, a gene in the homologous recombination DNA repair pathway. We also confirmed associations with loci on chromosomes 2q35, 5p12, 5q11.2, 8q24, 10q26 and 16q12.1...
  18. pmc Association between genetic variants in the 8q24 cancer risk regions and circulating levels of androgens and sex hormone-binding globulin
    Lisa W Chu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
    Cancer Epidemiol Biomarkers Prev 19:1848-54. 2010
    ..Genome-wide association studies have identified multiple independent regions on chromosome 8q24 that are associated with cancers of the prostate, breast, colon, and bladder...
  19. ncbi request reprint MAX-rank: a simple and robust genome-wide scan for case-control association studies
    Qizhai Li
    Biostatistics Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Hum Genet 123:617-23. 2008
    ..Thus, we recommend to use MAX-rank for genome-wide scans. After the top-ranked SNPs are identified, their P-values based on MAX can be calculated and compared with the significance level...
  20. pmc Identification of a new prostate cancer susceptibility locus on chromosome 8q24
    Meredith Yeager
    Core Genotyping Facility, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland, USA
    Nat Genet 41:1055-7. 2009
    ..3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24...
  21. pmc Genetic variants in fas signaling pathway genes and risk of gastric cancer
    Paula L Hyland
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD, USA Cancer Prevention Fellowship Program, Division of Cancer Prevention, NCI, NIH, Bethesda, MD, USA
    Int J Cancer 134:822-31. 2014
    ..As one of the first attempts to investigate a pathway-level association, our results suggest that these genes and the Fas signaling pathway warrant further evaluation in relation to GC risk in other populations. ..
  22. pmc Single nucleotide polymorphisms in the PRDX3 and RPS19 and risk of HPV persistence and cervical precancer/cancer
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e33619. 2012
    ..Host genetic factors might affect the risk of progression from infection with carcinogenic human papillomavirus (HPV), the etiologic agent for cervical cancer, to persistent HPV infection, and hence to cervical precancer and cancer...
  23. pmc Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility
    Hong Lou
    Laboratory of Experimental Immunology, Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 106:7933-8. 2009
    ..Further investigation is warranted to determine whether rs10993994 alone or in combination with additional variants contributes to prostate cancer susceptibility...
  24. pmc Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer
    Charles C Chung
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute NIH, 8717 Grovemont Circle, Bethesda, MD 20892, USA
    Hum Mol Genet 20:2869-78. 2011
    ..We estimate that at least 63 common variants should be considered in future studies designed to investigate the biological basis of the multiple association signals...
  25. pmc An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population
    Alison P Klein
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS ONE 8:e72311. 2013
    ..We developed an absolute risk model to identify individuals in the general population at elevated risk of pancreatic cancer...
  26. pmc Genetic variants reflecting higher vitamin e status in men are associated with reduced risk of prostate cancer
    Jacqueline M Major
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, NIH, Bethesda, MD
    J Nutr 144:729-33. 2014
    ..This study suggests that polymorphisms near BUD13/ZNF259/APOA5, involved in vitamin E transport and metabolism, may be associated with lower risk of prostate cancer. This trial was registered at clinicaltrials.gov as NCT00002540. ..
  27. pmc Using principal components of genetic variation for robust and powerful detection of gene-gene interactions in case-control and case-only studies
    Samsiddhi Bhattacharjee
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    Am J Hum Genet 86:331-42. 2010
    ....
  28. pmc Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression
    Melissa Rotunno
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e5652. 2009
    ..Our findings emphasize the necessity of post-GWAS fine mapping and SNP functional assessment to further elucidate cancer risk associations...
  29. ncbi request reprint Multiple loci identified in a genome-wide association study of prostate cancer
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nat Genet 40:310-5. 2008
    ..Our findings point to multiple loci with moderate effects associated with susceptibility to prostate cancer that, taken together, in the future may predict high risk in select individuals...
  30. pmc Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
    Rachael Z Stolzenberg-Solomon
    National Cancer Institute, Bethesda, Maryland 20852, USA
    Am J Epidemiol 172:81-93. 2010
    ..12, 95% confidence interval: 1.23, 3.64). Given this result, recommendations to increase vitamin D concentrations in healthy persons for the prevention of cancer should be carefully considered...
  31. pmc Circulating 25-hydroxyvitamin D and risk of esophageal and gastric cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
    Christian C Abnet
    National Cancer Institute, Bethesda, Maryland 20852, USA
    Am J Epidemiol 172:94-106. 2010
    ..31, 0.96). Subgroup analyses by alcohol consumption produced opposing trends. Results do not support the hypothesis that interventions aimed at increasing vitamin D status would lead to a lower risk of these highly fatal cancers...
  32. pmc Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies
    Christian C Abnet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7236, USA
    Hum Mol Genet 21:2132-41. 2012
    ..Future studies of esophageal and other cancers should focus on comprehensive sequencing of this 2q33 locus and functional analysis of rs13016963 and rs10201587 and other strongly correlated variants...
  33. pmc Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2
    Ludmila Prokunina-Olsson
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 8717 Grovemont Circle, Bethesda, MD 20892 4605, USA
    Cancer Epidemiol Biomarkers Prev 19:1349-55. 2010
    ..2, showed a promising association with PrCa overall (P=2.14x10(-6)), with a suggestion of stronger association with aggressive disease (P=1.2x10(-7))...
  34. pmc The association of telomere length and genetic variation in telomere biology genes
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Hum Mutat 31:1050-8. 2010
    ..The combination of limited diversity and evolutionary conservation suggest that these genes may be under selective pressure. More work is needed to explore the role of genetic variants in telomere length regulation...
  35. pmc Polymorphisms of estrogen receptors and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China
    Sue K Park
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, EPS MSC 7234, 6120 Executive Boulevard, Bethesda, MD 20892 7234, USA
    Carcinogenesis 31:842-6. 2010
    ..1). No association was found for ESR1 haplotype based on four SNPs. These preliminary results suggest that variants in ESR genes could play a role in the etiology of biliary tract cancers, especially bile duct cancer in men...
  36. doi request reprint Improved genetic association tests for an ordinal outcome representing the disease progression process
    Hong Zhang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Bethesda, MD 20892, USA
    Genet Epidemiol 35:499-505. 2011
    ..As a demonstration, we applied the considered tests to a genetic association study of cervical cancer...
  37. pmc Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population
    Wen Qing Li
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD 20852, USA
    Carcinogenesis 34:1536-42. 2013
    ..05). We provide evidence for an association between specific genes in the DNA repair pathways and the risk of ESCC and GC. Further studies are warranted to validate these associations and to investigate underlying mechanisms...
  38. pmc Inflammatory gene variants and the risk of biliary tract cancers and stones: a population-based study in China
    Felipe A Castro
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Rockville, MD 20892, USA
    BMC Cancer 12:468. 2012
    ..Genetic variants in inflammation-related genes have been associated with biliary stones and biliary tract cancers in previous studies...
  39. pmc Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium
    Joanne W Elena
    Division of Cancer Control and Population Science, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Causes Control 24:13-25. 2013
    ..This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan)...
  40. pmc Genome-wide and candidate gene association study of cigarette smoking behaviors
    Neil Caporaso
    Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland, United States of America
    PLoS ONE 4:e4653. 2009
    ..4x10(-5)), our analysis provides independent replication of the association between the chr15q25.1 region and smoking intensity and data for multiple other loci associated with smoking behavior that merit further follow-up...
  41. pmc Genome-wide association study of circulating retinol levels
    Alison M Mondul
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hum Mol Genet 20:4724-31. 2011
    ..31× 10(-5)). Discovery of common genetic variants associated with serum retinol levels may provide further insight into the contribution of retinol and other vitamin A compounds to the development of cancer and other complex diseases...
  42. pmc Prospective evaluation of serum sarcosine and risk of prostate cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 34:2281-5. 2013
    ..95-1.59, P-interaction = 0.01). This study found that elevated levels of serum sarcosine are associated with an increased prostate cancer risk and evidence to suggest that sarcosine may be an early biomarker for this disease. ..
  43. pmc Genetic variation in the vitamin d pathway in relation to risk of prostate cancer--results from the breast and prostate cancer cohort consortium
    Alison M Mondul
    National Cancer Institute, NIH, 6120 Executive Blvd, Suite 320, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 22:688-96. 2013
    ..We examined prostate cancer risk in relation to single-nucleotide polymorphisms (SNP) in four genes shown to predict circulating levels of 25(OH)D...
  44. pmc Serum 25-hydroxy vitamin D and prostate cancer risk in a large nested case-control study
    Demetrius Albanes
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Suite 320, Bethesda, MD 20982, USA
    Cancer Epidemiol Biomarkers Prev 20:1850-60. 2011
    ..Vitamin D compounds inhibit prostate tumorigenesis experimentally, but epidemiologic data are inconsistent with respect to prostate cancer risk, with some studies suggesting nonsignificant positive associations...
  45. pmc Serum 25-hydroxyvitamin D and risk of lung cancer in male smokers: a nested case-control study
    Stephanie J Weinstein
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e20796. 2011
    ....
  46. pmc A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
    Christian C Abnet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 42:764-7. 2010
    ..19 x 10(-15); OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China...
  47. pmc Large-scale exploration of gene-gene interactions in prostate cancer using a multistage genome-wide association study
    Julia Ciampa
    Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, USA
    Cancer Res 71:3287-95. 2011
    ..Overall, the interactions we have identified merit follow-up study, particularly the EPAS1 interaction, which has implications not only in prostate cancer but also in other epithelial cancers that are associated with the 8q24 locus...
  48. pmc A population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasia
    Mark Schiffman
    Divisions of Cancer Epidemiology and Genetics and Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20852, USA
    Cancer Res 70:3159-69. 2010
    ..Larger viral genomic studies are warranted, especially to identify the genetic basis for HPV16's unique carcinogenicity...
  49. pmc Genetic variants in sex hormone metabolic pathway genes and risk of esophageal squamous cell carcinoma
    Paula L Hyland
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Institutes of Health, Rockville, MA 20852
    Carcinogenesis 34:1062-8. 2013
    ..These positive findings warrant further evaluation in relation to ESCC risk and replication in other populations...
  50. ncbi request reprint Improved correction for population stratification in genome-wide association studies by identifying hidden population structures
    Qizhai Li
    Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland
    Genet Epidemiol 32:215-26. 2008
    ..We show through simulation studies that, compared with the EIGENSTRAT method, the new method requires a smaller number of markers and yields a more appropriate correction for population stratification...
  51. pmc Intra-individual variability over time in serum cytokine levels among participants in the prostate, lung, colorectal, and ovarian cancer screening Trial
    Jonathan N Hofmann
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, United States
    Cytokine 56:145-8. 2011
    ..We assessed the reproducibility of serum cytokine measurements over a five-year period among participants in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO)...
  52. pmc Genome-wide association study identifies common variants associated with circulating vitamin E levels
    Jacqueline M Major
    Division of Cancer Epidemiology and Genetics and Core Genotyping Facility, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Hum Mol Genet 20:3876-83. 2011
    ..In one of the two male GWAS cohorts (n= 992), no SNPs were significantly associated with gamma-tocopherol concentrations after including data from the replication sample for 71 independent SNPs with P< 1 × 10(-4) identified...
  53. doi request reprint Correlation between circadian gene variants and serum levels of sex steroids and insulin-like growth factor-I
    Lisa W Chu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, MSC 7234, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 17:3268-73. 2008
    ..Our findings, although in need of confirmation, suggest that variations in circadian genes are associated with serum hormone levels, providing biological support for the role of circadian genes in hormone-related cancers...
  54. pmc Circulating 25-hydroxyvitamin D and risk of non-hodgkin lymphoma: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
    Mark P Purdue
    National Cancer Institute, Bethesda, Maryland, USA
    Am J Epidemiol 172:58-69. 2010
    ..Future research investigating the biologic basis for the sunlight-NHL association should consider alternative mechanisms, such as immunologic effects...
  55. pmc Serum 25-hydroxyvitamin D and risks of colon and rectal cancer in Finnish men
    Stephanie J Weinstein
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Epidemiol 173:499-508. 2011
    ..These results provide no evidence to support an inverse association between vitamin D status and colon or rectal cancer risk; instead, they suggest a positive association for colon cancer...
  56. pmc Pesticide use modifies the association between genetic variants on chromosome 8q24 and prostate cancer
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland 20852, USA
    Cancer Res 70:9224-33. 2010
    ..This is the first report of effect modification between 8q24 and an environmental exposure on prostate cancer risk...
  57. doi request reprint Nightshift work job exposure matrices and urinary 6-sulfatoxymelatonin levels among healthy Chinese women
    Bu Tian Ji
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Scand J Work Environ Health 38:553-9. 2012
    ..We examined the association between aMT6s levels and shift work estimated by a job exposure matrix (JEM) among healthy participants of the Shanghai Women's Health Study...
  58. pmc Detectable clonal mosaicism and its relationship to aging and cancer
    Kevin B Jacobs
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
    Nat Genet 44:651-8. 2012
    ..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...
  59. ncbi request reprint Robust tests for single-marker analysis in case-control genetic association studies
    Qizhai Li
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Ann Hum Genet 73:245-52. 2009
    ..We found that each test has its own "sweet" spots. Among the three tests considered, MAX appears to have the most robust performance...
  60. doi request reprint Efficient approximation of P-value of the maximum of correlated tests, with applications to genome-wide association studies
    Qizhai Li
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Ann Hum Genet 72:397-406. 2008
    ..We use simulation studies as well as real datasets on 17 confirmed disease-associated SNPs to assess the accuracy of the proposed method. We also apply the method to the GWAS of coronary artery disease...
  61. pmc Statistical inference on the penetrances of rare genetic mutations based on a case-family design
    Hong Zhang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Biostatistics 11:519-32. 2010
    ..The validity of the approach is confirmed by simulation studies. We apply the proposed approach to estimating the age-dependent cancer risk among carriers of the MSH2 or MLH1 mutation...
  62. pmc Individual Variations in Serum Melatonin Levels through Time: Implications for Epidemiologic Studies
    Leticia M Nogueira
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 8:e83208. 2013
    ..Furthermore, our results reiterate the need to record season of sample collection, and individual characteristics in order to maximize study power and prevent confounding. ..
  63. pmc A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    BMC Cancer 11:209. 2011
    ..We evaluated these hypotheses in an OS association study of genes from growth/hormone, bone formation, DNA repair, and ribosomal pathways...
  64. pmc Personal use of hair dye and cancer risk in a prospective cohort of Chinese women
    Julie Bloch Mendelsohn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health, Bethesda, MD, USA
    Cancer Sci 100:1088-91. 2009
    ..We generally found no evidence of an association between personal use of hair dye and cancer risk, although our study is limited by small numbers for certain cancer types...
  65. pmc Leukocyte DNA methylation and colorectal cancer among male smokers
    Ying Gao
    Ying Gao, Kai Yu, Stephanie Weinstein, Margaret Tucker, Philip Taylor, Demetrius Albanes, Neil Caporaso, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, United States
    World J Gastrointest Oncol 4:193-201. 2012
    ..To explore the association between methylation in leukocyte DNA and colorectal cancer (CRC) risk in male smokers using the α-tocopherol, β-carotene cancer prevention study...
  66. pmc Long-term variation in serum 25-hydroxyvitamin D concentration among participants in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
    Jonathan N Hofmann
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8109, Bethesda, MD 20892 7240, USA
    Cancer Epidemiol Biomarkers Prev 19:927-31. 2010
    ..These findings suggest that serum 25(OH)D concentration at a single time point may be a useful biomarker of long-term vitamin D status in population-based studies of various diseases...
  67. pmc Androgen receptor CAG repeat length and risk of biliary tract cancer and stones
    Tamra E Meyer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS Room 5032, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 19:787-93. 2010
    ..Further studies are needed to confirm these findings and clarify the mechanisms involved...
  68. ncbi request reprint Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies
    Kim N Danforth
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Carcinogenesis 29:568-72. 2008
    ....
  69. pmc Serum 25-hydroxyvitamin D and risk of oropharynx and larynx cancers in Finnish men
    Hannah Arem
    Yale School of Public Health, Department ofChronic Disease Epidemiology, New Haven, Connecticut, USA
    Cancer Epidemiol Biomarkers Prev 20:1178-84. 2011
    ..Prolonged darker months in Finland are associated with lower levels of ultraviolet B radiation, raising concerns about low vitamin D levels...
  70. ncbi request reprint Variants in circadian genes and prostate cancer risk: a population-based study in China
    L W Chu
    Cancer Prevention Fellowship Program, Office of Preventive Oncology, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Prostate Cancer Prostatic Dis 11:342-8. 2008
    ..5, 95% CI, 0.3-1.0) as compared to the GG genotype. Our findings, although in need of confirmation, suggest that variations in circadian genes may alter prostate cancer risk and some biological processes may modify this effect...
  71. ncbi request reprint Identification of several human homologs of hamster DNA damage-inducible transcripts. Cloning and characterization of a novel UV-inducible cDNA that codes for a putative RNA-binding protein
    M S Sheikh
    Laboratory of Molecular Pharmacology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:26720-6. 1997
    ..Thus the putative A18 hnRNP is the first hnRNP whose mRNA is specifically regulated in response to UV-induced DNA damage; accordingly, it may play some role in repair of UV-type DNA damage...
  72. ncbi request reprint Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors
    M C Hollander
    Basic Research Laboratory, Division of Basic Science, National Cancer Institute, Bethesda, Maryland 20892, USA
    Int J Cancer 96:22-31. 2001
    ..5. Thus, activation of Gadd34 is a downstream event in apoptotic signaling pathways and may directly contribute to the apoptotic process...
  73. ncbi request reprint Expectancies and other psychosocial factors associated with alcohol use among early adolescent boys and girls
    B Simons-Morton
    National Institutes of Health, Prevention Research Branch, DESPR, NICHD, Bethesda, MD 20892 7510, USA
    Addict Behav 24:229-38. 1999
    ..Alcohol use in our sample of early adolescent boys and girls was better explained by modifiable psychosocial factors such as alcohol expectancies, perceived prevalence, and self-control than by grade...
  74. pmc Diabetes in relation to biliary tract cancer and stones: a population-based study in Shanghai, China
    F M Shebl
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA
    Br J Cancer 103:115-9. 2010
    ..Biliary tract cancers are rare but fatal malignancies. Diabetes has been related to biliary stones, but its association with biliary tract cancers is less conclusive...
  75. ncbi request reprint Psychosocial, school, and parent factors associated with recent smoking among early-adolescent boys and girls
    B Simons-Morton
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Prev Med 28:138-48. 1999
    ..Experimentation with smoking often begins during adolescence, but an adequate understanding of the factors associated with early initiation remains elusive...
  76. pmc Increased levels of circulating cytokines with HIV-related immunosuppression
    Fatma M Shebl
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    AIDS Res Hum Retroviruses 28:809-15. 2012
    ..0001]. CD4 deficiency is associated with generalized increases in cytokines of various functions. Racial differences in cytokine response to HIV infection could contribute to disparities in disease progression...
  77. pmc Cigarette smoking and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium
    Shannon M Lynch
    National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA
    Am J Epidemiol 170:403-13. 2009
    ..This finding and the decline in risk after smoking cessation suggest that smoking has a late-stage effect on pancreatic carcinogenesis...
  78. pmc An evaluation of the natural history of bacterial vaginosis using transition models
    Katherine Leanne Sanders
    Department of Statistics, The Ohio State University, Columbus, OH, USA
    Sex Transm Dis 38:1131-6. 2011
    ..The natural history of bacterial vaginosis (BV) is complex given the variability across and within women over time. This article considers 3 different transition models for analyzing longitudinal BV data...
  79. pmc Inside the black box: starting to uncover the underlying decision rules used in a one-by-one expert assessment of occupational exposure in case-control studies
    David C Wheeler
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Occup Environ Med 70:203-10. 2013
    ..We aimed to identify the underlying rules to enable documentation, review and future use of these expert-based exposure decisions...
  80. ncbi request reprint Circulating angiogenic factors and placental abruption
    Caroline Signore
    Epidemiology Branch and the Biometry and Mathematical Statistics Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Obstet Gynecol 108:338-44. 2006
    ..Our objective was to determine whether circulating angiogenic factors are altered in another placental vascular disease, abruptio placentae...
  81. ncbi request reprint A haplotype similarity based transmission/disequilibrium test under founder heterogeneity
    Kai Yu
    Division of Biostatistics, School of Medicine, Washington University, 660 S Euclid, Campus Box 8067, St Louis, MO 63110, USA
    Ann Hum Genet 69:455-67. 2005
    ..Finally, we apply the proposed method to study the association of the leptin gene with obesity from the National Heart, Lung, and Blood Institute Family Heart Study...
  82. ncbi request reprint Using tree-based recursive partitioning methods to group haplotypes for increased power in association studies
    Kai Yu
    Division of Biostatistics, School of Medicine, Washington University, St Louis, MO 63110, USA
    Ann Hum Genet 69:577-89. 2005
    ..Simulation studies suggest that the proposed method has the right type I error rate, and is more powerful than some existing haplotype-based tests...
  83. ncbi request reprint Measuring marker information content by the ambiguity of block boundaries observed in dense SNP data
    C Charles Gu
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Hum Genet 71:127-40. 2007
    ..This approach can quantify the information content of individual markers in the context of highly dense SNP data, which may have important implications in designing efficient genome-wide association mapping projects...
  84. ncbi request reprint A partially linear tree-based regression model for assessing complex joint gene-gene and gene-environment effects
    Jinbo Chen
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genet Epidemiol 31:238-51. 2007
    ..The proposed model is also useful for exploring gene-environment interactions and has broad implications for applying the tree methodology to genetic epidemiology research...
  85. pmc A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
    David J Hunter
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 39:870-4. 2007
    ..Our summary results from the GWAS are available online in a form that should speed the identification of additional risk loci...
  86. ncbi request reprint Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
    Meredith Yeager
    SAIC Frederick, National Cancer Institute NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Nat Genet 39:645-9. 2007
    ..We estimate that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked by rs1447295 (21% versus 9%)...
  87. ncbi request reprint Power and sample size for clinical trials when efficacy is required in multiple endpoints: application to an Alzheimer's treatment trial
    Chengjie Xiong
    Division of Biostatistics, Washington University in St Louis, MO 63110, USA
    Clin Trials 2:387-93. 2005
    ..When the efficacy of a treatment in a randomized controlled trial is required for multiple primary endpoints, trial design and analysis differ from trial requiring efficacy in only one of the multiple endpoints...
  88. ncbi request reprint Characterization of the major histocompatibility complex class II DQB (MhcMamu-DQB1) alleles in a cohort of Chinese rhesus macaques (Macaca mulatta)
    Chen Li Qiu
    State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS STD Control and Prevention, Beijing 100050, People s Republic of China
    Hum Immunol 69:513-21. 2008
    ....
  89. doi request reprint Characterization of LD structures and the utility of HapMap in genetic association studies
    C Charles Gu
    Division of Biostatistics and Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Adv Genet 60:407-35. 2008
    ....
  90. ncbi request reprint A parametric comparison of diagnostic accuracy with three ordinal diagnostic groups
    Chengjie Xiong
    Division of Biostatistics, Washington University in St Louis, St Louis, MO 63110, USA
    Biom J 49:682-93. 2007
    ..Finally, we apply our proposed methodology to a real data set of 118 subjects to compare the diagnostic accuracy of early stage Alzheimer's disease (AD) from multiple neuropsychological tests...
  91. ncbi request reprint Karyotyping of comparative genomic hybridization human metaphases using kernel nearest-neighbor algorithm
    Kai Yu
    State Key Laboratory of Intelligent Technology and Systems, Department of Automation, Tsinghua University, Beijing, People s Republic of China
    Cytometry 48:202-8. 2002
    ..In the past, computer-aided karyotyping was done by using the 4',6-diamidino-2-phenylindole, dihydrochloride (DAPI)-inverse images, which required complex image enhancement procedures...
  92. ncbi request reprint Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse
    Yingli Wang
    Institute of Genetic Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Development 132:3537-48. 2005
    ..Our results suggest that altered cartilage and bone development play a significant role in the pathogenesis of the Apert syndrome phenotype...
  93. ncbi request reprint Toxicogenomics strategies for predicting drug toxicity
    Rory Martin
    Millennium Pharmaceuticals, Cambridge, MA 02139, USA
    Pharmacogenomics 7:1003-16. 2006
    ....
  94. ncbi request reprint Global transmission/disequilibrium tests based on haplotype sharing in multiple candidate genes
    Kai Yu
    Division of Statistical Genomics, Department of Genetics Washington University, School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 29:323-35. 2005
    ..Compared with the gene-by-gene test, the new global tests appear to be more powerful in situations where all candidate genes are associated with the disease...
  95. ncbi request reprint Assessing performance of prediction rules in machine learning
    Rory Martin
    Millennium Pharmaceuticals, Cambridge MA 02139, USA
    Pharmacogenomics 7:543-50. 2006
    ..This study illustrates and compares different methods for estimating true error with the aim of providing practical guidance to users of machine learning techniques...
  96. ncbi request reprint Methods for analyzing the spatial distribution of chiasmata during meiosis based on recombination data
    Kai Yu
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Biometrics 58:369-77. 2002
    ..We apply our improved methods to reanalyze a dataset from the literature studying the association between crossover location and meiotic nondisjunction of chromosome 21...