Matthew R Young

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. pmc Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion
    M R Young
    Basic Research Laboratory, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 96:9827-32. 1999
  2. pmc Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently
    Matthew R Young
    Basic Research Laboratory, National Cancer Institute Frederick Intramural Research Support Program, Science Applications International Corporation Frederick, Frederick, Maryland 21702, USA
    Mol Cell Biol 22:587-98. 2002
  3. pmc Monitoring of tumor promotion and progression in a mouse model of inflammation-induced colon cancer with magnetic resonance colonography
    Matthew R Young
    Laboratory of Cancer Prevention, National Cancer Institute, Frederick, MD 21702, USA
    Neoplasia 11:237-46, 1p following 246. 2009
  4. ncbi request reprint Promising molecular targets for cancer prevention: AP-1, NF-kappa B and Pdcd4
    Matthew R Young
    The Gene Regulation Section, Basic Research Laboratory, National Cancer Institute Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Trends Mol Med 9:36-41. 2003
  5. ncbi request reprint Fra-1 a target for cancer prevention or intervention
    Matthew R Young
    Laboratory of Cancer Prevention, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Gene 379:1-11. 2006
  6. pmc Inflammation-associated serum and colon markers as indicators of dietary attenuation of colon carcinogenesis in ob/ob mice
    Roycelynn A Mentor-Marcel
    Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute Frederick, 1050 Boyles Street, Frederick, MD 21702, USA
    Cancer Prev Res (Phila) 2:60-9. 2009
  7. pmc Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin
    Shakir M Saud
    Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, Corvallis, Oregon, USA
    Cancer Res 73:5473-84. 2013
  8. pmc A selective small-molecule nuclear factor-kappaB inhibitor from a high-throughput cell-based assay for "activator protein-1 hits"
    Moon Il Kang
    Laboratory of Cancer Prevention, Gene Regulation Section, Molecular Targets Development Program, National Cancer Institute Frederick, Room 187, Building 567, Frederick, MD 21702, USA
    Mol Cancer Ther 8:571-81. 2009
  9. ncbi request reprint Dominant-negative activator protein 1 (TAM67) targets cyclooxygenase-2 and osteopontin under conditions in which it specifically inhibits tumorigenesis
    Connie P Matthews
    Laboratory of Cancer Prevention, National Cancer Institute, Frederick, Maryland 21702, USA
    Cancer Res 67:2430-8. 2007
  10. pmc Loss of sulfiredoxin renders mice resistant to azoxymethane/dextran sulfate sodium-induced colon carcinogenesis
    Qiou Wei
    Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Carcinogenesis 34:1403-10. 2013

Collaborators

Detail Information

Publications25

  1. pmc Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion
    M R Young
    Basic Research Laboratory, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 96:9827-32. 1999
    ..We conclude that transactivation of a subset of AP-1-dependent genes is required for tumor promotion and may be targeted for cancer prevention...
  2. pmc Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently
    Matthew R Young
    Basic Research Laboratory, National Cancer Institute Frederick Intramural Research Support Program, Science Applications International Corporation Frederick, Frederick, Maryland 21702, USA
    Mol Cell Biol 22:587-98. 2002
    ..These observations suggest that ERK-dependent activation of Fra-1 is required for AP-1 transactivation in JB6 cells...
  3. pmc Monitoring of tumor promotion and progression in a mouse model of inflammation-induced colon cancer with magnetic resonance colonography
    Matthew R Young
    Laboratory of Cancer Prevention, National Cancer Institute, Frederick, MD 21702, USA
    Neoplasia 11:237-46, 1p following 246. 2009
    ....
  4. ncbi request reprint Promising molecular targets for cancer prevention: AP-1, NF-kappa B and Pdcd4
    Matthew R Young
    The Gene Regulation Section, Basic Research Laboratory, National Cancer Institute Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Trends Mol Med 9:36-41. 2003
    ..A protein known as programmed-cell-death-4 is a new potential molecular target that has a surprising mode of action...
  5. ncbi request reprint Fra-1 a target for cancer prevention or intervention
    Matthew R Young
    Laboratory of Cancer Prevention, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Gene 379:1-11. 2006
    ..This review focuses on the regulation of fosl1 expression, stabilization and activation of the Fra-1 polypeptide and on Fra-1-mediated tumorigenesis...
  6. pmc Inflammation-associated serum and colon markers as indicators of dietary attenuation of colon carcinogenesis in ob/ob mice
    Roycelynn A Mentor-Marcel
    Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute Frederick, 1050 Boyles Street, Frederick, MD 21702, USA
    Cancer Prev Res (Phila) 2:60-9. 2009
    ..Changes in a subset of inflammation-associated serum proteins and colon gene expression may serve as response indicators of dietary attenuation of colon carcinogenesis...
  7. pmc Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin
    Shakir M Saud
    Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, Corvallis, Oregon, USA
    Cancer Res 73:5473-84. 2013
    ....
  8. pmc A selective small-molecule nuclear factor-kappaB inhibitor from a high-throughput cell-based assay for "activator protein-1 hits"
    Moon Il Kang
    Laboratory of Cancer Prevention, Gene Regulation Section, Molecular Targets Development Program, National Cancer Institute Frederick, Room 187, Building 567, Frederick, MD 21702, USA
    Mol Cancer Ther 8:571-81. 2009
    ..These results suggest that NSC 676914 could be a novel inhibitor having potential therapeutic activity to target NF-kappaB for cancer treatment or prevention...
  9. ncbi request reprint Dominant-negative activator protein 1 (TAM67) targets cyclooxygenase-2 and osteopontin under conditions in which it specifically inhibits tumorigenesis
    Connie P Matthews
    Laboratory of Cancer Prevention, National Cancer Institute, Frederick, Maryland 21702, USA
    Cancer Res 67:2430-8. 2007
    ..Results identify both Cox-2 and Opn as transcriptional targets of TAM67 with CRE, but not NFkappaB sites important in the Cox-2 promoter and an AP-1 site important in the Opn promoter...
  10. pmc Loss of sulfiredoxin renders mice resistant to azoxymethane/dextran sulfate sodium-induced colon carcinogenesis
    Qiou Wei
    Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Carcinogenesis 34:1403-10. 2013
    ....
  11. doi request reprint Fluorescence endoscopic detection of murine colitis-associated colon cancer by topically applied enzymatically rapid-activatable probe
    Makoto Mitsunaga
    Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room B3B69, MSC1088, Bethesda, MD 20892 1088, USA
    Gut 62:1179-86. 2013
    ....
  12. pmc Bioactive food components, inflammatory targets, and cancer prevention
    Young S Kim
    Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD, USA
    Cancer Prev Res (Phila) 2:200-8. 2009
    ..Unquestionably, the societal benefits of using foods and their components to prevent chronic inflammation and associated complications, including cancer, are enormous...
  13. ncbi request reprint AP-1 a target for cancer prevention
    Connie P Matthews
    Laboratory of Cancer Prevention, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    Curr Cancer Drug Targets 7:317-24. 2007
    ..AP-1 is a recognized molecular target of many antioxidant and anti-inflammatory chemopreventive compounds. This review focuses on the AP-1 family proteins as targets for chemoprevention...
  14. pmc Do interleukin polymorphisms play a role in the prevention of colorectal adenoma recurrence by dietary flavonols?
    Gerd Bobe
    Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Eur J Cancer Prev 20:86-95. 2011
    ..In conclusion, our results suggest that IL SNPs, in combination with a flavonol-rich diet or decreased serum IL, may lower the risk of adenoma recurrence...
  15. pmc Dietary cooked navy beans and their fractions attenuate colon carcinogenesis in azoxymethane-induced ob/ob mice
    Gerd Bobe
    Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    Nutr Cancer 60:373-81. 2008
    ..04; bean residue 67%, P=0.01; bean extract 87%, P=0.0003. These results suggest that both the soluble and the insoluble fraction of the extract contribute to the cancer-protective effect of cooked navy beans...
  16. ncbi request reprint Lights on for low oxygen: a noninvasive mouse model useful for sensing oxygen deficiency
    Tobias Schmid
    Laboratory of Cancer Prevention, National Cancer Institute Frederick, Maryland 21702, USA
    Mol Interv 6:20-2, 2. 2006
    ..Implicit is the adaptability of this model, wherein other promoters (e.g., tissue-specific) can be utilized or other disease models can be studied...
  17. pmc Targeting of Noncanonical Wnt5a Signaling by AP-1 Blocker Dominant-Negative Jun When It Inhibits Skin Carcinogenesis
    Moon Il Kang
    Laboratory of Cancer Prevention, National Cancer Institute, Frederick, MD, USA
    Genes Cancer 3:37-50. 2012
    ..Coordinate overactivation of Wnt5a expression and STAT3 signaling is observed in human skin and colon cancers as well as glioblastoma...
  18. ncbi request reprint A high-throughput cell-based assay to identify specific inhibitors of transcription factor AP-1
    Katie M Ruocco
    Laboratory of Cancer Prevention, Gene Regulation Section, National Cancer Institute Frederick, Frederick, MD, USA
    J Biomol Screen 12:133-9. 2007
    ..Screening of synthetic compounds and natural products should identify novel AP-1 inhibitors that may be useful in the prevention and treatment of cancers...
  19. ncbi request reprint Protection against human papillomavirus type 16-E7 oncogene-induced tumorigenesis by in vivo expression of dominant-negative c-jun
    Matthew R Young
    Basic Research Laboratory, National Institute of Cancer Frederick, Maryland, USA
    Mol Carcinog 34:72-7. 2002
    ..We showed that expression of TAM67 protected mice from HPV-16 E7-enhanced tumorigenesis, suggesting AP-1 as a target for prevention of HPV-induced cancer...
  20. pmc Epigenetic regulation of SOX9 by the NF-κB signaling pathway in pancreatic cancer stem cells
    Lei Sun
    Cancer Stem Cell Section, Laboratory of Cancer Prevention, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA
    Stem Cells 31:1454-66. 2013
    ....
  21. pmc Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling
    Qiou Wei
    Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 108:7004-9. 2011
    ..Our work reveals that the Srx-Prx IV axis is critical for lung cancer maintenance and metastasis, suggesting that targeting the Srx-Prx IV axis may provide unique effective strategies for cancer prevention and treatment...
  22. pmc Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities
    Dehui Duan
    Laboratory of Medicinal Chemistry, National Cancer Institute at Frederick, National Institutes of Health, 376 Boyles Street, Frederick, Maryland 21702, USA
    J Med Chem 51:5198-220. 2008
    ..Multiple cellular bioassays show that DAG-lactones, which bind in vitro to PKCalpha to varying degrees, expand their biological repertoire into a larger domain, eliciting distinct cellular responses...
  23. ncbi request reprint A dominant negative c-jun specifically blocks okadaic acid-induced skin tumor promotion
    Eric J Thompson
    Department of Pharmacology and Toxicology, The University of Arizona, Tucson, AZ 85724, USA
    Cancer Res 62:3044-7. 2002
    ..A determination of the mechanism by which TAM-67 can block tumor promotion without affecting hyperplasia will be important...
  24. ncbi request reprint Expression of dominant negative c-jun inhibits ultraviolet B-induced squamous cell carcinoma number and size in an SKH-1 hairless mouse model
    Simon J Cooper
    Department of Radiation Oncology, Arizona Cancer Center, College of Public Health, The University of Arizona, Tucson, AZ, USA
    Mol Cancer Res 1:848-54. 2003
    ..These data show that TAM67 can inhibit UVB-induced squamous cell carcinoma formation, suggesting that AP-1 is a good candidate target for the development of new chemoprevention strategies to prevent sunlight-induced skin cancers...
  25. ncbi request reprint The AP-1 transcription factor regulates postnatal mammary gland development
    Qiang Shen
    Breast Center, Baylor College of Medicine, MS600, 1 Baylor Plaza, Houston, TX 77030, USA
    Dev Biol 295:589-603. 2006
    ..We therefore conclude that AP-1 factor is a pivotal regulator of postnatal mammary gland growth and development...