Matthew R Young
Affiliation: National Cancer Institute
- Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotionM R Young
Basic Research Laboratory, National Cancer Institute, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 96:9827-32. 1999..We conclude that transactivation of a subset of AP-1-dependent genes is required for tumor promotion and may be targeted for cancer prevention...
- Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependentlyMatthew R Young
Basic Research Laboratory, National Cancer Institute Frederick Intramural Research Support Program, Science Applications International Corporation Frederick, Frederick, Maryland 21702, USA
Mol Cell Biol 22:587-98. 2002..These observations suggest that ERK-dependent activation of Fra-1 is required for AP-1 transactivation in JB6 cells...
- Monitoring of tumor promotion and progression in a mouse model of inflammation-induced colon cancer with magnetic resonance colonographyMatthew R Young
Laboratory of Cancer Prevention, National Cancer Institute, Frederick, MD 21702, USA
Neoplasia 11:237-46, 1p following 246. 2009....
- Promising molecular targets for cancer prevention: AP-1, NF-kappa B and Pdcd4Matthew R Young
The Gene Regulation Section, Basic Research Laboratory, National Cancer Institute Frederick, National Institutes of Health, Frederick, MD 21702, USA
Trends Mol Med 9:36-41. 2003..A protein known as programmed-cell-death-4 is a new potential molecular target that has a surprising mode of action...
- Fra-1 a target for cancer prevention or interventionMatthew R Young
Laboratory of Cancer Prevention, National Cancer Institute Frederick, Frederick, MD 21702, USA
Gene 379:1-11. 2006..This review focuses on the regulation of fosl1 expression, stabilization and activation of the Fra-1 polypeptide and on Fra-1-mediated tumorigenesis...
- Inflammation-associated serum and colon markers as indicators of dietary attenuation of colon carcinogenesis in ob/ob miceRoycelynn A Mentor-Marcel
Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute Frederick, 1050 Boyles Street, Frederick, MD 21702, USA
Cancer Prev Res (Phila) 2:60-9. 2009..Changes in a subset of inflammation-associated serum proteins and colon gene expression may serve as response indicators of dietary attenuation of colon carcinogenesis...
- A selective small-molecule nuclear factor-kappaB inhibitor from a high-throughput cell-based assay for "activator protein-1 hits"Moon Il Kang
Laboratory of Cancer Prevention, Gene Regulation Section, Molecular Targets Development Program, National Cancer Institute Frederick, Room 187, Building 567, Frederick, MD 21702, USA
Mol Cancer Ther 8:571-81. 2009..These results suggest that NSC 676914 could be a novel inhibitor having potential therapeutic activity to target NF-kappaB for cancer treatment or prevention...
- Dominant-negative activator protein 1 (TAM67) targets cyclooxygenase-2 and osteopontin under conditions in which it specifically inhibits tumorigenesisConnie P Matthews
Laboratory of Cancer Prevention, National Cancer Institute, Frederick, Maryland 21702, USA
Cancer Res 67:2430-8. 2007..Results identify both Cox-2 and Opn as transcriptional targets of TAM67 with CRE, but not NFkappaB sites important in the Cox-2 promoter and an AP-1 site important in the Opn promoter...
- Bioactive food components, inflammatory targets, and cancer preventionYoung S Kim
Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD, USA
Cancer Prev Res (Phila) 2:200-8. 2009..Unquestionably, the societal benefits of using foods and their components to prevent chronic inflammation and associated complications, including cancer, are enormous...
- Do interleukin polymorphisms play a role in the prevention of colorectal adenoma recurrence by dietary flavonols?Gerd Bobe
Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Eur J Cancer Prev 20:86-95. 2011..In conclusion, our results suggest that IL SNPs, in combination with a flavonol-rich diet or decreased serum IL, may lower the risk of adenoma recurrence...
- AP-1 a target for cancer preventionConnie P Matthews
Laboratory of Cancer Prevention, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
Curr Cancer Drug Targets 7:317-24. 2007..AP-1 is a recognized molecular target of many antioxidant and anti-inflammatory chemopreventive compounds. This review focuses on the AP-1 family proteins as targets for chemoprevention...
- Dietary cooked navy beans and their fractions attenuate colon carcinogenesis in azoxymethane-induced ob/ob miceGerd Bobe
Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
Nutr Cancer 60:373-81. 2008..04; bean residue 67%, P=0.01; bean extract 87%, P=0.0003. These results suggest that both the soluble and the insoluble fraction of the extract contribute to the cancer-protective effect of cooked navy beans...
- Lights on for low oxygen: a noninvasive mouse model useful for sensing oxygen deficiencyTobias Schmid
Laboratory of Cancer Prevention, National Cancer Institute Frederick, Maryland 21702, USA
Mol Interv 6:20-2, 2. 2006..Implicit is the adaptability of this model, wherein other promoters (e.g., tissue-specific) can be utilized or other disease models can be studied...
- Targeting of Noncanonical Wnt5a Signaling by AP-1 Blocker Dominant-Negative Jun When It Inhibits Skin CarcinogenesisMoon Il Kang
Laboratory of Cancer Prevention, National Cancer Institute, Frederick, MD, USA
Genes Cancer 3:37-50. 2012..Coordinate overactivation of Wnt5a expression and STAT3 signaling is observed in human skin and colon cancers as well as glioblastoma...
- Protection against human papillomavirus type 16-E7 oncogene-induced tumorigenesis by in vivo expression of dominant-negative c-junMatthew R Young
Basic Research Laboratory, National Institute of Cancer-Frederick, Maryland, USA
Mol Carcinog 34:72-7. 2002..We showed that expression of TAM67 protected mice from HPV-16 E7-enhanced tumorigenesis, suggesting AP-1 as a target for prevention of HPV-induced cancer...
- A high-throughput cell-based assay to identify specific inhibitors of transcription factor AP-1Katie M Ruocco
Laboratory of Cancer Prevention, Gene Regulation Section, National Cancer Institute Frederick, Frederick, MD, USA
J Biomol Screen 12:133-9. 2007..Screening of synthetic compounds and natural products should identify novel AP-1 inhibitors that may be useful in the prevention and treatment of cancers...
- Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signalingQiou Wei
Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 108:7004-9. 2011..Our work reveals that the Srx-Prx IV axis is critical for lung cancer maintenance and metastasis, suggesting that targeting the Srx-Prx IV axis may provide unique effective strategies for cancer prevention and treatment...
- Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activitiesDehui Duan
Laboratory of Medicinal Chemistry, National Cancer Institute at Frederick, National Institutes of Health, 376 Boyles Street, Frederick, Maryland 21702, USA
J Med Chem 51:5198-220. 2008..Multiple cellular bioassays show that DAG-lactones, which bind in vitro to PKCalpha to varying degrees, expand their biological repertoire into a larger domain, eliciting distinct cellular responses...
- A dominant negative c-jun specifically blocks okadaic acid-induced skin tumor promotionEric J Thompson
Department of Pharmacology and Toxicology, The University of Arizona, Tucson, AZ 85724, USA
Cancer Res 62:3044-7. 2002..A determination of the mechanism by which TAM-67 can block tumor promotion without affecting hyperplasia will be important...
- Expression of dominant negative c-jun inhibits ultraviolet B-induced squamous cell carcinoma number and size in an SKH-1 hairless mouse modelSimon J Cooper
Department of Radiation Oncology, Arizona Cancer Center, College of Public Health, The University of Arizona, Tucson, AZ, USA
Mol Cancer Res 1:848-54. 2003..These data show that TAM67 can inhibit UVB-induced squamous cell carcinoma formation, suggesting that AP-1 is a good candidate target for the development of new chemoprevention strategies to prevent sunlight-induced skin cancers...
- The AP-1 transcription factor regulates postnatal mammary gland developmentQiang Shen
Breast Center, Baylor College of Medicine, MS600, 1 Baylor Plaza, Houston, TX 77030, USA
Dev Biol 295:589-603. 2006..We therefore conclude that AP-1 factor is a pivotal regulator of postnatal mammary gland growth and development...