Jonathan W Yewdell

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Youth has its privileges: maturation inhibits DC cross-priming
    Heather D Hickman-Miller
    Nat Immunol 7:125-6. 2006
  2. ncbi request reprint Understanding presentation of viral antigens to CD8+ T cells in vivo: the key to rational vaccine design
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0440, USA
    Annu Rev Immunol 23:651-82. 2005
  3. ncbi request reprint Quantitating defective ribosome products
    Shu Bing Qian
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 301:271-81. 2005
  4. ncbi request reprint The seven dirty little secrets of major histocompatibility complex class I antigen processing
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Immunol Rev 207:8-18. 2005
  5. pmc Influenza A virus hemagglutinin antibody escape promotes neuraminidase antigenic variation and drug resistance
    Scott E Hensley
    Laboratory of Viral Diseases, Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e15190. 2011
  6. pmc Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors
    Luis C Anton
    1 NIAID, NIH, Bldg 33, Bethesda, MD 20892, USA
    J Leukoc Biol 95:551-62. 2014
  7. pmc To dream the impossible dream: universal influenza vaccination
    Jonathan W Yewdell
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, United States
    Curr Opin Virol 3:316-21. 2013
  8. pmc Back to the fold: T cell recognition of HFE, a MHC class Ib molecule that regulates iron metabolism
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Proc Natl Acad Sci U S A 102:12649-50. 2005
  9. ncbi request reprint The DRiP hypothesis decennial: support, controversy, refinement and extension
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Trends Immunol 27:368-73. 2006
  10. pmc How to succeed in science: a concise guide for young biomedical scientists. Part I: taking the plunge
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 9:413-6. 2008

Detail Information

Publications95

  1. ncbi request reprint Youth has its privileges: maturation inhibits DC cross-priming
    Heather D Hickman-Miller
    Nat Immunol 7:125-6. 2006
  2. ncbi request reprint Understanding presentation of viral antigens to CD8+ T cells in vivo: the key to rational vaccine design
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0440, USA
    Annu Rev Immunol 23:651-82. 2005
    ..These studies point the way to detailed understanding and provide some key information for vaccine development, although much remains to be learned to enable truly rational vaccine design...
  3. ncbi request reprint Quantitating defective ribosome products
    Shu Bing Qian
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 301:271-81. 2005
    ..Protein degradation kinetics can be determined by either acid precipitation or SDS-PAGE. The introduction of proteasome inhibitors enables quantitation of proteasome-mediated protein degradation in vivo...
  4. ncbi request reprint The seven dirty little secrets of major histocompatibility complex class I antigen processing
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Immunol Rev 207:8-18. 2005
    ..Here, I discuss some of the DLSs of major histocompatibility complex class I antigen processing...
  5. pmc Influenza A virus hemagglutinin antibody escape promotes neuraminidase antigenic variation and drug resistance
    Scott E Hensley
    Laboratory of Viral Diseases, Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e15190. 2011
    ..These findings indicate that influenza A virus resistance to NA inhibitors can potentially arise from antibody driven HA escape, confounding analysis of influenza NA evolution in nature...
  6. pmc Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors
    Luis C Anton
    1 NIAID, NIH, Bldg 33, Bethesda, MD 20892, USA
    J Leukoc Biol 95:551-62. 2014
    ....
  7. pmc To dream the impossible dream: universal influenza vaccination
    Jonathan W Yewdell
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, United States
    Curr Opin Virol 3:316-21. 2013
    ....
  8. pmc Back to the fold: T cell recognition of HFE, a MHC class Ib molecule that regulates iron metabolism
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Proc Natl Acad Sci U S A 102:12649-50. 2005
  9. ncbi request reprint The DRiP hypothesis decennial: support, controversy, refinement and extension
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Trends Immunol 27:368-73. 2006
    ..Here, we consider findings that address the DRiP hypothesis, and extend the hypothesis by proposing that cells possess specialized machinery, possibly in the form of "immunoribosomes", to couple protein synthesis to antigen presentation...
  10. pmc How to succeed in science: a concise guide for young biomedical scientists. Part I: taking the plunge
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 9:413-6. 2008
    ..Although my advice is geared towards succeeding in the United States, many aspects apply to other countries...
  11. pmc How to succeed in science: a concise guide for young biomedical scientists. Part II: making discoveries
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 9:491-4. 2008
    ..Here, I provide practical advice to young scientists on choosing a research topic, designing, performing and interpreting experiments and, last but not least, on maintaining your sanity in the process...
  12. pmc Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent
    Avital Lev
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 183:4205-10. 2009
    ..In demonstrating the dispensability of GRP94, our finding points to the importance of alternative mechanisms for generation of class I peptide complexes from endogenous and exogenous Ags and immunogens...
  13. ncbi request reprint Tight linkage between translation and MHC class I peptide ligand generation implies specialized antigen processing for defective ribosomal products
    Shu Bing Qian
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 177:227-33. 2006
    ..We propose that specialized machinery exists to link protein synthesis with class I peptide ligand generation to enable the rapid detection of viral gene expression...
  14. ncbi request reprint CD8+ T cell cross-priming via transfer of proteasome substrates
    Christopher C Norbury
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892 0440, USA
    Science 304:1318-21. 2004
    ..We show here that cross-priming is based on the transfer of proteasome substrates rather than peptides. These findings are potentially important for the rational design of vaccines that elicit CD8+ T cell responses...
  15. pmc Unexpected role for the immunoproteasome subunit LMP2 in antiviral humoral and innate immune responses
    Scott E Hensley
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:4115-22. 2010
    ..These findings demonstrate an important role for immunoproteasomes in immune cell function beyond their contribution to Ag processing...
  16. ncbi request reprint CD8 alpha alpha-mediated intraepithelial lymphocyte snatching of thymic leukemia MHC class Ib molecules in vitro and in vivo
    Nathalie Pardigon
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 177:1590-8. 2006
    ..Induction of bowel inflammation results in the presence of TL on IELs, probably via in vivo snatching, providing the initial evidence for the interaction of CD8alphaalpha IELs with intestinal cells...
  17. pmc Defective ribosomal products are the major source of antigenic peptides endogenously generated from influenza A virus neuraminidase
    Brian P Dolan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:1419-24. 2010
    ..These observations extend the relevance of the DRiP hypothesis to viral proteins generated in their natural context...
  18. pmc RNA polymerase II inhibitors dissociate antigenic peptide generation from normal viral protein synthesis: a role for nuclear translation in defective ribosomal product synthesis?
    Brian P Dolan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 185:6728-33. 2010
    ..These data support the idea that Ag processing uses compartmentalized translation, perhaps even in the nucleus itself, to increase the efficiency of the generation of class I peptide ligands...
  19. ncbi request reprint Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes
    Heather D Hickman
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nat Immunol 9:155-65. 2008
    ..Thus, antigen presentation at the lymph node periphery, not at lymphocyte exit sites in deeper lymph node venules, as dogma dictates, has a dominant function in antiviral CD8+ T cell activation...
  20. pmc Fitness costs limit influenza A virus hemagglutinin glycosylation as an immune evasion strategy
    Suman R Das
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:E1417-22. 2011
    ..These findings show that, although N-linked glycosylation can broadly diminish HA antigenicity, fitness costs restrict its deployment in immune evasion...
  21. pmc Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action
    Avital Lev
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:6964-9. 2010
    ..This provides an explanation for the exquisite ability of T cells to recognize peptides generated from otherwise undetected gene products...
  22. pmc Hemagglutinin receptor binding avidity drives influenza A virus antigenic drift
    Scott E Hensley
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Science 326:734-6. 2009
    ....
  23. pmc Heat-aggregated noninfectious influenza virus induces a more balanced CD8(+)-T-lymphocyte immunodominance hierarchy than infectious virus
    Yunjung Cho
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:4679-84. 2003
    ..Furthermore, they demonstrate that the form of antigen administered can influence immunodominance hierarchies and that exogenous-antigen vaccines can induce broad and balanced T(CD8+) responses...
  24. ncbi request reprint Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities
    S M Mansour Haeryfar
    Laboratory of Viral Diseases, National Institute of Allergies and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:3344-51. 2005
    ..Therefore, Treg influence TCD8 immunodominance hierarchies by moderating disparities in responses to different determinants...
  25. pmc Terminal deoxynucleotidyl transferase establishes and broadens antiviral CD8+ T cell immunodominance hierarchies
    S M Mansour Haeryfar
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:649-59. 2008
    ....
  26. pmc Poxvirus CD8+ T-cell determinants and cross-reactivity in BALB/c mice
    David C Tscharke
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, USA
    J Virol 80:6318-23. 2006
    ..We then use these determinants to test if predicted conservation across orthopoxvirus species matches experimental observation and find an unexpectedly cross-reactive variant peptide encoded by ectromelia (mousepox) virus...
  27. pmc Cutting edge: Sympathetic nervous system increases proinflammatory cytokines and exacerbates influenza A virus pathogenesis
    Kristie M Grebe
    Laboratories of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:540-4. 2010
    ..These findings demonstrate an unexpected role for the sympathetic nervous system in innate antiviral immunity and in exacerbating the pathology of a virus of great significance to human and animal health...
  28. pmc Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines
    David C Tscharke
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 201:95-104. 2005
    ..These findings have important implications for understanding poxvirus immunity in animal models and bench-marking immune responses to poxvirus vaccines in humans...
  29. ncbi request reprint Quantitating protein synthesis, degradation, and endogenous antigen processing
    Michael F Princiotta
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Immunity 18:343-54. 2003
    ....
  30. pmc Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin
    Heather D Hickman
    Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Host Microbe 13:155-68. 2013
    ..These findings highlight previously unappreciated differences in the anatomic specialization of antiviral immune cell subsets...
  31. pmc Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters
    Xiuju Lu
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:15407-12. 2012
    ..We propose that endogenous processing generates peptide-specific clusters of class I molecules to maximize the sensitivity and speed of T-cell immunosurveillance...
  32. pmc Distinct pathways generate peptides from defective ribosomal products for CD8+ T cell immunosurveillance
    Brian P Dolan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 186:2065-72. 2011
    ....
  33. ncbi request reprint Characterization of rapidly degraded polypeptides in mammalian cells reveals a novel layer of nascent protein quality control
    Shu Bing Qian
    Laboratory of Viral Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0440, USA
    J Biol Chem 281:392-400. 2006
    ..The dichotomy in the behavior of RDPs points to a novel quality control level for nascent proteins that is independent of the well established Hsc70-ubiquitin 26 S proteasome pathway...
  34. pmc Quantitating T cell cross-reactivity for unrelated peptide antigens
    Jeffrey Ishizuka
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda MD 20892, USA
    J Immunol 183:4337-45. 2009
    ....
  35. pmc Defining influenza A virus hemagglutinin antigenic drift by sequential monoclonal antibody selection
    Suman R Das
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Cell Host Microbe 13:314-23. 2013
    ..Since each hemagglutinin mutation potentially sculpts future mutation space, drift can follow many stochastic paths, undermining its unpredictability and underscoring the need for drift-insensitive vaccines...
  36. pmc Influenza A virus hemagglutinin trimerization completes monomer folding and antigenicity
    Javier G Magadán
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 87:9742-53. 2013
    ..Once this conformational change occurs, HA trimers themselves would not necessarily be required to induce a highly diverse neutralizing response to epitopes in the globular domain. ..
  37. pmc Vaccinia and influenza A viruses select rather than adjust tRNAs to optimize translation
    Mariana Pavon-Eternod
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Nucleic Acids Res 41:1914-21. 2013
    ..The changes in polysome-associated tRNA levels reflect the codon usage of viral genes, suggesting the existence of local tRNA pools optimized for viral translation...
  38. pmc Viral infection triggers rapid differentiation of human blood monocytes into dendritic cells
    Wanqiu Hou
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 119:3128-31. 2012
    ..These findings demonstrate that monocytes are uniquely susceptible to viral infection among blood mononuclear cells, with the likely purpose of generating cells with enhanced capacity to activate innate and acquired antiviral immunity...
  39. pmc MHC class I antigen processing distinguishes endogenous antigens based on their translation from cellular vs. viral mRNA
    Brian P Dolan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:7025-30. 2012
    ..virus-encoded mRNA. Thus, class I antigen-processing machinery can distinguish folded proteins based on the precise details of their synthesis to modulate antigen presentation efficiency...
  40. pmc Nuclear translation visualized by ribosome-bound nascent chain puromycylation
    Alexandre David
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 197:45-57. 2012
    ..In this paper, we use the RPM to provide evidence for translation in the nucleoplasm and nucleolus, which is regulated by infectious and chemical stress...
  41. pmc Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells
    Heather D Hickman
    Cell Biology and Viral Immunology Sections, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 208:2511-24. 2011
    ..Thus, virus-induced chemokines in DLNs enable antiviral CD8(+) T cells to distinguish DCs from macrophages to optimize T cell priming...
  42. ncbi request reprint Immunology. Hide and seek in the peptidome
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Science 301:1334-5. 2003
  43. pmc RNA binding targets aminoacyl-tRNA synthetases to translating ribosomes
    Alexandre David
    Laboratory of Viral Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:20688-700. 2011
    ..S., Embry, A., Dolan, B., Das, S., Hickman, H. D., Berglund, P., Bennink, J. R., Yewdell, J. W., and Pan, T. (2009) Nature 462, 522-526) can be modulated at the level of individual mRNAs to modify decoding of specific gene products...
  44. pmc From optical bench to cageside: intravital microscopy on the long road to rational vaccine design
    Heather D Hickman
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Immunol Rev 239:209-20. 2011
    ....
  45. pmc Heterosubtypic immunity to influenza A virus: where do we stand?
    Kristie M Grebe
    Viral Immunology and Cellular Biology Sections, NIAID, National Institutes of Health, DHHS, Bethesda, MD 20892 3209, USA
    Microbes Infect 10:1024-9. 2008
    ..Here we review current knowledge of the mechanisms contributing to HSI to influenza and speculate on the potential for this approach to contribute to public health...
  46. pmc The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation
    Avital Lev
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 28:787-98. 2008
    ....
  47. pmc Sympathetic nervous system control of anti-influenza CD8+ T cell responses
    Kristie M Grebe
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:5300-5. 2009
    ....
  48. ncbi request reprint Immunodominance in TCD8+ responses to viruses: cell biology, cellular immunology, and mathematical models
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Immunity 21:149-53. 2004
    ....
  49. pmc Mice deficient in perforin, CD4+ T cells, or CD28-mediated signaling maintain the typical immunodominance hierarchies of CD8+ T-cell responses to influenza virus
    Weisan Chen
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIH, 4 Center Drive, Bethesda, MD 20892 0440, USA
    J Virol 76:10332-7. 2002
    ..This points to intrinsic features of the T(CD8+) repertoire as major contributors to immunodominance...
  50. pmc Murine norovirus infection has no significant effect on adaptive immunity to vaccinia virus or influenza A virus
    Scott E Hensley
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 208921, USA
    J Virol 83:7357-60. 2009
    ....
  51. pmc Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands
    Brian P Dolan
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Cell Mol Life Sci 68:1481-9. 2011
    ....
  52. ncbi request reprint Proteasomes get by with lots of help from their friends
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 208920 USA
    Immunity 20:362-3. 2004
    ..Now it appears that another protease, tripeptidyl peptidase II (TPP II), plays a critical role in cleaving proteasomal produced peptides into shorter peptides that can then be degraded by aminopeptidases...
  53. ncbi request reprint Systematic search fails to detect immunogenic MHC class-I-restricted determinants encoded by influenza A virus noncoding sequences
    Weisan Chen
    Laboratory of Viral Diseases Natonal Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0440, USA
    Virology 305:50-4. 2003
    ..These findings suggest that alternative reading frames are not a significant source of antigenic peptides in influenza virus infections and raise doubts regarding the general biological significance of ARF determinants...
  54. pmc Biogenesis of influenza a virus hemagglutinin cross-protective stem epitopes
    Javier G Magadán
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 10:e1004204. 2014
    ..Our findings indicate that StRAb binding to HA is precarious, raising the possibility that sufficient immune pressure on the HA stem region could select for viral escape mutants with increased steric hindrance from N-linked glycans. ..
  55. pmc The influenza A virus PB1-F2 protein targets the inner mitochondrial membrane via a predicted basic amphipathic helix that disrupts mitochondrial function
    James S Gibbs
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:7214-24. 2003
    ..These findings demonstrate that PB1-F2 possesses an MTS similar to other viral proteins and that this MTS, when fused to EGFP, is capable of independently compromising mitochondrial function and cellular viability...
  56. ncbi request reprint Immune recognition of a human renal cancer antigen through post-translational protein splicing
    Ken ichi Hanada
    Surgery Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building10, Room 2B42, Bethesda, Maryland 20892, USA
    Nature 427:252-6. 2004
    ..The occurrence of protein splicing in vertebrates has important implications for the complexity of the vertebrate proteome and for the immune recognition of self and foreign peptides...
  57. pmc Glycosylation focuses sequence variation in the influenza A virus H1 hemagglutinin globular domain
    Suman R Das
    NIAID, Bethesda, MA, USA
    PLoS Pathog 6:e1001211. 2010
    ..This supports the conclusion that glycosylation generally shields HA from antibody-mediated neutralization, and implies that fitness costs in accommodating oligosaccharides limit virus escape via HA hyperglycosylation...
  58. pmc Most influenza a virions fail to express at least one essential viral protein
    Christopher B Brooke
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    J Virol 87:3155-62. 2013
    ....
  59. pmc Cysteinyl-tRNA deacylation can be uncoupled from protein synthesis
    Alexandre David
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
    PLoS ONE 7:e33072. 2012
    ..We discuss possible translation independent functions for tRNA(Cys)...
  60. pmc New lane in the information highway: alternative reading frame peptides elicit T cells with potent antiretrovirus activity
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Exp Med 204:2501-4. 2007
    ..ARF-specific T cells control retroviral replication and select for viral escape in monkeys, providing the most compelling evidence to date for the biological relevance of ARF immunosurveillance...
  61. pmc Reassortment complements spontaneous mutation in influenza A virus NP and M1 genes to accelerate adaptation to a new host
    William L Ince
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
    J Virol 87:4330-8. 2013
    ....
  62. pmc Designing CD8+ T cell vaccines: it's not rocket science (yet)
    Jonathan W Yewdell
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Curr Opin Immunol 22:402-10. 2010
    ..With the rapid advances in this area of research, the dawn of rational vaccine design is at hand...
  63. pmc Viral alteration of cellular translational machinery increases defective ribosomal products
    Peter Berglund
    Laboratory of Viral Diseases, NIAID, 4 Center Drive, NIH, Bethesda, MD 20892 0440, USA
    J Virol 81:7220-9. 2007
    ....
  64. ncbi request reprint Making sense of mass destruction: quantitating MHC class I antigen presentation
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0440, USA
    Nat Rev Immunol 3:952-61. 2003
  65. pmc Out with the old, in with the new? Comparing methods for measuring protein degradation
    Jonathan W Yewdell
    Cell Biology Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, U S A
    Cell Biol Int 35:457-62. 2011
    ....
  66. ncbi request reprint Viral interference with antigen presentation
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    Nat Immunol 3:1019-25. 2002
    ....
  67. ncbi request reprint The TL MHC class Ib molecule has only marginal effects on the activation, survival and trafficking of mouse small intestinal intraepithelial lymphocytes
    Nathalie Pardigon
    Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD, USA
    Int Immunol 16:1305-13. 2004
    ....
  68. pmc Monoclonal antibodies specific for discontinuous epitopes direct refolding of influenza A virus hemagglutinin
    Jonathan W Yewdell
    Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD 20892 03209, USA
    Mol Immunol 47:1132-6. 2010
    ....
  69. ncbi request reprint Confronting complexity: real-world immunodominance in antiviral CD8+ T cell responses
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Immunity 25:533-43. 2006
    ..Here, I review work that has extended immunodominance studies to viruses of greater complexity and to the real world of human antiviral immunity...
  70. pmc Innate immune and chemically triggered oxidative stress modifies translational fidelity
    Nir Netzer
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nature 462:522-6. 2009
    ..In demonstrating an unexpected conditional aspect of decoding mRNA, our findings illustrate the importance of considering alternative iterations of the genetic code...
  71. pmc Viva la revolución: rethinking influenza a virus antigenic drift
    Jonathan W Yewdell
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Curr Opin Virol 1:177-83. 2011
    ....
  72. pmc DRiPs solidify: progress in understanding endogenous MHC class I antigen processing
    Jonathan W Yewdell
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Trends Immunol 32:548-58. 2011
    ..DRiPs enable the immune system to rapidly detect alterations in cellular gene expression with great sensitivity...
  73. ncbi request reprint Plumbing the sources of endogenous MHC class I peptide ligands
    Jonathan W Yewdell
    Cellular Biology Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Curr Opin Immunol 19:79-86. 2007
    ....
  74. pmc Caught in the act: intravital multiphoton microscopy of host-pathogen interactions
    Heather D Hickman
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Cell Host Microbe 5:13-21. 2009
    ..Here we provide an overview of multiphoton microscopy with particular attention to its application for studying host-pathogen interactions...
  75. pmc Immunoproteasomes: regulating the regulator
    Jonathan W Yewdell
    Cellular Biology Section, Laboratory of Viral Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0440, USA
    Proc Natl Acad Sci U S A 102:9089-90. 2005
  76. pmc MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines
    Surender Khurana
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Sci Transl Med 3:85ra48. 2011
    ..Thus, MF59 quantitatively and qualitatively enhances functional antibody responses to HA-based vaccines by improving both epitope breadth and binding affinity, demonstrating the added value of such adjuvants for influenza vaccines...
  77. ncbi request reprint Fusion proteins with COOH-terminal ubiquitin are stable and maintain dual functionality in vivo
    Shu Bing Qian
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0440, USA
    J Biol Chem 277:38818-26. 2002
    ..The multifunctionality of X-Ub fusion proteins opens the possibility for a number of novel practical applications, including the imaging of Ub conjugate formation in living cells...
  78. ncbi request reprint Inhibitory effects of cytomegalovirus proteins US2 and US11 point to contributions from direct priming and cross-priming in induction of vaccinia virus-specific CD8(+) T cells
    Sameh Basta
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 168:5403-8. 2002
    ....
  79. pmc Viruses in control of the immune system. Workshop on molecular mechanisms of immune modulation: lessons from viruses
    Antonio Alcami
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, UK
    EMBO Rep 3:927-32. 2002
  80. ncbi request reprint Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo
    Christopher C Norbury
    Present address Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Nat Immunol 3:265-71. 2002
    ..These data provide direct evidence that virus-infected APCs prime naïve CD8+ T cells in vivo...
  81. ncbi request reprint Inside the professionals
    Jonathan W Yewdell
    Nature 418:923-4. 2002
  82. pmc Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia
    Julie L McAuley
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Host Microbe 2:240-9. 2007
    ..These findings help explain both the unparalleled virulence of the 1918 strain and the high incidence of fatal pneumonia during the pandemic...
  83. ncbi request reprint HLA-A*0201, HLA-A*1101, and HLA-B*0702 transgenic mice recognize numerous poxvirus determinants from a wide variety of viral gene products
    Valerie Pasquetto
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92109, USA
    J Immunol 175:5504-15. 2005
    ..These findings have implications for the design of new smallpox vaccines and the understanding of immune responses to large DNA viruses in general...
  84. ncbi request reprint Self-reporting peptides illuminate the MHC groove
    Jonathan W Yewdell
    Nat Chem Biol 3:201-2. 2007
  85. ncbi request reprint T cells bite the hand that feeds them
    David C Tscharke
    Nat Med 9:647-8. 2003
  86. pmc Comparative immunopeptidomics of humans and their pathogens
    Sorin Istrail
    Celera Genomics, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 101:13268-72. 2004
    ....
  87. ncbi request reprint Cross-priming of CD8+ T cells by viral and tumor antigens is a robust phenomenon
    Weisan Chen
    T Cell Laboratory, Cancer Vaccine Unit, Ludwig Institute for Cancer Research, Austin and Repatriation Medical Centre, Heidelberg, Australia
    Eur J Immunol 34:194-9. 2004
    ..Our findings support the relevance of cross-priming in CD8+ T cell responses to viruses and tumor cells, and demonstrate that cross-priming elicits CD8+ T cells to determinants generated by the endogenous processing pathway...
  88. pmc HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation
    Carla Oseroff
    La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, CA 92109, USA
    Proc Natl Acad Sci U S A 102:13980-5. 2005
    ..Finally, most epitopes were highly conserved among vaccinia virus Western Reserve, variola major and modified vaccinia Ankara, supporting their potential use in vaccine and diagnostic applications...
  89. ncbi request reprint Recycling CD1d1 molecules present endogenous antigens processed in an endocytic compartment to NKT cells
    Tonya J Roberts
    Department of Microbiology and Immunology, Indiana University School of Medicine and Walther Oncology Center, Indianapolis, IN 46202, USA
    J Immunol 168:5409-14. 2002
    ..These results suggest that the loading of a subset of glycolipid ligands onto CD1d1 molecules entails the delivery of cell surface CD1d1 molecules and an acidic environment in the endocytic pathway...
  90. ncbi request reprint Reversal in the immunodominance hierarchy in secondary CD8+ T cell responses to influenza A virus: roles for cross-presentation and lysis-independent immunodomination
    Weisan Chen
    T Cell Laboratory, Ludwig Institute for Cancer Research, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    J Immunol 173:5021-7. 2004
    ..We further show that immunodomination of PA(224-233)-specific TCD8+ by nucleoprotein 366-374-specific TCD8+ plays a critical role in the phenomena, and that this is unlikely to be mediated by TCD8+ lysis of APCs or other cells...
  91. ncbi request reprint Dissection of the interaction of the human cytomegalovirus-derived US2 protein with major histocompatibility complex class I molecules: prominent role of a single arginine residue in human leukocyte antigen-A2
    Claudia Thilo
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    J Biol Chem 281:8950-7. 2006
    ..However, although the presence of Arg181 seems to be a prerequisite for US2 binding to HLA-A2, it is not sufficient for binding to all MHC class I alleles...
  92. pmc Cutting edge: MHC class I-Ly49 interaction regulates neuronal function
    Ofer Zohar
    Blanchette Rockefeller Neurosciences Institute, Johns Hopkins University Montgomery County Campus, Rockville, MD 20850, USA
    J Immunol 180:6447-51. 2008
    ..Because we show that Ly49 genes are selectively expressed in the adult brain, these findings suggest an unsuspected role for the MHC-I-Ly49 interaction in the development and function of the brain...
  93. ncbi request reprint The latest killer AP
    Margarita Del Val
    Nat Immunol 4:1049-50. 2003
  94. ncbi request reprint Comment on "Large-scale sequence analysis of avian influenza isolates"
    Edward C Holmes
    Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, Mueller Laboratory, University Park, PA 16802, USA
    Science 313:1573; author reply 1573. 2006
    ..However, we show that this observation is likely to be an artifact related to the location of PB1-F2 in the +1 reading frame of the PB1 gene...
  95. ncbi request reprint Mild acid treatment induces cross-reactivity of 4H84 monoclonal antibody specific to nonclassical HLA-G antigen with classical HLA class I molecules
    Katarina Polakova
    Cancer Research Institute, Bratislava, Slovak Republic
    Hum Immunol 64:256-64. 2003
    ..In view of the unexpected cross-reactivity, detection of HLA-G with this mAb must be carefully evaluated to avoid false detection...