J Yewdell

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The latest killer AP
    Margarita Del Val
    Nat Immunol 4:1049-50. 2003
  2. ncbi request reprint Serendipity strikes twice: the discovery and rediscovery of defective ribosomal products (DRiPS)
    J W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Cell Mol Biol (Noisy-le-grand) 51:635-41. 2005
  3. pmc Innate immune and chemically triggered oxidative stress modifies translational fidelity
    Nir Netzer
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nature 462:522-6. 2009
  4. pmc New lane in the information highway: alternative reading frame peptides elicit T cells with potent antiretrovirus activity
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Exp Med 204:2501-4. 2007
  5. pmc Cysteinyl-tRNA deacylation can be uncoupled from protein synthesis
    Alexandre David
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
    PLoS ONE 7:e33072. 2012
  6. pmc Glycosylation focuses sequence variation in the influenza A virus H1 hemagglutinin globular domain
    Suman R Das
    NIAID, Bethesda, MA, USA
    PLoS Pathog 6:e1001211. 2010
  7. pmc Nuclear translation visualized by ribosome-bound nascent chain puromycylation
    Alexandre David
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 197:45-57. 2012
  8. pmc Vaccinia and influenza A viruses select rather than adjust tRNAs to optimize translation
    Mariana Pavon-Eternod
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Nucleic Acids Res 41:1914-21. 2013
  9. pmc Greasing the SCIDs for universal flu antibodies
    Jonathan W Yewdell
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Cell Host Microbe 14:7-8. 2013
  10. pmc Amsterdamming DRiPs
    Jonathan W Yewdell
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Mol Immunol 55:110-2. 2013

Collaborators

Detail Information

Publications87

  1. ncbi request reprint The latest killer AP
    Margarita Del Val
    Nat Immunol 4:1049-50. 2003
  2. ncbi request reprint Serendipity strikes twice: the discovery and rediscovery of defective ribosomal products (DRiPS)
    J W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Cell Mol Biol (Noisy-le-grand) 51:635-41. 2005
    ..This story is used as a canvas for discussing how the imperfections in human nature retard scientific progress...
  3. pmc Innate immune and chemically triggered oxidative stress modifies translational fidelity
    Nir Netzer
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nature 462:522-6. 2009
    ..In demonstrating an unexpected conditional aspect of decoding mRNA, our findings illustrate the importance of considering alternative iterations of the genetic code...
  4. pmc New lane in the information highway: alternative reading frame peptides elicit T cells with potent antiretrovirus activity
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Exp Med 204:2501-4. 2007
    ..ARF-specific T cells control retroviral replication and select for viral escape in monkeys, providing the most compelling evidence to date for the biological relevance of ARF immunosurveillance...
  5. pmc Cysteinyl-tRNA deacylation can be uncoupled from protein synthesis
    Alexandre David
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
    PLoS ONE 7:e33072. 2012
    ..We discuss possible translation independent functions for tRNA(Cys)...
  6. pmc Glycosylation focuses sequence variation in the influenza A virus H1 hemagglutinin globular domain
    Suman R Das
    NIAID, Bethesda, MA, USA
    PLoS Pathog 6:e1001211. 2010
    ..This supports the conclusion that glycosylation generally shields HA from antibody-mediated neutralization, and implies that fitness costs in accommodating oligosaccharides limit virus escape via HA hyperglycosylation...
  7. pmc Nuclear translation visualized by ribosome-bound nascent chain puromycylation
    Alexandre David
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 197:45-57. 2012
    ..In this paper, we use the RPM to provide evidence for translation in the nucleoplasm and nucleolus, which is regulated by infectious and chemical stress...
  8. pmc Vaccinia and influenza A viruses select rather than adjust tRNAs to optimize translation
    Mariana Pavon-Eternod
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Nucleic Acids Res 41:1914-21. 2013
    ..The changes in polysome-associated tRNA levels reflect the codon usage of viral genes, suggesting the existence of local tRNA pools optimized for viral translation...
  9. pmc Greasing the SCIDs for universal flu antibodies
    Jonathan W Yewdell
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Cell Host Microbe 14:7-8. 2013
    ..As proof of principle, they isolate human mAbs that could potentially be used to treat or prevent human infection with any influenza A virus strain. ..
  10. pmc Amsterdamming DRiPs
    Jonathan W Yewdell
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Mol Immunol 55:110-2. 2013
    ..Here I discuss the most recent findings regarding the nature of substrates for the MHC class I antigen processing pathways which provide glimpses of the mist shrouded features remaining to be discovered...
  11. pmc Viva la revolución: rethinking influenza a virus antigenic drift
    Jonathan W Yewdell
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Curr Opin Virol 1:177-83. 2011
    ....
  12. pmc Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens
    W Chen
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 193:1319-26. 2001
    ..These findings indicate that in addition to their effects on the presentation of foreign antigens, immunoproteasomes influence T(CD8+) responses by modifying the repertoire of responding T(CD8+)...
  13. ncbi request reprint Immunology. Hide and seek in the peptidome
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Science 301:1334-5. 2003
  14. ncbi request reprint Confronting complexity: real-world immunodominance in antiviral CD8+ T cell responses
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Immunity 25:533-43. 2006
    ..Here, I review work that has extended immunodominance studies to viruses of greater complexity and to the real world of human antiviral immunity...
  15. ncbi request reprint Influenza virus still surprises
    Jonathan Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Room 211, Building 4, 4 Center Drive, Bethesda, Maryland 20892 0440, USA
    Curr Opin Microbiol 5:414-8. 2002
    ....
  16. ncbi request reprint Immunodominance in TCD8+ responses to viruses: cell biology, cellular immunology, and mathematical models
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Immunity 21:149-53. 2004
    ....
  17. ncbi request reprint Plumbing the sources of endogenous MHC class I peptide ligands
    Jonathan W Yewdell
    Cellular Biology Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Curr Opin Immunol 19:79-86. 2007
    ....
  18. ncbi request reprint The seven dirty little secrets of major histocompatibility complex class I antigen processing
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Immunol Rev 207:8-18. 2005
    ..Here, I discuss some of the DLSs of major histocompatibility complex class I antigen processing...
  19. pmc Immunoproteasomes: regulating the regulator
    Jonathan W Yewdell
    Cellular Biology Section, Laboratory of Viral Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0440, USA
    Proc Natl Acad Sci U S A 102:9089-90. 2005
  20. pmc Monoclonal antibodies specific for discontinuous epitopes direct refolding of influenza A virus hemagglutinin
    Jonathan W Yewdell
    Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD 20892 03209, USA
    Mol Immunol 47:1132-6. 2010
    ....
  21. ncbi request reprint Generating MHC class I ligands from viral gene products
    J Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 0440, USA
    Immunol Rev 172:97-108. 1999
    ....
  22. pmc DRiPs solidify: progress in understanding endogenous MHC class I antigen processing
    Jonathan W Yewdell
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Trends Immunol 32:548-58. 2011
    ..DRiPs enable the immune system to rapidly detect alterations in cellular gene expression with great sensitivity...
  23. pmc Out with the old, in with the new? Comparing methods for measuring protein degradation
    Jonathan W Yewdell
    Cell Biology Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, U S A
    Cell Biol Int 35:457-62. 2011
    ....
  24. ncbi request reprint Mechanisms of viral interference with MHC class I antigen processing and presentation
    J W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0440, USA
    Annu Rev Cell Dev Biol 15:579-606. 1999
    ..In addition, studies on viral interference provide unique insights into unfettered antigen processing and normal cellular functions that are exploited and exaggerated by viruses...
  25. ncbi request reprint To DRiP or not to DRiP: generating peptide ligands for MHC class I molecules from biosynthesized proteins
    Jonathan Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 211 Bldg 4, 4 Center Drive, Bethesda, MD 20892 0440, USA
    Mol Immunol 39:139-46. 2002
  26. pmc Designing CD8+ T cell vaccines: it's not rocket science (yet)
    Jonathan W Yewdell
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Curr Opin Immunol 22:402-10. 2010
    ..With the rapid advances in this area of research, the dawn of rational vaccine design is at hand...
  27. ncbi request reprint Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses
    J W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0440, USA
    Annu Rev Immunol 17:51-88. 1999
    ..Little is known about how immunodominant and subdominant determinants are distinguished by the TCD8+ repertoire, or how (and why) immunodomination occurs, but new tools are available to address these questions...
  28. ncbi request reprint Viral interference with antigen presentation
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    Nat Immunol 3:1019-25. 2002
    ....
  29. ncbi request reprint Not such a dismal science: the economics of protein synthesis, folding, degradation and antigen processing
    J W Yewdell
    Cellular Biology Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Disease, 20892 0440, Bethesda, MD, USA
    Trends Cell Biol 11:294-7. 2001
    ....
  30. ncbi request reprint Quantitating protein synthesis, degradation, and endogenous antigen processing
    Michael F Princiotta
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Immunity 18:343-54. 2003
    ....
  31. ncbi request reprint CD8+ T cell cross-priming via transfer of proteasome substrates
    Christopher C Norbury
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892 0440, USA
    Science 304:1318-21. 2004
    ..We show here that cross-priming is based on the transfer of proteasome substrates rather than peptides. These findings are potentially important for the rational design of vaccines that elicit CD8+ T cell responses...
  32. ncbi request reprint Tight linkage between translation and MHC class I peptide ligand generation implies specialized antigen processing for defective ribosomal products
    Shu Bing Qian
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 177:227-33. 2006
    ..We propose that specialized machinery exists to link protein synthesis with class I peptide ligand generation to enable the rapid detection of viral gene expression...
  33. pmc Defective ribosomal products are the major source of antigenic peptides endogenously generated from influenza A virus neuraminidase
    Brian P Dolan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:1419-24. 2010
    ..These observations extend the relevance of the DRiP hypothesis to viral proteins generated in their natural context...
  34. doi request reprint Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes
    Heather D Hickman
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nat Immunol 9:155-65. 2008
    ..Thus, antigen presentation at the lymph node periphery, not at lymphocyte exit sites in deeper lymph node venules, as dogma dictates, has a dominant function in antiviral CD8+ T cell activation...
  35. pmc Quantitating T cell cross-reactivity for unrelated peptide antigens
    Jeffrey Ishizuka
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda MD 20892, USA
    J Immunol 183:4337-45. 2009
    ....
  36. pmc Poxvirus CD8+ T-cell determinants and cross-reactivity in BALB/c mice
    David C Tscharke
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, USA
    J Virol 80:6318-23. 2006
    ..We then use these determinants to test if predicted conservation across orthopoxvirus species matches experimental observation and find an unexpectedly cross-reactive variant peptide encoded by ectromelia (mousepox) virus...
  37. pmc Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action
    Avital Lev
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:6964-9. 2010
    ..This provides an explanation for the exquisite ability of T cells to recognize peptides generated from otherwise undetected gene products...
  38. ncbi request reprint CD8 alpha alpha-mediated intraepithelial lymphocyte snatching of thymic leukemia MHC class Ib molecules in vitro and in vivo
    Nathalie Pardigon
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 177:1590-8. 2006
    ..Induction of bowel inflammation results in the presence of TL on IELs, probably via in vivo snatching, providing the initial evidence for the interaction of CD8alphaalpha IELs with intestinal cells...
  39. pmc Mice deficient in perforin, CD4+ T cells, or CD28-mediated signaling maintain the typical immunodominance hierarchies of CD8+ T-cell responses to influenza virus
    Weisan Chen
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIH, 4 Center Drive, Bethesda, MD 20892 0440, USA
    J Virol 76:10332-7. 2002
    ..This points to intrinsic features of the T(CD8+) repertoire as major contributors to immunodominance...
  40. ncbi request reprint Proteasomes get by with lots of help from their friends
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 208920 USA
    Immunity 20:362-3. 2004
    ..Now it appears that another protease, tripeptidyl peptidase II (TPP II), plays a critical role in cleaving proteasomal produced peptides into shorter peptides that can then be degraded by aminopeptidases...
  41. pmc Heat-aggregated noninfectious influenza virus induces a more balanced CD8(+)-T-lymphocyte immunodominance hierarchy than infectious virus
    Yunjung Cho
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:4679-84. 2003
    ..Furthermore, they demonstrate that the form of antigen administered can influence immunodominance hierarchies and that exogenous-antigen vaccines can induce broad and balanced T(CD8+) responses...
  42. pmc Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent
    Avital Lev
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 183:4205-10. 2009
    ..In demonstrating the dispensability of GRP94, our finding points to the importance of alternative mechanisms for generation of class I peptide complexes from endogenous and exogenous Ags and immunogens...
  43. pmc Caught in the act: intravital multiphoton microscopy of host-pathogen interactions
    Heather D Hickman
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Cell Host Microbe 5:13-21. 2009
    ..Here we provide an overview of multiphoton microscopy with particular attention to its application for studying host-pathogen interactions...
  44. ncbi request reprint The DRiP hypothesis decennial: support, controversy, refinement and extension
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Trends Immunol 27:368-73. 2006
    ..Here, we consider findings that address the DRiP hypothesis, and extend the hypothesis by proposing that cells possess specialized machinery, possibly in the form of "immunoribosomes", to couple protein synthesis to antigen presentation...
  45. ncbi request reprint Immune recognition of a human renal cancer antigen through post-translational protein splicing
    Ken ichi Hanada
    Surgery Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building10, Room 2B42, Bethesda, Maryland 20892, USA
    Nature 427:252-6. 2004
    ..The occurrence of protein splicing in vertebrates has important implications for the complexity of the vertebrate proteome and for the immune recognition of self and foreign peptides...
  46. pmc How to succeed in science: a concise guide for young biomedical scientists. Part I: taking the plunge
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 9:413-6. 2008
    ..Although my advice is geared towards succeeding in the United States, many aspects apply to other countries...
  47. pmc How to succeed in science: a concise guide for young biomedical scientists. Part II: making discoveries
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 9:491-4. 2008
    ..Here, I provide practical advice to young scientists on choosing a research topic, designing, performing and interpreting experiments and, last but not least, on maintaining your sanity in the process...
  48. ncbi request reprint The TL MHC class Ib molecule has only marginal effects on the activation, survival and trafficking of mouse small intestinal intraepithelial lymphocytes
    Nathalie Pardigon
    Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD, USA
    Int Immunol 16:1305-13. 2004
    ....
  49. ncbi request reprint Making sense of mass destruction: quantitating MHC class I antigen presentation
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0440, USA
    Nat Rev Immunol 3:952-61. 2003
  50. pmc Unexpected role for the immunoproteasome subunit LMP2 in antiviral humoral and innate immune responses
    Scott E Hensley
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:4115-22. 2010
    ..These findings demonstrate an important role for immunoproteasomes in immune cell function beyond their contribution to Ag processing...
  51. ncbi request reprint Understanding presentation of viral antigens to CD8+ T cells in vivo: the key to rational vaccine design
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0440, USA
    Annu Rev Immunol 23:651-82. 2005
    ..These studies point the way to detailed understanding and provide some key information for vaccine development, although much remains to be learned to enable truly rational vaccine design...
  52. pmc Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines
    David C Tscharke
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 201:95-104. 2005
    ..These findings have important implications for understanding poxvirus immunity in animal models and bench-marking immune responses to poxvirus vaccines in humans...
  53. pmc Back to the fold: T cell recognition of HFE, a MHC class Ib molecule that regulates iron metabolism
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Proc Natl Acad Sci U S A 102:12649-50. 2005
  54. pmc The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation
    Avital Lev
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 28:787-98. 2008
    ....
  55. ncbi request reprint Inhibitory effects of cytomegalovirus proteins US2 and US11 point to contributions from direct priming and cross-priming in induction of vaccinia virus-specific CD8(+) T cells
    Sameh Basta
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 168:5403-8. 2002
    ....
  56. pmc Terminal deoxynucleotidyl transferase establishes and broadens antiviral CD8+ T cell immunodominance hierarchies
    S M Mansour Haeryfar
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:649-59. 2008
    ....
  57. ncbi request reprint Characterization of rapidly degraded polypeptides in mammalian cells reveals a novel layer of nascent protein quality control
    Shu Bing Qian
    Laboratory of Viral Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0440, USA
    J Biol Chem 281:392-400. 2006
    ..The dichotomy in the behavior of RDPs points to a novel quality control level for nascent proteins that is independent of the well established Hsc70-ubiquitin 26 S proteasome pathway...
  58. pmc Hemagglutinin receptor binding avidity drives influenza A virus antigenic drift
    Scott E Hensley
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Science 326:734-6. 2009
    ....
  59. ncbi request reprint Quantitating defective ribosome products
    Shu Bing Qian
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 301:271-81. 2005
    ..Protein degradation kinetics can be determined by either acid precipitation or SDS-PAGE. The introduction of proteasome inhibitors enables quantitation of proteasome-mediated protein degradation in vivo...
  60. ncbi request reprint Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities
    S M Mansour Haeryfar
    Laboratory of Viral Diseases, National Institute of Allergies and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:3344-51. 2005
    ..Therefore, Treg influence TCD8 immunodominance hierarchies by moderating disparities in responses to different determinants...
  61. pmc Sympathetic nervous system control of anti-influenza CD8+ T cell responses
    Kristie M Grebe
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:5300-5. 2009
    ....
  62. ncbi request reprint Systematic search fails to detect immunogenic MHC class-I-restricted determinants encoded by influenza A virus noncoding sequences
    Weisan Chen
    Laboratory of Viral Diseases Natonal Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0440, USA
    Virology 305:50-4. 2003
    ..These findings suggest that alternative reading frames are not a significant source of antigenic peptides in influenza virus infections and raise doubts regarding the general biological significance of ARF determinants...
  63. pmc Heterosubtypic immunity to influenza A virus: where do we stand?
    Kristie M Grebe
    Viral Immunology and Cellular Biology Sections, NIAID, National Institutes of Health, DHHS, Bethesda, MD 20892 3209, USA
    Microbes Infect 10:1024-9. 2008
    ..Here we review current knowledge of the mechanisms contributing to HSI to influenza and speculate on the potential for this approach to contribute to public health...
  64. ncbi request reprint LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies
    A L Dent
    Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 88:1423-6. 1996
    ..By double-immunogold labeling of PML and LYSP100, some LANDs were shown to contain both PML and LYSP100. Thus, PML is localized to a second subnuclear domain that is morphologically and biochemically distinct from PML NBs...
  65. pmc Cutting edge: Sympathetic nervous system increases proinflammatory cytokines and exacerbates influenza A virus pathogenesis
    Kristie M Grebe
    Laboratories of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:540-4. 2010
    ..These findings demonstrate an unexpected role for the sympathetic nervous system in innate antiviral immunity and in exacerbating the pathology of a virus of great significance to human and animal health...
  66. pmc Murine norovirus infection has no significant effect on adaptive immunity to vaccinia virus or influenza A virus
    Scott E Hensley
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 208921, USA
    J Virol 83:7357-60. 2009
    ....
  67. ncbi request reprint Jaw1, A lymphoid-restricted membrane protein localized to the endoplasmic reticulum
    T W Behrens
    Metabolism Branch National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892
    J Immunol 153:682-90. 1994
    ..These findings suggest that the function and/or the structure of the ER in lymphocytes may be modified by lymphoid-restricted resident ER proteins...
  68. ncbi request reprint Fusion proteins with COOH-terminal ubiquitin are stable and maintain dual functionality in vivo
    Shu Bing Qian
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0440, USA
    J Biol Chem 277:38818-26. 2002
    ..The multifunctionality of X-Ub fusion proteins opens the possibility for a number of novel practical applications, including the imaging of Ub conjugate formation in living cells...
  69. pmc The influenza A virus PB1-F2 protein targets the inner mitochondrial membrane via a predicted basic amphipathic helix that disrupts mitochondrial function
    James S Gibbs
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:7214-24. 2003
    ..These findings demonstrate that PB1-F2 possesses an MTS similar to other viral proteins and that this MTS, when fused to EGFP, is capable of independently compromising mitochondrial function and cellular viability...
  70. pmc Viral alteration of cellular translational machinery increases defective ribosomal products
    Peter Berglund
    Laboratory of Viral Diseases, NIAID, 4 Center Drive, NIH, Bethesda, MD 20892 0440, USA
    J Virol 81:7220-9. 2007
    ....
  71. ncbi request reprint Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo
    Christopher C Norbury
    Present address Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Nat Immunol 3:265-71. 2002
    ..These data provide direct evidence that virus-infected APCs prime naïve CD8+ T cells in vivo...
  72. pmc HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation
    Carla Oseroff
    La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, CA 92109, USA
    Proc Natl Acad Sci U S A 102:13980-5. 2005
    ..Finally, most epitopes were highly conserved among vaccinia virus Western Reserve, variola major and modified vaccinia Ankara, supporting their potential use in vaccine and diagnostic applications...
  73. ncbi request reprint Self-reporting peptides illuminate the MHC groove
    Jonathan W Yewdell
    Nat Chem Biol 3:201-2. 2007
  74. ncbi request reprint Inside the professionals
    Jonathan W Yewdell
    Nature 418:923-4. 2002
  75. ncbi request reprint HLA-A*0201, HLA-A*1101, and HLA-B*0702 transgenic mice recognize numerous poxvirus determinants from a wide variety of viral gene products
    Valerie Pasquetto
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92109, USA
    J Immunol 175:5504-15. 2005
    ..These findings have implications for the design of new smallpox vaccines and the understanding of immune responses to large DNA viruses in general...
  76. pmc Viruses in control of the immune system. Workshop on molecular mechanisms of immune modulation: lessons from viruses
    Antonio Alcami
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, UK
    EMBO Rep 3:927-32. 2002
  77. pmc Comparative immunopeptidomics of humans and their pathogens
    Sorin Istrail
    Celera Genomics, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 101:13268-72. 2004
    ....
  78. ncbi request reprint Youth has its privileges: maturation inhibits DC cross-priming
    Heather D Hickman-Miller
    Nat Immunol 7:125-6. 2006
  79. ncbi request reprint T cells bite the hand that feeds them
    David C Tscharke
    Nat Med 9:647-8. 2003
  80. ncbi request reprint Cross-priming of CD8+ T cells by viral and tumor antigens is a robust phenomenon
    Weisan Chen
    T Cell Laboratory, Cancer Vaccine Unit, Ludwig Institute for Cancer Research, Austin and Repatriation Medical Centre, Heidelberg, Australia
    Eur J Immunol 34:194-9. 2004
    ..Our findings support the relevance of cross-priming in CD8+ T cell responses to viruses and tumor cells, and demonstrate that cross-priming elicits CD8+ T cells to determinants generated by the endogenous processing pathway...
  81. pmc Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia
    Julie L McAuley
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Host Microbe 2:240-9. 2007
    ..These findings help explain both the unparalleled virulence of the 1918 strain and the high incidence of fatal pneumonia during the pandemic...
  82. ncbi request reprint Comment on "Large-scale sequence analysis of avian influenza isolates"
    Edward C Holmes
    Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, Mueller Laboratory, University Park, PA 16802, USA
    Science 313:1573; author reply 1573. 2006
    ..However, we show that this observation is likely to be an artifact related to the location of PB1-F2 in the +1 reading frame of the PB1 gene...
  83. ncbi request reprint Reversal in the immunodominance hierarchy in secondary CD8+ T cell responses to influenza A virus: roles for cross-presentation and lysis-independent immunodomination
    Weisan Chen
    T Cell Laboratory, Ludwig Institute for Cancer Research, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    J Immunol 173:5021-7. 2004
    ..We further show that immunodomination of PA(224-233)-specific TCD8+ by nucleoprotein 366-374-specific TCD8+ plays a critical role in the phenomena, and that this is unlikely to be mediated by TCD8+ lysis of APCs or other cells...
  84. ncbi request reprint Recycling CD1d1 molecules present endogenous antigens processed in an endocytic compartment to NKT cells
    Tonya J Roberts
    Department of Microbiology and Immunology, Indiana University School of Medicine and Walther Oncology Center, Indianapolis, IN 46202, USA
    J Immunol 168:5409-14. 2002
    ..These results suggest that the loading of a subset of glycolipid ligands onto CD1d1 molecules entails the delivery of cell surface CD1d1 molecules and an acidic environment in the endocytic pathway...
  85. ncbi request reprint Mild acid treatment induces cross-reactivity of 4H84 monoclonal antibody specific to nonclassical HLA-G antigen with classical HLA class I molecules
    Katarina Polakova
    Cancer Research Institute, Bratislava, Slovak Republic
    Hum Immunol 64:256-64. 2003
    ..In view of the unexpected cross-reactivity, detection of HLA-G with this mAb must be carefully evaluated to avoid false detection...
  86. pmc Cutting edge: MHC class I-Ly49 interaction regulates neuronal function
    Ofer Zohar
    Blanchette Rockefeller Neurosciences Institute, Johns Hopkins University Montgomery County Campus, Rockville, MD 20850, USA
    J Immunol 180:6447-51. 2008
    ..Because we show that Ly49 genes are selectively expressed in the adult brain, these findings suggest an unsuspected role for the MHC-I-Ly49 interaction in the development and function of the brain...
  87. ncbi request reprint Dissection of the interaction of the human cytomegalovirus-derived US2 protein with major histocompatibility complex class I molecules: prominent role of a single arginine residue in human leukocyte antigen-A2
    Claudia Thilo
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    J Biol Chem 281:8950-7. 2006
    ..However, although the presence of Arg181 seems to be a prerequisite for US2 binding to HLA-A2, it is not sufficient for binding to all MHC class I alleles...