Paul M Yen

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Physiological and molecular basis of thyroid hormone action
    P M Yen
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Physiol Rev 81:1097-142. 2001
  2. ncbi request reprint Germline and somatic thyroid hormone receptor mutations in man
    P M Yen
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes, Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD 20892, USA
    J Endocrinol Invest 26:780-7. 2003
  3. ncbi request reprint Molecular basis of resistance to thyroid hormone
    Paul M Yen
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, NIDDK NIH, Bethesda, MD 20892, USA
    Trends Endocrinol Metab 14:327-33. 2003
  4. pmc Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice
    Paul M Yen
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Room 8D12, Building 10, Bethesda, MD 20892, USA
    EMBO Rep 4:581-7. 2003
  5. pmc Cell cycle-dependent expression of thyroid hormone receptor-beta is a mechanism for variable hormone sensitivity
    Padma Maruvada
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Biol Cell 15:1895-903. 2004
  6. ncbi request reprint p62, A TFIIH subunit, directly interacts with thyroid hormone receptor and enhances T3-mediated transcription
    Ying Liu
    Molecular Regulation and Neuroendocrinology Section, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Endocrinol 19:879-84. 2005
  7. ncbi request reprint New insights into thyroid hormone action
    Alexis Oetting
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Development, National Institute of Health, Bethesda, MD, USA
    Best Pract Res Clin Endocrinol Metab 21:193-208. 2007
  8. ncbi request reprint Transgenic targeting of a dominant negative corepressor to liver and analyses by cDNA microarray
    Xu Feng
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 202:31-54. 2002
  9. pmc Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism
    Ty C Voss
    Laboratory of Receptor Biology and Gene Expression, Building 41, B602, 41 Library Drive, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 146:544-54. 2011
  10. ncbi request reprint Dynamic shuttling and intranuclear mobility of nuclear hormone receptors
    Padma Maruvada
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:12425-32. 2003

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Physiological and molecular basis of thyroid hormone action
    P M Yen
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Physiol Rev 81:1097-142. 2001
    ....
  2. ncbi request reprint Germline and somatic thyroid hormone receptor mutations in man
    P M Yen
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes, Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD 20892, USA
    J Endocrinol Invest 26:780-7. 2003
    ..Herein we review the occurrence and identification of germline and somatic TR mutations and characterization of their pathological effects on hormone resistance and tumorigenesis...
  3. ncbi request reprint Molecular basis of resistance to thyroid hormone
    Paul M Yen
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, NIDDK NIH, Bethesda, MD 20892, USA
    Trends Endocrinol Metab 14:327-33. 2003
    ..This dominant-negative activity has important implications for other hormone-resistant conditions and in hormone-sensitive tumors. This article examines the molecular basis of RTH...
  4. pmc Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice
    Paul M Yen
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Room 8D12, Building 10, Bethesda, MD 20892, USA
    EMBO Rep 4:581-7. 2003
    ..This large-scale study of hormonal regulation reveals the functions of Th and of Tr isoforms in the regulation of gene expression patterns...
  5. pmc Cell cycle-dependent expression of thyroid hormone receptor-beta is a mechanism for variable hormone sensitivity
    Padma Maruvada
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Biol Cell 15:1895-903. 2004
    ..These novel observations of cell cycle-dependent expression of TR suggest that differential hormone sensitivity can occur during the cell cycle and may contribute to cell cycle progression during normal development and oncogenesis...
  6. ncbi request reprint p62, A TFIIH subunit, directly interacts with thyroid hormone receptor and enhances T3-mediated transcription
    Ying Liu
    Molecular Regulation and Neuroendocrinology Section, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Endocrinol 19:879-84. 2005
    ..Taken together, these data suggest that TRs can interact directly with a subunit of TFIIH and may provide an alternative pathway for nuclear receptor communication with the general transcription machinery that circumvents coactivators...
  7. ncbi request reprint New insights into thyroid hormone action
    Alexis Oetting
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Development, National Institute of Health, Bethesda, MD, USA
    Best Pract Res Clin Endocrinol Metab 21:193-208. 2007
    ..TR isoform- or pathway-specific drugs might provide the therapeutic benefits of TH action such as decreasing obesity or lowering cholesterol levels without some of the side effects of hyperthyroidism...
  8. ncbi request reprint Transgenic targeting of a dominant negative corepressor to liver and analyses by cDNA microarray
    Xu Feng
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 202:31-54. 2002
  9. pmc Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism
    Ty C Voss
    Laboratory of Receptor Biology and Gene Expression, Building 41, B602, 41 Library Drive, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 146:544-54. 2011
    ..Temporally sparse transcription factor-DNA interactions induce local chromatin reorganization, resulting in transient access for binding of secondary regulatory factors...
  10. ncbi request reprint Dynamic shuttling and intranuclear mobility of nuclear hormone receptors
    Padma Maruvada
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:12425-32. 2003
    ..They also show that ligand-binding and protein-protein interactions can affect the intracellular mobility of some NRs and thereby may contribute to their biological activity...
  11. ncbi request reprint Thyroid hormone action at the cellular, genomic and target gene levels
    Paul M Yen
    Department of Medicine, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue Rm B114, Baltimore, MD, USA
    Mol Cell Endocrinol 246:121-7. 2006
    ....
  12. ncbi request reprint Microarray analysis of knockout mice identifies cyclin D2 as a possible mediator for the action of thyroid hormone during the postnatal development of the cerebellum
    Anne Lise Poguet
    Laboratoire de Biologie Moléculaire et Cellulaire de l Ecole Normale Supérieure de Lyon UMR CNRS 5665 LA INRA913, 46 Allée d ltalie 69364 Lyon CEDEX07France
    Dev Biol 254:188-99. 2003
    ....
  13. pmc The rat thyroid hormone receptor (TR) Deltabeta3 displays cell-, TR isoform-, and thyroid hormone response element-specific actions
    Clare B Harvey
    Molecular Endocrinology Group, Division of Medicine and Medical Research Council Clinical Sciences Centre, Imperial College London, Clinical Research Building 5th Floor, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Endocrinology 148:1764-73. 2007
    ..Analysis of these complex responses implicates a range of nuclear corepressors and coactivators as cell-, TR isoform-, and TRE-specific modulators of T3 action...
  14. ncbi request reprint Editorial: studying hormonal regulation by microarrays: distinguishing the trees from the forest
    Paul M Yen
    J Clin Endocrinol Metab 90:1241-2. 2005
  15. ncbi request reprint Thyroid hormone-regulated target genes have distinct patterns of coactivator recruitment and histone acetylation
    Ying Liu
    Endocrinology Division, Department of Medicine, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, Room B114, Baltimore, Maryland 21224, USA
    Mol Endocrinol 20:483-90. 2006
    ..Our findings suggest that thyroid hormone-regulated target genes may have distinct patterns of coactivator recruitment and histone acetylation that may enable highly specific regulation...