Research Topics
Genomes and Genes
| Meredith YeagerSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomasStephen J Chanock
Section of Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4605, USA
Breast Cancer Res 9:R5. 2007....- A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)David G Cox
Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Breast Cancer Res 8:R54. 2006..Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)... - Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic densityMargarethe Biong
Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello 0310, Oslo, Norway
BMC Med Genomics 3:9. 2010..The associations between genetic polymorphisms in genes from the IGF pathway on mammographic density and circulating levels of IGF1, its binding protein IGFBP3, and their ratio in postmenopausal women are reported here... - High-throughput single nucleotide polymorphism genotyping using nanofluidic Dynamic ArraysJun Wang
Fluidigm Corporation, South San Francisco, CA, USA
BMC Genomics 10:561. 2009..This is also important for those who work on high throughput genotyping in non-model systems where off-the-shelf assays are not available and a flexible platform is needed... - Cis sequence effects on gene expressionAndrew W Bergen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD USA
BMC Genomics 8:296. 2007.... - Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control studyMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20952 7234, USA
BMC Cancer 7:60. 2007..We evaluated whether common genetic variation in SHBG and its 3' neighbor ATP1B2, in linkage disequilibrium, is associated with the risk of epithelial ovarian cancer... - Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancerMeredith Yeager
Core Genotyping Facility, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
Hum Genet 126:743-50. 2009..No sites were observed to be polymorphic within the exons of MSMB... - Identification of a new prostate cancer susceptibility locus on chromosome 8q24Meredith Yeager
Core Genotyping Facility, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland, USA
Nat Genet 41:1055-7. 2009..3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24... - Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancersMeredith Yeager
Core Genotyping Facility, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
Hum Genet 124:161-70. 2008.... - SNP500Cancer: a public resource for sequence validation, assay development, and frequency analysis for genetic variation in candidate genesBernice R Packer
Intramural Research Support Program, SAIC Frederick, NCI FCRDC, Frederick, MD, USA
Nucleic Acids Res 34:D617-21. 2006..The SNP500Cancer database is freely accessible via the web page at http://snp500cancer.nci.nih.gov... 
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24Meredith Yeager
SAIC Frederick, National Cancer Institute NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
Nat Genet 39:645-9. 2007..We estimate that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked by rs1447295 (21% versus 9%)...- A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)Gilles Thomas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Nat Genet 41:579-84. 2009..1 (rs999737; P = 1.74 x 10(-7)) localizes to RAD51L1, a gene in the homologous recombination DNA repair pathway. We also confirmed associations with loci on chromosomes 2q35, 5p12, 5q11.2, 8q24, 10q26 and 16q12.1... - Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibilityHong Lou
Laboratory of Experimental Immunology, Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 106:7933-8. 2009..Further investigation is warranted to determine whether rs10993994 alone or in combination with additional variants contributes to prostate cancer susceptibility... - Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancerMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
Int J Cancer 121:2532-8. 2007..However, data suggested that common variation in TP53 or WDR79 could be associated with ER negative breast cancers... - MBL2 and hepatitis C virus infection among injection drug usersElizabeth E Brown
Division of Cancer Epidemiology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
BMC Infect Dis 8:57. 2008..We examined whether MBL2 variants influence the outcome of hepatitis C virus (HCV) infection... - Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in ConnecticutKyoung Mu Lee
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Am J Hematol 85:560-3. 2010..Additional studies are needed to replicate these findings and, more generally, to explore the manner in which genes and receptors may influence the pathogenesis of this poorly understood malignancy... - SLC6A3 and body mass index in the Prostate, Lung, Colorectal and Ovarian Cancer Screening TrialElizabeth M Azzato
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland, USA
BMC Med Genet 10:9. 2009.... - Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-hodgkin lymphomaKathryn Hughes Barry
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Am J Epidemiol 173:404-13. 2011..77, 95% CI: 1.06, 2.97; P(interaction) = 0.06). In contrast, no effect was observed among AG/GG women. Additional studies with larger sample size are needed to replicate these findings... 
Promoter variants in the MSMB gene associated with prostate cancer regulate MSMB/NCOA4 fusion transcriptsHong Lou
Human Genetics Section, Basic Research Program, SAIC Frederick Inc, National Cancer Institute Frederick, Frederick, MD 21702, USA
Hum Genet 131:1453-66. 2012..The data provide an example of how GWAS-associated variants may have multiple genetic and epigenetic effects...- RNASEL Arg462Gln polymorphism and prostate cancer in PLCOSarah E Daugherty
Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Prostate 67:849-54. 2007..The relationship of this variant to sporadic prostate cancer remains uncertain... - A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinomaChristian C Abnet
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Nat Genet 42:764-7. 2010..19 x 10(-15); OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China... - Detectable clonal mosaicism and its relationship to aging and cancerKevin B Jacobs
Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
Nat Genet 44:651-8. 2012..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases... - Insulin resistance-related genes and advanced left-sided colorectal adenomaMarc J Gunter
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
Cancer Epidemiol Biomarkers Prev 16:703-8. 2007.... - A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility lociNathaniel Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Nat Genet 42:978-84. 2010..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis... - CYBB, an NADPH-oxidase gene: restricted diversity in humans and evidence for differential long-term purifying selection on transmembrane and cytosolic domainsEduardo Tarazona-Santos
Section of Genomic Variation, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Gaithersburg, Maryland, USA
Hum Mutat 29:623-32. 2008..Comparison of CYBB coding sequences among mammals evidences the action of long-term purifying selection, which is stronger on the C-terminal cytosolic domain than on the N-terminal transmembrane domain of gp91-phox... - SNP500Cancer: a public resource for sequence validation and assay development for genetic variation in candidate genesBernice R Packer
Intramural Research Support Program, SAIC Frederick, NCI FCRDC, Frederick, MD, USA
Nucleic Acids Res 32:D528-32. 2004..The SNP500Cancer Database is freely accessible via the web page at http://snp500cancer.nci.nih.gov/... - Validation of the performance of a comprehensive genotyping assay panel of single nucleotide polymorphisms in drug metabolism enzyme genesRobert A Welch
Core Genotyping Facility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Hum Mutat 29:750-6. 2008..Here, we present the results of these analyses, which strongly suggest that this panel of DME assays are of extremely high quality and produce robust, accurate, and reproducible results... - Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicityQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Carcinogenesis 30:50-8. 2009..Our findings suggest that SNPs involved in DNA repair and genomic maintenance, with particular clustering in the homologous DNA recombination pathway, play an important role in benzene-induced hematotoxicity... - Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathwayH Dean Hosgood
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Carcinogenesis 29:1938-43. 2008..These results should be viewed as exploratory until they are replicated in a larger study... - Folate metabolism genes, vegetable intake and renal cancer risk in central EuropeLee E Moore
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
Int J Cancer 122:1710-5. 2008..04 for all). In summary, these findings suggest that common variation in MTHFR and TYMS genes may be associated with RCC risk, particularly when vegetable intake is low... - Genetic variants in the 8q24 locus and risk of testicular germ cell tumorsMichael B Cook
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7234, USA
Hum Genet 123:409-18. 2008..In conclusion, this study has found little evidence for an association between the reported 8q24 SNPs and TGCTs, although the findings for nonseminoma may be worth further investigation... - Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studiesKim N Danforth
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
Carcinogenesis 29:568-72. 2008.... - Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancerNeal D Freedman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA
Carcinogenesis 30:71-7. 2009..These findings should be interpreted cautiously until replicated in other studies... - A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphomaMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
Carcinogenesis 30:275-81. 2009..No associations with TLR4 variants were observed. This pooled analysis provides strong evidence that variation in the TLR10-TLR1-TLR6 region is associated with NHL risk and suggests that TLR2 variants may influence susceptibility to MZL... - Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumourChristian P Kratz
Division of CancerEpidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
J Med Genet 48:473-6. 2011..Familial testicular germ cell tumours (TGCTs) and bilateral TGCTs comprise 1-2% and 5% of all TGCTs, respectively, but their genetic basis remains largely unknown... - Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in SpainKenneth P Cantor
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
Environ Health Perspect 118:1545-50. 2010..Bladder cancer has been linked with long-term exposure to disinfection by-products (DBPs) in drinking water... - Variation in innate immunity genes and risk of multiple myelomaMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, Bethesda, MD, USA
Hematol Oncol 29:42-6. 2011..0 × 10(-5) , P(permutation) = 0.07). Our findings suggest that genetic variants in SERPINE1 and HGF, and possibly CCR7, are associated with MM risk, and warrant further investigation in other studies... - Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutationsXiaohong Rose Yang
Division of Cancer Epidemiology and Genetics, NCI NIH DHHS, Bethesda, MD, USA
Fam Cancer 9:625-33. 2010..These genetic variants may, at least partially, exert their effects through nevi and tanning ability... - Risk of meningioma and common variation in genes related to innate immunityPreetha Rajaraman
Division of Cancer Epidemiology and Genetics, Neuro Oncology Branch, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS Room 7058, Bethesda, MD 20892 7238, USA
Cancer Epidemiol Biomarkers Prev 19:1356-61. 2010..The etiology of meningioma, the second most common type of adult brain tumor in the United States, is largely unknown. Prior studies indicate that history of immune-related conditions may affect the risk of meningioma... - Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2Ludmila Prokunina-Olsson
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 8717 Grovemont Circle, Bethesda, MD 20892 4605, USA
Cancer Epidemiol Biomarkers Prev 19:1349-55. 2010..2, showed a promising association with PrCa overall (P=2.14x10(-6)), with a suggestion of stronger association with aggressive disease (P=1.2x10(-7))... - Variants in blood pressure genes and the risk of renal cell carcinomaGabriella Andreotti
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852 4906, USA
Carcinogenesis 31:614-20. 2010..003). Our findings suggest that common genetic variants of AGT, particularly those in the promoter, increase RCC risk among subjects who are hypertensive or overweight... - A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinomaMaria Teresa Landi
Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Am J Hum Genet 85:679-91. 2009..In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma... - Genetic variation in N-acetyltransferases 1 and 2, cigarette smoking, and risk of non-Hodgkin lymphomaBriseis A Kilfoy
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Cancer Causes Control 21:127-33. 2010..We conclude that these findings require replication in larger studies and ultimately in pooled analyses... - Identification of modifier genes for cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutationsXiaohong Rose Yang
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI NIH DHHS, Bethesda, MD 20852, USA
Int J Cancer 125:2912-7. 2009..Our findings support the hypothesis that common genetic polymorphisms in DNA repair, apoptosis and immune response pathways may modify the risk of CMM in CMM-prone families with or without CDKN2A mutations... - Common gene variants in the tumor necrosis factor (TNF) and TNF receptor superfamilies and NF-kB transcription factors and non-Hodgkin lymphoma riskSophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America
PLoS ONE 4:e5360. 2009..We hypothesized that the TNF and NF-kappaB pathways are important for NHL and that gene variations across the pathways may alter NHL risk... - Apolipoprotein E/C1 locus variants modify renal cell carcinoma riskLee E Moore
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
Cancer Res 69:8001-8. 2009..In two large case-control studies, our findings further define a functional region of interest at the APOE locus that increases RCC susceptibility... - Genetic variation in cell cycle and apoptosis related genes and multiple myeloma riskH Dean Hosgood
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, United States
Leuk Res 33:1609-14. 2009..005). Haplotype analyses supported the SNP findings. These findings suggest that genetic variation in cell cycle and apoptosis genes may play a key role in multiple myeloma and warrant further investigation through replication studies... - Genome-wide and candidate gene association study of cigarette smoking behaviorsNeil Caporaso
Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland, United States of America
PLoS ONE 4:e4653. 2009..4x10(-5)), our analysis provides independent replication of the association between the chr15q25.1 region and smoking intensity and data for multiple other loci associated with smoking behavior that merit further follow-up... - Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, ChinaMin Shen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, Maryland 20892 7240, USA
Environ Mol Mutagen 50:285-90. 2009..Integrin/receptor and complement pathways as well as IgE regulation are particularly noteworthy... - Common variation in genes related to innate immunity and risk of adult gliomaPreetha Rajaraman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 18:1651-8. 2009..We have identified a promising set of innate immunity-related genetic regions for further investigation... - Hemochromatosis gene mutations and distal adenomatous colorectal polypsKatherine A McGlynn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS 7060, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
Cancer Epidemiol Biomarkers Prev 14:158-63. 2005..These results do not support a relationship between HFE heterozygosity and risk of advanced distal adenoma... - Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer riskJonine D Figueroa
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
Carcinogenesis 28:1788-93. 2007..17 (1.00-1.36). Results from this study provide evidence for associations between variants in genes in the DSBR pathway and bladder cancers risk that warrant replication in other study populations... - Genetic variation of Cytochrome P450 1B1 (CYP1B1) and risk of breast cancer among Polish womenMia M Gaudet
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland 20852, USA
Pharmacogenet Genomics 16:547-53. 2006..The present study provides strong evidence against the existence of a substantial overall association between common genetic variation in CYP1B1 and breast cancer risk... - Cigarette smoking, N-acetyltransferase genes and the risk of advanced colorectal adenomaRoxana Moslehi
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd, EPS 8047, Rockville, MD 20852 USA
Pharmacogenomics 7:819-29. 2006..Our interest is in the polymorphisms within the NAT1 and NAT2 genes that influence the tobacco-colorectal tumor relationship by impacting on the metabolic activation and detoxification of tobacco smoke-derived carcinogens... - Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer riskMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland, United States of America
PLoS Genet 3:e29. 2007..In conclusion, this large-scale evaluation of candidate cancer genes has identified common genetic variants in the regulatory regions of VEGF that could be associated with bladder cancer risk... - Common genetic variants in proinflammatory and other immunoregulatory genes and risk for non-Hodgkin lymphomaSophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20892 7234, USA
Cancer Res 66:9771-80. 2006..Our results require replication but potentially provide important clues for investigating common genetic variants as susceptibility factors and in disease outcomes, treatment responses, and immunotherapy targets... - Comprehensive assessment of genetic variation of catechol-O-methyltransferase and breast cancer riskMia M Gaudet
Division of Cancer Epidemiology, National Cancer Institute, 6120 Executive Boulevard, EPS 7055, Rockville, MD 20852, USA
Cancer Res 66:9781-5. 2006..The suggestion of increased risk associated with a haplotype in the 3' UTR of COMT needs to be confirmed in independent study populations... - Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphomaQing Lan
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, DHHS, Bethesda, MD 20892 7240, USA
Carcinogenesis 28:823-7. 2007..The striking protective associations observed for polymorphisms in all four genes for NHL and/or one or more subtypes suggest that genetic variation in CASP genes may play an important role in the etiology of NHL... - Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer riskMia M Gaudet
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Hum Genet 121:483-90. 2007..Additional studies are required to replicate these findings and to determine whether rs361525 is a causative SNP or is a marker of a causative SNP... - Interleukin-8 polymorphisms are not associated with gastric cancer risk in a Polish populationSharon A Savage
Section of Genomic Variation, Pediatric Oncology Branch, National Cancer Institute, Advanced Technology Center, 8717 Grovemont Circle, Bethesda, MD 20892-4605, USA
Cancer Epidemiol Biomarkers Prev 15:589-91. 2006 - Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicityMin Shen
Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892, USA
Carcinogenesis 27:2083-9. 2006..The effect of BRCA2 Ex11 +1487 A > G polymorphism was limited to granulocytes. These results suggest that genetic polymorphisms in WRN, TP53 and BRCA2 that maintain genomic stability impact benzene-induced hematotoxicity... - Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphomaQing Lan
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, MSC 7240, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
Blood 107:4101-8. 2006..84; 95% CI = 1.79-8.22; P < .001). Further, the IL10 and IL4 SNP associations remained significant after adjusting for multiple comparisons. These results suggest that SNPs in Th2 cytokine genes may be associated with risk of NHL... - Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, ChinaMin Shen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
Int J Cancer 116:768-73. 2005..However, due to the small sample size, additional studies are needed to evaluate these associations within Xuan Wei and in other populations with substantial environmental exposure to PAHs... - Association of multiple DRD2 polymorphisms with anorexia nervosaAndrew W Bergen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
Neuropsychopharmacology 30:1703-10. 2005..Genetically transmitted variation in D2 dopamine receptor expression mediated by functional polymorphisms affecting transcription and translation efficiency may play a role in vulnerability to AN... - Smoky coal exposure, NBS1 polymorphisms, p53 protein accumulation, and lung cancer risk in Xuan Wei, ChinaQing Lan
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
Lung Cancer 49:317-23. 2005..However, additional studies in other populations with substantial environmental exposures to PAHs are needed to confirm our findings... - GSTM1, GSTT1, and GSTP1 polymorphisms and risk of advanced colorectal adenomaLee E Moore
National Cancer Institute, 6120 Executive Boulevard, EPS 7034, Bethesda, MD 20892 7240, USA
Cancer Epidemiol Biomarkers Prev 14:1823-7. 2005..These findings only became apparent using a newly developed assay able to distinguish heterozygous from wild-type individuals. Our data provide evidence that phenotypic differences between these two groups exist... - Delta-aminolevulinic acid dehydratase polymorphism and risk of brain tumors in adultsPreetha Rajaraman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Environ Health Perspect 113:1209-11. 2005..2; 95% CI, 0.7-2.2). No increased risk associated with the ALAD2 variant was observed for glioma or acoustic neuroma. These findings suggest that the ALAD2 allele may increase genetic susceptibility to meningioma... - Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissionsQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
Carcinogenesis 25:2177-81. 2004..However, due to the small sample size, additional studies are needed to evaluate these associations within Xuan Wei and other populations with substantial exposure to PAHs... - Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzeneQing Lan
Division of Cancer Epidemiology, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
Cancer Res 65:9574-81. 2005..041) and increased (P = 0.076) CFU-GEMM progenitor cell colony formation in 29 benzene-exposed workers. This is the first report to provide evidence that SNPs in genes that regulate hematopoiesis influence benzene-induced hematotoxicity... - Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph ConsortiumNathaniel Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Lancet Oncol 7:27-38. 2006..We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph)... - Haplotypes of IL6 and IL10 and susceptibility to human T lymphotropic virus type I infection among childrenElizabeth E Brown
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
J Infect Dis 194:1565-9. 2006..2-17.6], and OR, 3.5 [95% CI, 1.4-9.0], respectively). Our findings are the first, to our knowledge, to suggest that host variation in both proinflammatory and anti-inflammatory genes could influence susceptibility to HTLV-I infection... - Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong KongQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
Eur J Haematol 85:492-5. 2010..5%) lower in the Chinese population compared with Caucasians. These results suggest that variants in three loci may contribute to risk of CLL among Chinese... - Lead, genetic susceptibility, and risk of adult brain tumorsPreetha Rajaraman
Division of Cancer Epidemiology Branch, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS Room 7085, Bethesda, MD 20892 7238, USA
Cancer Epidemiol Biomarkers Prev 15:2514-20. 2006..The ALAD G177C polymorphism affects the toxicokinetics of lead and may confer genetic susceptibility to adverse effects of lead exposure... - The future of pediatric cancer and complex diseases: aren't they all?Stephen Chanock
Section on Genomic Variation, Pediatric Oncology Branch and Core Genotyping Facility, National Cancer Institute, Bethesda, Maryland 20892 4065, USA
Pediatr Blood Cancer 48:719-22. 2007..It is evident that common genetic variation has emerged as a key component of a comprehensive understanding of pediatric cancer and its outcome. Future studies should unravel the complex interaction between genes and the environment... - Genetic polymorphisms in folate metabolism and the risk of stomach cancerFang Fang Zhang
Division of Cancer Epidemiology and Genetics, Advanced Technology Center, National Cancer Institute, Gaithersburg, Maryland, USA
Cancer Epidemiol Biomarkers Prev 16:115-21. 2007..Our study did not identify strong genetic determinants in the folate metabolism pathway for stomach cancer risk... - Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3Mark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, USA
Nat Genet 43:60-5. 2011..31 for rs4765623, which maps to SCARB1, the scavenger receptor class B, member 1 gene (P = 2.6 × 10⁻⁸). Our study reports previously unidentified genomic regions associated with RCC risk that may lead to new etiological insights... - Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer riskSara Karami
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland, USA
PLoS ONE 4:e7013. 2009..This study comprehensively evaluated genetic variation across eight vitamin D pathway genes in relation to RCC risk. We found increased risk associated with VDR and RXRA. Replication studies are warranted to confirm these findings... - A mutation in KIR3DS1 that results in truncation and lack of cell surface expressionMaureen P Martin
Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
Immunogenetics 59:823-9. 2007..The data indicate that the null KIR3DS1 allele is uncommon, arose on a single haplotype, and spread across geographically distinct populations... - GWASdb: a database for human genetic variants identified by genome-wide association studiesMulin Jun Li
Department of Biochemistry, The University of Hong Kong, Hong Kong SAR, China
Nucleic Acids Res 40:D1047-54. 2012..GWASdb provides an intuitive, multifunctional database for biologists and clinicians to explore GVs and their functional inferences. It is freely available at http://jjwanglab.org/gwasdb and will be updated frequently... - Genetic variation in base excision repair pathway genes, pesticide exposure, and prostate cancer riskKathryn Hughes Barry
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20892 7240, USA
Environ Health Perspect 119:1726-32. 2011..Previous research indicates increased prostate cancer risk for pesticide applicators and pesticide manufacturing workers. Although underlying mechanisms are unknown, evidence suggests a role of oxidative DNA damage... - Genotype frequency and F ST analysis of polymorphisms in immunoregulatory genes in Chinese and Caucasian populationsQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
Immunogenetics 59:839-52. 2007..25). These results suggest that there is substantial genetic diversity in immune genes and exploration of SNP associations with immune-related diseases that vary in incidence across these two populations may be warranted... - CYP17 genetic variation and risk of breast and prostate cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)Veronica Wendy Setiawan
Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
Cancer Epidemiol Biomarkers Prev 16:2237-46. 2007..Our findings do not support the hypothesis that common germ line variation in CYP17 makes a substantial contribution to postmenopausal breast or prostate cancer susceptibility... - Prostaglandin-endoperoxide synthase 2 (PTGS2) gene polymorphisms and risk of biliary tract cancer and gallstones: a population-based study in Shanghai, ChinaLori C Sakoda
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7234, USA
Carcinogenesis 27:1251-6. 2006..Further investigation is needed to confirm and extend our findings in studies of biliary tract cancer that more comprehensively examine PTGS2 and other inflammation-related genes... - Green tea consumption, genetic susceptibility, PAH-rich smoky coal, and the risk of lung cancerMatthew R Bonner
Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 8121, MSC 7240, Bethesda, MD 20892 7240, USA
Mutat Res 582:53-60. 2005..The chemopreventive effects of green tea in this population may be restricted to individuals who are particularly susceptible to oxidative stress and oxidative DNA damage... - Haplotypes of the estrogen receptor beta gene and breast cancer riskDavid G Cox
Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, Boston, MA, USA
Int J Cancer 122:387-92. 2008..These data suggest that inherited variants in ESR2 (while possibly conferring a small increased risk of breast cancer) are not associated with appreciable (OR > 1.2) changes in breast cancer risk among Caucasian women... - TNF polymorphisms and prostate cancer riskKim N Danforth
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20852, USA
Prostate 68:400-7. 2008..Inflammation has been hypothesized to increase prostate cancer risk. Tumor necrosis factor (TNF) is an important mediator of the inflammatory process, but the relationship between TNF variants and prostate cancer remains unclear... - Global diversity and evidence for coevolution of KIR and HLARichard M Single
The Department of Mathematics and Statistics, University of Vermont, Burlington, Vermont 05405, USA
Nat Genet 39:1114-9. 2007.... - Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenomaWen Yi Huang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 14:152-7. 2005..02). In conclusion, EPHX1 variants at codon 113 and 139 associated with high predicted enzymatic activity appear to increase risk for colorectal adenoma, particularly among recent and current smokers... - Association of genetic variants in the calcium-sensing receptor with risk of colorectal adenomaUlrike Peters
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
Cancer Epidemiol Biomarkers Prev 13:2181-6. 2004..We assessed the associations between CASR gene variants and risk for colorectal adenoma, a cancer precursor. We further investigated gene-diet interactions between the CASR variants and calcium intake on adenoma risk... - Common genetic variation in GATA-binding protein 3 and differential susceptibility to breast cancer by estrogen receptor alpha tumor statusMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, Room 7076, MSC 7234, Rockville, MD 20852 7234, USA
Cancer Epidemiol Biomarkers Prev 16:2269-75. 2007..These differential associations are consistent with markedly different levels of GATA3 protein by ER status. Additional epidemiologic studies are needed to clarify these intriguing relationships... - Genetic polymorphisms in alcohol metabolism, alcohol intake and the risk of stomach cancer in Warsaw, PolandFang Fang Zhang
Department of Epidemiology, School of Public Health, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Int J Cancer 121:2060-4. 2007..Furthermore, heavy drinkers of alcohol who were genetically prone to accumulate acetaldehyde may face an increased risk of stomach cancer... - COX1 and COX2 polymorphisms and gastric cancer risk in a Polish populationLifang Hou
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Drive, Chicago, IL 60611, USA
Anticancer Res 27:4243-7. 2007..Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied... - Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish populationRajeev Mahajan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Jpn J Clin Oncol 38:626-33. 2008..7-1.3) for C/T and 0.6 (95% CI, 0.3-1.0) T/T carriers compared with C/C carriers (P = 0.03). These results suggest that IL5 rs2069812 and IL7R rs1389832, rs1494556 and rs1494555 polymorphisms may contribute to gastric cancer etiology... - Metabolic gene variants and risk of non-Hodgkin's lymphomaAnneclaire J De Roos
Fred Hutchinson Cancer Research Center and University of Washington, 1100 Fairview Avenue North, M4 B874, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 15:1647-53. 2006..There was no overall association with non-Hodgkin's lymphoma for the other gene variants we examined. The modest effects we observed may reflect the context of exposures within the general population represented in our study... - IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3)Alpa V Patel
Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, United States of America
PLoS ONE 3:e2578. 2008..In summary, the impact of genetic variation in IGF1 and IGFBP3 on circulating IGF levels does not appear to substantially influence breast cancer risk substantially among primarily Caucasian postmenopausal women... - Polymorphisms in immunoregulatory genes, smoky coal exposure and lung cancer risk in Xuan Wei, ChinaKyoung Mu Lee
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
Carcinogenesis 28:1437-41. 2007..11, 95% CI = 0.03-0.44; P(interaction) = 0.03). In conclusion, genetic variation in immunoregulatory genes may play an important role in the development of lung cancer in this population... - A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancerDavid J Hunter
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Genet 39:870-4. 2007..Our summary results from the GWAS are available online in a form that should speed the identification of additional risk loci... - Hair dye use is not associated with risk for bladder cancer: evidence from a case-control study in SpainManolis Kogevinas
Municipal Institute of Medical Research, Centre for Research in Environmental Epidemiology CREAL, Respiratory and Environmental Health Research Unit, Dr Aiguader 80, 08003 Barcelona, Spain
Eur J Cancer 42:1448-54. 2006..None of the polymorphisms examined significantly modified the hair dye associated risk. Overall, this study does not support an association between hair dye use and bladder cancer... - Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in ConnecticutMin Shen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
Hum Genet 119:659-68. 2006..Further work is needed to extend these findings by carrying out extended haplotype analyses of these and related genes and to replicate the observations in other studies... - Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, ChinaGabriella Andreotti
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 8011, MSC 7240, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 17:525-34. 2008..5-fold risk of bile duct cancer. Our findings suggest that gene variants in the lipid metabolism pathway contribute to the risk of biliary tract stones and cancers, particularly of the bile duct... - Genetic polymorphisms of interleukin-1B (IL-1B), IL-6, IL-8, and IL-10 and risk of prostate cancerDominique S Michaud
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer Res 66:4525-30. 2006..At least seven common polymorphisms in genes of inflammatory cytokines IL-1B, IL-6, IL-8, and IL-10 do not seem to play a role in the risk of prostate cancer...