Fumihiko Yasuno

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint 11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux
    Sami S Zoghbi
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 0135, USA
    J Nucl Med 49:649-56. 2008
  2. doi request reprint PET study of brain acetylcholinesterase in cerebellar degenerative disorders
    Shigeki Hirano
    Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan
    Mov Disord 23:1154-60. 2008
  3. ncbi request reprint Quantification of serotonin 5-HT1A receptors in humans with [11C](R)-(-)-RWAY: radiometabolite(s) likely confound brain measurements
    Xiang Yang Zhang
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    Synapse 61:469-77. 2007
  4. ncbi request reprint PET imaging of neurokinin-1 receptors with [(18)F]SPA-RQ in human subjects: assessment of reference tissue models and their test-retest reproducibility
    Fumihiko Yasuno
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Synapse 61:242-51. 2007
  5. ncbi request reprint Synthesis and initial evaluation of [11C](R)-RWAY in monkey-a new, simply labeled antagonist radioligand for imaging brain 5-HT1A receptors with PET
    Julie A McCarron
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, B3 C346A, 10 Center Drive, Bethesda, MD 20892, USA
    Eur J Nucl Med Mol Imaging 34:1670-82. 2007
  6. pmc Decreased neurokinin-1 (substance P) receptor binding in patients with panic disorder: positron emission tomographic study with [18F]SPA-RQ
    Yota Fujimura
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 66:94-7. 2009
  7. ncbi request reprint The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain
    Fumihiko Yasuno
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 2035, USA
    Neuropsychopharmacology 33:259-69. 2008
  8. ncbi request reprint Quantification of serotonin 5-HT1A receptors in monkey brain with [11C](R)-(-)-RWAY
    Fumihiko Yasuno
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 0135, USA
    Synapse 60:510-20. 2006
  9. ncbi request reprint Decreased 5-HT1A receptor binding in amygdala of schizophrenia
    Fumihiko Yasuno
    Department of Psychiatry YO, Nippon Medical School, Tokyo, Japan
    Biol Psychiatry 55:439-44. 2004
  10. ncbi request reprint Comparative evaluation of two serotonin transporter ligands in the human brain: [(11)C](+)McN5652 and [(11)C]cyanoimipramine
    Akihiro Takano
    Brain Imaging Project, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Eur J Nucl Med Mol Imaging 29:1289-97. 2002

Collaborators

Detail Information

Publications30

  1. doi request reprint 11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux
    Sami S Zoghbi
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 0135, USA
    J Nucl Med 49:649-56. 2008
    ..We evaluated 11C-loperamide as a PET radiotracer to measure P-gp function in vivo...
  2. doi request reprint PET study of brain acetylcholinesterase in cerebellar degenerative disorders
    Shigeki Hirano
    Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan
    Mov Disord 23:1154-60. 2008
    ..Reduction of AChE activities in the thalamus and cerebellum in MSA and in the thalamus in SCA-3 suggest that cholinergic modulating drugs may have a role in the treatment of ataxia and other symptoms in these disorders...
  3. ncbi request reprint Quantification of serotonin 5-HT1A receptors in humans with [11C](R)-(-)-RWAY: radiometabolite(s) likely confound brain measurements
    Xiang Yang Zhang
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    Synapse 61:469-77. 2007
    ..Although prior studies in rodents and nonhuman primates showed [(11)C](R)-(-)-RWAY to be a promising radiotracer, we suspect that a species difference in metabolism caused this serious deficiency in humans...
  4. ncbi request reprint PET imaging of neurokinin-1 receptors with [(18)F]SPA-RQ in human subjects: assessment of reference tissue models and their test-retest reproducibility
    Fumihiko Yasuno
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Synapse 61:242-51. 2007
    ..7 in gray matter regions. In conclusion, a two-parameter reference tissue method (MRTM2) provided reproducible and reliable measurements of [(18)F]SPA-RQ brain uptake using 240 min of both regional and voxel-wise data...
  5. ncbi request reprint Synthesis and initial evaluation of [11C](R)-RWAY in monkey-a new, simply labeled antagonist radioligand for imaging brain 5-HT1A receptors with PET
    Julie A McCarron
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, B3 C346A, 10 Center Drive, Bethesda, MD 20892, USA
    Eur J Nucl Med Mol Imaging 34:1670-82. 2007
    ..We aimed to fulfill a need for a radioligand that may be simply labeled with carbon-11 for effective positron emission tomography (PET) imaging of brain 5-HT(1A) receptors...
  6. pmc Decreased neurokinin-1 (substance P) receptor binding in patients with panic disorder: positron emission tomographic study with [18F]SPA-RQ
    Yota Fujimura
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 66:94-7. 2009
    ..We also sought to determine if a drug-induced panic attack releases substance P in brain, as measured by decreased binding of [(18)F]SPA-RQ...
  7. ncbi request reprint The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain
    Fumihiko Yasuno
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 2035, USA
    Neuropsychopharmacology 33:259-69. 2008
    ..These promising results in monkey justify studying this radioligand in human subjects...
  8. ncbi request reprint Quantification of serotonin 5-HT1A receptors in monkey brain with [11C](R)-(-)-RWAY
    Fumihiko Yasuno
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 0135, USA
    Synapse 60:510-20. 2006
    ....
  9. ncbi request reprint Decreased 5-HT1A receptor binding in amygdala of schizophrenia
    Fumihiko Yasuno
    Department of Psychiatry YO, Nippon Medical School, Tokyo, Japan
    Biol Psychiatry 55:439-44. 2004
    ....
  10. ncbi request reprint Comparative evaluation of two serotonin transporter ligands in the human brain: [(11)C](+)McN5652 and [(11)C]cyanoimipramine
    Akihiro Takano
    Brain Imaging Project, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Eur J Nucl Med Mol Imaging 29:1289-97. 2002
    ..Both [(11)C](+)McN5652 and [(11)C]cyanoimipramine showed sufficient specific binding for performance of a quantitative analysis in the brain. [(11)C](+)McN5652 could be superior because of its higher distribution to the brain...
  11. ncbi request reprint Changes in central 5-HT(1A) receptor binding in mesial temporal epilepsy measured by positron emission tomography with [(11)C]WAY100635
    Shigeo Ito
    Section of Psychiatry and Behavioral Science, Graduate School of Tokyo Medical and Dental University, Tokyo, Japan
    Epilepsy Res 73:111-8. 2007
    ....
  12. ncbi request reprint Quantitative analysis for estimating binding potential of the peripheral benzodiazepine receptor with [(11)C]DAA1106
    Yoko Ikoma
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    J Cereb Blood Flow Metab 27:173-84. 2007
    ..However, there was no correlation between BP with NLS and DV with NLS, GA, and MA, because of the variation of K(1)/k(2) between individuals. In conclusion, BP is estimated most reliably by NLS with the two-tissue compartment model...
  13. ncbi request reprint An automated method for the extraction of regional data from PET images
    Pablo Rusjan
    PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Psychiatry Res 147:79-89. 2006
    ....
  14. ncbi request reprint Quantitative analysis of dopamine synthesis in human brain using positron emission tomography with L-[beta-11C]DOPA
    Hiroshi Ito
    Departments of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Nucl Med Commun 27:723-31. 2006
    ..In the present study, the regional kinetics of L-[beta-C]DOPA in normal human brain and the accuracy of the method for quantifying L-[beta-C]DOPA kinetics, employing reference regions, were investigated...
  15. ncbi request reprint Effects of smoking on the lung accumulation of [11C]McN5652
    Akihiro Takano
    Clinical Neuroimaging Section, Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Ann Nucl Med 21:349-54. 2007
    ..Various factors influence the accumulation of drugs. In this study, we investigated the effects of smoking on drug distribution to the lung using radiolabeled drugs...
  16. ncbi request reprint Time course of in vivo 5-HTT transporter occupancy by fluvoxamine
    Akihiro Takano
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    J Clin Psychopharmacol 26:188-91. 2006
    ..1 +/- 3.2 ng/mL at 26 hours, and 1.5 +/- 1.7 ng/mL at 53 hours. The relationship between the plasma concentration of fluvoxamine and 5-HTT occupancy at these different time points was fitted to the law of mass action...
  17. ncbi request reprint Age-related decline of dopamine synthesis in the living human brain measured by positron emission tomography with L-[beta-11C]DOPA
    Miho Ota
    Clinical Neuroimaging Section, Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Life Sci 79:730-6. 2006
    ..These results indicate that the previously demonstrated age-related decline in striatal dopamine synthesis extends to several extrastriatal regions in normal human brain...
  18. ncbi request reprint Quantitative analysis for estimating binding potential of the brain serotonin transporter with [11 C]McN5652
    Yoko Ikoma
    Department of Science and Engineering, Waseda University, Tokyo, Japan
    J Cereb Blood Flow Metab 22:490-501. 2002
    ....
  19. ncbi request reprint In vivo drug action of tandospirone at 5-HT1A receptor examined using positron emission tomography and neuroendocrine response
    Takashi Nakayama
    CREST, Japan Science and Technology Corporation, Kawaguchi, Japan
    Psychopharmacology (Berl) 165:37-42. 2002
    ..Tandospirone is a selective 5-hydroxytryptamine (HT)(1A) receptor agonist and is clinically used as an anxiolytic in Japan. However, there are no data concerning the occupancy of these receptors by tandospirone in the living human brain...
  20. ncbi request reprint Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory
    Fumihiko Yasuno
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Am J Psychiatry 160:334-40. 2003
    ..To clarify this relationship, the authors determined the availability of 5-HT(1A) receptors in the human brain and the relationship between regional receptor binding and memory function...
  21. ncbi request reprint No association between genotype of the promoter region of serotonin transporter gene and serotonin transporter binding in human brain measured by PET
    Kunihiko Shioe
    Department of Neuropsychiatry, Faculty of Medicine, University of Yamanashi, Tamaho, Japan
    Synapse 48:184-8. 2003
    ..118, s/s: 0.825 +/- 0.209). In conclusion, this study does not support the assumption that the genotype-dependent differences of 5-HTTLPR directly contributes to the regulation of the 5-HTT binding site in the living human brain...
  22. ncbi request reprint Estimation of the time-course of dopamine D2 receptor occupancy in living human brain from plasma pharmacokinetics of antipsychotics
    Akihiro Takano
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Int J Neuropsychopharmacol 7:19-26. 2004
    ..3 h respectively. Using plasma pharmacokinetics and in-vivo ED50, the time-course of receptor occupancy could be calculated. Simulation of drug kinetics at receptors would provide useful information for the evaluation of antipsychotics...
  23. ncbi request reprint Novel peripheral benzodiazepine receptor ligand [11C]DAA1106 for PET: an imaging tool for glial cells in the brain
    Jun Maeda
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Synapse 52:283-91. 2004
    ..11)C]DAA1106 binding was four times higher compared to the binding of [(11)C]PK11195 in the monkey occipital cortex. These results indicated that [(11)C]DAA1106 might be a good ligand for in vivo imaging of PBR...
  24. ncbi request reprint Low dopamine d(2) receptor binding in subregions of the thalamus in schizophrenia
    Fumihiko Yasuno
    National Institute of Radioloogical Sciences, Chiba, Japan
    Am J Psychiatry 161:1016-22. 2004
    ..The aim of the present study was to examine dopamine D(2) receptor binding in subregions of the thalamus in patients with schizophrenia...
  25. ncbi request reprint [Hippocampal serotonin 1A receptor and memory function]
    Fumihiko Yasuno
    Brain Imaging Project, National Institute of Radiological Sciences
    Seishin Shinkeigaku Zasshi 106:1314-22. 2004
    ..The results show that the postsynaptic 5-HT1A receptors localized in the hippocampal formation have a negative influence on explicit memory function...
  26. ncbi request reprint Abnormal effective connectivity of dopamine D2 receptor binding in schizophrenia
    Fumihiko Yasuno
    Brain Imaging Project, National Institute of Radiological Sciences, Inage Ku, Chiba 263 8555, Japan
    Psychiatry Res 138:197-207. 2005
    ..These results suggest that a systems-level change reflected in the connectivity of D2 receptor binding is present in schizophrenia...
  27. ncbi request reprint Time course of dopamine D2 receptor occupancy by clozapine with medium and high plasma concentrations
    Akihiro Takano
    Brain Imaging Project, National Institute of Radiological Sciences, 9 1 4 chome, Anagawa, Inage Ku, Chiba shi, Chiba 263 8555, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:75-81. 2006
    ..At high plasma concentration, clozapine can induce high extrastriatal dopamine D2 receptor occupancy in the human brain, and this finding fitted well with the theoretical estimation...
  28. ncbi request reprint The antipsychotic sultopride is overdosed--a PET study of drug-induced receptor occupancy in comparison with sulpiride
    Akihiro Takano
    Brain Imaging Project, National Institute of Radiological Sciences, 9 1, Anagawa 4 chome, Inage Ku, Chiba, Japan
    Int J Neuropsychopharmacol 9:539-45. 2006
    ..Evidence for the optimal doses of conventional antipsychotics based on dopamine D2 receptor occupancy would be helpful for rational antipsychotic therapy...
  29. ncbi request reprint Quantitative analyses of 18F-FEDAA1106 binding to peripheral benzodiazepine receptors in living human brain
    Yota Fujimura
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 47:43-50. 2006
    ..To our knowledge, this is the first study to investigate the (18)F-FEDAA1106 binding to PBR in living human brain by PET. We also aimed to evaluate various analytic methods to quantify the density of PBR...
  30. ncbi request reprint Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia
    Tetsuya Suhara
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, 9 1, Anagawa 4 chome, Inage Ku, Chiba shi, 263 8555 Japan
    Arch Gen Psychiatry 59:25-30. 2002
    ..On the other hand, a number of studies have reported abnormalities in the cerebral cortex of schizophrenia. The aim of this study was to examine the extrastriatal D2 receptors of patients with schizophrenia...