Genomes and Genes
Affiliation: National Institutes of Health
- Structural determinants of the anti-HIV activity of a CCR5 antagonist derived from Toxoplasma gondiiFelix Yarovinsky
Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Biol Chem 279:53635-42. 2004..These findings shed light on the structural basis of the molecular mimicry of the chemokine function by a pathogen-derived protein and provide a basis for further modification of C-18 into an antiviral agent...
- Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 responseFabienne Plattner
Department of Microbiology and Molecular Medicine, CMU, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
Cell Host Microbe 3:77-87. 2008..Thus, profilin is an essential element of two aspects of T. gondii infection. Like bacterial flagellin, profilin plays a role in motility while serving as a microbial ligand recognized by the host innate immune system...
- TLR11 activation of dendritic cells by a protozoan profilin-like proteinFelix Yarovinsky
Immunobiology Section, Laboratory of Parasitic Diseases National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Science 308:1626-9. 2005..Moreover, TLR11 is required in vivo for parasite-induced IL-12 production and optimal resistance to infection, thereby establishing a role for the receptor in host recognition of protozoan pathogens...
- Toll-like receptor recognition of Toxoplasma gondiiFelix Yarovinsky
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bld 50, Rm 6144, 50 South Drive MSC 8003, Bethesda, MD 20892 8003, USA
Int J Parasitol 36:255-9. 2006..Finally, we review the evidence for involvement of other TLR and TLR ligands in host resistance to T. gondii and discuss how such receptors might synergise with TLR11 in the innate response to the parasite...
- Toxoplasma gondii inhibits R5 HIV-1 replication in human lymphoid tissues ex vivoAtfa Sassi
Section of Intercellular Interactions, Program of Physical Biology, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Microbes Infect 11:1106-13. 2009..These ex vivo findings raise the possibility that, in addition to being a co-factor in HIV disease, T. gondii may influence the outcome of viral infection by preferentially suppressing R5 variants...
- Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell responseFelix Yarovinsky
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Immunity 25:655-64. 2006..These findings support a major influence of TLR recognition in antigen presentation by DC in vivo and establish a mechanism by which TLR ligand association regulates the immunogenicity of microbial antigens...
- CCR5 N-terminal region plays a critical role in HIV-1 inhibition by Toxoplasma gondii-derived cyclophilin-18Hana Golding
Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
J Biol Chem 280:29570-7. 2005..The elucidation of the functional C-18-binding mechanism may help in the rational design of novel antiviral agents against HIV...
- Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infectionsMark S Wilson
Immunopathogensis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 184:4378-90. 2010..The IL-22 pathway has emerged as a possible target for control of inflammation in certain autoimmune diseases. Our findings suggest that few if any infectious complications would be expected with the suppression of IL-22 signaling...
- Mouse cathelin-related antimicrobial peptide chemoattracts leukocytes using formyl peptide receptor-like 1/mouse formyl peptide receptor-like 2 as the receptor and acts as an immune adjuvantKahori Kurosaka
Laboratory of Molecular Immunoregulation, Center for Cancer Research, and Basic Research Program, Science Applications International Corporation Frederick, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
J Immunol 174:6257-65. 2005..Thus, CRAMP functions as both a chemoattractant for phagocytic leukocytes and an enhancer of adaptive immune response...
- Plasmacytoid dendritic cells are activated by Toxoplasma gondii to present antigen and produce cytokinesMarion Pepper
Department of Pathobiology, University of Pennsylvania, 380 South University Avenue, Philadelphia, PA 19104, USA
J Immunol 180:6229-36. 2008..Together these studies suggest that pDCs are a prominent DC subset involved in the initial stages of T. gondii infection, presenting parasite Ags and producing cytokines that are important for controlling infection...