Research Topics
Genomes and Genes
| Yingzi YangSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
Cbfbeta interacts with Runx2 and has a critical role in bone developmentMondira Kundu
Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Building 49, Room 3A26, Bethesda, Maryland 20892, USA
Nat Genet 32:639-44. 2002..Our findings raise the possibility that mutations in CBFB may be responsible for some cases of cleidocranial dysplasia that are not linked to mutations in RUNX2...
Wnt signaling in development and diseaseYingzi Yang
Genetic Disease Research Branch, National Human Genome Research Institute, 49 Convent Drive, MSC 4472, Bethesda, MD, 20892, USA
Cell Biosci 2:14. 2012..Our work also provides important insights in disease like Robinow syndrome, brachydactyly type B1 (BDB1) and spina bifida, which can be caused by human mutations in the Wnt/PCP signaling pathway...- Skeletal morphogenesis during embryonic developmentYingzi Yang
Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
Crit Rev Eukaryot Gene Expr 19:197-218. 2009..This review will particularly focus on how cell-cell signaling and transcription factors regulate multiple aspects of skeletal development... 
Growth and patterning in the limb: signaling gradients make the decisionYingzi Yang
Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Building 49, Room 4A68, 49 Convent Drive, MSC 4472, Bethesda, MD 20892, USA
Sci Signal 2:pe3. 2009..Alterations in the duration and range of the signaling gradients may underlie many of the morphological differences in the evolution of vertebrate limbs...- Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesisYingzi Yang
Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
Birth Defects Res C Embryo Today 69:305-17. 2003..As Wnt signaling in tumor formation has been reviewed extensively elsewhere, this part is not included in the review of the clinical significance of Wnt signaling... - The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturationXizhi Guo
Developmental Genetics Section, National Human Genome Research Institute, Bethesda, MD, USA
PLoS ONE 4:e6067. 2009..Furthermore, Wnt/beta-catenin signaling also controls final maturation of hypertrophic chondrocytes, but such regulation is PTHrP signaling-independent... - Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesisTimothy F Day
Geneti Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Dev Cell 8:739-50. 2005..Controlling Wnt/beta-catenin signaling is a common molecular mechanism underlying chondrocyte and osteoblast differentiation and specification of intramembranous and endochondral ossification... - Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2Bo Gao
National Human Genome Research Institute, Bethesda, MD 20892, USA
Dev Cell 20:163-76. 2011..Our studies have provided new insight to Robinow syndrome, Brachydactyly Type B1, and spinal bifida which are caused by mutations in human ROR2, WNT5A, or VANGL... - Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophyKinglun Kingston Mak
Genetic Disease Research Branch, National Human Genome Research Institute, 49 Convent Drive, MSC 4472, Bethesda, MD 20892, USA
Development 135:1947-56. 2008..In addition, we found that bone morphogenetic protein (Bmp) and Wnt/beta-catenin signaling in the cartilage may both mediate the effect of upregulated Ihh signaling in promoting chondrocyte hypertrophy... - Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expressionKinglun Kingston Mak
Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
Dev Cell 14:674-88. 2008..Our results demonstrate that Hh signaling in mature osteoblasts regulates both bone formation and resorption and that inhibition of Hh signaling reduces bone loss in aged mice... - Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formationXizhi Guo
Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
Genes Dev 18:2404-17. 2004..Wnt4, Wnt14, and Wnt16 may play redundant roles in synovial joint induction by signaling through the beta-catenin-mediated canonical Wnt pathway... - Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formationKingston Kinglun Mak
Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
Development 133:3695-707. 2006..However, there is a strong synergistic interaction between Wnt/beta-catenin and Ihh signaling in regulating synovial joint formation... - Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiationYingzi Yang
Genetic Disease Research Branch, National Human Genome Research Institute, National Institute of Health, Bethesda, MD 20892, USA
Development 130:1003-15. 2003..Our data indicate that Wnt5a and Wnt5b control the pace of transitions between different chondrocyte zones... 
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradationLilia Topol
Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Biol 162:899-908. 2003..Furthermore, we provide evidence that Wnt-5a also acts in vivo to promote beta-catenin degradation in regulating mammalian limb development and possibly in suppressing tumor formation...- beta-Catenin expression in the bone marrow microenvironment is required for long-term maintenance of primitive hematopoietic cellsMichael J Nemeth
Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892 4442, USA
Stem Cells 27:1109-19. 2009..From these data, we propose a model in which beta-catenin in the microenvironment is required noncell autonomously for long-term maintenance of hematopoietic progenitors... - Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppressionHai Song
Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 107:1431-6. 2010.... - LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growthItai Tzchori
Section on Mammalian Molecular Genetics, Laboratory of Mammalian Genes and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Development 136:1375-85. 2009.... - Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulationMichael J Nemeth
Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, MD 20892 4442, USA
Proc Natl Acad Sci U S A 104:15436-41. 2007..From these data, we propose that Wnt5a regulates hematopoiesis by the antagonism of the canonical Wnt pathway, resulting in a pool of quiescent HSCs... - Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleusLilia Topol
Genetics Disease Research Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
J Biol Chem 284:3323-33. 2009..This mechanism may be broadly employed by other intrinsic cell fate determining transcription factors to promptly turn off extrinsic inhibitory Wnt signaling mediated by beta-catenin... - Wnt and hedgehog signaling pathways in bone developmentTimothy F Day
Genetic Disease Research Branch, National Human Genome Research Institute, Building 49, Room 4A68, 49 Convent Drive, MSC 4472, Bethesda, MD 20892, USA
J Bone Joint Surg Am 90:19-24. 2008.... - Planar cell polarity breaks bilateral symmetry by controlling ciliary positioningHai Song
Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
Nature 466:378-82. 2010..Our data suggest that PCP acts earlier than the unidirectional nodal flow during bilateral symmetry breaking in vertebrates and provide insight into the functional mechanism of PCP in organizing the vertebrate tissues in development... - Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasiaJean B Regard
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 108:20101-6. 2011..Our data suggest that activated Gα proteins are playing physiologically significant roles during both skeletal development and disease by modulating Wnt/β-catenin signaling strength... - The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signalingDerek E Gildea
Institute for Biomedical Sciences, George Washington University, Washington, District of Columbia, USA
FASEB J 25:1596-605. 2011.... - Xom as a novel partner of Lef/Tcfs during dorsal-ventral patterning of the Xenopus embryoYingzi Yang
Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
Cell Res 17:307-8. 2007 - The wnt coreceptor ryk regulates wnt/planar cell polarity by modulating the degradation of the core planar cell polarity component vangl2Philipp Andre
From the Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892
J Biol Chem 287:44518-25. 2012..As human mutations in WNT5A and VANGL2 are found to cause Robinow syndrome and neural tube defects, respectively, our results further suggest that human mutations in RYK may also be involved in these diseases... - Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrPTatsuya Kobayashi
Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA
J Clin Invest 115:1734-42. 2005..These results demonstrate that Ihh acts on periarticular chondrocytes to stimulate their differentiation, thereby regulating the columnar cell mass independently of PTHrP...