Yingzi Yang

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Cbfbeta interacts with Runx2 and has a critical role in bone development
    Mondira Kundu
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Building 49, Room 3A26, Bethesda, Maryland 20892, USA
    Nat Genet 32:639-44. 2002
  2. ncbi request reprint Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis
    Yingzi Yang
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    Birth Defects Res C Embryo Today 69:305-17. 2003
  3. ncbi request reprint Skeletal morphogenesis during embryonic development
    Yingzi Yang
    Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    Crit Rev Eukaryot Gene Expr 19:197-218. 2009
  4. pmc Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning
    Hai Song
    Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    Nature 466:378-82. 2010
  5. pmc Wnt signaling in development and disease
    Yingzi Yang
    Genetic Disease Research Branch, National Human Genome Research Institute, 49 Convent Drive, MSC 4472, Bethesda, MD, 20892, USA
    Cell Biosci 2:14. 2012
  6. doi request reprint Growth and patterning in the limb: signaling gradients make the decision
    Yingzi Yang
    Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Building 49, Room 4A68, 49 Convent Drive, MSC 4472, Bethesda, MD 20892, USA
    Sci Signal 2:pe3. 2009
  7. pmc The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation
    Xizhi Guo
    Developmental Genetics Section, National Human Genome Research Institute, Bethesda, MD, USA
    PLoS ONE 4:e6067. 2009
  8. ncbi request reprint Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis
    Timothy F Day
    Geneti Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 8:739-50. 2005
  9. pmc Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2
    Bo Gao
    National Human Genome Research Institute, Bethesda, MD 20892, USA
    Dev Cell 20:163-76. 2011
  10. doi request reprint Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy
    Kinglun Kingston Mak
    Genetic Disease Research Branch, National Human Genome Research Institute, 49 Convent Drive, MSC 4472, Bethesda, MD 20892, USA
    Development 135:1947-56. 2008

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Cbfbeta interacts with Runx2 and has a critical role in bone development
    Mondira Kundu
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Building 49, Room 3A26, Bethesda, Maryland 20892, USA
    Nat Genet 32:639-44. 2002
    ..Our findings raise the possibility that mutations in CBFB may be responsible for some cases of cleidocranial dysplasia that are not linked to mutations in RUNX2...
  2. ncbi request reprint Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis
    Yingzi Yang
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    Birth Defects Res C Embryo Today 69:305-17. 2003
    ..As Wnt signaling in tumor formation has been reviewed extensively elsewhere, this part is not included in the review of the clinical significance of Wnt signaling...
  3. ncbi request reprint Skeletal morphogenesis during embryonic development
    Yingzi Yang
    Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    Crit Rev Eukaryot Gene Expr 19:197-218. 2009
    ..This review will particularly focus on how cell-cell signaling and transcription factors regulate multiple aspects of skeletal development...
  4. pmc Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning
    Hai Song
    Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    Nature 466:378-82. 2010
    ..Our data suggest that PCP acts earlier than the unidirectional nodal flow during bilateral symmetry breaking in vertebrates and provide insight into the functional mechanism of PCP in organizing the vertebrate tissues in development...
  5. pmc Wnt signaling in development and disease
    Yingzi Yang
    Genetic Disease Research Branch, National Human Genome Research Institute, 49 Convent Drive, MSC 4472, Bethesda, MD, 20892, USA
    Cell Biosci 2:14. 2012
    ..Our work also provides important insights in disease like Robinow syndrome, brachydactyly type B1 (BDB1) and spina bifida, which can be caused by human mutations in the Wnt/PCP signaling pathway...
  6. doi request reprint Growth and patterning in the limb: signaling gradients make the decision
    Yingzi Yang
    Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Building 49, Room 4A68, 49 Convent Drive, MSC 4472, Bethesda, MD 20892, USA
    Sci Signal 2:pe3. 2009
    ..Alterations in the duration and range of the signaling gradients may underlie many of the morphological differences in the evolution of vertebrate limbs...
  7. pmc The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation
    Xizhi Guo
    Developmental Genetics Section, National Human Genome Research Institute, Bethesda, MD, USA
    PLoS ONE 4:e6067. 2009
    ..Furthermore, Wnt/beta-catenin signaling also controls final maturation of hypertrophic chondrocytes, but such regulation is PTHrP signaling-independent...
  8. ncbi request reprint Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis
    Timothy F Day
    Geneti Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 8:739-50. 2005
    ..Controlling Wnt/beta-catenin signaling is a common molecular mechanism underlying chondrocyte and osteoblast differentiation and specification of intramembranous and endochondral ossification...
  9. pmc Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2
    Bo Gao
    National Human Genome Research Institute, Bethesda, MD 20892, USA
    Dev Cell 20:163-76. 2011
    ..Our studies have provided new insight to Robinow syndrome, Brachydactyly Type B1, and spinal bifida which are caused by mutations in human ROR2, WNT5A, or VANGL...
  10. doi request reprint Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy
    Kinglun Kingston Mak
    Genetic Disease Research Branch, National Human Genome Research Institute, 49 Convent Drive, MSC 4472, Bethesda, MD 20892, USA
    Development 135:1947-56. 2008
    ..In addition, we found that bone morphogenetic protein (Bmp) and Wnt/beta-catenin signaling in the cartilage may both mediate the effect of upregulated Ihh signaling in promoting chondrocyte hypertrophy...
  11. pmc Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation
    Xizhi Guo
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    Genes Dev 18:2404-17. 2004
    ..Wnt4, Wnt14, and Wnt16 may play redundant roles in synovial joint induction by signaling through the beta-catenin-mediated canonical Wnt pathway...
  12. ncbi request reprint Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation
    Yingzi Yang
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institute of Health, Bethesda, MD 20892, USA
    Development 130:1003-15. 2003
    ..Our data indicate that Wnt5a and Wnt5b control the pace of transitions between different chondrocyte zones...
  13. doi request reprint Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression
    Kinglun Kingston Mak
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Dev Cell 14:674-88. 2008
    ..Our results demonstrate that Hh signaling in mature osteoblasts regulates both bone formation and resorption and that inhibition of Hh signaling reduces bone loss in aged mice...
  14. ncbi request reprint Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation
    Kingston Kinglun Mak
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Development 133:3695-707. 2006
    ..However, there is a strong synergistic interaction between Wnt/beta-catenin and Ihh signaling in regulating synovial joint formation...
  15. pmc Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation
    Lilia Topol
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 162:899-908. 2003
    ..Furthermore, we provide evidence that Wnt-5a also acts in vivo to promote beta-catenin degradation in regulating mammalian limb development and possibly in suppressing tumor formation...
  16. pmc The Wnt coreceptor Ryk regulates Wnt/planar cell polarity by modulating the degradation of the core planar cell polarity component Vangl2
    Philipp Andre
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    J Biol Chem 287:44518-25. 2012
    ..As human mutations in WNT5A and VANGL2 are found to cause Robinow syndrome and neural tube defects, respectively, our results further suggest that human mutations in RYK may also be involved in these diseases...
  17. pmc Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleus
    Lilia Topol
    Genetics Disease Research Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
    J Biol Chem 284:3323-33. 2009
    ..This mechanism may be broadly employed by other intrinsic cell fate determining transcription factors to promptly turn off extrinsic inhibitory Wnt signaling mediated by beta-catenin...
  18. pmc Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
    Hai Song
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:1431-6. 2010
    ....
  19. pmc LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth
    Itai Tzchori
    Section on Mammalian Molecular Genetics, Laboratory of Mammalian Genes and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Development 136:1375-85. 2009
    ....
  20. pmc beta-Catenin expression in the bone marrow microenvironment is required for long-term maintenance of primitive hematopoietic cells
    Michael J Nemeth
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892 4442, USA
    Stem Cells 27:1109-19. 2009
    ..From these data, we propose a model in which beta-catenin in the microenvironment is required noncell autonomously for long-term maintenance of hematopoietic progenitors...
  21. pmc Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation
    Michael J Nemeth
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, MD 20892 4442, USA
    Proc Natl Acad Sci U S A 104:15436-41. 2007
    ..From these data, we propose that Wnt5a regulates hematopoiesis by the antagonism of the canonical Wnt pathway, resulting in a pool of quiescent HSCs...
  22. doi request reprint Wnt and hedgehog signaling pathways in bone development
    Timothy F Day
    Genetic Disease Research Branch, National Human Genome Research Institute, Building 49, Room 4A68, 49 Convent Drive, MSC 4472, Bethesda, MD 20892, USA
    J Bone Joint Surg Am 90:19-24. 2008
    ....
  23. pmc Planar cell polarity in vertebrate limb morphogenesis
    Bo Gao
    National Human Genome Research Institute, Bethesda, MD 20892, United States
    Curr Opin Genet Dev 23:438-44. 2013
    ..Directional information coded in the morphogen gradient may be interpreted by responding cells through regulating the activities of PCP components in a Wnt morphogen dose-dependent manner. ..
  24. pmc Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia
    Jean B Regard
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:20101-6. 2011
    ..Our data suggest that activated Gα proteins are playing physiologically significant roles during both skeletal development and disease by modulating Wnt/β-catenin signaling strength...
  25. pmc The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling
    Derek E Gildea
    Institute for Biomedical Sciences, George Washington University, Washington, District of Columbia, USA
    FASEB J 25:1596-605. 2011
    ....
  26. ncbi request reprint Xom as a novel partner of Lef/Tcfs during dorsal-ventral patterning of the Xenopus embryo
    Yingzi Yang
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Cell Res 17:307-8. 2007
  27. pmc Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis
    Yoshimi Endo Greer
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892
    Mol Biol Cell 25:1629-40. 2014
    ....
  28. pmc Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP
    Tatsuya Kobayashi
    Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA
    J Clin Invest 115:1734-42. 2005
    ..These results demonstrate that Ihh acts on periarticular chondrocytes to stimulate their differentiation, thereby regulating the columnar cell mass independently of PTHrP...