Yili Yang

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Regulation of apoptosis: the ubiquitous way
    Yili Yang
    Regulation of Cell Growth Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    FASEB J 17:790-9. 2003
  2. ncbi request reprint A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer
    Angelika M Burger
    Laboratories of Molecular Pathology, Department of Anatomic Pathology, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Cancer Res 65:10401-12. 2005
  3. pmc Targeting the ubiquitin-proteasome system for cancer therapy
    Yili Yang
    Cancer and Developmental Biology Laboratory, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Cancer Sci 100:24-8. 2009
  4. ncbi request reprint Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics
    Yili Yang
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, Maryland 21702, USA
    Cancer Res 67:9472-81. 2007
  5. ncbi request reprint Regulating the p53 system through ubiquitination
    Yili Yang
    Regulation of Protein Function Laboratory, Center for Cancer Research, National Cancer Institute Frederick, 1050 Boyles Street, 560 22 64, Frederick, MD 21702, USA
    Oncogene 23:2096-106. 2004
  6. ncbi request reprint Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
    Yili Yang
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, 1050 Boyles Street, Frederick, MD 21702, USA
    Cancer Cell 7:547-59. 2005
  7. doi request reprint Studies of the ubiquitin proteasome system
    Kevin L Lorick
    National Cancer Institute, Frederick, Maryland, USA
    Curr Protoc Cell Biol . 2006
  8. ncbi request reprint Expression and evaluation of RING finger proteins
    Yili Yang
    Dynamics and Signaling, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Methods Enzymol 398:103-12. 2005
  9. doi request reprint Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen
    CHRISTY A SASIELA
    Molecular Targets Development Program, National Cancer Institute, Frederick, Maryland 21702, USA
    J Biomol Screen 13:229-37. 2008
  10. pmc STAT1 activation regulates proliferation and differentiation of renal progenitors
    Honghe Wang
    Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702 1201, USA
    Cell Signal 22:1717-26. 2010

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Regulation of apoptosis: the ubiquitous way
    Yili Yang
    Regulation of Cell Growth Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    FASEB J 17:790-9. 2003
    ..These new findings also suggest that ubiquitination is one of the major mechanisms that regulate apoptotic cell death and could be a unique target for therapeutic intervention...
  2. ncbi request reprint A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer
    Angelika M Burger
    Laboratories of Molecular Pathology, Department of Anatomic Pathology, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Cancer Res 65:10401-12. 2005
    ..Its association with clinical measures and its effects on cell growth indicate that BCA2 may be important for the ubiquitin modification of proteins crucial to breast carcinogenesis and growth...
  3. pmc Targeting the ubiquitin-proteasome system for cancer therapy
    Yili Yang
    Cancer and Developmental Biology Laboratory, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Cancer Sci 100:24-8. 2009
    ....
  4. ncbi request reprint Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics
    Yili Yang
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, Maryland 21702, USA
    Cancer Res 67:9472-81. 2007
    ..These inhibitors can also be valuable tools for studying ubiquitylation...
  5. ncbi request reprint Regulating the p53 system through ubiquitination
    Yili Yang
    Regulation of Protein Function Laboratory, Center for Cancer Research, National Cancer Institute Frederick, 1050 Boyles Street, 560 22 64, Frederick, MD 21702, USA
    Oncogene 23:2096-106. 2004
    ..It is conceivable that new chemotherapeutic agents based on these studies will be generated in the not-so-distant future...
  6. ncbi request reprint Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
    Yili Yang
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, 1050 Boyles Street, Frederick, MD 21702, USA
    Cancer Cell 7:547-59. 2005
    ..In cells, the compounds allow the stabilization of p53 and HDM2 and activation of p53-dependent transcription and apoptosis, although other p53-independent toxicity was also observed...
  7. doi request reprint Studies of the ubiquitin proteasome system
    Kevin L Lorick
    National Cancer Institute, Frederick, Maryland, USA
    Curr Protoc Cell Biol . 2006
    ..Because another protein modifier, NEDD8, itself regulates aspects of the ubiquitin system, basic protocols on neddylation are also included in this unit...
  8. ncbi request reprint Expression and evaluation of RING finger proteins
    Yili Yang
    Dynamics and Signaling, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Methods Enzymol 398:103-12. 2005
    ..Use of these methods may help identify new E3s, dissect factors involved in ubiquitylation of substrates, and screen for molecules that affect ubiquitylation...
  9. doi request reprint Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen
    CHRISTY A SASIELA
    Molecular Targets Development Program, National Cancer Institute, Frederick, Maryland 21702, USA
    J Biomol Screen 13:229-37. 2008
    ..Sempervirine preferentially induced apoptosis in transformed cells expressing wild-type p53, suggesting that it could be a potential lead for anticancer therapeutics...
  10. pmc STAT1 activation regulates proliferation and differentiation of renal progenitors
    Honghe Wang
    Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702 1201, USA
    Cell Signal 22:1717-26. 2010
    ..These findings show that both metanephric progenitors and renal tumor cells utilize a STAT1-dependent mechanism for growth or survival...
  11. pmc Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism
    Shunsuke Tanigawa
    Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702 1201, USA
    Dev Biol 352:58-69. 2011
    ....
  12. pmc Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53
    Jason A Clement
    Molecular Targets Development Program, Center for Cancer Research, National Cancer Institute Frederick, National Institutes of Health, Frederick, MD 21702 1201, USA
    Bioorg Med Chem 16:10022-8. 2008
    ..badium. Lissoclinidine B inhibited ubiquitylation and degradation of p53, and selectively killed transformed cells harboring wild-type p53, suggesting this compound could be used to develop new treatments...
  13. pmc Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2
    Jirouta Kitagaki
    Laboratory of Protein Dynamics and Signaling, National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, MD 21702, USA
    Mol Cancer Ther 7:2445-54. 2008
    ..These results suggest that HLI373 could serve as a potential lead for developing cancer therapeutics based on inhibition of the ubiquitin ligase activity of Hdm2...
  14. ncbi request reprint TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
    Xiaoming Li
    Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Nature 416:345-7. 2002
    ..These findings identify a physiologic role for c-IAP1 and define a mechanism by which TNF-RII-regulated ubiquitin protein ligase activity can potentiate TNF-induced apoptosis...
  15. ncbi request reprint Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis
    Ivana Munitic
    Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 104:4165-72. 2004
    ..Therefore, the down-regulation of IL-7R on DP cells is an "altruistic" act required for maintaining an adequate supply of local IL-7 for DN cells...
  16. pmc Inheritance of susceptibility to induction of nephroblastomas in the Noble rat
    Bhalchandra A Diwan
    Basic Research Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
    Differentiation 77:424-32. 2009
    ..These studies demonstrate the value of this model for genetic analysis of nephroblastoma development and implicate both the Wnt and Notch pathways in its pathogenesis...
  17. pmc Interleukin-15 enhances proteasomal degradation of bid in normal lymphocytes: implications for large granular lymphocyte leukemias
    Deborah L Hodge
    Laboratory of Experimental Immunology, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute Frederick, and SAIC Frederick, Frederick, Maryland 21702 1201, USA
    Cancer Res 69:3986-94. 2009
    ....
  18. ncbi request reprint HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter
    Yili Yang
    Laboratory of Immune Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:19482-7. 2002
    ....
  19. doi request reprint DNA intercalator korkormicin A preferentially kills tumor cells expressing wild type p53
    Jirouta Kitagaki
    Cancer and Developmental Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Biochem Biophys Res Commun 414:186-91. 2011
    ..As it has been shown that p53 usually induces apoptosis in transformed cells, but only growth arrest in untransformed cells, these results indicate that korkormicin A is a potential antitumor agent for cancers with wild type p53...