Research Topics
Genomes and Genes | Yili YangSummaryAffiliation: National Cancer Institute Country: USA Publications
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Detail Information
Publications
Regulation of apoptosis: the ubiquitous wayYili Yang
Regulation of Cell Growth Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
FASEB J 17:790-9. 2003..These new findings also suggest that ubiquitination is one of the major mechanisms that regulate apoptotic cell death and could be a unique target for therapeutic intervention...- A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancerAngelika M Burger
Laboratories of Molecular Pathology, Department of Anatomic Pathology, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
Cancer Res 65:10401-12. 2005..Its association with clinical measures and its effects on cell growth indicate that BCA2 may be important for the ubiquitin modification of proteins crucial to breast carcinogenesis and growth... 
Targeting the ubiquitin-proteasome system for cancer therapyYili Yang
Cancer and Developmental Biology Laboratory, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
Cancer Sci 100:24-8. 2009....- Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeuticsYili Yang
Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, Maryland 21702, USA
Cancer Res 67:9472-81. 2007..These inhibitors can also be valuable tools for studying ubiquitylation... - Regulating the p53 system through ubiquitinationYili Yang
Regulation of Protein Function Laboratory, Center for Cancer Research, National Cancer Institute Frederick, 1050 Boyles Street, 560 22 64, Frederick, MD 21702, USA
Oncogene 23:2096-106. 2004..It is conceivable that new chemotherapeutic agents based on these studies will be generated in the not-so-distant future... - Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cellsYili Yang
Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, 1050 Boyles Street, Frederick, MD 21702, USA
Cancer Cell 7:547-59. 2005..In cells, the compounds allow the stabilization of p53 and HDM2 and activation of p53-dependent transcription and apoptosis, although other p53-independent toxicity was also observed... - Studies of the ubiquitin proteasome systemKevin L Lorick
National Cancer Institute, Frederick, Maryland, USA
Curr Protoc Cell Biol . 2006..Because another protein modifier, NEDD8, itself regulates aspects of the ubiquitin system, basic protocols on neddylation are also included in this unit... - Expression and evaluation of RING finger proteinsYili Yang
Dynamics and Signaling, National Cancer Institute at Frederick, Frederick, MD 21702, USA
Methods Enzymol 398:103-12. 2005..Use of these methods may help identify new E3s, dissect factors involved in ubiquitylation of substrates, and screen for molecules that affect ubiquitylation... 
Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screenCHRISTY A SASIELA
Molecular Targets Development Program, National Cancer Institute, Frederick, Maryland 21702, USA
J Biomol Screen 13:229-37. 2008..Sempervirine preferentially induced apoptosis in transformed cells expressing wild-type p53, suggesting that it could be a potential lead for anticancer therapeutics...- STAT1 activation regulates proliferation and differentiation of renal progenitorsHonghe Wang
Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702 1201, USA
Cell Signal 22:1717-26. 2010..These findings show that both metanephric progenitors and renal tumor cells utilize a STAT1-dependent mechanism for growth or survival... - Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanismShunsuke Tanigawa
Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702 1201, USA
Dev Biol 352:58-69. 2011.... - Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53Jason A Clement
Molecular Targets Development Program, Center for Cancer Research, National Cancer Institute Frederick, National Institutes of Health, Frederick, MD 21702 1201, USA
Bioorg Med Chem 16:10022-8. 2008..badium. Lissoclinidine B inhibited ubiquitylation and degradation of p53, and selectively killed transformed cells harboring wild-type p53, suggesting this compound could be used to develop new treatments... - Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2Jirouta Kitagaki
Laboratory of Protein Dynamics and Signaling, National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, MD 21702, USA
Mol Cancer Ther 7:2445-54. 2008..These results suggest that HLI373 could serve as a potential lead for developing cancer therapeutics based on inhibition of the ubiquitin ligase activity of Hdm2... - TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2Xiaoming Li
Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Nature 416:345-7. 2002..These findings identify a physiologic role for c-IAP1 and define a mechanism by which TNF-RII-regulated ubiquitin protein ligase activity can potentiate TNF-induced apoptosis... - Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesisIvana Munitic
Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 104:4165-72. 2004..Therefore, the down-regulation of IL-7R on DP cells is an "altruistic" act required for maintaining an adequate supply of local IL-7 for DN cells... - Inheritance of susceptibility to induction of nephroblastomas in the Noble ratBhalchandra A Diwan
Basic Research Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
Differentiation 77:424-32. 2009..These studies demonstrate the value of this model for genetic analysis of nephroblastoma development and implicate both the Wnt and Notch pathways in its pathogenesis... - Interleukin-15 enhances proteasomal degradation of bid in normal lymphocytes: implications for large granular lymphocyte leukemiasDeborah L Hodge
Laboratory of Experimental Immunology, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute Frederick, and SAIC Frederick, Frederick, Maryland 21702 1201, USA
Cancer Res 69:3986-94. 2009.... - HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoterYili Yang
Laboratory of Immune Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:19482-7. 2002.... - DNA intercalator korkormicin A preferentially kills tumor cells expressing wild type p53Jirouta Kitagaki
Cancer and Developmental Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
Biochem Biophys Res Commun 414:186-91. 2011..As it has been shown that p53 usually induces apoptosis in transformed cells, but only growth arrest in untransformed cells, these results indicate that korkormicin A is a potential antitumor agent for cancers with wild type p53...