Xiaohong R Yang

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Estrogen receptor and progesterone receptor expression in normal terminal duct lobular units surrounding invasive breast cancer
    Xiaohong R Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Blvd, Bethesda, MD USA
    Breast Cancer Res Treat 137:837-47. 2013
  2. ncbi Analysis of terminal duct lobular unit involution in luminal A and basal breast cancers
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res 14:R64. 2012
  3. ncbi Identification of susceptibility loci for complex diseases in a case-control association study using the Genetic Analysis Workshop 14 dataset
    Kimberly F Kerstann
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA
    BMC Genet 6:S102. 2005
  4. ncbi Genomic regions linked to alcohol consumption in the Framingham Heart Study
    Andrew W Bergen
    Core Genotyping Facility, Advanced Technology Center, National Cancer Institute, NIH, DHHS, Gaithersburg, Maryland, USA
    BMC Genet 4:S101. 2003
  5. ncbi Identification of modifier genes for cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations
    Xiaohong Rose Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI NIH DHHS, Bethesda, MD 20852, USA
    Int J Cancer 125:2912-7. 2009
  6. ncbi Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations
    Xiaohong Rose Yang
    Division of Cancer Epidemiology and Genetics, NCI NIH DHHS, Bethesda, MD, USA
    Fam Cancer 9:625-33. 2010
  7. ncbi Linkage analysis of anti-CCP levels as dichotomized and quantitative traits using GAW15 single-nucleotide polymorphism scan of NARAC families
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7236, Bethesda, Maryland 20892, USA
    BMC Proc 1:S107. 2007
  8. ncbi Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies
    Xiaohong R Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Sciences, Rockville, MD 20852, USA
    J Natl Cancer Inst 103:250-63. 2011
  9. ncbi Hormonal markers in breast cancer: coexpression, relationship with pathologic characteristics, and risk factor associations in a population-based study
    Xiaohong R Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Cancer Res 67:10608-17. 2007
  10. ncbi Differences in risk factors for breast cancer molecular subtypes in a population-based study
    Xiaohong R Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 7014, 6120 Executive Boulevard, Bethesda, MD 20892 7236, USA
    Cancer Epidemiol Biomarkers Prev 16:439-43. 2007

Detail Information

Publications29

  1. ncbi Estrogen receptor and progesterone receptor expression in normal terminal duct lobular units surrounding invasive breast cancer
    Xiaohong R Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Blvd, Bethesda, MD USA
    Breast Cancer Res Treat 137:837-47. 2013
    ..Analyses of mapped TDLUs may provide information about the sequence of molecular changes occurring in breast carcinogenesis...
  2. ncbi Analysis of terminal duct lobular unit involution in luminal A and basal breast cancers
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res 14:R64. 2012
    ..Accordingly, we performed a masked microscopic assessment of TDLU involution in benign tissues associated with luminal A and CBP breast cancers diagnosed among women less than age 55 years...
  3. ncbi Identification of susceptibility loci for complex diseases in a case-control association study using the Genetic Analysis Workshop 14 dataset
    Kimberly F Kerstann
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA
    BMC Genet 6:S102. 2005
    ..This result was most likely due to the method used for data simulation. In general, this study showed that conventional case-control association methods could detect disease loci responsible for the development of complex traits...
  4. ncbi Genomic regions linked to alcohol consumption in the Framingham Heart Study
    Andrew W Bergen
    Core Genotyping Facility, Advanced Technology Center, National Cancer Institute, NIH, DHHS, Gaithersburg, Maryland, USA
    BMC Genet 4:S101. 2003
    ....
  5. ncbi Identification of modifier genes for cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations
    Xiaohong Rose Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI NIH DHHS, Bethesda, MD 20852, USA
    Int J Cancer 125:2912-7. 2009
    ..Our findings support the hypothesis that common genetic polymorphisms in DNA repair, apoptosis and immune response pathways may modify the risk of CMM in CMM-prone families with or without CDKN2A mutations...
  6. ncbi Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations
    Xiaohong Rose Yang
    Division of Cancer Epidemiology and Genetics, NCI NIH DHHS, Bethesda, MD, USA
    Fam Cancer 9:625-33. 2010
    ..These genetic variants may, at least partially, exert their effects through nevi and tanning ability...
  7. ncbi Linkage analysis of anti-CCP levels as dichotomized and quantitative traits using GAW15 single-nucleotide polymorphism scan of NARAC families
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7236, Bethesda, Maryland 20892, USA
    BMC Proc 1:S107. 2007
    ..Our study also highlighted that quantitative trait linkage results are highly sensitive to phenotype transformation and analytic approaches...
  8. ncbi Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies
    Xiaohong R Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Sciences, Rockville, MD 20852, USA
    J Natl Cancer Inst 103:250-63. 2011
    ..Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors...
  9. ncbi Hormonal markers in breast cancer: coexpression, relationship with pathologic characteristics, and risk factor associations in a population-based study
    Xiaohong R Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Cancer Res 67:10608-17. 2007
    ....
  10. ncbi Differences in risk factors for breast cancer molecular subtypes in a population-based study
    Xiaohong R Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 7014, 6120 Executive Boulevard, Bethesda, MD 20892 7236, USA
    Cancer Epidemiol Biomarkers Prev 16:439-43. 2007
    ..Results from this study have shown that breast cancer risk factors may vary by molecular subtypes identified in expression studies, suggesting etiologic, in addition to clinical, heterogeneity of breast cancer...
  11. ncbi CYP1A1 and GSTM1 polymorphisms in relation to lung cancer risk in Chinese women
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, Bethesda MD 20892, USA
    Cancer Lett 214:197-204. 2004
    ..In summary, our case-control study of lung cancer among women in northeast China revealed an elevated risk associated with the CYP1A1 I462V genotype, but no interaction with smoking or indoor air pollution was found...
  12. ncbi Construction and validation of tissue microarrays of ductal carcinoma in situ and terminal duct lobular units associated with invasive breast carcinoma
    Xiaohong Rose Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20852, USA
    Diagn Mol Pathol 15:157-61. 2006
    ..Additional exploration of this approach is needed...
  13. ncbi Linkage analysis of the GAW14 simulated dataset with microsatellite and single-nucleotide polymorphism markers in large pedigrees
    Xiaohong Rose Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA
    BMC Genet 6:S14. 2005
    ..Finally, our results suggested that each linkage program had limitations in handling the large, complex pedigrees as well as a high-density SNP marker set...
  14. ncbi Distribution of Epstein-Barr viral load in serum of individuals from nasopharyngeal carcinoma high-risk families in Taiwan
    Xiaohong Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USA
    Int J Cancer 118:780-4. 2006
    ....
  15. ncbi Evaluation of risk factors for nasopharyngeal carcinoma in high-risk nasopharyngeal carcinoma families in Taiwan
    Xiaohong Rose Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 7014, Bethesda, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 14:900-5. 2005
    ..The results from the two methods were similar indicating that the risk estimates from conditional logistic regression were unbiased...
  16. ncbi Corroboration of a familial chordoma locus on chromosome 7q and evidence of genetic heterogeneity using single nucleotide polymorphisms (SNPs)
    Xiaohong Rose Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Int J Cancer 116:487-91. 2005
    ..Our study also provided insights into some limitations and analytical complexities associated with using a dense SNP marker set in linkage analysis of complex pedigrees...
  17. ncbi Genetic variants in DNA repair genes and the risk of cutaneous malignant melanoma in melanoma-prone families with/without CDKN2A mutations
    Xueying Sharon Liang
    Division of Cancer Epidemiology and Genetics, NCI NIH, Bethesda, MD, USA
    Int J Cancer 130:2062-6. 2012
    ..Our finding suggests that polymorphisms in DNA repair genes, POLN and PRKDC, were associated with increased melanoma risk in melanoma families with and without CDKN2A mutations...
  18. ncbi Variation in breast cancer hormone receptor and HER2 levels by etiologic factors: a population-based analysis
    Mark E Sherman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    Int J Cancer 121:1079-85. 2007
    ..07) for low PR and HER2 expression vs. OR = 1.78 (95% CI = 1.25-2.55) for high expression (p-heterogeneity = 0.001). PR and HER2 levels in breast cancer vary by BMI, suggesting a heterogeneous etiology for tumors related to these markers...
  19. ncbi T (brachyury) gene duplication confers major susceptibility to familial chordoma
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Nat Genet 41:1176-8. 2009
    ..Our findings highlight the value of screening for complex genomic rearrangements in searches for cancer-susceptibility genes...
  20. ncbi Lack of germline PALB2 mutations in melanoma-prone families with CDKN2A mutations and pancreatic cancer
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    Fam Cancer 10:545-8. 2011
    ..The results suggested that PALB2 does not explain the relationship between CDKN2A, melanoma, and pancreatic cancer in these melanoma-prone families...
  21. ncbi Assessment of automated image analysis of breast cancer tissue microarrays for epidemiologic studies
    Kelly L Bolton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 19:992-9. 2010
    ..We assessed agreement between automated and pathologist scores of a diverse set of immunohistochemical assays done on breast cancer tissue microarrays (TMA)...
  22. ncbi Duplication of CXC chemokine genes on chromosome 4q13 in a melanoma-prone family
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, MD, USA
    Pigment Cell Melanoma Res 25:243-7. 2012
    ..Our data suggest that the alteration of CXC chemokine genes may confer susceptibility to melanoma...
  23. ncbi Expression of TGF-beta signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res Treat 121:727-35. 2010
    ..These results warrant analysis in studies of clinical outcomes accounting for age, ER status and treatment...
  24. ncbi LINE-1 methylation in peripheral blood and the risk of melanoma in melanoma-prone families with and without CDKN2A mutations
    Paula L Hyland
    Division of Cancer Epidemiology and Genetics DCEG, National Cancer Institute NCI, National Institutes of Health NIH, DHHS, Division of Cancer Prevention, NCI, NIH, Bethesda, Maryland, USA
    Melanoma Res 23:55-60. 2013
    ..Our findings did not support a significant association between constitutional LINE-1 methylation in PBMCs and risk of CMM in melanoma-prone families with or without CDKN2A mutations...
  25. ncbi Identifying rheumatoid arthritis susceptibility genes using high-dimensional methods
    Xueying Liang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, Maryland 20892, USA
    BMC Proc 3:S79. 2009
    ..We conclude that the three high-dimensional methods are useful as an initial screening for gene associations to identify promising genes for further modeling and additional replication studies...
  26. ncbi On the interplay of telomeres, nevi and the risk of melanoma
    Clara Bodelon
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e52466. 2012
    ..Larger studies across different populations are necessary to clarify these associations...
  27. ncbi Mutation screening of CHD5 in melanoma-prone families linked to 1p36 revealed no deleterious coding or splice site changes
    David Ng
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA
    BMC Res Notes 1:86. 2008
    ..Based on these findings, we felt it was important to screen CHD5 as a familial CMM/DN susceptibility gene...
  28. ncbi Estimating age-specific breast cancer risks: a descriptive tool to identify age interactions
    William F Anderson
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Executive Plaza South 8070, 6120 Executive Plaza Blvd, Rockville, MD 20892 7242, USA
    Cancer Causes Control 18:439-47. 2007
    ..Clarifying age-specific female breast cancer risks and interactions may provide important etiologic clues...
  29. ncbi Genetic variation of Cytochrome P450 1B1 (CYP1B1) and risk of breast cancer among Polish women
    Mia M Gaudet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland 20852, USA
    Pharmacogenet Genomics 16:547-53. 2006
    ..The present study provides strong evidence against the existence of a substantial overall association between common genetic variation in CYP1B1 and breast cancer risk...