Mu Yang

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Low sociability in BTBR T+tf/J mice is independent of partner strain
    Mu Yang
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892 3730, USA
    Physiol Behav 107:649-62. 2012
  2. ncbi Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice
    Mu Yang
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Neurosci 32:6525-41. 2012
  3. ncbi Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication
    Ozlem Bozdagi
    Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Autism 1:15. 2010
  4. ncbi Social peers rescue autism-relevant sociability deficits in adolescent mice
    Mu Yang
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, Maryland 20892 3730, USA
    Autism Res 4:17-27. 2011
  5. ncbi Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability
    Mu Yang
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, NIH Building 35, Room 1C 909, Mail Code 3730, Bethesda, MD 20892 3730, USA
    Eur J Neurosci 29:1663-77. 2009
  6. ncbi Social deficits in BTBR T+tf/J mice are unchanged by cross-fostering with C57BL/6J mothers
    Mu Yang
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892 1375, USA
    Int J Dev Neurosci 25:515-21. 2007
  7. ncbi Behavioural phenotyping assays for mouse models of autism
    Jill L Silverman
    National Institute of Mental Health, Porter Neuroscience Research Center, Bethesda, MD 20892 3730, USA
    Nat Rev Neurosci 11:490-502. 2010
  8. ncbi Automated three-chambered social approach task for mice
    Mu Yang
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, NIH, Bethesda, Maryland, USA
    Curr Protoc Neurosci . 2011
  9. ncbi Criteria for validating mouse models of psychiatric diseases
    Kathryn K Chadman
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda 20892 3730, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 150:1-11. 2009
  10. ncbi Light phase testing of social behaviors: not a problem
    Mu Yang
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health Bethesda, MD, USA
    Front Neurosci 2:186-91. 2008

Collaborators

Detail Information

Publications16

  1. ncbi Low sociability in BTBR T+tf/J mice is independent of partner strain
    Mu Yang
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892 3730, USA
    Physiol Behav 107:649-62. 2012
    ..Our findings suggest that BTBR has poor abilities to modulate its responses to different social partners, which may be analogous to social cognition deficits in autism, adding to the value of this strain as a mouse model of autism...
  2. ncbi Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice
    Mu Yang
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Neurosci 32:6525-41. 2012
    ..These results demonstrate the exquisite specificity of deletions in discrete domains within the Shank3 gene in determining severity of symptoms...
  3. ncbi Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication
    Ozlem Bozdagi
    Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Autism 1:15. 2010
    ..abstract:..
  4. ncbi Social peers rescue autism-relevant sociability deficits in adolescent mice
    Mu Yang
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, Maryland 20892 3730, USA
    Autism Res 4:17-27. 2011
    ..This novel paradigm may prove useful for discovering factors that are essential for effective behavioral treatments, and biological mechanisms underlying effective behavioral interventions...
  5. ncbi Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability
    Mu Yang
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, NIH Building 35, Room 1C 909, Mail Code 3730, Bethesda, MD 20892 3730, USA
    Eur J Neurosci 29:1663-77. 2009
    ....
  6. ncbi Social deficits in BTBR T+tf/J mice are unchanged by cross-fostering with C57BL/6J mothers
    Mu Yang
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892 1375, USA
    Int J Dev Neurosci 25:515-21. 2007
    ..These findings favor a genetic interpretation of the unusual social behaviors and self-grooming traits of BTBR, and support the use of the BTBR inbred strain as a mouse model to study genetic mechanism of autism...
  7. ncbi Behavioural phenotyping assays for mouse models of autism
    Jill L Silverman
    National Institute of Mental Health, Porter Neuroscience Research Center, Bethesda, MD 20892 3730, USA
    Nat Rev Neurosci 11:490-502. 2010
    ..Robust phenotypes in mouse models hold great promise as translational tools for discovering effective treatments for components of autism spectrum disorders...
  8. ncbi Automated three-chambered social approach task for mice
    Mu Yang
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, NIH, Bethesda, Maryland, USA
    Curr Protoc Neurosci . 2011
    ..The Basic Protocol describes procedures for testing one subject at a time in a single apparatus. A Support Protocol addresses data collection...
  9. ncbi Criteria for validating mouse models of psychiatric diseases
    Kathryn K Chadman
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda 20892 3730, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 150:1-11. 2009
    ..We address the common question raised by molecular geneticists and clinical researchers in psychiatry, "what is a 'good enough' mouse model"?..
  10. ncbi Light phase testing of social behaviors: not a problem
    Mu Yang
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health Bethesda, MD, USA
    Front Neurosci 2:186-91. 2008
    ..Here we offer a comprehensive review on mouse social behaviors measured in light and dark phases and explain why it is reasonable to test laboratory mice in experimental social tasks in the light phase...
  11. ncbi Simple behavioral assessment of mouse olfaction
    Mu Yang
    National Institute of Mental Health, NIH, Bethesda, Maryland, USA
    Curr Protoc Neurosci . 2009
    ..The tests described in this unit only require simple equipment and can be adopted readily by most laboratories...
  12. ncbi The rat exposure test: a model of mouse defensive behaviors
    Mu Yang
    Pacific Biomedical Research Center, University of Hawaii, Honolulu 96822, USA
    Physiol Behav 81:465-73. 2004
    ..In particular, SAP levels were substantial in all strains tested, suggesting the usefulness of this test in assessment of the role of risk assessment in defense...
  13. ncbi Effects of the CRF1 antagonist SSR125543A on aggressive behaviors in hamsters
    Catherine Farrokhi
    Department of Psychology, University of Hawaii, 2430 Campus Road, Honolulu, HI 96822, USA
    Pharmacol Biochem Behav 77:465-9. 2004
    ....
  14. ncbi AVP V1b selective antagonist SSR149415 blocks aggressive behaviors in hamsters
    Robert J Blanchard
    Department of Psychology, University of Hawaii, 2430 Campus Road, Honolulu, HI 96822, USA
    Pharmacol Biochem Behav 80:189-94. 2005
    ..These findings agree with previous research on V1b receptor effects in suggesting that antagonism of this receptor may be useful in modulating a range of emotional responses to highly stressful or threatening conditions...
  15. ncbi Vaccination with dendritic cells transfected with BAK and BAX siRNA enhances antigen-specific immune responses by prolonging dendritic cell life
    Shiwen Peng
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Hum Gene Ther 16:584-93. 2005
    ..Our data indicate that transfection of dendritic cells with BAK/BAX siRNA represents a plausible strategy for enhancing dendritic cell-based vaccine potency...
  16. ncbi Dorsal premammillary nucleus differentially modulates defensive behaviors induced by different threat stimuli in rats
    D Caroline Blanchard
    Pacific Biomedical Research Center, University of Hawaii, Honolulu, HI 96822, USA
    Neurosci Lett 345:145-8. 2003
    ....