Genomes and Genes
Affiliation: National Institutes of Health
- The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell deathBin Yan
Center for Molecular Biology and Gene Therapy, The Department of Microbiology, Loma Linda University School of Medicine, Loma Linda, California 92354, USA
J Biol Chem 278:45358-67. 2003..Our results indicate that pim-2 functions similarly to pim-1 as a pro-survival kinase and suggest that BAD is a legitimate PIM-2 substrate...
- Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-kappaB and other signal transcription factors in head and neck squamous cell carcinomaBin Yan
Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Center Drive, Bethesda, Maryland 20892, USA
Genome Biol 8:R78. 2007..However, the molecular expression signatures and transcriptional regulatory controls that underlie the heterogeneity in HNSCCs are not well defined...
- Systems biology-defined NF-kappaB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 statusBin Yan
Head and Neck Surgery Branch, NIDCD, National Institutes of Health, Bethesda, MD 20892, USA
Genome Biol 9:R53. 2008..However, how NF-kappaB acts as a key regulatory node to modulate global gene expression, and contributes to the malignant heterogeneity of head and neck cancer, is not well understood...
- A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomasTin Lap Lee
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 1419, USA
Int J Cancer 122:1987-98. 2008..Inhibition of signal activation of both NF-kappaB and STAT3 together with reexpression of p53 could be the most effective strategy to restore BAX/BCL-XL regulation and for cytotoxic therapy of HNSCC...
- TNF-α promotes c-REL/ΔNp63α interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancerHai Lu
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland, USA
Cancer Res 71:6867-77. 2011....
- Proteomic signatures of epidermal growth factor receptor and survival signal pathways correspond to gefitinib sensitivity in head and neck cancerFrancisco G Pernas
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Clin Cancer Res 15:2361-72. 2009..To investigate the underlying molecular mechanism, the proteomic signatures and responses of EGFR and downstream signals have been studied in a panel of HNSCC cell lines and tumor specimens pre- and post-gefitinib treatment...
- A novel nuclear factor-kappaB gene signature is differentially expressed in head and neck squamous cell carcinomas in association with TP53 statusTin Lap Lee
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892 1419, USA
Clin Cancer Res 13:5680-91. 2007....
- ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammationXinping Yang
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892, USA
Cancer Res 71:3688-700. 2011..Our study reveals ΔNp63 as a master transcription factor that, in coordination with NF-κB/Rels, orchestrates a broad gene program promoting epidermal hyperplasia, inflammation, and the malignant phenotype of HNSCC...
- Deficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancerJay Friedman
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
Clin Cancer Res 13:6568-78. 2007....
- Attenuated transforming growth factor beta signaling promotes nuclear factor-kappaB activation in head and neck cancerJonah Cohen
Howard Hughes Medical Institute NIH Research Scholars Program, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland, USA
Cancer Res 69:3415-24. 2009..Together, these findings elucidate a regulatory framework in which attenuated TGFbeta signaling promotes NF-kappaB activation and squamous epithelial malignancy in the setting of altered TP53 status...
- A novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cellsQian Huang
Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
Clin Cancer Res 10:1439-45. 2004..CONCLUSIONS: The telomerase-targeted adenovirus vector has significant potential as an oncolytic virus as well as a tumor-specific therapeutic gene delivery vehicle...
- Characterizing regulation of metabolism in Geobacter sulfurreducens through genome-wide expression data and sequence analysisRadhakrishnan Mahadevan
Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada
OMICS 12:33-59. 2008..sulfurreducens and simulated Fe(II)-limited growth. The resulting prediction was consistent with data, suggesting that regulatory constraints are important for simulating growth phenotypes in nonoptimal environments...
- Computational prediction of conserved operons and phylogenetic footprinting of transcription regulatory elements in the metal-reducing bacterial family GeobacteraceaeBin Yan
Department of Preventive Medicine, Center of Genomics and Bioinformatics, University of Tennesee Health Science Center, 66 N. Pauline St, Ste. 633, Memphis, TN 38163, USA
J Theor Biol 230:133-44. 2004..These predictions will aid in further elucidation of regulatory networks of gene interactions in Geobacteraceae...
- Site-directed mutagenesis of substrate binding sites of azoreductase from Rhodobacter sphaeroidesGuangfei Liu
School of Environmental and Biological Science and Technology, Dalian University of Technology, 116024, Dalian, P R China
Biotechnol Lett 30:869-75. 2008..K109 might only be involved in the binding of the 2'-phosphate group of NADPH and have no effect on the binding of NADH. Y74W and H75N mutations decreased the binding of methyl red/nitrofurazone and had no affect on the binding of NADPH...
- Improved temporal clustering analysis method for detecting multiple response peaks in fMRINa Lu
Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, 19 Yuquan Road, Beijing 100-049, China
J Magn Reson Imaging 23:285-90. 2006..CONCLUSION: The new method is effective in detecting multiple activations even when the timing and location of the brain activation are completely unknown...
- A unique role of the DNA fragmentation factor in maintaining genomic stabilityBin Yan
Departments of Radiation Oncology and Pathology, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 103:1504-9. 2006....
- Regulation of HIF-1alpha stability through S-nitrosylationFang Li
Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Mol Cell 26:63-74. 2007..This interaction between NO and HIF-1 sheds new light on their involvement in tumor response to treatment as well as mammalian inflammation process in general...
- Small interfering RNA-mediated caveolin-1 knockout on plasminogen activator inhibitor-1 expression in insulin-stimulated human vascular endothelial cellsHuiling Yang
Institute of Clinic Medicine, The First Affiliated Hospital of Nanhua University, Hengyang, China
Acta Biochim Biophys Sin (Shanghai) 39:224-33. 2007....
- Construction and functional analysis of a lentiviral expression vector containing a scavenger receptor (SR-PSOX) that binds uniquely phosphatidylserine and oxidized lipoproteinZhihua Quan
Institute of Cardiovascular Disease, Nanhua University, Hengyang, China
Acta Biochim Biophys Sin (Shanghai) 39:208-16. 2007..Our data suggested that the overexpression of recombinant human SR-PSOX protein can promote foam cell formation and upregulate the expression of the inflammatory factor TNF-alpha...
- Genome-wide similarity search for transcription factors and their binding sites in a metal-reducing prokaryote Geobacter sulfurreducensBin Yan
Department of Preventive Medicine, University of Tennessee Health Science Center, 66 N Pauline St, Ste 633, Memphis, TN 38163, USA
Biosystems 90:421-41. 2007..The closest homolog of E. coli RpoE in G. sulfurreducens may be more similar to FecI than to RpoE. These findings represent the first step in the understanding of the regulatory relationships in G. sulfurreducens on the genome scale...
- Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformationBin Yan
Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
Cancer Res 66:11565-70. 2006....
- Computational prediction of RpoS and RpoD regulatory sites in Geobacter sulfurreducens using sequence and gene expression informationBin Yan
Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA
Gene 384:73-95. 2006....