Jerrel L Yakel

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Cholinergic receptors: functional role of nicotinic ACh receptors in brain circuits and disease
    Jerrel L Yakel
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P O Box 12233, Mail Drop F2 08, Research Triangle Park, NC 27709, USA
    Pflugers Arch 465:441-50. 2013
  2. pmc Nicotinic ACh receptors in the hippocampus: role in excitability and plasticity
    Jerrel L Yakel
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, P O Box 12233, Mail Drop F2 08, Research Triangle Park, NC 27709, USA
    Nicotine Tob Res 14:1249-57. 2012
  3. ncbi request reprint Functional and molecular characterization of neuronal nicotinic ACh receptors in rat hippocampal interneurons
    Jerrel L Yakel
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, F2 08, 111 T W Alexander Drive, P O Box 12233, Research Triangle Park, NC 27709, USA
    Prog Brain Res 145:95-107. 2004
  4. pmc Gating of nicotinic ACh receptors: latest insights into ligand binding and function
    Jerrel L Yakel
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 588:597-602. 2010
  5. pmc Dendritic Ca2+ signalling due to activation of alpha 7-containing nicotinic acetylcholine receptors in rat hippocampal neurons
    Dmitriy Fayuk
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 582:597-611. 2007
  6. pmc Paired-pulse potentiation of alpha7-containing nAChRs in rat hippocampal CA1 stratum radiatum interneurones
    Rebecca C Klein
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, NIH, DHHS, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 568:881-9. 2005
  7. pmc Cholinergic coordination of presynaptic and postsynaptic activity induces timing-dependent hippocampal synaptic plasticity
    Zhenglin Gu
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 32:12337-48. 2012
  8. pmc Inhibition of native and recombinant nicotinic acetylcholine receptors by the myristoylated alanine-rich C kinase substrate peptide
    Elaine A Gay
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 327:884-90. 2008
  9. pmc Functional somato-dendritic alpha7-containing nicotinic acetylcholine receptors in the rat basolateral amygdala complex
    Rebecca C Klein
    NIEHS, F2 08, PO Box 12233, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    J Physiol 576:865-72. 2006
  10. pmc Allosteric modulators of the α4β2 subtype of neuronal nicotinic acetylcholine receptors
    Anshul Pandya
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Biochem Pharmacol 82:952-8. 2011

Collaborators

Detail Information

Publications33

  1. pmc Cholinergic receptors: functional role of nicotinic ACh receptors in brain circuits and disease
    Jerrel L Yakel
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P O Box 12233, Mail Drop F2 08, Research Triangle Park, NC 27709, USA
    Pflugers Arch 465:441-50. 2013
    ..Here, I will briefly review this work, and where we are going in our attempts to further understand the role of these receptors in learning and memory, as well as in disease and neuroprotection...
  2. pmc Nicotinic ACh receptors in the hippocampus: role in excitability and plasticity
    Jerrel L Yakel
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, P O Box 12233, Mail Drop F2 08, Research Triangle Park, NC 27709, USA
    Nicotine Tob Res 14:1249-57. 2012
    ....
  3. ncbi request reprint Functional and molecular characterization of neuronal nicotinic ACh receptors in rat hippocampal interneurons
    Jerrel L Yakel
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, F2 08, 111 T W Alexander Drive, P O Box 12233, Research Triangle Park, NC 27709, USA
    Prog Brain Res 145:95-107. 2004
  4. pmc Gating of nicotinic ACh receptors: latest insights into ligand binding and function
    Jerrel L Yakel
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 588:597-602. 2010
    ....
  5. pmc Dendritic Ca2+ signalling due to activation of alpha 7-containing nicotinic acetylcholine receptors in rat hippocampal neurons
    Dmitriy Fayuk
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 582:597-611. 2007
    ..These results may have implications for the role that alpha 7 nAChRs have in regulating various signal transduction cascades, synaptic plasticity, and memory processes, via significant changes in [Ca(2+)]i levels...
  6. pmc Paired-pulse potentiation of alpha7-containing nAChRs in rat hippocampal CA1 stratum radiatum interneurones
    Rebecca C Klein
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, NIH, DHHS, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 568:881-9. 2005
    ..Thus, rat hippocampal alpha7-containing nAChRs possess a newly described phenomenon of paired-pulse potentiation that may be involved in regulating synaptic plasticity in the hippocampus...
  7. pmc Cholinergic coordination of presynaptic and postsynaptic activity induces timing-dependent hippocampal synaptic plasticity
    Zhenglin Gu
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 32:12337-48. 2012
    ....
  8. pmc Inhibition of native and recombinant nicotinic acetylcholine receptors by the myristoylated alanine-rich C kinase substrate peptide
    Elaine A Gay
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 327:884-90. 2008
    ..The MARCKS ED peptide represents a novel antagonist of neuronal nAChRs that has considerable utility as a research tool...
  9. pmc Functional somato-dendritic alpha7-containing nicotinic acetylcholine receptors in the rat basolateral amygdala complex
    Rebecca C Klein
    NIEHS, F2 08, PO Box 12233, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    J Physiol 576:865-72. 2006
    ..This is the first report demonstrating the presence of functional nAChR-mediated current responses from rat amygdala slices, where they may be playing a significant role in fear and aversively motivated memory...
  10. pmc Allosteric modulators of the α4β2 subtype of neuronal nicotinic acetylcholine receptors
    Anshul Pandya
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Biochem Pharmacol 82:952-8. 2011
    ..Here we discuss the concept of allosterism as it pertains to the α4β2 receptors and summarize the important features of allosteric modulators for this nicotinic receptor subtype...
  11. pmc Structural determinates for apolipoprotein E-derived peptide interaction with the alpha7 nicotinic acetylcholine receptor
    Elaine A Gay
    NIEHS, F2 08, P O Box 12233, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 72:838-49. 2007
    ..The current data suggest a mode for apoE peptide binding that directly blocks alpha7 nAChR activity and consequently may disrupt nAChR signaling...
  12. ncbi request reprint Inhibition of neuronal nicotinic acetylcholine receptor channels expressed in Xenopus oocytes by beta-amyloid1-42 peptide
    Patricia W Lamb
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709 lt f
    J Mol Neurosci 27:13-21. 2005
    ..The relative block by Abeta1-42 was dependent on the subunit makeup and apparent stoichiometry of these receptors. These data further support our previous findings that Abeta1-42 directly and preferentially inhibits non-alpha7 nAChRs...
  13. pmc Aromatic residues at position 55 of rat alpha7 nicotinic acetylcholine receptors are critical for maintaining rapid desensitization
    Elaine A Gay
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 586:1105-15. 2008
    ..Furthermore, these data suggest that W55 may be a potential target for modulatory agents operating via hydrophobic interactions...
  14. pmc Presynaptic α7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activation
    Qing Cheng
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709
    J Neurosci 34:124-33. 2014
    ..Our findings indicate that activation of α7 nAChRs at presynaptic sites, via a mechanism involving PKA, plays a critical role in enhancing synaptic efficiency of hippocampal mossy fiber transmission. ..
  15. pmc Characterization of a nicotine-sensitive neuronal population in rat entorhinal cortex
    Bin Tu
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    J Neurosci 29:10436-48. 2009
    ..Our data suggest that ECVI neurons are important regulators of hippocampal function and plasticity during smoking...
  16. pmc Functional alpha7-containing nicotinic acetylcholine receptors localize to cell bodies and proximal dendrites in the rat substantia nigra pars reticulata
    Olga V Poisik
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and HumanServices, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 586:1365-78. 2008
    ..Our data are paving the way to a better understanding of the physiological roles of nAChRs in the BG...
  17. pmc Timing-dependent septal cholinergic induction of dynamic hippocampal synaptic plasticity
    Zhenglin Gu
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Neuron 71:155-65. 2011
    ..These results have revealed the remarkable temporal precision of cholinergic functions, providing a novel mechanism for information processing in cholinergic-dependent higher cognitive functions...
  18. pmc The frequency-dependence of the nicotine-induced inhibition of dopamine is controlled by the α7 nicotinic receptor
    Andrew T Seipel
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    J Neurochem 114:1659-66. 2010
    ..The frequency dependence of the low dose nicotine inhibition therefore requires functional α7 nAChRs, and may arise from differing levels of endogenous acetylcholine evoked by the stimulation...
  19. doi request reprint Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system
    Jian Xin Shen
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health DHHS, Research Triangle Park, NC 27709, USA
    Acta Pharmacol Sin 30:673-80. 2009
    ....
  20. ncbi request reprint Functional mapping and Ca2+ regulation of nicotinic acetylcholine receptor channels in rat hippocampal CA1 neurons
    Leonard Khiroug
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 23:9024-31. 2003
    ..Our results demonstrate the strategic location and Ca2+ regulation of alpha7-containing nAChRs, which may contribute to understanding their involvement in hippocampal plasticity...
  21. pmc Rapid desensitization of the rat α7 nAChR is facilitated by the presence of a proline residue in the outer β-sheet
    Thomas J McCormack
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    J Physiol 588:4415-29. 2010
    ..Our results indicate that rapid desensitization of the wild-type rat α7 nAChR is facilitated by the presence of the proline residue within the β9 strand...
  22. pmc Inhibition of alpha 7-containing nicotinic ACh receptors by muscarinic M1 ACh receptors in rat hippocampal CA1 interneurones in slices
    Jian Xin Shen
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 587:1033-42. 2009
    ..This information will help to understand how these cholinergic receptor systems might be regulating neuronal excitability in the hippocampus in a manner that has relevance for synaptic plasticity and cognition...
  23. ncbi request reprint Apolipoprotein E-derived peptides block alpha7 neuronal nicotinic acetylcholine receptors expressed in xenopus oocytes
    Elaine A Gay
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 316:835-42. 2006
    ..These results may be useful in elucidating the mechanisms underlying memory loss and cognitive decline seen in Alzheimer's disease as well as aid in the development of novel therapeutics using apoE-derived peptides...
  24. pmc Ca2+ permeability of nicotinic acetylcholine receptors in rat hippocampal CA1 interneurones
    Dmitriy Fayuk
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, NIH, DHHS, PO Box 12233, Research Triangle Park, NC 27709, USA corrected
    J Physiol 566:759-68. 2005
    ..Therefore, the alpha7-containing nAChRs in rat hippocampal interneurones are significantly less permeable to Ca2+ than not only NMDA receptors but also alpha7 nAChRs in PC12 cells...
  25. pmc Allosteric modulator Desformylflustrabromine relieves the inhibition of α2β2 and α4β2 nicotinic acetylcholine receptors by β-amyloid(1-42) peptide
    Anshul Pandya
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    J Mol Neurosci 45:42-7. 2011
    ..This study demonstrates that PAMs for the non-α7 nAChRs have the potential to develop into clinically applicable drugs for AD and other disorders...
  26. ncbi request reprint Regulation of nicotinic acetylcholine receptor channel function by acetylcholinesterase inhibitors in rat hippocampal CA1 interneurons
    Dmitriy Fayuk
    National Institute of Environmental Health Scinces, F2 08, P O Box 12233, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 66:658-66. 2004
    ..Therefore, drugs that target AChE are likely to be important regulators of cholinergic signaling in the hippocampus...
  27. pmc Gating of nicotinic ACh receptors; new insights into structural transitions triggered by agonist binding that induce channel opening
    Elaine A Gay
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    J Physiol 584:727-33. 2007
    ....
  28. doi request reprint Identification and functional characterization of a novel acetylcholine-binding protein from the marine annelid Capitella teleta
    Thomas McCormack
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 49:2279-87. 2010
    ....
  29. pmc Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT₁a receptor antagonist
    Anshul A Pandya
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, MD F2 08, PO Box 12233, NC 27709, USA
    Neuropharmacology 70:35-42. 2013
    ..These results suggest that α7 nAChR PAMs are pharmacologically advantageous over agonists, and should be considered for further development as therapeutic drugs targeting the α7 receptors...
  30. pmc The α7 nicotinic acetylcholine receptor function in hippocampal neurons is regulated by the lipid composition of the plasma membrane
    José O Colón-Sáez
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    J Physiol 589:3163-74. 2011
    ..These data provide new insights into themechanism of desensitization of α7 nAChRs by providing evidence that the lipid composition of the plasma membrane can modulate the activity of the α7 nAChRs...
  31. pmc Serotonin 5-HT(3) receptors in rat CA1 hippocampal interneurons: functional and molecular characterization
    Sterling N Sudweeks
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 544:715-26. 2002
    ..Using non-stationary fluctuation analysis, we obtained an estimate of the single-channel conductance of 4 pS, which is well below that expected for channels containing both the 5-HT(3A) and 5-HT(3B) subunits...
  32. pmc Rat nicotinic ACh receptor alpha7 and beta2 subunits co-assemble to form functional heteromeric nicotinic receptor channels
    Serguei S Khiroug
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 540:425-34. 2002
    ..This co-assembly may help to explain nAChR channel diversity in rat hippocampal interneurons, and perhaps in other areas of the nervous system...
  33. ncbi request reprint Desensitization of nicotinic ACh receptors: shaping cholinergic signaling
    Rashid Giniatullin
    Neurobiology Sector and INFM Unit, International School for Advanced Studies SISSA, Via Beirut 4, 34014, Trieste, Italy
    Trends Neurosci 28:371-8. 2005
    ....