Research Topics
| Jerrel L YakelSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Cholinergic receptors: functional role of nicotinic ACh receptors in brain circuits and diseaseJerrel L Yakel
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P O Box 12233, Mail Drop F2 08, Research Triangle Park, NC, 27709, USA
Pflugers Arch 465:441-50. 2013..Here, I will briefly review this work, and where we are going in our attempts to further understand the role of these receptors in learning and memory, as well as in disease and neuroprotection...
Nicotinic ACh receptors in the hippocampus: role in excitability and plasticityJerrel L Yakel
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, P O Box 12233, Mail Drop F2 08, Research Triangle Park, NC 27709, USA
Nicotine Tob Res 14:1249-57. 2012....
Functional and molecular characterization of neuronal nicotinic ACh receptors in rat hippocampal interneuronsJerrel L Yakel
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, F2-08, 111 T.W. Alexander Drive, P.O. Box 12233, Research Triangle Park, NC 27709, USA
Prog Brain Res 145:95-107. 2004- Gating of nicotinic ACh receptors: latest insights into ligand binding and functionJerrel L Yakel
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC 27709, USA
J Physiol 588:597-602. 2010.... - Dendritic Ca2+ signalling due to activation of alpha 7-containing nicotinic acetylcholine receptors in rat hippocampal neuronsDmitriy Fayuk
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC 27709, USA
J Physiol 582:597-611. 2007..These results may have implications for the role that alpha 7 nAChRs have in regulating various signal transduction cascades, synaptic plasticity, and memory processes, via significant changes in [Ca(2+)]i levels... - Paired-pulse potentiation of alpha7-containing nAChRs in rat hippocampal CA1 stratum radiatum interneuronesRebecca C Klein
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, NIH, DHHS, PO Box 12233, Research Triangle Park, NC 27709, USA
J Physiol 568:881-9. 2005..Thus, rat hippocampal alpha7-containing nAChRs possess a newly described phenomenon of paired-pulse potentiation that may be involved in regulating synaptic plasticity in the hippocampus... - Inhibition of native and recombinant nicotinic acetylcholine receptors by the myristoylated alanine-rich C kinase substrate peptideElaine A Gay
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
J Pharmacol Exp Ther 327:884-90. 2008..The MARCKS ED peptide represents a novel antagonist of neuronal nAChRs that has considerable utility as a research tool... - Functional somato-dendritic alpha7-containing nicotinic acetylcholine receptors in the rat basolateral amygdala complexRebecca C Klein
NIEHS, F2 08, PO Box 12233, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
J Physiol 576:865-72. 2006..This is the first report demonstrating the presence of functional nAChR-mediated current responses from rat amygdala slices, where they may be playing a significant role in fear and aversively motivated memory... - Allosteric modulators of the α4β2 subtype of neuronal nicotinic acetylcholine receptorsAnshul Pandya
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Biochem Pharmacol 82:952-8. 2011..Here we discuss the concept of allosterism as it pertains to the α4β2 receptors and summarize the important features of allosteric modulators for this nicotinic receptor subtype... - Cholinergic coordination of presynaptic and postsynaptic activity induces timing-dependent hippocampal synaptic plasticityZhenglin Gu
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
J Neurosci 32:12337-48. 2012.... - Inhibition of neuronal nicotinic acetylcholine receptor channels expressed in Xenopus oocytes by beta-amyloid1-42 peptidePatricia W Lamb
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709 <f
J Mol Neurosci 27:13-21. 2005..The relative block by Abeta1-42 was dependent on the subunit makeup and apparent stoichiometry of these receptors. These data further support our previous findings that Abeta1-42 directly and preferentially inhibits non-alpha7 nAChRs... - Structural determinates for apolipoprotein E-derived peptide interaction with the alpha7 nicotinic acetylcholine receptorElaine A Gay
NIEHS, F2 08, P O Box 12233, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
Mol Pharmacol 72:838-49. 2007..The current data suggest a mode for apoE peptide binding that directly blocks alpha7 nAChR activity and consequently may disrupt nAChR signaling... - Aromatic residues at position 55 of rat alpha7 nicotinic acetylcholine receptors are critical for maintaining rapid desensitizationElaine A Gay
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services PO Box 12233, Research Triangle Park, NC 27709, USA
J Physiol 586:1105-15. 2008..Furthermore, these data suggest that W55 may be a potential target for modulatory agents operating via hydrophobic interactions... - Characterization of a nicotine-sensitive neuronal population in rat entorhinal cortexBin Tu
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
J Neurosci 29:10436-48. 2009..Our data suggest that ECVI neurons are important regulators of hippocampal function and plasticity during smoking... - Timing-dependent septal cholinergic induction of dynamic hippocampal synaptic plasticityZhenglin Gu
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Neuron 71:155-65. 2011..These results have revealed the remarkable temporal precision of cholinergic functions, providing a novel mechanism for information processing in cholinergic-dependent higher cognitive functions... - Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous systemJian Xin Shen
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health DHHS, Research Triangle Park, NC 27709, USA
Acta Pharmacol Sin 30:673-80. 2009.... - The frequency-dependence of the nicotine-induced inhibition of dopamine is controlled by the α7 nicotinic receptorAndrew T Seipel
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
J Neurochem 114:1659-66. 2010..The frequency dependence of the low dose nicotine inhibition therefore requires functional α7 nAChRs, and may arise from differing levels of endogenous acetylcholine evoked by the stimulation... - Functional alpha7-containing nicotinic acetylcholine receptors localize to cell bodies and proximal dendrites in the rat substantia nigra pars reticulataOlga V Poisik
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and HumanServices, PO Box 12233, Research Triangle Park, NC 27709, USA
J Physiol 586:1365-78. 2008..Our data are paving the way to a better understanding of the physiological roles of nAChRs in the BG... - Functional mapping and Ca2+ regulation of nicotinic acetylcholine receptor channels in rat hippocampal CA1 neuronsLeonard Khiroug
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
J Neurosci 23:9024-31. 2003..Our results demonstrate the strategic location and Ca2+ regulation of alpha7-containing nAChRs, which may contribute to understanding their involvement in hippocampal plasticity... - Rapid desensitization of the rat α7 nAChR is facilitated by the presence of a proline residue in the outer β-sheetThomas J McCormack
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
J Physiol 588:4415-29. 2010..Our results indicate that rapid desensitization of the wild-type rat α7 nAChR is facilitated by the presence of the proline residue within the β9 strand... - Inhibition of alpha 7-containing nicotinic ACh receptors by muscarinic M1 ACh receptors in rat hippocampal CA1 interneurones in slicesJian Xin Shen
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC 27709, USA
J Physiol 587:1033-42. 2009..This information will help to understand how these cholinergic receptor systems might be regulating neuronal excitability in the hippocampus in a manner that has relevance for synaptic plasticity and cognition... - Apolipoprotein E-derived peptides block alpha7 neuronal nicotinic acetylcholine receptors expressed in xenopus oocytesElaine A Gay
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
J Pharmacol Exp Ther 316:835-42. 2006..These results may be useful in elucidating the mechanisms underlying memory loss and cognitive decline seen in Alzheimer's disease as well as aid in the development of novel therapeutics using apoE-derived peptides... - Ca2+ permeability of nicotinic acetylcholine receptors in rat hippocampal CA1 interneuronesDmitriy Fayuk
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, NIH, DHHS, PO Box 12233, Research Triangle Park, NC 27709, USA [corrected
J Physiol 566:759-68. 2005..Therefore, the alpha7-containing nAChRs in rat hippocampal interneurones are significantly less permeable to Ca2+ than not only NMDA receptors but also alpha7 nAChRs in PC12 cells... - Allosteric modulator Desformylflustrabromine relieves the inhibition of α2β2 and α4β2 nicotinic acetylcholine receptors by β-amyloid(1-42) peptideAnshul Pandya
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
J Mol Neurosci 45:42-7. 2011..This study demonstrates that PAMs for the non-α7 nAChRs have the potential to develop into clinically applicable drugs for AD and other disorders... - Identification and functional characterization of a novel acetylcholine-binding protein from the marine annelid Capitella teletaThomas McCormack
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
Biochemistry 49:2279-87. 2010.... - Regulation of nicotinic acetylcholine receptor channel function by acetylcholinesterase inhibitors in rat hippocampal CA1 interneuronsDmitriy Fayuk
National Institute of Environmental Health Scinces, F2-08, P.O. Box 12233, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA
Mol Pharmacol 66:658-66. 2004..Therefore, drugs that target AChE are likely to be important regulators of cholinergic signaling in the hippocampus... - Gating of nicotinic ACh receptors; new insights into structural transitions triggered by agonist binding that induce channel openingElaine A Gay
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
J Physiol 584:727-33. 2007.... - The α7 nicotinic acetylcholine receptor function in hippocampal neurons is regulated by the lipid composition of the plasma membraneJosé O Colón-Sáez
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
J Physiol 589:3163-74. 2011..These data provide new insights into themechanism of desensitization of α7 nAChRs by providing evidence that the lipid composition of the plasma membrane can modulate the activity of the α7 nAChRs... - Serotonin 5-HT(3) receptors in rat CA1 hippocampal interneurons: functional and molecular characterizationSterling N Sudweeks
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
J Physiol 544:715-26. 2002..Using non-stationary fluctuation analysis, we obtained an estimate of the single-channel conductance of 4 pS, which is well below that expected for channels containing both the 5-HT(3A) and 5-HT(3B) subunits... - Rat nicotinic ACh receptor alpha7 and beta2 subunits co-assemble to form functional heteromeric nicotinic receptor channelsSerguei S Khiroug
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
J Physiol 540:425-34. 2002..This co-assembly may help to explain nAChR channel diversity in rat hippocampal interneurons, and perhaps in other areas of the nervous system... - Desensitization of nicotinic ACh receptors: shaping cholinergic signalingRashid Giniatullin
Neurobiology Sector and INFM Unit, International School for Advanced Studies (SISSA, Via Beirut 4, 34014, Trieste, Italy
Trends Neurosci 28:371-8. 2005....