Xiangru Xu

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender
    Xiangru Xu
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Genome Biol 8:R234. 2007
  2. pmc Dietary restriction mitigates cocaine-induced alterations of olfactory bulb cellular plasticity and gene expression, and behavior
    Xiangru Xu
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    J Neurochem 114:323-34. 2010
  3. ncbi request reprint Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization
    Zhihong Guo
    Laboratory of Neurosciences and National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    J Biol Chem 283:1754-63. 2008
  4. ncbi request reprint Paroxetine retards disease onset and progression in Huntingtin mutant mice
    Wenzhen Duan
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, NIH, Baltimore, MD 21224, USA
    Ann Neurol 55:590-4. 2004
  5. ncbi request reprint TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons
    Peisu Zhang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    J Neurochem 97:567-81. 2006
  6. ncbi request reprint Conservation and variation of gene regulation in embryonic stem cells assessed by comparative genomics
    Ming Zhan
    Bioinformatics Unit, Branch of Research Resources, National Institute on Aging, NIH, Baltimore, MD, 21224, USA
    Cell Biochem Biophys 43:379-405. 2005
  7. pmc Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
    Sung Chun Tang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:13798-803. 2007
  8. pmc Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1
    Hyeung Jin Jang
    National Institute on Aging National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:15069-74. 2007
  9. pmc AGEMAP: a gene expression database for aging in mice
    Jacob M Zahn
    Department of Developmental Biology, Stanford University Medical Center, Stanford, California, United States of America
    PLoS Genet 3:e201. 2007

Detail Information

Publications9

  1. pmc Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender
    Xiangru Xu
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Genome Biol 8:R234. 2007
    ..The structural and functional complexity of the mammalian central nervous system (CNS) is organized and modified by complicated molecular signaling processes that are poorly understood...
  2. pmc Dietary restriction mitigates cocaine-induced alterations of olfactory bulb cellular plasticity and gene expression, and behavior
    Xiangru Xu
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    J Neurochem 114:323-34. 2010
    ..The data further suggest that modification of dietary energy intake could provide a novel potential approach to addiction treatments...
  3. ncbi request reprint Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization
    Zhihong Guo
    Laboratory of Neurosciences and National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    J Biol Chem 283:1754-63. 2008
    ..By enhancing mitochondrial resistance to apoptosis and excitotoxicity, our findings suggest that leptin signaling serves a neurotrophic function in the developing and adult hippocampus...
  4. ncbi request reprint Paroxetine retards disease onset and progression in Huntingtin mutant mice
    Wenzhen Duan
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, NIH, Baltimore, MD 21224, USA
    Ann Neurol 55:590-4. 2004
    ..Paroxetine was beneficial when treatment was initiated before or after the onset of motor dysfunction, suggesting a potential for such antidepressant drugs in the treatment of presymptomatic and symptomatic HD patients...
  5. ncbi request reprint TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons
    Peisu Zhang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    J Neurochem 97:567-81. 2006
    ....
  6. ncbi request reprint Conservation and variation of gene regulation in embryonic stem cells assessed by comparative genomics
    Ming Zhan
    Bioinformatics Unit, Branch of Research Resources, National Institute on Aging, NIH, Baltimore, MD, 21224, USA
    Cell Biochem Biophys 43:379-405. 2005
    ..These results provide a framework for examining the current reported differences between rodent and human ES cells and define targets for future perturbation studies...
  7. pmc Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
    Sung Chun Tang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:13798-803. 2007
    ..Our findings establish a proapoptotic signaling pathway for TLR2 and -4 in neurons that may render them vulnerable to ischemic death...
  8. pmc Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1
    Hyeung Jin Jang
    National Institute on Aging National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:15069-74. 2007
    ..Modulating GLP-1 secretion in gut "taste cells" may provide an important treatment for obesity, diabetes and abnormal gut motility...
  9. pmc AGEMAP: a gene expression database for aging in mice
    Jacob M Zahn
    Department of Developmental Biology, Stanford University Medical Center, Stanford, California, United States of America
    PLoS Genet 3:e201. 2007
    ..However, we saw no overall correlation of age regulation between mice and humans, suggesting that aging processes in mice and humans may be fundamentally different...