R P Xiao

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The enigma of beta2-adrenergic receptor Gi signaling in the heart: the good, the bad, and the ugly
    Weizhong Zhu
    Circ Res 97:507-9. 2005
  2. ncbi request reprint Subtype-specific alpha1- and beta-adrenoceptor signaling in the heart
    Rui Ping Xiao
    Institute of Molecular Medicine, Peking University, Beijing 100871, China
    Trends Pharmacol Sci 27:330-7. 2006
  3. pmc Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases
    R P Xiao
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Clin Invest 101:1273-82. 1998
  4. ncbi request reprint Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts
    Rui Ping Xiao
    The Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Circulation 108:1633-9. 2003
  5. ncbi request reprint Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications
    Rui Ping Xiao
    Laboratory of Cardiovascular Science, National Institute on Aging NIH, Baltimore, MD 21224, USA
    Trends Pharmacol Sci 25:358-65. 2004
  6. ncbi request reprint Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins
    R P Xiao
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224, USA
    Sci STKE 2001:re15. 2001
  7. ncbi request reprint Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes
    R P Xiao
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA
    Circ Res 84:43-52. 1999
  8. ncbi request reprint Recent advances in cardiac beta(2)-adrenergic signal transduction
    R P Xiao
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224, USA
    Circ Res 85:1092-100. 1999
  9. ncbi request reprint beta2-adrenergic cAMP signaling is uncoupled from phosphorylation of cytoplasmic proteins in canine heart
    M Kuschel
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA
    Circulation 99:2458-65. 1999
  10. pmc Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes
    W Z Zhu
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 98:1607-12. 2001

Collaborators

Detail Information

Publications44

  1. ncbi request reprint The enigma of beta2-adrenergic receptor Gi signaling in the heart: the good, the bad, and the ugly
    Weizhong Zhu
    Circ Res 97:507-9. 2005
  2. ncbi request reprint Subtype-specific alpha1- and beta-adrenoceptor signaling in the heart
    Rui Ping Xiao
    Institute of Molecular Medicine, Peking University, Beijing 100871, China
    Trends Pharmacol Sci 27:330-7. 2006
    ....
  3. pmc Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases
    R P Xiao
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Clin Invest 101:1273-82. 1998
    ..Neither GRKs nor Gi proteins appear to contribute to the age-associated reduction in cardiac beta-AR responsiveness...
  4. ncbi request reprint Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts
    Rui Ping Xiao
    The Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Circulation 108:1633-9. 2003
    ....
  5. ncbi request reprint Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications
    Rui Ping Xiao
    Laboratory of Cardiovascular Science, National Institute on Aging NIH, Baltimore, MD 21224, USA
    Trends Pharmacol Sci 25:358-65. 2004
  6. ncbi request reprint Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins
    R P Xiao
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224, USA
    Sci STKE 2001:re15. 2001
    ..Because of these differences, selective activation of cardiac beta2AR may provide catecholamine-dependent inotropic support without cardiotoxic consequences, which might have beneficial effects in the failing heart...
  7. ncbi request reprint Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes
    R P Xiao
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA
    Circ Res 84:43-52. 1999
    ....
  8. ncbi request reprint Recent advances in cardiac beta(2)-adrenergic signal transduction
    R P Xiao
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224, USA
    Circ Res 85:1092-100. 1999
    ....
  9. ncbi request reprint beta2-adrenergic cAMP signaling is uncoupled from phosphorylation of cytoplasmic proteins in canine heart
    M Kuschel
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA
    Circulation 99:2458-65. 1999
    ....
  10. pmc Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes
    W Z Zhu
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 98:1607-12. 2001
    ..The survival effect appears to predominate and is mediated by the G(i)-G(beta gamma)-PI3K-Akt signaling pathway...
  11. pmc G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels
    Y Chen-Izu
    Laboratory of Cardiovascular Sciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224 6823, USA
    Biophys J 79:2547-56. 2000
    ..Our results suggest that the dual coupling of beta(2)-AR to both G(s)- and G(i)-proteins leads to a highly localized beta(2)-AR signaling pathway to modulate sarcolemmal L-type Ca(2+) channels in rat ventricular myocytes...
  12. ncbi request reprint beta-Adrenergic stimulation synchronizes intracellular Ca(2+) release during excitation-contraction coupling in cardiac myocytes
    L S Song
    Laboratory of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Circ Res 88:794-801. 2001
    ....
  13. pmc {Beta}2-adrenergic receptor agonists inhibit the proliferation of 1321N1 astrocytoma cells
    L Toll
    SRI International, Menlo Park, California, USA
    J Pharmacol Exp Ther 336:524-32. 2011
    ..Because a significant portion of brain tumors contain β(2)-ARs to a greater extent than whole brain, (R,R')-fenoterol, or some analog, may be useful in the treatment of brain tumors after biopsy to determine β(2)-AR expression...
  14. ncbi request reprint Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes
    Veronique Leblais
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Circ Res 95:1183-90. 2004
    ....
  15. ncbi request reprint Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility
    Wei Zhong Zhu
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Circ Res 97:244-51. 2005
    ....
  16. pmc The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy
    P Liao
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 98:12283-8. 2001
    ....
  17. pmc Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II
    Wei Zhong Zhu
    Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
    J Clin Invest 111:617-25. 2003
    ..These findings indicate that CaMKII constitutes a novel PKA-independent linkage of beta(1)AR stimulation to cardiomyocyte apoptosis that has been implicated in the overall process of chronic heart failure...
  18. ncbi request reprint The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor
    Khalid Chakir
    Laboratory of Cardiovascular Science, Gerontology Research Center, NIA, NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Mol Pharmacol 64:1048-58. 2003
    ....
  19. ncbi request reprint Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway
    Wang Wang
    Laboratory of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Circ Res 95:798-806. 2004
    ..This finding may bear important etiological and therapeutical ramifications in understanding beta1AR signaling in chronic heart failure...
  20. ncbi request reprint Acidosis-induced p38 MAPK activation and its implication in regulation of cardiac contractility
    Ming Zheng
    The Institute of Cardiovascular Sciences, Peking University, Beijing 100083, China
    Acta Pharmacol Sin 25:1299-305. 2004
    ..To determine the possible role of pH in mediating activation of p38 mitogen-activated protein kinase (MAPK) and the consequent function of activated p38 MAPK in regulating cardiac contractility...
  21. ncbi request reprint Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes
    Dongmei Yang
    Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Circ Res 100:399-407. 2007
    ....
  22. ncbi request reprint High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells
    Tatiana M Vinogradova
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224 6825, USA
    Circ Res 98:505-14. 2006
    ....
  23. ncbi request reprint Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol
    Farideh Beigi
    Laboratory of Clinical Investigation, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    Chirality 18:822-7. 2006
    ..It has two chiral centers and is marketed as a racemic mixture of R,R'- and S,S'-fenoterol (R-F and S-F). Here we report the separation of the R-F and S-F enantiomers and the evaluation of their binding to and activation of the beta2-AR...
  24. ncbi request reprint Calmodulin regulation of excitation-contraction coupling in cardiac myocytes
    Dongmei Yang
    National Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing, China
    Circ Res 92:659-67. 2003
    ..A novel finding of this study is that expression of a Ca2+-insensitive CaM mutant can lead to activation of CaMKII in cardiac myocytes...
  25. pmc p38 Mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes
    Pu Liao
    Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD 21224, USA
    Circ Res 90:190-6. 2002
    ..These findings reveal a novel function of p38 MAPK and shed a new light on our understanding of the coincidence of p38 MAPK activation and the onset of heart failure...
  26. ncbi request reprint Dual site phospholamban phosphorylation and its physiological relevance in the heart
    Dirk Hagemann
    National Institute on Aging, NIH, Gerontology Research Center, Laboratory of Cardiovascular Science, Baltimore, MD 21224, USA
    Trends Cardiovasc Med 12:51-6. 2002
    ..Further studies are required to determine the exact process of dual site PLB phosphorylation and its functional roles in healthy and diseased hearts...
  27. ncbi request reprint Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during beta2-adrenergic stimulation
    Su Hyun Jo
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institute of Health, Baltimore, MD 21224, USA
    Circ Res 91:46-53. 2002
    ..Thus, PI3K constitutes a key downstream event of beta2-AR-G(i) signaling, which confines and negates the concurrent beta2-AR/G(s)-mediated PKA signaling...
  28. ncbi request reprint Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis
    Tao Shen
    Institute of Cardiovascular Sciences, Peking University, Beijing 100083, China
    J Biol Chem 282:23354-61. 2007
    ....
  29. ncbi request reprint Activation of CaMKIIdeltaC is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis
    Weizhong Zhu
    Laboratory of Cardiovascular Science, Gerontology Research Center, NIA, National Institutes of Health, Baltimore, Maryland 21224
    J Biol Chem 282:10833-9. 2007
    ..Thus, activation of CaMKII(deltaC) constitutes a common intermediate by which various death-inducing stimuli trigger cardiomyocyte apoptosis via the primary mitochondrial death pathway...
  30. ncbi request reprint Ca(2+) signaling in cardiac myocytes overexpressing the alpha(1) subunit of L-type Ca(2+) channel
    Long Sheng Song
    Laboratory of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Circ Res 90:174-81. 2002
    ..These results also suggest that a modest but sustained increase in Ca(2+) influx triggers a coordinated remodeling of Ca(2+) handling to maintain Ca(2+) homeostasis...
  31. pmc MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning
    Norihito Sasaki
    Laboratory of the Institute of Molecular Cardiobiology, Johns Hopkins University, Baltimore, MD 21205, USA
    Circulation 107:1183-8. 2003
    ..A mixed agonist/blocker with differential effects on the two channel types would help to clarify the role of K(ATP) channels in cardioprotection...
  32. ncbi request reprint Dysregulation of HSG triggers vascular proliferative disorders
    Kuang Hueih Chen
    The Institute of Cardiovascular Science and The Institute of Molecular Medicine, Peking University, Beijing 100083, China
    Nat Cell Biol 6:872-83. 2004
    ..Thus, rHSG functions as a cell proliferation suppressor, whereas dysregulation of rHSG results in proliferative disorders...
  33. ncbi request reprint G-protein-coupled receptor chromatographic stationary phases. 2. Ligand-induced conformational mobility in an immobilized beta2-adrenergic receptor
    Farideh Beigi
    Laboratory of Clinical Investigation and Laboratory of Cardiovascular Science, NIA, NIH, Baltimore, Maryland 21224 6825, USA
    Anal Chem 76:7187-93. 2004
    ..The data from this study suggest that the immobilized beta(2)-AR can be used to screen for ligand binding interactions in both the resting and active states of the receptor...
  34. ncbi request reprint Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor
    Krzysztof Jozwiak
    Department of Chemistry, Medical University of Lublin, Lublin, Poland
    J Med Chem 50:2903-15. 2007
    ....
  35. pmc Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart
    Jian Hua Ding
    Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093 0651, USA
    EMBO J 23:885-96. 2004
    ..These studies raise a new paradigm for the etiology of certain human heart diseases of genetic or environmental origin that may be triggered by dysfunction in RNA processing...
  36. ncbi request reprint Phosphoproteome analysis of cardiomyocytes subjected to beta-adrenergic stimulation: identification and characterization of a cardiac heat shock protein p20
    Guoxiang Chu
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0575, USA
    Circ Res 94:184-93. 2004
    ..These findings suggest that cardiomyocytes undergo significant posttranslational modification via phosphorylation in a multitude of proteins to dynamically fine-tune cardiac responses to beta-adrenergic signaling...
  37. ncbi request reprint Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling
    Ming Zheng
    Institute of Cardiovascular Sciences, Peking University, Beijing 100083, People s Republic of China
    Pharmacol Ther 108:257-68. 2005
    ....
  38. pmc Nuclear Ca2+ sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes
    Dali Luo
    Department of Pharmacology, School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China
    Cell Calcium 43:165-74. 2008
    ....
  39. ncbi request reprint Intracellular acidosis-activated p38 MAPK signaling and its essential role in cardiomyocyte hypoxic injury
    Ming Zheng
    Institute of Cardiovascular Sciences, Peking University, Beijing, People s Republic of China
    FASEB J 19:109-11. 2005
    ..These results demonstrate, for the first time, that intracellular acidosis constitutes a necessary and sufficient link responsible for hypoxia-activated p38 MAPK signaling and the subsequent hypoxic cardiomyocyte injury and death...
  40. ncbi request reprint Calmodulin kinase II inhibition protects against myocardial cell apoptosis in vivo
    Yingbo Yang
    Dept of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Am J Physiol Heart Circ Physiol 291:H3065-75. 2006
    ..These findings indicate CaMKII is proapoptotic in vivo and suggest that regulation of SR Ca(2+) content by PLN contributes to the antiapoptotic mechanism of CaMKII inhibition...
  41. ncbi request reprint Role of inositol 1,4,5-trisphosphate receptors in alpha1-adrenergic receptor-induced cardiomyocyte hypertrophy
    Da li Luo
    Department of Pharmacology, School of Chemical Biology and Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing 100069, China
    Acta Pharmacol Sin 27:895-900. 2006
    ..Thus, we hypothesized that Ca2+ release through IP3Rs was necessary for alpha1AR-stimulated cardiac hypertrophy...
  42. ncbi request reprint Cross-talk of opioid peptide receptor and beta-adrenergic receptor signalling in the heart
    Salvatore Pepe
    Laboratory of Cardiac Surgical Research, Wynn Domain, Baker Heart Research Institute and The Alfred Hospital, Monash University Faculty of Medicine, Melbourne, Australia
    Cardiovasc Res 63:414-22. 2004
    ..This brief review will focus on the interaction between beta-AR and OPR and its potential physiological and pathophysiological relevance in the heart...
  43. ncbi request reprint ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle
    Xiangdong Xu
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 120:59-72. 2005
    ..Our results validate ASF/SF2 as a fundamental splicing regulator in the reprogramming pathway and reveal the central contribution of ASF/SF2-regulated CaMKIIdelta alternative splicing to functional remodeling in developing heart...
  44. ncbi request reprint Distinct beta-adrenergic receptor subtype signaling in the heart and their pathophysiological relevance
    Ming Zheng
    The Institute of Molecular Medicine, Peking University, Beijing 100083 China
    Sheng Li Xue Bao 56:1-15. 2004
    ....