T A Wynn

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint T(H)-17: a giant step from T(H)1 and T(H)2
    Thomas A Wynn
    Nat Immunol 6:1069-70. 2005
  2. pmc Macrophage biology in development, homeostasis and disease
    Thomas A Wynn
    Immunopathogenesis Section, Program in Tissue Immunity and Repair and Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20877 8003, USA
    Nature 496:445-55. 2013
  3. pmc Mechanisms of fibrosis: therapeutic translation for fibrotic disease
    Thomas A Wynn
    Immunopathogenesis Section, Program in Barrier Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Med 18:1028-40. 2012
  4. pmc High-Throughput GoMiner, an 'industrial-strength' integrative gene ontology tool for interpretation of multiple-microarray experiments, with application to studies of Common Variable Immune Deficiency (CVID)
    Barry R Zeeberg
    Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Bioinformatics 6:168. 2005
  5. pmc Integrating mechanisms of pulmonary fibrosis
    Thomas A Wynn
    Program in Barrier Immunity and Repair and the Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 208:1339-50. 2011
  6. pmc Cellular and molecular mechanisms of fibrosis
    T A Wynn
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Pathol 214:199-210. 2008
  7. ncbi request reprint P-selectin suppresses hepatic inflammation and fibrosis in mice by regulating interferon gamma and the IL-13 decoy receptor
    Thomas A Wynn
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6154, MSC 8003, Bethesda, MD 20892, USA
    Hepatology 39:676-87. 2004
  8. ncbi request reprint IL-13 effector functions
    Thomas A Wynn
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 21:425-56. 2003
  9. ncbi request reprint Immunopathogenesis of schistosomiasis
    Thomas A Wynn
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Immunol Rev 201:156-67. 2004
  10. pmc Fibrotic disease and the T(H)1/T(H)2 paradigm
    Thomas A Wynn
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Room 6154, MSC 8003, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 4:583-94. 2004

Detail Information

Publications74

  1. ncbi request reprint T(H)-17: a giant step from T(H)1 and T(H)2
    Thomas A Wynn
    Nat Immunol 6:1069-70. 2005
  2. pmc Macrophage biology in development, homeostasis and disease
    Thomas A Wynn
    Immunopathogenesis Section, Program in Tissue Immunity and Repair and Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20877 8003, USA
    Nature 496:445-55. 2013
    ..It is essential to understand this diversity because macrophages have emerged as important therapeutic targets in many human diseases...
  3. pmc Mechanisms of fibrosis: therapeutic translation for fibrotic disease
    Thomas A Wynn
    Immunopathogenesis Section, Program in Barrier Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Med 18:1028-40. 2012
    ..Finally, we highlight some of the key mechanisms and pathways of fibrosis that are being targeted as potential therapies for a variety of important human diseases...
  4. pmc High-Throughput GoMiner, an 'industrial-strength' integrative gene ontology tool for interpretation of multiple-microarray experiments, with application to studies of Common Variable Immune Deficiency (CVID)
    Barry R Zeeberg
    Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Bioinformatics 6:168. 2005
    ..We wanted to provide a computational resource that automates the analysis of multiple microarrays and then integrates the results across all of them in useful exportable output files and visualizations...
  5. pmc Integrating mechanisms of pulmonary fibrosis
    Thomas A Wynn
    Program in Barrier Immunity and Repair and the Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 208:1339-50. 2011
    ..A more detailed and integrated understanding of the cellular and molecular mechanisms of pulmonary fibrosis could help pave the way for effective therapeutics for this devastating and complex disease...
  6. pmc Cellular and molecular mechanisms of fibrosis
    T A Wynn
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Pathol 214:199-210. 2008
    ..This review explores our current understanding of the cellular and molecular mechanisms of fibrogenesis...
  7. ncbi request reprint P-selectin suppresses hepatic inflammation and fibrosis in mice by regulating interferon gamma and the IL-13 decoy receptor
    Thomas A Wynn
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6154, MSC 8003, Bethesda, MD 20892, USA
    Hepatology 39:676-87. 2004
    ..By suppressing IFN-gamma and up-regulating the decoy IL-13 receptor, P-selectin dramatically inhibits the pathologic tissue remodeling that results from chronic type 2 cytokine-mediated inflammation...
  8. ncbi request reprint IL-13 effector functions
    Thomas A Wynn
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 21:425-56. 2003
    ..This review highlights the effector functions of IL-13 and describes multiple pathways for modulating its activity in vivo...
  9. ncbi request reprint Immunopathogenesis of schistosomiasis
    Thomas A Wynn
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Immunol Rev 201:156-67. 2004
    ..mansoni infection, and succumb to the disease at an accelerated rate; thus, identifying the 'decoy' IL-13 receptor as a critical life sustaining 'off' switch for tissue damaging egg-induced inflammation...
  10. pmc Fibrotic disease and the T(H)1/T(H)2 paradigm
    Thomas A Wynn
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Room 6154, MSC 8003, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 4:583-94. 2004
  11. pmc Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
    Thomas A Wynn
    Immunopathogenesis Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    J Clin Invest 117:524-9. 2007
    ....
  12. ncbi request reprint IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis
    K F Hoffmann
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 164:6406-16. 2000
    ....
  13. ncbi request reprint CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism
    M G Chiaramonte
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 164:973-85. 2000
    ..These findings illustrate the utility of CpG DNA as adjuvants for vaccines designed to prevent Th2-dependent immunopathology...
  14. ncbi request reprint Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-gamma-dependent effector mechanisms
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0425, USA
    J Immunol 162:345-51. 1999
    ....
  15. ncbi request reprint Failure of P strain mice to respond to vaccination against schistosomiasis correlates with impaired production of IL-12 and up-regulation of Th2 cytokines that inhibit macrophage activation
    I P Oswald
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA
    Eur J Immunol 28:1762-72. 1998
    ..These studies indicate that a genetic predisposition toward an impaired production of IL-12 and an increased production of down-regulatory Th2 cytokines correlate with low response to vaccination against S. mansoni...
  16. ncbi request reprint IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite
    T A Wynn
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 157:4068-78. 1996
    ..Together, these data demonstrate that IL-12, initially described as an adjuvant for cell-mediated immunity, may be used to simultaneously to promote both humoral and cell-mediated protective responses against infection...
  17. ncbi request reprint Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni
    K F Hoffmann
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 163:927-38. 1999
    ..These results suggest that optimal vaccine-induced immunity against schistosomes is linked not to the development of a highly polarized response, but, rather, to the induction of both type 1- and type 2-associated immune responses...
  18. ncbi request reprint Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions
    K F Hoffmann
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 15:2545-7. 2001
    ..Moreover, they illustrate the potential of genome-wide approaches for generating comprehensive views on the molecular and biochemical mechanisms regulating infectious disease pathogenesis...
  19. pmc An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
    M G Chiaramonte
    Schistosomiasis Immunology and Pathology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 104:777-85. 1999
    ..Thus, our findings provide evidence that IL-13 inhibitors may be of general therapeutic benefit in preventing damaging tissue fibrosis resulting from Th2-dominated inflammatory responses...
  20. pmc CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signaling
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 187:619-29. 1998
    ..Together, the data demonstrate that humoral immune response/FcR interactions can play a major role in negatively controlling inflammatory disease induced by CD4+ T cells...
  21. pmc NOS-2 mediates the protective anti-inflammatory and antifibrotic effects of the Th1-inducing adjuvant, IL-12, in a Th2 model of granulomatous disease
    M Hesse
    Schistosomiasis Immunology and Pathology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Pathol 157:945-55. 2000
    ....
  22. pmc Patterns of chemokine expression in models of Schistosoma mansoni inflammation and infection reveal relationships between type 1 and type 2 responses and chemokines in vivo
    M K Park
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 69:6755-68. 2001
    ....
  23. pmc Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: cytokine requirements for the induction and maintenance of intestinal inflammation
    M C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0425, USA
    Infect Immun 69:4232-41. 2001
    ..Taken together, our results demonstrate a crucial role for IL-12 in both inducing and sustaining intestinal inflammation through recruitment and maintenance of a pool of pathogenic Th1 cells...
  24. ncbi request reprint Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo
    T A Wynn
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0425, USA
    J Immunol 159:5014-23. 1997
    ..Together, these results argue first that IL-10 is an important endogenous down-regulator of type 2 as well as type 1 cytokine synthesis, and second, that its induction is critical for type 2 response polarization in vivo...
  25. ncbi request reprint Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis
    M G Chiaramonte
    Schistosomiasis Immunology and Pathology Unit, Immunobiology Section, Laboratory of Parasitic Diseases and the Center for Information Technology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Hepatology 34:273-82. 2001
    ....
  26. ncbi request reprint IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease
    T A Wynn
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 160:4473-80. 1998
    ..We conclude that while IL-10 plays an important role in controlling acute granulomatous inflammation, it plays no essential role in the process of immune down-modulation in chronic schistosome infection...
  27. ncbi request reprint Regulation of hepatic fibrosis and extracellular matrix genes by the th response: new insight into the role of tissue inhibitors of matrix metalloproteinases
    B Vaillant
    Schistosomiasis Immunology and Pathology Unit, Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 167:7017-26. 2001
    ..Indeed, our findings suggest that inhibiting profibrotic cytokines or specific MMP may be a more effective strategy to ameliorate fibrotic pathology...
  28. ncbi request reprint Role of cytokines in the formation and downregulation of hepatic circumoval granulomas and hepatic fibrosis in Schistosoma mansoni-infected mice
    A W Cheever
    Immunobiology Section, NIAID, NIH, Bethesda, MD 20892 0425, USA
    Mem Inst Oswaldo Cruz 93:25-32. 1998
    ..It is evident that the participation of cytokines in granuloma formation and regulation is complicated and that the mechanisms controlling both these phenomena are likely to involve both T cells and antibody/FcR interactions...
  29. ncbi request reprint IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs
    M G Chiaramonte
    Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0425, USA
    J Immunol 162:920-30. 1999
    ..Together, these data demonstrate that IL-13 serves as an important mediator of Th2-mediated inflammation and plays a role in eliciting IgE responses triggered by schistosome eggs...
  30. pmc The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure
    Y Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4 Rm 126, Center Dr MSC 0425, Bethesda, MD 20892, USA
    J Exp Med 194:1497-506. 2001
    ....
  31. pmc Inducible nitric oxide synthase-deficient mice develop enhanced type 1 cytokine-associated cellular and humoral immune responses after vaccination with attenuated Schistosoma mansoni cercariae but display partially reduced resistance
    S L James
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Infect Immun 66:3510-8. 1998
    ..mansoni, both in the effector mechanism of resistance and in the down regulation of the type 1 cytokine response, which is ultimately required for NO production...
  32. pmc The p47(phox-/-) mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs
    B H Segal
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 67:1659-65. 1999
    ..Appropriate regression of established tissue granulomata in p47(phox-/-) mice challenged with SME suggests that abnormal granuloma formation in CGD is stimulus dependent and is not an invariant feature of the disease...
  33. ncbi request reprint Defining a schistosomiasis vaccination strategy - is it really Th1 versus Th2?
    T A Wynn
    Schistosomiasis Immunology and Pathology Unit, Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Parasitol Today 16:497-501. 2000
    ..However, recent data from cytokine-knockout mice suggest that choosing between these opposing pathways may be less important than previously hypothesized, as discussed here by Thomas Wynn and Karl Hoffmann...
  34. pmc Pulmonary fibrosis: pathogenesis, etiology and regulation
    M S Wilson
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mucosal Immunol 2:103-21. 2009
    ..Restoring homeostasis to these dysregulated healing responses, or simply neutralizing the key pro-fibrotic mediators may prevent or slow the progression of pulmonary fibrosis...
  35. ncbi request reprint Characterization of the divergent eosinophil ribonuclease, mEar 6, and its expression in response to Schistosoma mansoni infection in vivo
    T Nitto
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N104, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Genes Immun 5:668-74. 2004
    ..In summary, we have identified mEar 6 as one of only two RNase A superfamily ribonucleases known to be expressed specifically in response to pathophysiologic stress in vivo...
  36. ncbi request reprint The guanine protein coupled receptor rhodopsin is developmentally regulated in the free-living stages of Schistosoma mansoni
    K F Hoffmann
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike Bldg 7 Room 318, Bethesda, MD 20892, USA
    Mol Biochem Parasitol 112:113-23. 2001
    ..Identifying and characterizing new GPCRs may uncover hidden aspects of parasite biology useful towards the development of novel intervention strategies...
  37. pmc Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1
    J L Gao
    Laboratory of Host Defenses, National Institute of Allergy and Infectio us Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 185:1959-68. 1997
    ..Thus CCR1 has nonredundant functions in hematopoiesis, host defense, and inflammation...
  38. pmc The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation
    F Meylan
    Immunoregulation Section, Autoimmunity Branch, NIAMS, Bethesda, Maryland, USA
    Mucosal Immunol 4:172-85. 2011
    ..These results establish a novel link between TL1A and interleukin 13 (IL-13) responses that results in small intestinal inflammation, and also establish that TL1A-DR3 interactions are necessary and sufficient for T cell-dependent IBD...
  39. ncbi request reprint In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection
    T M Scharton-Kersten
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 157:4045-54. 1996
    ..gondii: IL-12 precedes and initiates synthesis of IFN-gamma, while the latter lymphokine directly controls parasite growth and diminishes the contribution of IL-4- and IL-5-producing T cell subsets...
  40. ncbi request reprint IFN-gamma, IL-12, and TNF-alpha are required to maintain reduced liver pathology in mice vaccinated with Schistosoma mansoni eggs and IL-12
    K F Hoffmann
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 161:4201-10. 1998
    ..Together, these data reveal key roles for IFN-gamma, IL-12, and TNF-alpha in the protective effects mediated by this IL-12-based vaccine to prevent pathology...
  41. ncbi request reprint NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis
    Carl G Feng
    Immunobiology Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 8003, USA
    J Immunol 177:7086-93. 2006
    ..tuberculosis infection and suggest that this response could serve as an important barrier in AIDS patients or other individuals with compromised CD4+ T cell function...
  42. ncbi request reprint Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivo
    Jonas Bystrom
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1883, USA
    Eur J Haematol 77:181-90. 2006
    ..Two variants encoding soluble forms of the alpha subunit (sIL-5R alpha) have been described, although the signals promoting and/or limiting differential transcription remain to be clarified...
  43. pmc The IL-21 receptor augments Th2 effector function and alternative macrophage activation
    John Pesce
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 116:2044-55. 2006
    ..Collectively, these results illustrate an essential function for the IL-21R in the development of pathogen-induced Th2 responses, which may have relevance in therapies for both inflammatory and chronic fibrotic diseases...
  44. pmc Schistosoma mansoni infection in eosinophil lineage-ablated mice
    Jonathan M Swartz
    Laboratory of Allergic Diseases, NIAID, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 1883, USA
    Blood 108:2420-7. 2006
    ..However, eosinophils may have unexplored immunomodulatory contributions to this disease process...
  45. pmc Immunopathology of schistosomiasis
    Mark S Wilson
    Laboratory of Parasitic Diseases, Immunopathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Cell Biol 85:148-54. 2007
    ....
  46. pmc Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
    Dragana Jankovic
    Immunobiology Section and 2Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:273-83. 2007
    ..These findings indicate that IL-10 production by CD4(+) T lymphocytes need not involve a distinct regulatory Th cell subset but can be generated in Th1 cells as part of the effector response to intracellular pathogens...
  47. ncbi request reprint Structure of the catalytic domain of human polo-like kinase 1
    Michael Kothe
    Pfizer Global Research and Development, Research Technology Center, 620 Memorial Drive, Cambridge, Massachusetts 02139, USA
    Biochemistry 46:5960-71. 2007
    ....
  48. pmc T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses
    Tatyana Tarasenko
    Laboratories of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 104:11382-7. 2007
    ..Overall our experiments indicate that in T cells SHIP negatively regulates cytokine-mediated activation in a way that allows effective Th2 responses and limits T cell cytotoxicity...
  49. pmc IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice
    Mark S Wilson
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, and Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, Maryland, USA
    J Clin Invest 117:2941-51. 2007
    ..Thus, IL-10 and IL-13Ralpha2 are both required to control chronic Th2-driven pathological responses...
  50. pmc Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain
    Thirumalai R Ramalingam
    Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nat Immunol 9:25-33. 2008
    ..IL-13Ralpha1 was essential for allergen-induced airway hyperreactivity and mucus hypersecretion but not for fibroblast or alternative macrophage activation. Thus, type I and II IL-4 receptors exert distinct effects on immune responses...
  51. ncbi request reprint IL-10 and TGF-beta control the establishment of persistent and transmissible infections produced by Leishmania tropica in C57BL/6 mice
    Charles F Anderson
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    J Immunol 180:4090-7. 2008
    ..Thus, chronic infection with L. tropica appears to be established via multiple suppressive factors, which together maintain the host as a long-term reservoir of infection for vector sand flies...
  52. pmc Cationic amino acid transporter-2 regulates immunity by modulating arginase activity
    Robert W Thompson
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 4:e1000023. 2008
    ..Thus, by controlling NOS2 and arginase activity, CAT2 functions as a potent regulator of immunity...
  53. pmc Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages
    Aiping Zhao
    Department of Medicine and the Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Gastroenterology 135:217-225.e1. 2008
    ..The present study investigated the role of macrophages and the arginase pathway in nematode-induced changes in intestinal smooth muscle function and worm expulsion...
  54. ncbi request reprint Resistance of C57BL/6 mice to amoebiasis is mediated by nonhemopoietic cells but requires hemopoietic IL-10 production
    Shinjiro Hamano
    Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 177:1208-13. 2006
    ..We conclude that nonhemopoietic cells mediate the natural resistance to intestinal amoebiasis of B6 mice, yet this resistance depends on hemopoietic IL-10 activity...
  55. pmc Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activity
    Rachael M Reiman
    Immunopathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8003, USA
    Infect Immun 74:1471-9. 2006
    ..Thus, inhibiting the activity of IL-5 or eosinophils may prove effective for a variety of chronic fibrotic diseases...
  56. ncbi request reprint Inhibition of T helper 2-type responses, IgE production and eosinophilia by synthetic lipopeptides
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Eur J Immunol 33:2717-26. 2003
    ..These results demonstrate that stimulation of TLR-2 by lipopeptides represents a novel way for possible treatment of allergy and asthma by regulating the disrupted cytokine balance...
  57. ncbi request reprint A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases
    Monica Froicu
    Department of Nutrition, 126 South Henderson Building, University Park, Pennsylvania 16802, USA
    Mol Endocrinol 17:2386-92. 2003
    ..The data establishes an essential role for VDR signaling in the regulation of inflammation in the gastrointestinal tract...
  58. ncbi request reprint Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair
    Netanya G Sandler
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 171:3655-67. 2003
    ..Thus, Th1-mediated inflammation is characterized by tissue damage, while Th2 directs wound healing and fibrosis...
  59. pmc Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response
    Monica G Chiaramonte
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 197:687-701. 2003
    ..Together, these studies illustrate the central role played by the IL-13Ralpha2 in the down-regulation of a chronic and pathogenic Th2-mediated immune response...
  60. ncbi request reprint Cytokine-mediated host responses during schistosome infections; walking the fine line between immunological control and immunopathology
    Karl F Hoffmann
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Adv Parasitol 52:265-307. 2002
    ..Development of severe and non-overlapping immunopathological phenotypes will be discussed in the context of immune deviation and in the setting of chronic and/or hyper-polarised cytokine environments...
  61. ncbi request reprint Granulomas in schistosome and mycobacterial infections: a model of local immune responses
    Matyas Sandor
    Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Room 5468, Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA
    Trends Immunol 24:44-52. 2003
    ..In addition, different activation pathways for macrophages residing in granulomas are discussed. Granulomas are unique inflammatory sites that offer a challenging and rewarding model to study immunity...
  62. pmc Enhanced interleukin-12 and CD40 ligand activities but reduced Staphylococcus aureus Cowan 1-induced responses suggest a generalized and progressively impaired type 1 cytokine pattern for human schistosomiasis
    Silvia M L Montenegro
    Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães FIOCRUZ Universidade Federal de Pernambuco, Recife, Brazil
    Infect Immun 70:5903-12. 2002
    ....
  63. ncbi request reprint IL-10 is critical for host resistance and survival during gastrointestinal helminth infection
    Lisa R Schopf
    Immunology Disease Resistance Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, U S Department of Agriculture, Beltsville, MD 20705, USA
    J Immunol 168:2383-92. 2002
    ..Overall, these studies reveal a critical role for IL-10 in the polarization of Th2 responses, development of resistance during T. muris infection, and maintenance of barrier function in the colon...
  64. ncbi request reprint Gene microarray analysis reveals interleukin-5-dependent transcriptional targets in mouse bone marrow
    Jonas Bystrom
    NIAID, NIH, Bldg 10, Rm 11N104, 9000 Rockville Pike, Bethesda, MD, 20892, USA
    Blood 103:868-77. 2004
    ....
  65. pmc IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis
    Margaret M Mentink-Kane
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:586-90. 2004
    ..Here, we show that the IL-13 receptor alpha 2 (IL-13R alpha 2) is a critical mediator of immune down-modulation, identifying the receptor as a life-sustaining off signal for chronic and pernicious inflammation in schistosomiasis...
  66. ncbi request reprint The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells
    Matthias Hesse
    Laboratories of Parasitic Diseases and Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:3157-66. 2004
    ..Thus, innate effectors and regulatory T cells producing IL-10 cooperate to reduce morbidity and prolong survival in schistosomiasis...
  67. ncbi request reprint Immunopathogenic mechanisms in schistosomiasis: what can be learnt from human studies?
    Frederico G C Abath
    Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhaes, Fundacao Oswaldo Cruz, Avenida Professor Moraes Rego s n, Cidade Universitaria, 50670 420 Recife, Brazil
    Trends Parasitol 22:85-91. 2006
    ....
  68. ncbi request reprint Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut
    Motoko Morimoto
    Department of Medicine and Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 176:491-5. 2006
    ..The pronounced differences in the expression of IL-13Ralpha2 suggest that the gut has developed sophisticated mechanisms for controlling the physiological and pathophysiological activities of IL-13...
  69. ncbi request reprint Exploiting worm and allergy models to understand Th2 cytokine biology
    Thirumalai R Ramalingam
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Curr Opin Allergy Clin Immunol 5:392-8. 2005
    ..This review will discuss recent findings from the schistosomiasis model that may be relevant to the understanding of allergic inflammation, asthma and Th2 cytokine biology in general...
  70. ncbi request reprint Opposing roles for IL-13 and IL-13 receptor alpha 2 in health and disease
    Margaret M Mentink-Kane
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Rev 202:191-202. 2004
    ..Here, we summarize findings from the schistosomiasis model, which illustrate opposing activities for IL-13 and IL-13R alpha 2 in health and disease...
  71. pmc Immunoglobulin class switch recombination is impaired in Atm-deficient mice
    Joanne M Lumsden
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bldg 10, Room 4B10, 10 Center Dr, Bethesda, MD 20892, USA
    J Exp Med 200:1111-21. 2004
    ..These findings suggest a role of ATM in DNA DSB recognition and/or repair during CSR...
  72. ncbi request reprint IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent
    Mallika Kaviratne
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:4020-9. 2004
    ..Together, these studies provide unequivocal evidence of a pathway of fibrogenesis that is IL-13 dependent but TGF-beta1 independent, illustrating the importance of targeting IL-13 directly in the treatment of infection-induced fibrosis...
  73. ncbi request reprint Plasminogen activator inhibitor-2 (PAI-2) in eosinophilic leukocytes
    Jonathan M Swartz
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Leukoc Biol 76:812-9. 2004
    ....
  74. pmc Endogenous pro- and anti-inflammatory cytokines differentially regulate an in vivo humoral response to Streptococcus pneumoniae
    Abdul Q Khan
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Infect Immun 70:749-61. 2002
    ..These data suggest that proinflammatory and anti-inflammatory cytokines differentially regulate an in vivo protein- and polysaccharide-specific Ig response to an extracellular bacteria...