Li Wu

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. pmc Trans-dominant cellular inhibition of DC-SIGN-mediated HIV-1 transmission
    Li Wu
    Model Development Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    Retrovirology 1:14. 2004
  2. pmc Functional evaluation of DC-SIGN monoclonal antibodies reveals DC-SIGN interactions with ICAM-3 do not promote human immunodeficiency virus type 1 transmission
    Li Wu
    HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Virol 76:5905-14. 2002
  3. pmc HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN)
    Nancy P Y Chung
    HIV Drug Resistance Program, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 285:2100-12. 2010
  4. ncbi request reprint Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission
    Li Wu
    Model Development Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Virology 318:17-23. 2004
  5. pmc Novel member of the CD209 (DC-SIGN) gene family in primates
    Arman A Bashirova
    Science Application International Corporation at Frederick, Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Maryland 21702, USA
    J Virol 77:217-27. 2003
  6. ncbi request reprint Role of DC-SIGN in the activation of dendritic cells by HPV-16 L1 virus-like particle vaccine
    Alfonso J Garcia-Pineres
    SAIC Frederick NCI Frederick, Frederick, MD, USA
    Eur J Immunol 36:437-45. 2006
  7. pmc Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN
    Li Wu
    HIV Drug Resistance Program, Laboratory of Genomic Diversity, and Basic Research Program, Science Applications International Corporation Frederick, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 99:1568-73. 2002
  8. pmc Productive infection of human immunodeficiency virus type 1 in dendritic cells requires fusion-mediated viral entry
    Alicia M Janas
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Virology 375:442-51. 2008
  9. pmc Characterization of human immunodeficiency virus type 1 replication in immature and mature dendritic cells reveals dissociable cis- and trans-infection
    Chunsheng Dong
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Virol 81:11352-62. 2007
  10. ncbi request reprint Recruitment of HIV and its receptors to dendritic cell-T cell junctions
    David McDonald
    Department of Microbiology and Immunology, University of Illinois, Chicago, IL 60612, USA
    Science 300:1295-7. 2003

Collaborators

Detail Information

Publications37

  1. pmc Trans-dominant cellular inhibition of DC-SIGN-mediated HIV-1 transmission
    Li Wu
    Model Development Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    Retrovirology 1:14. 2004
    ..We thus examined whether K562 erythroleukemic cells could recapitulate efficient DC-SIGN-mediated HIV-1 transmission (DMHT)...
  2. pmc Functional evaluation of DC-SIGN monoclonal antibodies reveals DC-SIGN interactions with ICAM-3 do not promote human immunodeficiency virus type 1 transmission
    Li Wu
    HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Virol 76:5905-14. 2002
    ..While these findings do not discount the role of intercellular contact in facilitating HIV-1 transmission, our in vitro data indicate that DC-SIGN interactions with ICAM-3 do not promote DC-SIGN-mediated virus transmission...
  3. pmc HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN)
    Nancy P Y Chung
    HIV Drug Resistance Program, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 285:2100-12. 2010
    ..These data suggest that DC-SIGN structural elements distinct from the oligosaccharide-binding site are required for HIV-1 glycoprotein selectivity...
  4. ncbi request reprint Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission
    Li Wu
    Model Development Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Virology 318:17-23. 2004
    ..These data indicate that there are features common to B cells and DCs that facilitate transmission of HIV-1 and provide new insights toward the mechanism of DC-SIGN-mediated HIV-1 transmission...
  5. pmc Novel member of the CD209 (DC-SIGN) gene family in primates
    Arman A Bashirova
    Science Application International Corporation at Frederick, Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Maryland 21702, USA
    J Virol 77:217-27. 2003
    ....
  6. ncbi request reprint Role of DC-SIGN in the activation of dendritic cells by HPV-16 L1 virus-like particle vaccine
    Alfonso J Garcia-Pineres
    SAIC Frederick NCI Frederick, Frederick, MD, USA
    Eur J Immunol 36:437-45. 2006
    ..These results suggest that DC-SIGN has a functional role in DC activation induced by HPV-16 L1-VLP, and thus highlight new aspects of DC interactions with HPV VLP...
  7. pmc Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN
    Li Wu
    HIV Drug Resistance Program, Laboratory of Genomic Diversity, and Basic Research Program, Science Applications International Corporation Frederick, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 99:1568-73. 2002
    ....
  8. pmc Productive infection of human immunodeficiency virus type 1 in dendritic cells requires fusion-mediated viral entry
    Alicia M Janas
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Virology 375:442-51. 2008
    ..Together, these results provide functional evidence in understanding HIV-1 cis-infection of DCs, suggesting that different pathways of HIV-1 entry into DCs determine the outcome of viral infection...
  9. pmc Characterization of human immunodeficiency virus type 1 replication in immature and mature dendritic cells reveals dissociable cis- and trans-infection
    Chunsheng Dong
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Virol 81:11352-62. 2007
    ..Our results suggest that various DC subsets in vivo may differentially contribute to HIV-1 dissemination via dissociable cis- and trans-infections...
  10. ncbi request reprint Recruitment of HIV and its receptors to dendritic cell-T cell junctions
    David McDonald
    Department of Microbiology and Immunology, University of Illinois, Chicago, IL 60612, USA
    Science 300:1295-7. 2003
    ..We propose that contact between dendritic cells and T cells facilitates transmission of HIV by locally concentrating virus, receptor, and coreceptor during the formation of an infectious synapse...
  11. pmc Dendritic-cell interactions with HIV: infection and viral dissemination
    Li Wu
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Nat Rev Immunol 6:859-68. 2006
    ..This Review highlights the latest advances in our understanding of the interactions between DCs and HIV, focusing on the mechanisms of DC-mediated viral dissemination...
  12. pmc CD4 coexpression regulates DC-SIGN-mediated transmission of human immunodeficiency virus type 1
    Jian Hua Wang
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, BSB 203, Milwaukee, WI 53226, USA
    J Virol 81:2497-507. 2007
    ..These results suggest that CD4, which is present at various levels in DC-SIGN-positive primary cells, is a key regulator of HIV-1 transmission...
  13. pmc The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3
    Angela D'Amico
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Victoria 3050, Australia
    J Exp Med 198:293-303. 2003
    ..These findings demonstrate that the early precursors for all DC subtypes are within the BM Flt3+ precursor populations, regardless of their lymphoid or myeloid lineage orientation...
  14. ncbi request reprint Nortriterpenoids from Schisandra lancifolia
    Wei Lie Xiao
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People s Republic of China
    J Nat Prod 69:650-3. 2006
    ..In addition, all new compounds were tested for anti-HIV-1 activity...
  15. ncbi request reprint Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes
    Shalin H Naik
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Vaccine Technology, Parkville, Victoria 3050, Australia
    Nat Immunol 7:663-71. 2006
    ..Thus, the inflammatory status of the host influences the developmental origin and type of DC present in lymphoid tissues...
  16. ncbi request reprint Signal regulatory protein molecules are differentially expressed by CD8- dendritic cells
    Mireille H Lahoud
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Immunol 177:372-82. 2006
    ..Thus, we postulate that the differential expression of these molecules may confer the ability to regulate the phagocytosis of particular ligands to CD8(-) cDC...
  17. pmc Functionally distinct transmission of human immunodeficiency virus type 1 mediated by immature and mature dendritic cells
    Jian Hua Wang
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Virol 81:8933-43. 2007
    ..Our results provide new insights into the mechanisms underlying DC-mediated HIV-1 transmission, suggesting that HIV-1 exploits mDCs to facilitate its dissemination within lymphoid tissues...
  18. ncbi request reprint Development of dendritic-cell lineages
    Li Wu
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Immunity 26:741-50. 2007
    ..The development of different populations of DCs is differentially regulated by various transcription factors and cytokines. This review summarizes the recent advances made in the field of DC development...
  19. ncbi request reprint Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo
    Shalin H Naik
    The Walter and Eliza Hall Institute, Parkville, Victoria 3050, Australia
    Nat Immunol 8:1217-26. 2007
    ..Thus, commitment to particular DC subtypes begins mainly at this pro-DC stage...
  20. pmc Selective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subset
    Ming Lee Lin
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville VIC 3050, Australia
    Proc Natl Acad Sci U S A 105:3029-34. 2008
    ..Our model opens an avenue to specifically target cross-presenting DCs in vivo for manipulating cytotoxic T lymphocyte responses toward infections, tumors, and transplants...
  21. pmc The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement
    Irina Caminschi
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 112:3264-73. 2008
    ..Furthermore, targeting Ags to DCs with antibodies to Clec9A is a promising strategy to enhance the efficiency of vaccines, even in the absence of adjuvants...
  22. ncbi request reprint Triterpenoids from Schisandra lancifolia with anti-HIV-1 activity
    Wei Lie Xiao
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People s Republic of China
    J Nat Prod 69:277-9. 2006
    ..Compound 1 features a biosynthetically modified seven-membered lactone ring, which was confirmed by single-crystal X-ray diffraction. Compounds 1-3 exhibited weak anti-HIV-1 activity in vitro...
  23. ncbi request reprint Rubriflordilactones A and B, two novel bisnortriterpenoids from Schisandra rubriflora and their biological activities
    Wei Lie Xiao
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P R China
    Org Lett 8:991-4. 2006
    ..Compound 1 showed weak anti-HIV-1 activity, and compound 2 exhibited an EC50 value of 9.75 microg/mL (SI=12.39) against HIV-1 replication with low cytotoxicity...
  24. pmc Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus
    Meredith O'Keeffe
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    J Exp Med 196:1307-19. 2002
    ..Hence as well as activating preexistant DCs, microbial infection induces a wave of production of a new DC subtype. The functional implications of this shift in the DC network remain to be determined...
  25. pmc Regulation of tissue inhibitor of metalloproteinase-1 by astrocytes: links to HIV-1 dementia
    Radhika Suryadevara
    Laboratory of Cellular Neuroimmunology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Glia 44:47-56. 2003
    ..Our studies reveal new opportunities for repair-based therapeutic strategies in HAD...
  26. ncbi request reprint Hemopoietic precursors and development of dendritic cell populations
    Aleksandar Dakic
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, VIC 3050, Australia
    Leuk Lymphoma 44:1469-75. 2003
    ..The downstream points where the DC sub-lineages branch off from the conventional myeloid and lymphoid precursors, and the cytokines and environmental factors required for inducing their specialised functions are yet to be determined...
  27. ncbi request reprint Development of the dendritic cell system during mouse ontogeny
    Aleksandar Dakic
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Immunol 172:1018-27. 2004
    ..These results suggest that the neonatal DC system is not fully developed, and innate immunity is the dominant form of response. The complete DC system required for adaptive immunity in the mouse is not fully developed until 5 wk of age...
  28. ncbi request reprint The lymphoid past of mouse plasmacytoid cells and thymic dendritic cells
    Lynn Corcoran
    The Walter and Eliza Hall Institute, Melbourne, Australia
    J Immunol 170:4926-32. 2003
    ..Therefore, many plasmacytoid pre-DC and thymic CD8(+) DC have shared early steps of development with the lymphoid lineages, and differ in origin from conventional peripheral DC...
  29. ncbi request reprint The thymic stromal cell line MTSC4 induced thymocyte apoptosis in a non-MHC-restricted manner
    Xue Ying He
    Department of Immunology, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, China
    Cell Res 14:125-33. 2004
    ..Our study has also shown that the interaction of MTSC4 stromal cells and thymocytes is required for the induction of thymocyte apoptosis...
  30. ncbi request reprint Mutation of p53 in head and neck squamous cell carcinoma correlates with Bcl-2 expression and increased susceptibility to cisplatin-induced apoptosis
    Genevieve A Andrews
    Department of Otolaryngology, University of Pittsburgh School of Medicine and the University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Head Neck 26:870-7. 2004
    ..Mutation of p53 is one of the most common genetic alterations in squamous cell carcinomas of the head and neck (SCCHN). We hypothesized that p53 mutation is associated with Bcl-2 expression and susceptibility to apoptosis in SCCHN...
  31. ncbi request reprint Differential production of inflammatory chemokines by murine dendritic cell subsets
    Anna I Proietto
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, VIC 3050, Australia
    Immunobiology 209:163-72. 2004
    ..Thus, we report a new functional difference between the murine splenic cDC subsets, with the CD4+ cDC demonstrating the most efficient production of the inflammatory chemokines Mip-1alpha, Mip-1beta and Rantes...
  32. ncbi request reprint Are dendritic cells end cells?
    Ken Shortman
    Nat Immunol 5:1105-6. 2004
  33. ncbi request reprint Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures
    Shalin H Naik
    Immunology Division and the Cooperative Research Centre for Vaccine Technology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    J Immunol 174:6592-7. 2005
    ..This culture system allows access to bona fide counterparts of the splenic DC subsets...
  34. ncbi request reprint CD8alpha+ mouse spleen dendritic cells do not originate from the CD8alpha- dendritic cell subset
    Shalin Naik
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Blood 102:601-4. 2003
    ..Most of the immediate precursors of CD8alpha+ DCs are cells that lack the phenotype of a recognizable DC. CD8alpha- DCs and CD8alpha+ DCs are not precursor-product related, though these sublineages may be connected further upstream...
  35. ncbi request reprint Development of murine plasmacytoid dendritic cell subsets
    Shalin H Naik
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Vaccine Technology, Melbourne, Victoria, Australia
    Immunol Cell Biol 83:563-70. 2005
    ....
  36. ncbi request reprint Development of dendritic cell system
    Li Wu
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Victoria 3050, Australia
    Cell Mol Immunol 1:112-8. 2004
    ..These findings suggest an early developmental flexibility of precursors for DCs and pDCs. This review summarizes some recent observations on the development of DC system in both human and mouse...
  37. ncbi request reprint Heterogeneity of thymic dendritic cells
    Li Wu
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, VIC 3050, Australia
    Semin Immunol 17:304-12. 2005
    ..Thymic pDC can produce type-I interferon upon appropriate activation. However, their role in a steady state thymus is currently unclear...