Research Topics
Genomes and Genes
| Doris K WuSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Molecular mechanisms of inner ear developmentDoris K Wu
National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA
Cold Spring Harb Perspect Biol 4:a008409. 2012..This chapter focuses on molecular mechanisms of inner ear development derived from studies of model organisms...
Noggin heterozygous mice: an animal model for congenital conductive hearing loss in humansChan Ho Hwang
Lab of Molecular Biology, National Institute on Deafness and Other Communication Disorders, 5 Research Court, Rm 2B34, Rockville, MD 20850, USA
Hum Mol Genet 17:844-53. 2008..More importantly, these results establish Nog(+/-) mice as the first animal model for the study of conductive rather than neurosensory hearing loss that has direct relevance to human genetic disorders...- Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movementsWeise Chang
National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland, United States of America
PLoS Genet 4:e1000050. 2008..Our results suggest that, in comparison to sensory bristles, crista formation within the inner ear requires an additional step of sensory and non-sensory fate specification... 
Role of bone morphogenetic proteins on cochlear hair cell formation: analyses of Noggin and Bmp2 mutant miceChan Ho Hwang
Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland, USA
Dev Dyn 239:505-13. 2010..Furthermore, Gfi1(cre/+);Bmp2(lox/-) mice are viable and have largely normal hearing. The combined results of Noggin and Bmp2 mutants suggest that Noggin is likely to regulate other Bmps in the cochlea such as Bmp4...- Foxg1 is required for proper separation and formation of sensory cristae during inner ear developmentChan Ho Hwang
Lab of Molecular Biology, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA
Dev Dyn 238:2725-34. 2009..Our genetic fate-mapping analyses indicate an improper separation between anterior and lateral cristae in Foxg1(-/-) mutants. Our data further suggest that a function of Foxg1 in the inner ear is to restrict sensory fate... - Lmx1a maintains proper neurogenic, sensory, and non-sensory domains in the mammalian inner earSoo Kyung Koo
National Institute on Deafness and Other Communication Disorders, 5 Research Court, Rm 2B34, Rockville, Rockville, MD 20850, USA
Dev Biol 333:14-25. 2009..Furthermore, aberrant and ectopic sensory organs are observed; most striking among these is vestibular-like hair cells located in the cochlear duct... - Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signalingZhengshi Lin
Laboratory of Molecular Biology, National Institutes on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20850, USA
Development 132:2309-18. 2005..However, Gbx2 promotes ventral fates such as the saccule and cochlear duct, possibly by restricting Otx2 expression... - Role of hindbrain in inner ear morphogenesis: analysis of Noggin knockout miceJinwoong Bok
National Institute on Deafness and Other Communication Disorders, 5 Research Ct, Rm 2B34, Rockville, MD 20850, USA
Dev Biol 311:69-78. 2007..In addition, the size of the otic capsule is increased in Noggin -/- mutants, which most likely is due to unopposed BMP signaling for chondrogenesis in the peri-otic mesenchyme... - Distinct contributions from the hindbrain and mesenchyme to inner ear morphogenesisJennifer K Liang
National Institute on Deafness and Other Communication Disorders, 5 Research Court, Rockville, MD 20850, USA
Dev Biol 337:324-34. 2010..These results provide a basis for identifying factors that are essential to vestibular and auditory development in vertebrates... - The development of semicircular canals in the inner ear: role of FGFs in sensory cristaeWeise Chang
National Institute on Deafness and Other Communication Disorders, Rockville, MD 20850, USA
Development 131:4201-11. 2004..Thus, we provide the first molecular evidence whereby sensory organs direct the development of the associated non-sensory components, the semicircular canals, in vertebrate inner ears... - Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner earJinwoong Bok
National Institute on Deafness and Other Communication Disorders, Rockville, MD 20850, USA
Development 134:1713-22. 2007..Taken together, our data suggest that reciprocal gradients of GliA and GliR mediate the responses to Shh signaling along the dorsoventral axis of the inner ear... - The role of Pax2 in mouse inner ear developmentQuianna Burton
National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
Dev Biol 272:161-75. 2004.... - Patterning and morphogenesis of the vertebrate inner earJinwoong Bok
National Institute on Deafness and Other Communication Disorders, Rockville, MD, USA
Int J Dev Biol 51:521-33. 2007..In addition, this review addresses how genes induced within the otic epithelium as a result of axial specification continue to mediate inner ear morphogenesis... - BMP pathways are involved in otic capsule formation and epithelial-mesenchymal signaling in the developing chicken inner earWeise Chang
National Institute on Deafness and Other Communications Disorders, National Institutes of Health, Rockville, Maryland 20850, USA
Dev Biol 251:380-94. 2002.... - Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner earJinwoong Bok
National Institute on Deafness and Other Communication Disorders, 5 Research Court, Rockville, MD 20850, USA
Development 132:2115-24. 2005..Taken together, our studies suggest that tissue(s) other than the hindbrain confer AP axial information whereas signals from the hindbrain are necessary and sufficient for the DV axial patterning of the inner ear... - Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genesYoshiyuki Kawashima
Molecular Biology and Genetics Section, National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland 20850 3320, USA
J Clin Invest 121:4796-809. 2011..Our data also suggest that persistent TMC2 expression in vestibular hair cells may preserve vestibular function in humans with hearing loss caused by TMC1 mutations... - The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner earTiia Ponnio
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Cell Biol 22:935-45. 2002.... - EphB2 and ephrin-B2 regulate the ionic homeostasis of vestibular endolymphChristopher Dravis
Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, United States
Hear Res 223:93-104. 2007.... - Specification of the mammalian cochlea is dependent on Sonic hedgehogMartin M Riccomagno
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Genes Dev 16:2365-78. 2002..Taken together, our data support a model whereby auditory cell fates in the otic vesicle are established by the direct action of Shh...