Doris K Wu


Affiliation: National Institutes of Health
Country: USA


  1. Hwang C, Keller J, Renner C, Ohta S, Wu D. Genetic interactions support an inhibitory relationship between bone morphogenetic protein 2 and netrin 1 during semicircular canal formation. Development. 2019;146: pubmed publisher
  2. Huang Y, Hill J, Yatteau A, Wong L, Jiang T, Petrovic J, et al. Reciprocal Negative Regulation Between Lmx1a and Lmo4 Is Required for Inner Ear Formation. J Neurosci. 2018;38:5429-5440 pubmed publisher
    ..Identifying these key molecules that mediate formation of this important sensory organ will be helpful for designing strategies and therapeutics to alleviate hearing loss and balance disorders. ..
  3. Deng X, Wu D. Temporal coupling between specifications of neuronal and macular fates of the inner ear. Dev Biol. 2016;414:21-33 pubmed publisher
    ..Both of these results are consistent with a temporal coupling between neuronal and macular fate specifications. ..
  4. request reprint
    Hwang C, Wu D. Noggin heterozygous mice: an animal model for congenital conductive hearing loss in humans. Hum Mol Genet. 2008;17:844-53 pubmed
    ..More importantly, these results establish Nog(+/-) mice as the first animal model for the study of conductive rather than neurosensory hearing loss that has direct relevance to human genetic disorders...
  5. Wu D, Kelley M. Molecular mechanisms of inner ear development. Cold Spring Harb Perspect Biol. 2012;4:a008409 pubmed publisher
    ..This chapter focuses on molecular mechanisms of inner ear development derived from studies of model organisms. ..
  6. Raft S, Andrade L, Shao D, Akiyama H, Henkemeyer M, Wu D. Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear. Dev Biol. 2014;390:51-67 pubmed publisher
    ..We propose that developmental dysplasias described here are a gene dose-sensitive cause of the vestibular dysfunction observed in EphB-Efnb2 signaling-deficient mice. ..