Doris K Wu

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Molecular mechanisms of inner ear development
    Doris K Wu
    National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA
    Cold Spring Harb Perspect Biol 4:a008409. 2012
  2. ncbi request reprint Noggin heterozygous mice: an animal model for congenital conductive hearing loss in humans
    Chan Ho Hwang
    Lab of Molecular Biology, National Institute on Deafness and Other Communication Disorders, 5 Research Court, Rm 2B34, Rockville, MD 20850, USA
    Hum Mol Genet 17:844-53. 2008
  3. pmc Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements
    Weise Chang
    National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000050. 2008
  4. doi request reprint Role of bone morphogenetic proteins on cochlear hair cell formation: analyses of Noggin and Bmp2 mutant mice
    Chan Ho Hwang
    Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland, USA
    Dev Dyn 239:505-13. 2010
  5. doi request reprint Foxg1 is required for proper separation and formation of sensory cristae during inner ear development
    Chan Ho Hwang
    Lab of Molecular Biology, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA
    Dev Dyn 238:2725-34. 2009
  6. pmc Lmx1a maintains proper neurogenic, sensory, and non-sensory domains in the mammalian inner ear
    Soo Kyung Koo
    National Institute on Deafness and Other Communication Disorders, 5 Research Court, Rm 2B34, Rockville, Rockville, MD 20850, USA
    Dev Biol 333:14-25. 2009
  7. ncbi request reprint Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling
    Zhengshi Lin
    Laboratory of Molecular Biology, National Institutes on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20850, USA
    Development 132:2309-18. 2005
  8. pmc Role of hindbrain in inner ear morphogenesis: analysis of Noggin knockout mice
    Jinwoong Bok
    National Institute on Deafness and Other Communication Disorders, 5 Research Ct, Rm 2B34, Rockville, MD 20850, USA
    Dev Biol 311:69-78. 2007
  9. doi request reprint Distinct contributions from the hindbrain and mesenchyme to inner ear morphogenesis
    Jennifer K Liang
    National Institute on Deafness and Other Communication Disorders, 5 Research Court, Rockville, MD 20850, USA
    Dev Biol 337:324-34. 2010
  10. ncbi request reprint The development of semicircular canals in the inner ear: role of FGFs in sensory cristae
    Weise Chang
    National Institute on Deafness and Other Communication Disorders, Rockville, MD 20850, USA
    Development 131:4201-11. 2004

Collaborators

Detail Information

Publications21

  1. pmc Molecular mechanisms of inner ear development
    Doris K Wu
    National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA
    Cold Spring Harb Perspect Biol 4:a008409. 2012
    ..This chapter focuses on molecular mechanisms of inner ear development derived from studies of model organisms...
  2. ncbi request reprint Noggin heterozygous mice: an animal model for congenital conductive hearing loss in humans
    Chan Ho Hwang
    Lab of Molecular Biology, National Institute on Deafness and Other Communication Disorders, 5 Research Court, Rm 2B34, Rockville, MD 20850, USA
    Hum Mol Genet 17:844-53. 2008
    ..More importantly, these results establish Nog(+/-) mice as the first animal model for the study of conductive rather than neurosensory hearing loss that has direct relevance to human genetic disorders...
  3. pmc Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements
    Weise Chang
    National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000050. 2008
    ..Our results suggest that, in comparison to sensory bristles, crista formation within the inner ear requires an additional step of sensory and non-sensory fate specification...
  4. doi request reprint Role of bone morphogenetic proteins on cochlear hair cell formation: analyses of Noggin and Bmp2 mutant mice
    Chan Ho Hwang
    Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland, USA
    Dev Dyn 239:505-13. 2010
    ..Furthermore, Gfi1(cre/+);Bmp2(lox/-) mice are viable and have largely normal hearing. The combined results of Noggin and Bmp2 mutants suggest that Noggin is likely to regulate other Bmps in the cochlea such as Bmp4...
  5. doi request reprint Foxg1 is required for proper separation and formation of sensory cristae during inner ear development
    Chan Ho Hwang
    Lab of Molecular Biology, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA
    Dev Dyn 238:2725-34. 2009
    ..Our genetic fate-mapping analyses indicate an improper separation between anterior and lateral cristae in Foxg1(-/-) mutants. Our data further suggest that a function of Foxg1 in the inner ear is to restrict sensory fate...
  6. pmc Lmx1a maintains proper neurogenic, sensory, and non-sensory domains in the mammalian inner ear
    Soo Kyung Koo
    National Institute on Deafness and Other Communication Disorders, 5 Research Court, Rm 2B34, Rockville, Rockville, MD 20850, USA
    Dev Biol 333:14-25. 2009
    ..Furthermore, aberrant and ectopic sensory organs are observed; most striking among these is vestibular-like hair cells located in the cochlear duct...
  7. ncbi request reprint Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling
    Zhengshi Lin
    Laboratory of Molecular Biology, National Institutes on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20850, USA
    Development 132:2309-18. 2005
    ..However, Gbx2 promotes ventral fates such as the saccule and cochlear duct, possibly by restricting Otx2 expression...
  8. pmc Role of hindbrain in inner ear morphogenesis: analysis of Noggin knockout mice
    Jinwoong Bok
    National Institute on Deafness and Other Communication Disorders, 5 Research Ct, Rm 2B34, Rockville, MD 20850, USA
    Dev Biol 311:69-78. 2007
    ..In addition, the size of the otic capsule is increased in Noggin -/- mutants, which most likely is due to unopposed BMP signaling for chondrogenesis in the peri-otic mesenchyme...
  9. doi request reprint Distinct contributions from the hindbrain and mesenchyme to inner ear morphogenesis
    Jennifer K Liang
    National Institute on Deafness and Other Communication Disorders, 5 Research Court, Rockville, MD 20850, USA
    Dev Biol 337:324-34. 2010
    ..These results provide a basis for identifying factors that are essential to vestibular and auditory development in vertebrates...
  10. ncbi request reprint The development of semicircular canals in the inner ear: role of FGFs in sensory cristae
    Weise Chang
    National Institute on Deafness and Other Communication Disorders, Rockville, MD 20850, USA
    Development 131:4201-11. 2004
    ..Thus, we provide the first molecular evidence whereby sensory organs direct the development of the associated non-sensory components, the semicircular canals, in vertebrate inner ears...
  11. ncbi request reprint Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear
    Jinwoong Bok
    National Institute on Deafness and Other Communication Disorders, Rockville, MD 20850, USA
    Development 134:1713-22. 2007
    ..Taken together, our data suggest that reciprocal gradients of GliA and GliR mediate the responses to Shh signaling along the dorsoventral axis of the inner ear...
  12. ncbi request reprint The role of Pax2 in mouse inner ear development
    Quianna Burton
    National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
    Dev Biol 272:161-75. 2004
    ....
  13. ncbi request reprint Patterning and morphogenesis of the vertebrate inner ear
    Jinwoong Bok
    National Institute on Deafness and Other Communication Disorders, Rockville, MD, USA
    Int J Dev Biol 51:521-33. 2007
    ..In addition, this review addresses how genes induced within the otic epithelium as a result of axial specification continue to mediate inner ear morphogenesis...
  14. pmc Auditory ganglion source of Sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cells
    Jinwoong Bok
    Department of Anatomy, Department of Otorhinolaryngology, BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, 120 752, Korea and Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, Rockville, MD 20850
    Proc Natl Acad Sci U S A 110:13869-74. 2013
    ....
  15. doi request reprint Progression of neurogenesis in the inner ear requires inhibition of Sox2 transcription by neurogenin1 and neurod1
    Lale Evsen
    National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA
    J Neurosci 33:3879-90. 2013
    ..We propose that Sox2 confers neural competency by promoting Ngn1 expression, and that negative feedback inhibition of Sox2 by Ngn1 is an essential step in the progression from neural precursor to nascent neuron...
  16. ncbi request reprint BMP pathways are involved in otic capsule formation and epithelial-mesenchymal signaling in the developing chicken inner ear
    Weise Chang
    National Institute on Deafness and Other Communications Disorders, National Institutes of Health, Rockville, Maryland 20850, USA
    Dev Biol 251:380-94. 2002
    ....
  17. ncbi request reprint Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear
    Jinwoong Bok
    National Institute on Deafness and Other Communication Disorders, 5 Research Court, Rockville, MD 20850, USA
    Development 132:2115-24. 2005
    ..Taken together, our studies suggest that tissue(s) other than the hindbrain confer AP axial information whereas signals from the hindbrain are necessary and sufficient for the DV axial patterning of the inner ear...
  18. pmc Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes
    Yoshiyuki Kawashima
    Molecular Biology and Genetics Section, National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland 20850 3320, USA
    J Clin Invest 121:4796-809. 2011
    ..Our data also suggest that persistent TMC2 expression in vestibular hair cells may preserve vestibular function in humans with hearing loss caused by TMC1 mutations...
  19. pmc The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear
    Tiia Ponnio
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:935-45. 2002
    ....
  20. ncbi request reprint EphB2 and ephrin-B2 regulate the ionic homeostasis of vestibular endolymph
    Christopher Dravis
    Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, United States
    Hear Res 223:93-104. 2007
    ....
  21. pmc Specification of the mammalian cochlea is dependent on Sonic hedgehog
    Martin M Riccomagno
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 16:2365-78. 2002
    ..Taken together, our data support a model whereby auditory cell fates in the otic vesicle are established by the direct action of Shh...