Adam Woolfe

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Comparative genomics using Fugu reveals insights into regulatory subfunctionalization
    Adam Woolfe
    School of Biological Sciences, Queen Mary, University of London, London, UK
    Genome Biol 8:R53. 2007
  2. pmc CONDOR: a database resource of developmentally associated conserved non-coding elements
    Adam Woolfe
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    BMC Dev Biol 7:100. 2007
  3. pmc Genomic features defining exonic variants that modulate splicing
    Adam Woolfe
    Genomic Functional Analysis Section, National Human Genome Research Institute, National Institutes of Health, Rockville, Maryland 20892, USA
    Genome Biol 11:R20. 2010
  4. pmc Ancient duplicated conserved noncoding elements in vertebrates: a genomic and functional analysis
    Gayle K McEwen
    School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, United Kingdom
    Genome Res 16:451-65. 2006
  5. doi request reprint Organization of conserved elements near key developmental regulators in vertebrate genomes
    Adam Woolfe
    School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, United Kingdom
    Adv Genet 61:307-38. 2008
  6. pmc Highly conserved non-coding sequences are associated with vertebrate development
    Adam Woolfe
    Medical Research Council Rosalind Franklin Centre for Genomics Research Hinxton, Cambridge, United Kingdom
    PLoS Biol 3:e7. 2005
  7. ncbi request reprint Defining a genomic radius for long-range enhancer action: duplicated conserved non-coding elements hold the key
    Tanya Vavouri
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, CB10 1SA
    Trends Genet 22:5-10. 2006

Detail Information

Publications7

  1. pmc Comparative genomics using Fugu reveals insights into regulatory subfunctionalization
    Adam Woolfe
    School of Biological Sciences, Queen Mary, University of London, London, UK
    Genome Biol 8:R53. 2007
    ..We have exploited fish-mammal genomic alignments to identify and compare more than 800 conserved non-coding elements (CNEs) that associate with genes that have undergone fish-specific duplication and retention...
  2. pmc CONDOR: a database resource of developmentally associated conserved non-coding elements
    Adam Woolfe
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    BMC Dev Biol 7:100. 2007
    ..Despite this, there remains little in the way of user-friendly access to a large dataset of such elements in conjunction with the analysis and the visualization tools needed to study them...
  3. pmc Genomic features defining exonic variants that modulate splicing
    Adam Woolfe
    Genomic Functional Analysis Section, National Human Genome Research Institute, National Institutes of Health, Rockville, Maryland 20892, USA
    Genome Biol 11:R20. 2010
    ..In addition, little is known about which computational prediction approaches, such as those involving exonic splicing enhancers and exonic splicing silencers, are most informative...
  4. pmc Ancient duplicated conserved noncoding elements in vertebrates: a genomic and functional analysis
    Gayle K McEwen
    School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, United Kingdom
    Genome Res 16:451-65. 2006
    ..We propose a model whereby gene duplication and the evolution of cis-regulatory elements can be considered in the context of increased morphological diversity and the emergence of the modern vertebrate body plan...
  5. doi request reprint Organization of conserved elements near key developmental regulators in vertebrate genomes
    Adam Woolfe
    School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, United Kingdom
    Adv Genet 61:307-38. 2008
    ..This chapter describes the identification and characterization of these elements, with particular reference to their composition and organization...
  6. pmc Highly conserved non-coding sequences are associated with vertebrate development
    Adam Woolfe
    Medical Research Council Rosalind Franklin Centre for Genomics Research Hinxton, Cambridge, United Kingdom
    PLoS Biol 3:e7. 2005
    ..These highly conserved non-coding sequences are likely to form part of the genomic circuitry that uniquely defines vertebrate development...
  7. ncbi request reprint Defining a genomic radius for long-range enhancer action: duplicated conserved non-coding elements hold the key
    Tanya Vavouri
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, CB10 1SA
    Trends Genet 22:5-10. 2006
    ..This enables us to provide the first systematic estimate of the genomic range for distal cis-regulatory interactions in the human genome: half of CNEs are >250 kb away from their associated gene...