Karen Woodson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Hypermethylation of GSTP1, CD44, and E-cadherin genes in prostate cancer among US Blacks and Whites
    Karen Woodson
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Prostate 55:199-205. 2003
  2. pmc Promoter methylation in cytology specimens as an early detection marker for esophageal squamous dysplasia and early esophageal squamous cell carcinoma
    Lisa Adams
    Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Prev Res (Phila) 1:357-61. 2008
  3. ncbi request reprint Manganese superoxide dismutase (MnSOD) polymorphism, alpha-tocopherol supplementation and prostate cancer risk in the alpha-tocopherol, beta-carotene cancer prevention study (Finland)
    Karen Woodson
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 7058, USA
    Cancer Causes Control 14:513-8. 2003
  4. ncbi request reprint Lack of association between serum levels of 25-hydroxyvitamin D and the subsequent risk of prostate cancer in Finnish men
    Jessica M Faupel-Badger
    Cancer Prevention Fellowship Program, Division of Cancer Prevention and Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, 37 Convent Drive, Building 37, Room 1106, Bethesda, MD 20892 4254, USA
    Cancer Epidemiol Biomarkers Prev 16:2784-6. 2007
  5. ncbi request reprint Association of IL-10 polymorphisms with prostate cancer risk and grade of disease
    Jessica M Faupel-Badger
    Cancer Prevention Fellowship Program, Division of Cancer Prevention and Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 4254, USA
    Cancer Causes Control 19:119-24. 2008
  6. ncbi request reprint Gene-specific methylation and subsequent risk of colorectal adenomas among participants of the polyp prevention trial
    Karen Woodson
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:1219-23. 2005
  7. ncbi request reprint CD44 and PTGS2 methylation are independent prognostic markers for biochemical recurrence among prostate cancer patients with clinically localized disease
    Karen Woodson
    Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Epigenetics 1:183-6. 2006
  8. ncbi request reprint A survey of gene-specific methylation in human prostate cancer among black and white men
    Karen Woodson
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, 6116 Executive Blvd, MSC 8314, Bethesda, MD 20892 USA
    Cancer Lett 205:181-8. 2004
  9. pmc COX-2 (PTGS2) gene methylation in epithelial, subepithelial lymphocyte and stromal tissue compartments in a spectrum of esophageal squamous neoplasia
    Sonja P Dawsey
    Cancer Genetics Branch, Center for Cancer Research, National Cancer Institute, Rockville, MD 20892, USA
    Cancer Detect Prev 32:135-9. 2008
  10. ncbi request reprint Loss of insulin-like growth factor-II imprinting and the presence of screen-detected colorectal adenomas in women
    Karen Woodson
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 96:407-10. 2004

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Hypermethylation of GSTP1, CD44, and E-cadherin genes in prostate cancer among US Blacks and Whites
    Karen Woodson
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Prostate 55:199-205. 2003
    ..Epigenetic events such as promoter-region gene hypermethylation may be influenced by environmental exposures and have been implicated in prostate carcinogenesis (by the silencing of tumor suppressors and other regulatory genes)...
  2. pmc Promoter methylation in cytology specimens as an early detection marker for esophageal squamous dysplasia and early esophageal squamous cell carcinoma
    Lisa Adams
    Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Prev Res (Phila) 1:357-61. 2008
    ....
  3. ncbi request reprint Manganese superoxide dismutase (MnSOD) polymorphism, alpha-tocopherol supplementation and prostate cancer risk in the alpha-tocopherol, beta-carotene cancer prevention study (Finland)
    Karen Woodson
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 7058, USA
    Cancer Causes Control 14:513-8. 2003
    ..We hypothesized that MnSOD may be associated with prostate cancer and that long-term antioxidant supplementation (alpha-tocopherol 50 mg/day for five to eight years) could modify the effect on risk...
  4. ncbi request reprint Lack of association between serum levels of 25-hydroxyvitamin D and the subsequent risk of prostate cancer in Finnish men
    Jessica M Faupel-Badger
    Cancer Prevention Fellowship Program, Division of Cancer Prevention and Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, 37 Convent Drive, Building 37, Room 1106, Bethesda, MD 20892 4254, USA
    Cancer Epidemiol Biomarkers Prev 16:2784-6. 2007
  5. ncbi request reprint Association of IL-10 polymorphisms with prostate cancer risk and grade of disease
    Jessica M Faupel-Badger
    Cancer Prevention Fellowship Program, Division of Cancer Prevention and Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 4254, USA
    Cancer Causes Control 19:119-24. 2008
    ..56, 95% CI 1.26-5.20 for -819). These data demonstrate genotypes correlated with low IL-10 production are associated with increased risk of prostate cancer and with high-grade disease in this population...
  6. ncbi request reprint Gene-specific methylation and subsequent risk of colorectal adenomas among participants of the polyp prevention trial
    Karen Woodson
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:1219-23. 2005
    ..No association between CDKN2A, PTGS2, or PGR methylation and adenoma recurrence was observed. These data suggest that ESR1 methylation may play a role in subsequent adenoma recurrence...
  7. ncbi request reprint CD44 and PTGS2 methylation are independent prognostic markers for biochemical recurrence among prostate cancer patients with clinically localized disease
    Karen Woodson
    Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Epigenetics 1:183-6. 2006
    ..CD44 and PTGS2 methylation may predict biochemical recurrence in prostate cancer patients undergoing radical prostatectomy and if validated in larger studies, may identify patients with aggressive cancer...
  8. ncbi request reprint A survey of gene-specific methylation in human prostate cancer among black and white men
    Karen Woodson
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, 6116 Executive Blvd, MSC 8314, Bethesda, MD 20892 USA
    Cancer Lett 205:181-8. 2004
    ..In summary, our data suggest that evaluation of the methylation of a panel of genes may have diagnostic and prognostic utility in prostate cancer...
  9. pmc COX-2 (PTGS2) gene methylation in epithelial, subepithelial lymphocyte and stromal tissue compartments in a spectrum of esophageal squamous neoplasia
    Sonja P Dawsey
    Cancer Genetics Branch, Center for Cancer Research, National Cancer Institute, Rockville, MD 20892, USA
    Cancer Detect Prev 32:135-9. 2008
    ....
  10. ncbi request reprint Loss of insulin-like growth factor-II imprinting and the presence of screen-detected colorectal adenomas in women
    Karen Woodson
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 96:407-10. 2004
    ..These findings are intriguing and need to be confirmed in larger studies...
  11. ncbi request reprint The usefulness of the detection of GSTP1 methylation in urine as a biomarker in the diagnosis of prostate cancer
    Karen Woodson
    Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Urol 179:508-11; discussion 511-2. 2008
    ..To our knowledge the clinical usefulness of the detection of gene methylation is yet to be established...
  12. ncbi request reprint Association of the NAD(P)H:quinone oxidoreductase (NQO1) 609C->T polymorphism with lung cancer risk among male smokers
    Karla A Lawson
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 14:2275-6. 2005
  13. ncbi request reprint p16, MGMT, RARbeta2, CLDN3, CRBP and MT1G gene methylation in esophageal squamous cell carcinoma and its precursor lesions
    Mark J Roth
    National Cancer Institute, 6120 Executive Blvd, EPS 320, MSC 7232, Rockville, MD 20892, USA
    Oncol Rep 15:1591-7. 2006
    ..Balloon cytology may be able to screen the length of the esophagus effectively for a subset of cells with abnormal methylation, and may be useful in a primary screening test for ESCC and its precursor lesions...
  14. ncbi request reprint Serum insulin-like growth factor I: tumor marker or etiologic factor? A prospective study of prostate cancer among Finnish men
    Karen Woodson
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Res 63:3991-4. 2003
    ..It is possible that serum IGF-I may be serving as a tumor marker rather than an etiologic factor in prostate cancer...
  15. ncbi request reprint Heterogeneous gene methylation patterns among pre-invasive and cancerous lesions of the prostate: a histopathologic study of whole mount prostate specimens
    Karen Woodson
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Prostate 60:25-31. 2004
    ..This is the first study to evaluate gene methylation patterns across multiple pre-cancerous and invasive cancer foci from the same prostate gland...
  16. ncbi request reprint Long-term alpha-tocopherol supplementation is associated with lower serum vascular endothelial growth factor levels
    Karen Woodson
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Anticancer Res 22:375-8. 2002
    ..One potential mechanism explaining this is that alpha-tocopherol inhibited tumor angiogenesis, an effect demonstrated in animal models...
  17. pmc The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers
    Enrique Zudaire
    Angiogenesis Core Facility, NCI, NIH, Gaithersburg, Maryland 20892 4605, USA
    J Clin Invest 118:640-50. 2008
    ..These results therefore demonstrate that AHRR is a putative new tumor suppressor gene in multiple types of human cancers...
  18. ncbi request reprint CD44 and PTGS2 methylation are independent prognostic markers for biochemical recurrence among prostate cancer patients with clinically localized disease
    Karen Woodson
    Epigenetics 1:183-6. 2006
    ..CD44 and PTGS2 methylation may predict biochemical recurrence in prostate cancer patients undergoing radical prostatectomy and if validated in larger studies, may identify patients with aggressive cancer...
  19. ncbi request reprint Global expression analysis of prostate cancer-associated stroma and epithelia
    Annely M Richardson
    Pathogenetics Unit, National Cancer Institute at Frederick, Frederick, MD, USA
    Diagn Mol Pathol 16:189-97. 2007
    ..These data provide insight into the molecular changes occurring in tumor-associated stromal cells and suggest new potential targets for future diagnostic, imaging, or therapeutic intervention...
  20. ncbi request reprint Non-steroidal anti-inflammatory drug use is associated with reduction in recurrence of advanced and non-advanced colorectal adenomas (United States)
    Joseph A Tangrea
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 7058, USA
    Cancer Causes Control 14:403-11. 2003
    ....
  21. ncbi request reprint Analysis of genes critical for growth regulation identifies Insulin-like Growth Factor 2 Receptor variations with possible functional significance as risk factors for osteosarcoma
    Sharon A Savage
    Section of Genomic Variation, Pediatric Oncology Branch, National Cancer Institute, 6120 Executive Boulevard, EPS 7018, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 16:1667-74. 2007
    ..Osteosarcoma, the most common malignant primary bone tumor, typically occurs during the adolescent growth spurt. Germ-line genetic variation in genes critical in growth regulation could confer altered risk of osteosarcoma...
  22. ncbi request reprint Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene and risk of prostate cancer among men in a large cancer prevention study
    Dina Paltoo
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, 6116 Executive Boulevard, Suite 705, MSC 8314, Bethesda, MD 20892 7058, USA
    Cancer Lett 191:67-74. 2003
    ..28, 95% CI: 0.54-3.04 for metastatic disease) or grade (OR=1.57, 95% CI: 0.63-3.91 for poorly differentiated disease). The Pro12Ala polymorphism does not appear to play a significant role in prostate cancer risk in this cohort of men...
  23. ncbi request reprint Discovery of DNA hypermethylation using a DHPLC screening strategy
    Antoinette S Perry
    Department of Haematology and Academic Unit of Clinical and Molecular Oncology, Institute of Molecular Medicine, St James s Hospital and Trinity College, Dublin, Ireland
    Epigenetics 2:43-9. 2007
    ..We show that DHPLC has an application as a fast, sensitive, quantitative and cost effective method for screening novel targets or DNA samples for DNA methylation...
  24. ncbi request reprint The emerging roles of DNA methylation in the clinical management of prostate cancer
    Antoinette S Perry
    Institute of Molecular Medicine, Trinity College Dublin, Ireland
    Endocr Relat Cancer 13:357-77. 2006
    ....
  25. ncbi request reprint Genetic variation in interleukin 8 and its receptor genes and its influence on the risk and prognosis of prostate cancer among Finnish men in a large cancer prevention trial
    Hannah P Yang
    Emerging Leaders Program, DHHS, Washington, DC, USA
    Eur J Cancer Prev 15:249-53. 2006
    ..Although none of the SNPs studied are likely to have major effects on prostate cancer susceptibility, a role for other polymorphisms associated within these genes cannot be excluded...
  26. ncbi request reprint Increasing evidence for a human breast carcinoma virus with geographic differences
    Paul H Levine
    Department of Epidemiology and Biostatistics, The George Washington University School of Public Health and Health Services, Washington, DC 20037, USA
    Cancer 101:721-6. 2004
    ....