Catherine A Wolkow

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway
    Catherine A Wolkow
    Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Biol Chem 277:49591-7. 2002
  2. ncbi Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans
    Mark A Wilson
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
    Aging Cell 5:59-68. 2006
  3. ncbi Life span: getting the signal from the nervous system
    Catherine A Wolkow
    Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Trends Neurosci 25:212-6. 2002
  4. ncbi Identifying factors that promote functional aging in Caenorhabditis elegans
    Catherine A Wolkow
    Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Exp Gerontol 41:1001-6. 2006
  5. ncbi Uncoupling protein homologs may provide a link between mitochondria, metabolism and lifespan
    Catherine A Wolkow
    Invertebrate Molecular Genetics Unit, Laboratory of Neurosciences, NIA IRP, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Ageing Res Rev 5:196-208. 2006
  6. ncbi Activated AKT/PKB signaling in C. elegans uncouples temporally distinct outputs of DAF-2/insulin-like signaling
    Minaxi S Gami
    Laboratory of Neurosciences, NIA, NIH, Baltimore, MD, USA
    BMC Dev Biol 6:45. 2006
  7. ncbi Sarcopenia in the Caenorhabditis elegans pharynx correlates with muscle contraction rate over lifespan
    David K Chow
    Laboratory of Neurosciences, National Institute on Aging/Intramural Research Program (NIA/IRP, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Exp Gerontol 41:252-60. 2006
  8. ncbi Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs
    Wendy B Iser
    Laboratory of Neurosciences, National Institute on Aging IRP, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Dev Biol 303:434-47. 2007
  9. ncbi Co-regulation of the DAF-16 target gene, cyp-35B1/dod-13, by HSF-1 in C. elegans dauer larvae and daf-2 insulin pathway mutants
    Wendy B Iser
    Invertebrate Molecular Genetics Unit, Laboratory of Neurosciences, Research Resources Branch, NIA Intramural Research Program, NIH Biomedical Research Center, Baltimore, Maryland, United States of America
    PLoS ONE 6:e17369. 2011
  10. ncbi Dietary deprivation extends lifespan in Caenorhabditis elegans
    Garrick D Lee
    Laboratory of Experimental Gerontology, National Institute on Aging, Balimore, MD 21224, USA
    Aging Cell 5:515-24. 2006

Collaborators

Detail Information

Publications20

  1. ncbi Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway
    Catherine A Wolkow
    Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Biol Chem 277:49591-7. 2002
    ..elegans mutants with defects in DAF-2 signaling. Interestingly, IST-1 appears to be required for signaling through a pathway that may act in parallel to AGE-1/PI3K...
  2. ncbi Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans
    Mark A Wilson
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
    Aging Cell 5:59-68. 2006
    ..In conclusion, polyphenolic compounds in blueberries had robust and reproducible benefits during aging that were separable from antioxidant effects...
  3. ncbi Life span: getting the signal from the nervous system
    Catherine A Wolkow
    Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Trends Neurosci 25:212-6. 2002
    ..This review examines the evidence for nervous system control of longevity and discusses the implications for popular models for aging...
  4. ncbi Identifying factors that promote functional aging in Caenorhabditis elegans
    Catherine A Wolkow
    Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Exp Gerontol 41:1001-6. 2006
    ..This article will examine the current research into aging-related functional declines in this species, focusing on recent studies of locomotory and feeding decline during aging in the nematode, C. elegans...
  5. ncbi Uncoupling protein homologs may provide a link between mitochondria, metabolism and lifespan
    Catherine A Wolkow
    Invertebrate Molecular Genetics Unit, Laboratory of Neurosciences, NIA IRP, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Ageing Res Rev 5:196-208. 2006
    ..Future biochemical and genetic investigation of UCP-like proteins will do much to clarify their functions and to identify the regulatory networks in which they are involved...
  6. ncbi Activated AKT/PKB signaling in C. elegans uncouples temporally distinct outputs of DAF-2/insulin-like signaling
    Minaxi S Gami
    Laboratory of Neurosciences, NIA, NIH, Baltimore, MD, USA
    BMC Dev Biol 6:45. 2006
    ..In order to study the downstream effectors of AGE-1/PI3K signaling in C. elegans, we conducted a genetic screen for mutations that suppress the constitutive dauer arrest phenotype of age-1(mg109) animals...
  7. ncbi Sarcopenia in the Caenorhabditis elegans pharynx correlates with muscle contraction rate over lifespan
    David K Chow
    Laboratory of Neurosciences, National Institute on Aging/Intramural Research Program (NIA/IRP, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Exp Gerontol 41:252-60. 2006
    ..Further, characterization of the specific types of damage induced by muscle contraction will be helpful for understanding the underlying causes of sarcopenia...
  8. ncbi Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs
    Wendy B Iser
    Laboratory of Neurosciences, National Institute on Aging IRP, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Dev Biol 303:434-47. 2007
    ..Together, these results show that C. elegans insulin signaling has endocrine as well as tissue-specific outputs which could influence lifespan in a combinatorial fashion...
  9. ncbi Co-regulation of the DAF-16 target gene, cyp-35B1/dod-13, by HSF-1 in C. elegans dauer larvae and daf-2 insulin pathway mutants
    Wendy B Iser
    Invertebrate Molecular Genetics Unit, Laboratory of Neurosciences, Research Resources Branch, NIA Intramural Research Program, NIH Biomedical Research Center, Baltimore, Maryland, United States of America
    PLoS ONE 6:e17369. 2011
    ..Genetic analysis of the cyp-35B1 promoter showed both DAF-16 and HSF-1 are direct regulators. Based on these findings, we propose that hsf-1 may participate in the pathways mediating non-autonomous activities of age-1 in C. elegans...
  10. ncbi Dietary deprivation extends lifespan in Caenorhabditis elegans
    Garrick D Lee
    Laboratory of Experimental Gerontology, National Institute on Aging, Balimore, MD 21224, USA
    Aging Cell 5:515-24. 2006
    ..elegans. This study presents the first evidence that long-term DD, instead of being detrimental, can extend lifespan of a multicellular adult organism...
  11. ncbi Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms
    Piper R Hunt
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 6:e21922. 2011
    ..Our findings reveal the potential for low doses of naturally occurring naphthoquinones to extend lifespan by engaging a specific adaptive cellular stress response pathway...
  12. ncbi DAF-2/insulin-like signaling in C. elegans modifies effects of dietary restriction and nutrient stress on aging, stress and growth
    Wendy B Iser
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 2:e1240. 2007
    ..Genetic analysis in C. elegans nematodes has shown that DR and IIS couple to distinct cellular signaling pathways. However, it is not known whether these pathways ultimately converge on overlapping or distinct targets to extend lifespan...
  13. ncbi Regulation of Caenorhabditis elegans vitellogenesis by DAF-2/IIS through separable transcriptional and posttranscriptional mechanisms
    Ana S Depina
    Laboratory of Neurosciences, NIA Intramural Research Program, NIH, Baltimore, MD 21224, USA
    BMC Physiol 11:11. 2011
    ..However, little is known about the pathways regulating vitellogenesis in response to prolongevity cues...
  14. ncbi Quantitative measurement of aging using image texture entropy
    Lior Shamir
    Laboratory of Genetics, National Institute on Aging NIH, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Bioinformatics 25:3060-3. 2009
    ..Here we propose to use the image texture entropy as an objective measurement that reflects the structural deterioration of the C. elegans muscle tissues during aging...
  15. ncbi Studies of Caenorhabditis elegans DAF-2/insulin signaling reveal targets for pharmacological manipulation of lifespan
    Minaxi S Gami
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Aging Cell 5:31-7. 2006
    ..These insights into pathways affecting invertebrate lifespan may provide a basis for developing strategies for pharmacological manipulation of human lifespan...
  16. ncbi Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty
    Charles F Glenn
    Laboratory of Neuosciences, National Institue on Aging, Baltimore, MD 21224, USA
    J Gerontol A Biol Sci Med Sci 59:1251-60. 2004
    ..Treatment with a muscarinic agonist significantly improved locomotory behavior in aged animals, indicating that improved neuromuscular signaling may be one strategy for reducing the severity of age-related behavioral impairments...
  17. ncbi Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species
    Sige Zou
    National Institute on Aging, Intramural Research Program, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Mech Ageing Dev 128:222-6. 2007
    ..This study shows that a comparative approach, utilizing multiple invertebrate species, can increase the robustness of invertebrate-based pilot screens for prolongevity interventions...
  18. ncbi Methoxylation enhances stilbene bioactivity in Caenorhabditis elegans
    Mark A Wilson
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, NIH, Baltimore, MD 21224, USA
    BMC Pharmacol 8:15. 2008
    ....
  19. ncbi New haystacks reveal new needles: using Caenorhabditis elegans to identify novel targets for ameliorating body composition changes during human aging
    Catherine A Wolkow
    Laboratory of Neurosciences, NIA Intramural Research Program, NIH, Biomedical Research Center, Baltimore, MD 21224, USA
    Interdiscip Top Gerontol 37:84-93. 2010
    ..From this chapter, readers will develop a deeper understanding of the ways that C.elegans can be used for mechanistic gerontological studies...
  20. ncbi Quantitative image analysis reveals distinct structural transitions during aging in Caenorhabditis elegans tissues
    Josiah Johnston
    Laboratory of Genetics, NIA Intramural Research Program, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 3:e2821. 2008
    ..This work further demonstrates that pattern analysis of an image series offers a novel and generally accessible approach for quantifying morphological changes and identifying structural biomarkers...