Kristine L Witt

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals
    Kristine L Witt
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mutat Res 649:101-13. 2008
  2. pmc No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days
    Kristine L Witt
    Biomolecular Screening Branch, NIEHS NTP, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 51:80-8. 2010
  3. pmc Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD
    Kristine L Witt
    National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Triangle Park, NC 27709, USA
    J Am Acad Child Adolesc Psychiatry 47:1375-83. 2008
  4. ncbi request reprint Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment
    Kristine L Witt
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 44:321-8. 2004
  5. ncbi request reprint The genetic toxicity of 3,3',4,4'-tetrachloroazobenzene and 3,3',4, 4'-tetrachloroazoxybenzene: discordance between acute mouse bone marrow and subchronic mouse peripheral blood micronucleus test results
    K L Witt
    ILS Inc, P O Box 13501, Research Triangle Park, NC 27709, USA
    Mutat Res 472:147-54. 2000
  6. ncbi request reprint Micronucleated erythrocyte frequency in peripheral blood of B6C3F(1) mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program
    K L Witt
    ILS, Inc, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 36:163-94. 2000
  7. ncbi request reprint Mutagenicity of anticancer drugs in mammalian germ cells
    K L Witt
    Oak Ridge Institute for Science and Education, TN 37831 0117, USA
    Mutat Res 355:209-34. 1996
  8. doi request reprint Genetics and women's health issues--the commitment of EMS to women scientists and gender-associated disease topics
    Kristine L Witt
    National Toxicology Program, NIEHS NIH, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 51:774-80. 2010
  9. ncbi request reprint Induction of micronucleated erythrocytes in rodents by diisopropylcarbodiimide and dicyclohexylcarbodiimide: dependence on exposure protocol
    K L Witt
    Integrated Laboratory Systems, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 33:65-74. 1999
  10. ncbi request reprint Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage
    Jack B Bishop
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 43:3-9. 2004

Detail Information

Publications33

  1. pmc Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals
    Kristine L Witt
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mutat Res 649:101-13. 2008
    ..No significant differences were observed between results obtained by the two methods in either species. These results support the use of FCM for determining MN-RET frequency in rodents after chemical exposure...
  2. pmc No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days
    Kristine L Witt
    Biomolecular Screening Branch, NIEHS NTP, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 51:80-8. 2010
    ..Additionally, no histopathological changes in brain or heart, or elevated serum biomarkers of cardiac injury were observed in these MPH-exposed rats...
  3. pmc Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD
    Kristine L Witt
    National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Triangle Park, NC 27709, USA
    J Am Acad Child Adolesc Psychiatry 47:1375-83. 2008
    ....
  4. ncbi request reprint Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment
    Kristine L Witt
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 44:321-8. 2004
    ..Comparison of micronucleated cell frequencies induced by AZT alone or in combination with ddI suggests that ddI potentiates AZT-induced chromosomal damage following direct exposure...
  5. ncbi request reprint The genetic toxicity of 3,3',4,4'-tetrachloroazobenzene and 3,3',4, 4'-tetrachloroazoxybenzene: discordance between acute mouse bone marrow and subchronic mouse peripheral blood micronucleus test results
    K L Witt
    ILS Inc, P O Box 13501, Research Triangle Park, NC 27709, USA
    Mutat Res 472:147-54. 2000
    ..In addition, the integration of mutagenicity tests into general toxicity tests reduces the use of laboratory animals and the cost of the testing...
  6. ncbi request reprint Micronucleated erythrocyte frequency in peripheral blood of B6C3F(1) mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program
    K L Witt
    ILS, Inc, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 36:163-94. 2000
    ..Although results indicate that the test has low sensitivity for prediction of carcinogenicity, a convincingly positive result in this assay appears to be highly predictive of rodent carcinogenicity...
  7. ncbi request reprint Mutagenicity of anticancer drugs in mammalian germ cells
    K L Witt
    Oak Ridge Institute for Science and Education, TN 37831 0117, USA
    Mutat Res 355:209-34. 1996
    ..The implications for human risk are discussed...
  8. doi request reprint Genetics and women's health issues--the commitment of EMS to women scientists and gender-associated disease topics
    Kristine L Witt
    National Toxicology Program, NIEHS NIH, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 51:774-80. 2010
    ....
  9. ncbi request reprint Induction of micronucleated erythrocytes in rodents by diisopropylcarbodiimide and dicyclohexylcarbodiimide: dependence on exposure protocol
    K L Witt
    Integrated Laboratory Systems, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 33:65-74. 1999
    ..The data demonstrated a small but consistent induction of micronucleated erythrocytes in mice treated with DIC by skin painting...
  10. ncbi request reprint Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage
    Jack B Bishop
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 43:3-9. 2004
    ..The amount of genetic damage observed in treated pups raises concern for the potential of similar damage in humans. Investigations of chromosomal integrity in exposed newborns and children are recommended...
  11. doi request reprint Mechanistic insights from the NTP studies of chromium
    Kristine L Witt
    Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 41:326-42. 2013
    ..The multiple potential pathways of Cr-induced genotoxicity will be discussed...
  12. ncbi request reprint Mouse bone marrow micronucleus test results do not predict the germ cell mutagenicity of N-hydroxymethylacrylamide in the mouse dominant lethal assay
    Kristine L Witt
    Information Sciences Division, Integrated Laboratory Systems, Inc, Research Triangle Park, North Carolina, USA
    Environ Mol Mutagen 41:111-20. 2003
    ..Thus, NHMA appears to be unique in inducing genetic damage in germ cells but not somatic cells of male mice...
  13. pmc Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV
    Kristine L Witt
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Environ Mol Mutagen 48:322-9. 2007
    ..These results demonstrate that transplacentalZDV exposure is genotoxic in humans. Long-term monitoring of HIV-uninfected ZDV-exposed infants is recommended to ensure their continued health...
  14. pmc Dose-response assessment of four genotoxic chemicals in a combined mouse and rat micronucleus (MN) and Comet assay protocol
    Leslie Recio
    Genetic Toxicology Division, ILS, Inc, RTP, NC 27709, USA
    J Toxicol Sci 35:149-62. 2010
    ....
  15. pmc Genotoxicity of styrene-acrylonitrile trimer in brain, liver, and blood cells of weanling F344 rats
    Cheryl A Hobbs
    Department of Genetic and Molecular Toxicology, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 53:227-38. 2012
    ..The results of this subacute MN/Comet assay indicate induction of significant genetic damage in multiple tissues of weanling F344 male and female rats after oral exposure to SAN Trimer...
  16. doi request reprint Comparison of Comet assay dose-response for ethyl methanesulfonate using freshly prepared versus cryopreserved tissues
    Leslie Recio
    Genetic and Molecular Toxicology Division, ILS, Research Triangle Park, NC, USA
    Environ Mol Mutagen 53:101-13. 2012
    ..We also demonstrated that for three tissues (blood, liver, stomach), air transport did not alter the sensitivity of the Comet assay for detecting DNA damage...
  17. ncbi request reprint Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination
    Sherine S L Chan
    Laboratory of Molecular Genetics, National Institute of Environmental HealthSciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Environ Mol Mutagen 48:190-200. 2007
    ..Our data suggest that AZT/3TC combination treatment produces greater mtDNA damage than either agent individually, and that female mice are more sensitive than males to AZT/3TC-induced mtDNA damage...
  18. pmc Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach
    Sunita J Shukla
    NIH Chemical Genomics Center, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA
    Environ Health Perspect 120:1150-6. 2012
    ..Thus, assays that detect the up-regulation of this pathway could be useful for identifying chemicals that induce oxidative stress...
  19. pmc Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure
    Matthew D Stout
    National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 117:716-22. 2009
    ..Hexavalent chromium [Cr(VI)] is a human carcinogen after inhalation exposure. Humans also ingest Cr(VI) from contaminated drinking water and soil; however, limited data exist on the oral toxicity and carcinogenicity of Cr(VI)...
  20. ncbi request reprint Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: evidence consistent with a glycidamide-mediated effect
    B I Ghanayem
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, Research Triangle Park, NC 27709, USA
    Mutat Res 578:284-97. 2005
    ....
  21. ncbi request reprint Genetic toxicities of human teratogens
    J B Bishop
    Laboratory of Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mutat Res 396:9-43. 1997
    ..e. exhibit epigenetic activity, have likewise been identified. The information used in making these comparisons comes from the published literature as well as from unpublished data of the U.S. National Toxicology Program (NTP)...
  22. pmc Chronic toxicity and carcinogenicity studies of chromium picolinate monohydrate administered in feed to F344/N rats and B6C3F1 mice for 2 years
    M D Stout
    National Toxicology Program, National Institute of Environmental Health Sciences, NIEHS, Research Triangle Park, NC 27709, USA
    Food Chem Toxicol 47:729-33. 2009
    ..In male rats, a statistically significant increase in the incidence of preputial gland adenoma at 10,000 ppm was considered an equivocal finding. CPM was not carcinogenic to female rats or to male or female mice...
  23. ncbi request reprint Comparison of germ cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide: evidence supporting a glycidamide-mediated effect
    B I Ghanayem
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 72:157-63. 2005
    ..Thus, CYP2E1 polymorphisms in human populations, resulting in variable enzyme metabolic activities, may produce differential susceptibilities to acrylamide toxicities...
  24. ncbi request reprint Toxicology and carcinogenesis studies of microencapsulated trans-cinnamaldehyde in rats and mice
    M J Hooth
    National Institute of Environmental Health Sciences, Mail Drop EC 35, 79 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Food Chem Toxicol 42:1757-68. 2004
    ..Squamous cell papillomas and carcinomas of the forestomach were observed in male and female mice but the incidences were within the NTP historical control range and were not considered to be related to trans-cinnamaldehyde exposure...
  25. pmc Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway
    Ruili Huang
    NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA
    Sci Rep 4:5664. 2014
    ....
  26. pmc Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels
    Menghang Xia
    NIH Chemical Genomics Center, National Institutes of Health, Bethesda, MD 20892 3370, USA
    Toxicol Appl Pharmacol 252:250-8. 2011
    ..Profiling environmental compound libraries for hERG channel inhibition provides information useful in prioritizing these compounds for cardiotoxicity assessment in vivo...
  27. pmc An ethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents
    Minerva Mercado-Feliciano
    National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, NC, USA
    Toxicol Appl Pharmacol 263:138-47. 2012
    ..001, 0.01, 0.1, 1, 10, 100 and 500 mg/kg found no estrogenic or anti-estrogenic activity. These are the first studies to observe adverse effects of BCE in rodents...
  28. pmc Chemical genomics profiling of environmental chemical modulation of human nuclear receptors
    Ruili Huang
    National Institutes of Health Chemical Genomics Center, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 3370, USA
    Environ Health Perspect 119:1142-8. 2011
    ....
  29. pmc Toxicity and carcinogenicity of androstenedione in F344/N rats and B6C3F1 mice
    Chad R Blystone
    National Toxicology Program, National Institutes of Environmental Health Sciences, National Institute of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, United States
    Food Chem Toxicol 49:2116-24. 2011
    ..In conclusion, androstenedione was determined to be carcinogenic in male and female mice, and may have been carcinogenic in rats...
  30. ncbi request reprint Micronucleus induction in mice exposed to diazoaminobenzene or its metabolites, benzene and aniline: implications for diazoaminobenzene carcinogenicity
    Nancy B Ress
    National Institute of Environmental Health Sciences, 79 Alexander Drive, Mail Drop EC 34, Research Triangle Park, Triangle Park, NC 27709, USA
    Mutat Res 521:201-8. 2002
    ..The results are consistent with a prediction of carcinogenicity for DAAB...
  31. ncbi request reprint Phenolphthalein: induction of micronucleated erythrocytes in mice
    K L Witt
    Oak Ridge Institute for Science and Education, TN 37831 0117
    Mutat Res 341:151-60. 1995
    ....
  32. pmc Identification of chemical compounds that induce HIF-1alpha activity
    Menghang Xia
    NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Toxicol Sci 112:153-63. 2009
    ..Identification of environmental compounds having HIF-1alpha activation activity in cell-based assays may be useful for prioritizing chemicals for further testing as hypoxia-response inducers in vivo...
  33. ncbi request reprint Antiretroviral therapy effects on genetic and morphologic end points in lymphocytes and sperm of men with human immunodeficiency virus infection
    W A Robbins
    National Institute of Environmental Health Sciences, Laboratory of Toxicology, Research Triangle Park, North Carolina, USA
    J Infect Dis 184:127-35. 2001
    ..These findings suggest that nucleoside-containing antiretrovirals administered via recommended protocols do not induce chromosomal changes in lymphocytes or sperm but may produce improvements in semen quality...