Affiliation: National Institutes of Health
Fan J, Jia L, Li Y, Ebrahim S, May Simera H, Wood A, et al
. Maturation arrest in early postnatal sensory receptors by deletion of the miR-183/96/182 cluster in mouse. Proc Natl Acad Sci U S A. 2017;114:E4271-E4280 pubmed publisher
..Our study thus establishes a dedicated role of the miR-183/96/182 cluster in driving the terminal differentiation of multiple sensory receptor cells. ..
Wistow G. The human crystallin gene families. Hum Genomics. 2012;6:26 pubmed publisher
..Crystallin organization is essential for lens transparency and mutations; even minor changes to surface residues can cause cataract and loss of vision. ..
Sagar V, Chaturvedi S, Schuck P, Wistow G. Crystal Structure of Chicken ?S-Crystallin Reveals Lattice Contacts with Implications for Function in the Lens and the Evolution of the ??-Crystallins. Structure. 2017;25:1068-1078.e2 pubmed publisher
..The lattice contacts suggest how ?-crystallins allow close packing without aggregation in the crowded environment of the lens. ..
Fan J, Lerner J, Wyatt M, Cai P, Peterson K, Dong L, et al
. The klotho-related protein KLPH (lctl) has preferred expression in lens and is essential for expression of clic5 and normal lens suture formation. Exp Eye Res. 2018;169:111-121 pubmed publisher
..These results suggest that KLPH is required for lens-specific expression of Clic5 and that Clic5 has an important role in the machinery that controls lens fiber cell extension and organization. ..
Wistow G, Sardarian L, Gan W, Wyatt M. The human gene for gammaS-crystallin: alternative transcripts and expressed sequences from the first intron. Mol Vis. 2000;6:79-84 pubmed
..The identity and function Mys of is not yet known, however, the cryptic splicing of CRYGS could produce a defective protein product, with potentially deleterious results for the adult human lens. ..
Wistow G, Wyatt K, David L, Gao C, Bateman O, Bernstein S, et al
. gammaN-crystallin and the evolution of the betagamma-crystallin superfamily in vertebrates. FEBS J. 2005;272:2276-91 pubmed
..Although well conserved throughout vertebrate evolution, gammaN in primates has apparently undergone major changes and possible loss of functional expression. ..
Wistow G. The NEIBank project for ocular genomics: data-mining gene expression in human and rodent eye tissues. Prog Retin Eye Res. 2006;25:43-77 pubmed
..These point to specific adaptations and mechanisms in the human eye and emphasize that care needs to be taken in the application of appropriate animal model systems. ..
Rajapakse D, Peterson K, Mishra S, Wistow G. Serum starvation of ARPE-19 changes the cellular distribution of cholesterol and Fibulin3 in patterns reminiscent of age-related macular degeneration. Exp Cell Res. 2017;361:333-341 pubmed publisher