Research Topics
Species | R A WiseSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
Dual roles of dopamine in food and drug seeking: the drive-reward paradoxRoy A Wise
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland Electronic address
Biol Psychiatry 73:819-26. 2013..That the same brain circuitry is implicated in the motivation for and the reinforcement by both food and addictive drugs extends the argument for a common mechanism underlying compulsive overeating and compulsive drug taking...
Dopamine, learning and motivationRoy A Wise
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Rev Neurosci 5:483-94. 2004
Forebrain substrates of reward and motivationRoy A Wise
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Comp Neurol 493:115-21. 2005..This system is phasically activated by most drugs of abuse and such activation contributes to the habit-forming actions of these drugs...- Brain reward circuitry: insights from unsensed incentivesRoy A Wise
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA
Neuron 36:229-40. 2002..Comparisons of natural and laboratory incentives suggest hypotheses as to why some habits become compulsive and give insights into the roles of reinforcement and of prediction of reinforcement in habit formation... - Ventral tegmental glutamate: a role in stress-, cue-, and cocaine-induced reinstatement of cocaine-seekingRoy A Wise
Intramural Research Program, National Institute on Drug Abuse, National Institutes on Health, Department of Health and Human Services, 251 Bayview Blvd, Baltimore, MD 21224, USA
Neuropharmacology 56:174-6. 2009.... - Dopamine and reward: the anhedonia hypothesis 30 years onRoy A Wise
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, USA
Neurotox Res 14:169-83. 2008..Properly understood, it is also fundamental to recent theories of incentive motivation... - Roles for nigrostriatal--not just mesocorticolimbic--dopamine in reward and addictionRoy A Wise
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, USA
Trends Neurosci 32:517-24. 2009..Thus, the similarities between nigrostriatal and mesolimbic dopamine systems can be as important as their differences... - Differentiating the rapid actions of cocaineRoy A Wise
US National Institute on Drug Abuse, Behavioral Neuroscience Section, 251 Bayview Boulevard Baltimore, Maryland 21224, USA
Nat Rev Neurosci 12:479-84. 2011..The conditioned activation of the dopamine system by cocaine-predictive cues offers a new target for potential addiction therapies... - Role of brain dopamine in food reward and reinforcementRoy A Wise
Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Philos Trans R Soc Lond B Biol Sci 361:1149-58. 2006..While dopamine plays a central role in the feeding and food-seeking of normal animals, some food rewarded learning can be seen in genetically engineered dopamine-deficient mice... - Cocaine serves as a peripheral interoceptive conditioned stimulus for central glutamate and dopamine releaseRoy A Wise
Department of Health and Human Services, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States of America
PLoS ONE 3:e2846. 2008..These findings offer an explanation for short-latency behavioral responses and immediate dopamine elevations seen following cocaine injections in cocaine-experienced but not cocaine-naïve animals... - Dopamine and glutamate release in the nucleus accumbens and ventral tegmental area of rat following lateral hypothalamic self-stimulationZ B You
Center for Studies in Behavioural Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada
Neuroscience 107:629-39. 2001.... - Determinants of maximal inspiratory pressure. The Baltimore Longitudinal Study of AgingR I Harik-Khan
Laboratory of Clinical Investigation, National Institute on Aging, Gerontology Research Center, Baltimore, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Am J Respir Crit Care Med 158:1459-64. 1998..028 x age + 0.343 x weight (kg) +/- (22.4); and for women: MIP +/- SEE = 171 - 0.694 x age + 0. 861 x weight (kg) - 0.743 x height (cm) +/- (18.5). These equations may be used for the assessment of inspiratory muscle strength... - The effect of anthropometric and socioeconomic factors on the racial difference in lung functionR I Harik-Khan
Clinical Research Branch, National Institute on Aging, Gerontology Research Center, Baltimore, Maryland 21224, USA
Am J Respir Crit Care Med 164:1647-54. 2001..Although low socioeconomic indicators are related to lower lung function, they explain only a small proportion of this racial difference... - The effect of gestational parity on FEV1 in a group of healthy volunteer womenR Harik-Khan
Laboratory of Clinical Investigation, National Institute on Aging, Intramural Research Program, Gerontology Research Center, Baltimore, MD 21224 6823, USA
Respir Med 93:382-8. 1999..Thus the nulliparous state is associated with lower FEV1 in this group of healthy adult women of child-bearing age... - The effect of gender on the relationship between body fat distribution and lung functionR I Harik-Khan
Longitudinal Studies Section, Laboratory of Clinical Investigation, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224, USA
J Clin Epidemiol 54:399-406. 2001..383, P =.0005) compared to women (beta = -0.679, P =.02). Thus, body fat distribution has independent effects on lung function that are more prominent in men than women... - Neuroadaptations of total levels of adenylate cyclase, protein kinase A, tyrosine hydroxylase, cdk5 and neurofilaments in the nucleus accumbens and ventral tegmental area do not correlate with expression of sensitized or tolerant locomotor responses to coB T Hope
National Institute on Drug Abuse, National Institutes of Health DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
J Neurochem 92:536-45. 2005.... - Brain stimulation and morphine reward deficits in dopamine D2 receptor-deficient miceG I Elmer
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland, Maple and Locust Streets, Baltimore, MD 21228, USA
Psychopharmacology (Berl) 182:33-44. 2005..Genetically engineered animal models provide a complementary approach to pharmacological investigations... - Striatal hyperthermia associated with arousal: intracranial thermorecordings in behaving ratsE A Kiyatkin
Behavioral Neuroscience Branch, National Institute on Drug Abuse Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Brain Res 918:141-52. 2001..Because most neural processes are temperature-dependent, change in local temperature may result in dramatic modulation of the efficiency of neural processes in situations critical for life-support and during adaptive behavior... - Quality assessment through patient self-report of symptoms prefiberoptic and postfiberoptic bronchoscopyG B Diette
Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Chest 114:1446-53. 1998.... - Changing smoking patterns and mortality from chronic obstructive pulmonary diseaseR A Wise
Johns Hopkins University School of Medicine, Baltimore, Maryland 21212, USA
Prev Med 26:418-21. 1997..Recent studies indicate that early identification of individuals with airflow obstruction and smoking intervention can halt the progression of COPD, but widespread screening and intervention programs have not yet been established... - Leptin receptor polymorphisms and lung function decline in COPDN N Hansel
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Eur Respir J 34:103-10. 2009..We identified genetic variants in the LEPR gene significantly associated with lung function decline in a population of smokers with COPD. Our results support a role for LEPR as a novel candidate gene for COPD... - Dopamine and food reward: back to the elementsRoy A Wise
Am J Physiol Regul Integr Comp Physiol 286:R13. 2004 - Rewarding effects of the cholinergic agents carbachol and neostigmine in the posterior ventral tegmental areaSatoshi Ikemoto
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
J Neurosci 22:9895-904. 2002..These findings implicate both nicotinic and muscarinic cholinergic neurotransmission in ventral tegmental reward function and suggest special involvement of the posterior portion of the VTA in cholinergic reward function... - The parsing of food rewardRoy A Wise
Am J Physiol Regul Integr Comp Physiol 291:R1234-5. 2006 - Long-term upregulation of protein kinase A and adenylate cyclase levels in human smokersBruce T Hope
Behavioral Neuroscience Branch, Intramural Research Program National Institute on Drug Abuse National Institutes of Health Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 27:1964-72. 2007.... - Stress-induced relapse to cocaine seeking: roles for the CRF(2) receptor and CRF-binding protein in the ventral tegmental area of the ratBin Wang
Behavioral Neuroscience Branch, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 193:283-94. 2007..The effects of selective CRF antagonists have not yet been reported... - A role for conditioned ventral tegmental glutamate release in cocaine seekingZhi Bing You
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
J Neurosci 27:10546-55. 2007..The findings implicate glutamate as at least one of the sources of VTA signals from reward-associated environmental stimuli... - Rewarding and psychomotor stimulant effects of endomorphin-1: anteroposterior differences within the ventral tegmental area and lack of effect in nucleus accumbensAbraham Zangen
National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
J Neurosci 22:7225-33. 2002..The present findings implicate the posterior VTA as a highly specific and sensitive site for opioid reward and suggest a role for EM-1-containing projections to the posterior VTA in the rewarding effects of other reinforcers... - Rewarding effects of AMPA administration into the supramammillary or posterior hypothalamic nuclei but not the ventral tegmental areaSatoshi Ikemoto
Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 24:5758-65. 2004..These findings implicate posterior hypothalamic regions in reward function and suggest that reward mechanisms localized around the ventral tegmental area are more complex than has been assumed recently... - Acetylcholine release in the mesocorticolimbic dopamine system during cocaine seeking: conditioned and unconditioned contributions to reward and motivationZhi Bing You
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 28:9021-9. 2008.... - Brain temperature fluctuation: a reflection of functional neural activationEugene A Kiyatkin
Behavioural Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Eur J Neurosci 16:164-8. 2002..Thus, the local metabolic consequences of widely correlated neural activity appear to be the primary source of increases in brain temperature and a driving force behind the associated changes in body temperature... - Failure of intravenous morphine to serve as an effective instrumental reinforcer in dopamine D2 receptor knock-out miceGreg I Elmer
Neuroscience Program, Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
J Neurosci 22:RC224. 2002..Under this range of doses and response requirements, the rewarding effects of morphine appear to depend critically on an intact D2 receptor system... - Brain and body hyperthermia associated with heroin self-administration in ratsEugene A Kiyatkin
Behavioral Neuroscience Branch, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA
J Neurosci 22:1072-80. 2002.... - Heteromeric nicotinic acetylcholine-dopamine autoreceptor complexes modulate striatal dopamine releaseDavide Quarta
Behavioral Neuroscience Branch, National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA
Neuropsychopharmacology 32:35-42. 2007..These results reveal that striatal non-alpha(7) nicotinic acetylcholine receptors form part of heteromeric dopamine autoreceptor complexes that modulate dopamine release... - Two brain sites for cannabinoid rewardAbraham Zangen
National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 26:4901-7. 2006..These findings link the sites of rewarding action of Delta9THC to brain regions where such drugs as amphetamines, cocaine, heroin, and nicotine are also thought to have their sites of rewarding action... - Blockade of substantia nigra dopamine D1 receptors reduces intravenous cocaine reward in ratsMatthew G Quinlan
Department of Psychology, Queens College, CUNY, 65-30 Kissena Boulevard, Flushing, NY 11367, USA
Psychopharmacology (Berl) 175:53-9. 2004..These findings complement accumulating evidence that the rewarding effects of cocaine are not restricted to the drug's ability to elevate dopamine levels in the nucleus accumbens... - Brain hyperthermia is induced by methamphetamine and exacerbated by social interactionP Leon Brown
Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224, USA
J Neurosci 23:3924-9. 2003.... - Drive, incentive, and reinforcement: the antecedents and consequences of motivationRoy A Wise
Nebr Symp Motiv 50:159-95. 2004 - Unmet expectations: the brain mindsWilliam A Carlezon
Nat Med 9:15-6. 2003 - Mapping of chemical trigger zones for rewardSatoshi Ikemoto
Behavioral Neuroscience Branch, National Institute on Drug Abuse NIDA, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Neuropharmacology 47:190-201. 2004..This approach has identified GABAergic, dopaminergic, glutamatergic, and cholinergic trigger zones within meso-corticolimbic circuitry important for natural reward function... - Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaineJohn F Neumaier
Department of Psychiatry and Behavioral Sciences and Harborview Medical Center, University of Washington, Seattle, Washington 98195, USA
J Neurosci 22:10856-63. 2002.... - Study of the interaction of chlorisondamine and chlorisondamine analogues with an epitope of the alpha-2 neuronal acetylcholine nicotinic receptor subunitHay-Yan J Wang
Behavioral Neuroscience Branch, NIDA-IRP, National Institutes of Health, DHHS, 5500 Nathan Shock Drive, Baltimore Maryland 21224, USA
J Proteome Res 4:532-9. 2005..Overall, all three analogues showed better affinity than CHL for complex formation with both the nonphosphorylated and phosphorylated epitopes... - How can drug addiction help us understand obesity?Nora D Volkow
National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Neurosci 8:555-60. 2005 - Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: a role in stress-induced relapse to drug seekingBin Wang
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
J Neurosci 25:5389-96. 2005..Similar neuroadaptations may be important for the comorbidity between addiction and other stress-related psychiatric disorders... - Interaction of chlorisondamine with the neuronal nicotinic acetylcholine receptorAmina S Woods
The National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
J Proteome Res 2:207-12. 2003.... - Endomorphin-1 and -2 immunoreactive cells in the hypothalamus are labeled by fluoro-gold injections to the ventral tegmental areaThomas N Greenwell
Neuroscience Program, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
J Comp Neurol 454:320-8. 2002..The results support the idea that some endomorphin-containing neurons in the hypothalamus project to the VTA, where they may modulate reward and locomotor circuitry... - A new peptide input to learning and addictionRoy A Wise
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
Neuron 49:483-4. 2006..This parallels a similar effect of corticotropin-releasing factor and suggests a form of neuroadaptation that increases the likelihood of addiction relapse... - Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse linesJose A Morón
Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
J Neurosci 22:389-95. 2002..These data underscore the fact that which transporter clears dopamine from a given region depends on both the affinities and the local densities of the transporters...