Cheryl A Winkler

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Admixture mapping comes of age
    Cheryl A Winkler
    Basic Science Program, SAIC Frederick, Inc, Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Annu Rev Genomics Hum Genet 11:65-89. 2010
  2. pmc Worldwide distribution of the MYH9 kidney disease susceptibility alleles and haplotypes: evidence of historical selection in Africa
    Taras K Oleksyk
    Department of Biology, University of Puerto Rico at Mayaguez, Mayaguez, Puerto Rico
    PLoS ONE 5:e11474. 2010
  3. pmc Evidence for selection at HIV host susceptibility genes in a West Central African human population
    Kai Zhao
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    BMC Evol Biol 12:237. 2012
  4. ncbi request reprint Is there a genetic basis for health disparities in human immunodeficiency virus disease?
    Cheryl Winkler
    Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, MD, USA
    Mt Sinai J Med 77:149-59. 2010
  5. ncbi request reprint The effect of RANTES chemokine genetic variants on early HIV-1 plasma RNA among African American injection drug users
    Priya Duggal
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 38:584-9. 2005
  6. pmc Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS
    Ping An
    Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, National Cancer Institute Frederick, Frederick, Maryland, United States of America
    PLoS Pathog 3:e88. 2007
  7. pmc Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individuals
    Ping An
    Laboratory of Genomic Diversity, SAIC Frederick, Incorporated, National Cancer Institute, Frederick, Maryland, United States of America
    PLoS Genet 3:e19. 2007
  8. pmc Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15
    George W Nelson
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Hum Mol Genet 19:1805-15. 2010
  9. pmc Regulatory polymorphisms in the interleukin-18 promoter are associated with hepatitis C virus clearance
    Ping An
    Laboratory of Genomic Diversity, Science Applications International Corportation Frederick, MD, USA
    J Infect Dis 198:1159-65. 2008
  10. pmc APOBEC3B deletion and risk of HIV-1 acquisition
    Ping An
    Laboratory of Genomic Diversity, SAIC Frederick, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Infect Dis 200:1054-8. 2009

Detail Information

Publications27

  1. ncbi request reprint Admixture mapping comes of age
    Cheryl A Winkler
    Basic Science Program, SAIC Frederick, Inc, Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Annu Rev Genomics Hum Genet 11:65-89. 2010
    ..Here, we provide a historical perspective, review AIM panels and software packages, and discuss recent successes and unexpected insights into human diseases that exhibit disparate rates across human populations...
  2. pmc Worldwide distribution of the MYH9 kidney disease susceptibility alleles and haplotypes: evidence of historical selection in Africa
    Taras K Oleksyk
    Department of Biology, University of Puerto Rico at Mayaguez, Mayaguez, Puerto Rico
    PLoS ONE 5:e11474. 2010
    ..The population-specific divergence in MYH9 risk allele frequencies among the world's populations may prove important in risk assessment and public health policies to mitigate the burden of kidney disease in vulnerable populations...
  3. pmc Evidence for selection at HIV host susceptibility genes in a West Central African human population
    Kai Zhao
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    BMC Evol Biol 12:237. 2012
    ....
  4. ncbi request reprint Is there a genetic basis for health disparities in human immunodeficiency virus disease?
    Cheryl Winkler
    Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, MD, USA
    Mt Sinai J Med 77:149-59. 2010
    ....
  5. ncbi request reprint The effect of RANTES chemokine genetic variants on early HIV-1 plasma RNA among African American injection drug users
    Priya Duggal
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 38:584-9. 2005
    ..Because RANTES is a critical chemokine and competitively inhibits HIV-1 by binding to its receptor CCR5, treatment to enhance RANTES expression may assist in delaying the progression of AIDS by decreasing the initial viral load...
  6. pmc Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS
    Ping An
    Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, National Cancer Institute Frederick, Frederick, Maryland, United States of America
    PLoS Pathog 3:e88. 2007
    ..These results implicate regulatory PPIA polymorphisms as a component of genetic susceptibility to HIV-1 infection or disease progression, affirming the important role of PPIA in HIV-1 pathogenesis...
  7. pmc Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individuals
    Ping An
    Laboratory of Genomic Diversity, SAIC Frederick, Incorporated, National Cancer Institute, Frederick, Maryland, United States of America
    PLoS Genet 3:e19. 2007
    ....
  8. pmc Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15
    George W Nelson
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Hum Mol Genet 19:1805-15. 2010
    ..Rs5750250 combined with rs11912763 had receiver operator characteristic (ROC) C statistics of 0.80, 0.73 and 0.65 for HIVAN, FSGS and H-ESKD, respectively, allowing prediction of genetic risk by typing two SNPs...
  9. pmc Regulatory polymorphisms in the interleukin-18 promoter are associated with hepatitis C virus clearance
    Ping An
    Laboratory of Genomic Diversity, Science Applications International Corportation Frederick, MD, USA
    J Infect Dis 198:1159-65. 2008
    ..77-11.6]) was also strongly associated with viral clearance. No association was found among those with hemophilia. These results suggest that IL18 promoter polymorphism may affect the outcome of HCV infection in certain groups...
  10. pmc APOBEC3B deletion and risk of HIV-1 acquisition
    Ping An
    Laboratory of Genomic Diversity, SAIC Frederick, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Infect Dis 200:1054-8. 2009
    ..01; P=. 03), and viral set point (P= .04). These findings suggest that the loss of APOBEC3B may increase host susceptibility to HIV-1 acquisition and progression to AIDS and warrant further study...
  11. ncbi request reprint Dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progression
    Cheryl A Winkler
    Laboratory of Genomic Diversity, Division of Basic Research, SAIC Frederick, NCI, Frederick, MD, USA
    J Acquir Immune Defic Syndr 37:1534-8. 2004
    ....
  12. pmc Genome-wide association study implicates PARD3B-based AIDS restriction
    Jennifer L Troyer
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, Frederick, MD 21702, USA
    J Infect Dis 203:1491-502. 2011
    ..Here we used clinically well-characterized subjects from 5 pretreatment HIV/AIDS cohorts for a genome-wide association study to identify gene associations with rate of AIDS progression...
  13. pmc APOBEC3G genetic variants and their influence on the progression to AIDS
    Ping An
    Basic Research Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    J Virol 78:11070-6. 2004
    ..These studies suggest that there may be a modifying role of variants of APOBEC3G on HIV-1 disease progression that warrants further investigation...
  14. pmc Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumonia
    Ping An
    Basic Research Laboratory, SAIC Frederick, National Cancer Institute Frederick, Frederick, Maryland, USA
    PLoS Genet 7:e1002328. 2011
    ..28-6.31) among four major AIDS-defining conditions. Considering the newly defined role of CCRL2 in lung dendritic cell trafficking, this atypical chemokine receptor may affect PCP through immune regulation and inducing inflammation...
  15. doi request reprint Evaluation of nonviral risk factors for nasopharyngeal carcinoma in a high-risk population of Southern China
    Xiuchan Guo
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Int J Cancer 124:2942-7. 2009
    ..7% of NPC development in NPC high risk population. These findings should have important public health implications for NPC risk reduction in endemic regions...
  16. ncbi request reprint A tumor necrosis factor-alpha-inducible promoter variant of interferon-gamma accelerates CD4+ T cell depletion in human immunodeficiency virus-1-infected individuals
    Ping An
    Basic Research Program, SAIC Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
    J Infect Dis 188:228-31. 2003
    ..It is possible that increased IFN-gamma production induced by TNF-alpha when -179T is present causes CD4 cell depletion by apoptosis...
  17. pmc A high-density admixture map for disease gene discovery in african americans
    Michael W Smith
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD, USA
    Am J Hum Genet 74:1001-13. 2004
    ..The map is especially appropriate for those diseases that differ in incidence between the parental African and European populations...
  18. pmc Genetics of focal segmental glomerulosclerosis and human immunodeficiency virus-associated collapsing glomerulopathy: the role of MYH9 genetic variation
    Cheryl A Winkler
    Scientific Applications International Corporation Frederick, Inc, Laboratory of Genomic Diversity, Center for Cancer Research, National Cancer Institute Frederick, National Institutes of Health, Frederick, MD, USA
    Semin Nephrol 30:111-25. 2010
    ..The strong predicted power of MYH9 variation for disease indicates a clear role for genetic testing for these variants in personalized medicine, for assessment of genetic risk, and potentially for diagnosis...
  19. pmc Accounting for multiple comparisons in a genome-wide association study (GWAS)
    Randall C Johnson
    Basic Research Program, SAIC Frederick, Inc NCI Frederick, Frederick, MD, USA
    BMC Genomics 11:724. 2010
    ..We consider seven implementations of these commonly used methods using data from 1514 European American participants genotyped for 700,078 SNPs in a GWAS for AIDS...
  20. pmc Genetic factors leading to chronic Epstein-Barr virus infection and nasopharyngeal carcinoma in South East China: study design, methods and feasibility
    Xiu Chan Guo
    Laboratory of Genomic Diversity, SAIC Frederick, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Hum Genomics 2:365-75. 2006
    ....
  21. pmc A population-based study to investigate host genetic factors associated with hepatitis B infection and pathogenesis in the Chinese population
    Zheng Zeng
    SAIC Laboratory of Genomic Diversity, National Cancer Institute Frederick, National Institutes of Health, Frederick, USA
    BMC Infect Dis 8:1. 2008
    ..We believe that a better understanding of these factors and interactions will lead to more effective diagnostic and therapeutic options...
  22. pmc Modulating influence on HIV/AIDS by interacting RANTES gene variants
    Ping An
    Intramural Research Support Program, SAIC Frederick, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 99:10002-7. 2002
    ..The diminished transcription of RANTES afforded by the In1.1C regulatory allele is consistent with increased HIV-1 spread in vivo, leading to accelerated progression to AIDS...
  23. ncbi request reprint NPHS2 variation in sporadic focal segmental glomerulosclerosis
    Louise M McKenzie
    Laboratory of Genomic Diversity, SAIC Frederick, National Cancer Institute, NCI Frederick, Frederick, Maryland, USA
    J Am Soc Nephrol 18:2987-95. 2007
    ..5, P = 0.001). These results indicate that genetic variation or mutation of NPHS2 may play a role in late-onset sporadic FSGS...
  24. pmc MYH9 genetic variants associated with glomerular disease: what is the role for genetic testing?
    Jeffrey B Kopp
    Kidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1268, USA
    Semin Nephrol 30:409-17. 2010
    ..Such studies will address critical questions pertaining to MYH9-associated kidney disease, including mechanism, course, and response to therapy...
  25. doi request reprint Identifying host targets for drug development with knowledge from genome-wide studies: lessons from HIV-AIDS
    Cheryl A Winkler
    Laboratory of Genomic Diversity, CCR, NCI, SAIC Frederick, Frederick, MD 21702, USA
    Cell Host Microbe 3:203-5. 2008
    ..A major goal of these studies is to understand how human genetic variation contributes to individual differences in susceptibility and to exploit this knowledge for targeted drug development...
  26. pmc Host genes associated with HIV/AIDS: advances in gene discovery
    Ping An
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Trends Genet 26:119-31. 2010
    ..Multidisciplinary approaches integrating genetic epidemiology to systems biology will be required to fully understand virus-host interactions to effectively combat HIV/AIDS...
  27. pmc HIV-associated nephropathy patients with and without apolipoprotein L1 gene variants have similar clinical and pathological characteristics
    Mohamed G Atta
    Department of Medicine, Johns Hopkins Medical Center, Baltimore, MD 21205, USA
    Kidney Int 82:338-43. 2012
    ....