Research Topics
Species | Carl WhiteSummaryAffiliation: National Jewish Medical and Research Center Country: USA Publications
Research Grants
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Detail Information
Publications
Oxidized phospholipids derived from ozone-treated lung surfactant extract reduce macrophage and epithelial cell viabilityCharis Uhlson
Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
Chem Res Toxicol 15:896-906. 2002....- Elevated expression of surfactant proteins in newborn rats during adaptation to hyperoxiaC W White
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, Colorado, USA
Am J Respir Cell Mol Biol 25:51-9. 2001..Taken together, these data indicate that specific surfactant proteins are upregulated at both the pretranslational and post-translational levels in distal lung epithelium during adaptation to hyperoxia in the newborn rat... - Commentary on "Hypoxia, hypoxic signaling, tissue damage, and detection of reactive oxygen species (ROS)"Carl W White
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Room J-101, Denver, CO 80206-2761, USA
Free Radic Biol Med 40:923-7. 2006 
Chlorine gas inhalation: human clinical evidence of toxicity and experience in animal modelsCarl W White
Pediatrics, National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA
Proc Am Thorac Soc 7:257-63. 2010..As in humans, ALI/ARDS can occur, becoming more likely when the upper airways are bypassed. Inhalation models of chlorine toxicity provide unique opportunities for testing potential pharmacologic rescue agents...- Effect of preterm birth on hypoxia-inducible factors and vascular endothelial growth factor in primate lungsTiina M Asikainen
Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, USA
Pediatr Pulmonol 40:538-46. 2005..These results suggest that selective downregulation of HIFs in lungs of preterm neonates may contribute to the pathophysiology of BPD... - Extracellular adenosine triphosphate: a potential regulator of vasa vasorum neovascularization in hypoxia-induced pulmonary vascular remodelingEvgenia V Gerasimovskaya
University of Colorado Health Sciences Center, Denver, CO 80262, USA
Chest 128:608S-610S. 2005 - Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxiaMihalis I Panayiotidis
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Free Radic Biol Med 40:348-58. 2006..These results indicate activation of MAT 2A and the transmethylation pathway in the metabolic response to hyperoxia in lung epithelium... - Cholesterol interferes with the MTT assay in human epithelial-like (A549) and endothelial (HLMVE and HCAE) cellsShama Ahmad
Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Int J Toxicol 25:17-23. 2006..A careful validation of viability assay procedures is therefore suggested in experiments where cholesterol is a constituent, to avoid a potential bias in concluding results of cytotoxicity studies... - Endothelial Akt activation by hyperoxia: role in cell survivalAftab Ahmad
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Free Radic Biol Med 40:1108-18. 2006..That this event is a beneficial response is suggested by the finding that constitutive activation of Akt protects against hyperoxic stress, at least in part, by maintaining mitochondrial integrity... - Purinergic signaling and kinase activation for survival in pulmonary oxidative stress and diseaseShama Ahmad
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Free Radic Biol Med 41:29-40. 2006..Impairment of ATP release and transmission of such signals could limit cellular survival under oxidative stress. This may further contribute to disease pathogenesis or exacerbation... - Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurityTiina M Asikainen
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Rm. J-318, Denver, Colorado 80206, USA
FASEB J 20:1698-700. 2006..These findings indicate that HIF stimulation by PHD inhibition ameliorates pathological and physiological consequences of BPD... - Effect of cell cycle growth arrest on global DNA methylation status in human lung epithelial-like (A549) cellsMihalis I Panayiotidis
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
In Vivo 20:861-5. 2006..Because hyperoxia induces growth arrest in these cells, whether the status of global DNA methylation changed in response to cellular growth arrest was of interest... - Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lungTiina M Asikainen
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
Proc Natl Acad Sci U S A 102:10212-7. 2005..Through actions characterized above, FG-4095 could have desirable effects in enhancing lung growth in BPD... - Lung epithelial cells release ATP during ozone exposure: signaling for cell survivalShama Ahmad
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Free Radic Biol Med 39:213-26. 2005..Thus, extracellularly released ATP signals to prevent ozone-induced death and supplementation with ATP or its analogs can augment protection, at least in part via Akt and /or ERK signaling pathways and their metabolic effects... - Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cellsTiina M Asikainen
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
Free Radic Biol Med 38:1002-13. 2005.... - Extracellular ATP is an autocrine/paracrine regulator of hypoxia-induced adventitial fibroblast growth. Signaling through extracellular signal-regulated kinase-1/2 and the Egr-1 transcription factorEvgenia V Gerasimovskaya
Developmental Lung Biology Research Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Biol Chem 277:44638-50. 2002..We conclude that hypoxia induces ATP release from endothelial cells and fibroblasts and that the activation of P2 purinoceptors is involved in the regulation of DNA synthesis by fibroblasts under hypoxic conditions... - Pulmonary antioxidant defenses in the preterm newborn with respiratory distress and bronchopulmonary dysplasia in evolution: implications for antioxidant therapyTiina M Asikainen
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
Antioxid Redox Signal 6:155-67. 2004..An understanding of the processes involved in lung growth, especially in alveolarization and vascularization, as well as in repair of injured lung tissue, may facilitate development of strategies to enhance these processes... - Extracellular ATP-mediated signaling for survival in hyperoxia-induced oxidative stressShama Ahmad
Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Biol Chem 279:16317-25. 2004..These findings demonstrate that ATP release and subsequent ATP-mediated signaling events are vital for survival of HLMVEC in hyperoxia... - Antioxidant defenses in the preterm lung: role for hypoxia-inducible factors in BPD?Tiina M Asikainen
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
Toxicol Appl Pharmacol 203:177-88. 2005.... - Hypoxia protects human lung microvascular endothelial and epithelial-like cells against oxygen toxicity: role of phosphatidylinositol 3-kinaseShama Ahmad
Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado, USA
Am J Respir Cell Mol Biol 28:179-87. 2003..These results indicate that hypoxia-induced activation of PI3-K is an important event in the acquisition of resistance against subsequent hyperoxic toxicity... - HIF stabilizing agents: shotgun or scalpel?Tiina M Asikainen
Am J Physiol Lung Cell Mol Physiol 293:L555-6. 2007 - Reduced thioredoxin increases proinflammatory cytokines and neutrophil influx in rat airways: modulation by airway mucusRaymond C Rancourt
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Free Radic Biol Med 42:1441-53. 2007..In parallel studies, increased amounts of the p65 subunit of NF-kappaB were present in nuclear extracts from rat lungs administered reduced rhTrx, suggesting a role for NF-kappaB in these proinflammatory responses... - Hypoxia-inducible factors HIF-1alpha and HIF-2alpha are decreased in an experimental model of severe respiratory distress syndrome in preterm lambsTheresa R Grover
University of Colorado School of Medicine, Pediatric Heart Lung Center, Department of Pediatrics, and National Jewish Medical and Research Center, Denver, Colorado, USA
Am J Physiol Lung Cell Mol Physiol 292:L1345-51. 2007..We speculate that early disruption of HIF and VEGF expression after preterm birth and RDS may contribute to long-term abnormalities in lung growth, leading to bronchopulmonary dysplasia... - Lipoic acid suppression of neutrophil respiratory burst: effect of NADPHHeidi C O'Neill
Department of Pharmaceutical Sciences, Program in Toxicology, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado, USA
Antioxid Redox Signal 10:277-85. 2008..Further studies will be required to determine if LA can diminish excessive superoxide produced by PMN and/or alveolar macrophages in IPF or relevant disease models in vivo... - Hyperoxia-induced DNA damage causes decreased DNA methylation in human lung epithelial-like A549 cellsMihalis I Panayiotidis
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
Antioxid Redox Signal 6:129-36. 2004..Decreased DNA methylation also was observed at day 5 of hyperoxic exposure, suggesting that hyperoxia-induced DNA damage can influence patterns of DNA methylation in a lung-derived cell line... - Enhancement of angiogenic effectors through hypoxia-inducible factor in preterm primate lung in vivoTiina M Asikainen
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Rm. J-318, Denver, CO 80206, USA
Am J Physiol Lung Cell Mol Physiol 291:L588-95. 2006..These results indicate that HIF stimulation by PHD inhibition enhances lung angiogenesis in the primate model of BPD... - Potential role for antiangiogenic proteins in the evolution of bronchopulmonary dysplasiaMaria Lyn Quintos-Alagheband
Department of Critical Care and Cardiothoracic Surgery, Children's Hospital of Los Angeles USC-Keck School of Medicine, Los Angeles, CA 90027, USA
Antioxid Redox Signal 6:137-45. 2004.... - Cigarette smoke extract increases S-adenosylmethionine and cystathionine in human lung epithelial-like (A549) cellsMihalis I Panayiotidis
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Chem Biol Interact 147:87-97. 2004..The transsulfuration pathway was likely activated by CSE since cystathionine increased, potentially contributing to the increased total intracellular GSH content... - Redox systems of the cell: possible links and implicationsKumuda C Das
Department of Molecular Biology, University of Texas at Tyler, 11937 U.S. Highway 271, Tyler, TX 75708, USA
Proc Natl Acad Sci U S A 99:9617-8. 2002 - Elevated expression of hexokinase II protects human lung epithelial-like A549 cells against oxidative injuryAftab Ahmad
Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Am J Physiol Lung Cell Mol Physiol 283:L573-84. 2002..The present study demonstrates that HK-II protects human lung epithelial-like A549 cells against oxidative insults by protecting the mitochondria...
Research Grants
- Lung epithelial cell survival signaling in ozone in cystic fibrosis and normalsCarl White; Fiscal Year: 2009..These studies will increase our understanding of lung oxidant injury and repair in CF and normals, and of normal defense mechanisms of airway epithelium. ..
- Lung epithelial cell survival signaling in ozone in cystic fibrosis and normalsCarl White; Fiscal Year: 2007..These studies will increase our understanding of lung oxidant injury and repair in CF and normals, and of normal defense mechanisms of airway epithelium. ..
- Hypoxia-inducible factors bronchopulmonary dysplasia-BPDCarl White; Fiscal Year: 2006..Therapy at the level of HIF transcription factors to improve angiogenesis and alveolar development offers promise to prevent BPD. ..
- ROLE OF HEXOKINASE IN LUNG ADAPTATION TO OXIDANT STRESSCarl White; Fiscal Year: 2002..Together, these approaches will define the role of HK in adaptation to hyperoxia. ..