Research Topics
| Denise WhitbySummaryAffiliation: National Cancer Institute Country: USA Publications
| Collaborators
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Detail Information
Publications
Genotypic characterization of Kaposi's sarcoma-associated herpesvirus in asymptomatic infected subjects from isolated populationsDenise Whitby
Viral Epidemiology Section, AIDS Vaccine Program, SAIC Frederick, NCI Frederick, MD 21701, USA
J Gen Virol 85:155-63. 2004..The heterogeneity of the KSHV strains found in these subjects from Botswana contrasts with the homogeneity of KSHV strains in Amerindians, reflecting differences in the evolutionary history of these populations...
Reactivation of Kaposi's sarcoma-associated herpesvirus by natural products from Kaposi's sarcoma endemic regionsDenise Whitby
Viral Epidemiology Section, AIDS Vaccine Program, SAIC Frederick, NCI Frederick, Frederick, MD 21702, USA
Int J Cancer 120:321-8. 2007..These in vitro data provide support for the "oncoweed" hypothesis by demonstrating basic biological plausibility...- Sequence analysis of Kaposi sarcoma-associated herpesvirus (KSHV) microRNAs in patients with multicentric Castleman disease and KSHV-associated inflammatory cytokine syndromeAlex Ray
National Cancer Institute, Frederick, MD, USA
J Infect Dis 205:1665-76. 2012..We observed a high level of conservation for most sequences but also a divergent cluster of 5 KSHV sequences, including 2 from MCD patients... - Kaposi sarcoma (KS)-associated herpesvirus microRNA sequence analysis and KS risk in a European AIDS-KS case control studyVickie Marshall
Viral Oncology Section, SAIC Frederick, NCI Frederick, Frederick, Maryland 21702, USA
J Infect Dis 202:1126-35. 2010..Here, we examine whether any of these may contribute to KS risk in a European AIDS-KS case-control study... - An interleukin-6-related systemic inflammatory syndrome in patients co-infected with Kaposi sarcoma-associated herpesvirus and HIV but without Multicentric Castleman diseaseThomas S Uldrick
HIV and AIDS Malignancy Branch, National Cancer Institute Frederick, Frederick, MD, USA
Clin Infect Dis 51:350-8. 2010..Patients with KSHV-MCD develop fevers, wasting, hypoalbuminemia, cytopenias, and hyponatremia that are related to overproduction of KSHV-encoded viral interleukin (IL)-6 (vIL-6) and human IL-6 (hIL-6)... - Detection of antibodies to Kaposi's sarcoma-associated herpesvirus: a new approach using K8.1 ELISA and a newly developed recombinant LANA ELISAGeorgina L Mbisa
Viral Technology Laboratory, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, United States
J Immunol Methods 356:39-46. 2010..1 ELISA to enable the highly sensitive and specific detection of antibodies to KSHV. Use of this testing strategy will provide a more accurate and reliable diagnostic assessment of KSHV status... 
Kaposi's sarcoma-associated herpesvirus transmission and primary infectionRachel Bagni
Viral Oncology Section, AIDS and Cancer Virus Program, SAIC Frederick, NCI Frederick, Frederick, Maryland 21702, USA
Curr Opin HIV AIDS 4:22-6. 2009..Transmission and risk factors for infection by KSHV are not fully understood. The purpose of this review is to highlight recent advances in our understanding of KSHV transmission in various settings...- Conservation of virally encoded microRNAs in Kaposi sarcoma--associated herpesvirus in primary effusion lymphoma cell lines and in patients with Kaposi sarcoma or multicentric Castleman diseaseVickie Marshall
Viral Epidemiology Section, AIDS Vaccine Program, Science Applications International Corporation Frederick, National Cancer Institute Frederick, Frederick, MD 21701, USA
J Infect Dis 195:645-59. 2007..Kaposi sarcoma (KS)-associated herpesvirus (KSHV) encodes 12 distinct microRNA genes, all of which are located within the latency-associated region that is highly expressed in all KSHV-associated malignancies... - Novel Kaposi's sarcoma-associated herpesvirus homolog in baboonsDenise Whitby
Viral Epidemiology Section, AIDS Vaccine Program, SAIC-Frederick, National Cancer Institute, Frederick, MD 21702, USA
J Virol 77:8159-65. 2003..This establishes baboons as a novel resource to investigate rhadinovirus biology, which can be developed into an animal model system for KSHV-associated human diseases, vaccine development, and therapy evaluation... - Human herpesvirus 8 (HHV-8) infection in healthy urban employees from Greece: seroprevalence and associated factorsAssimina Zavitsanou
Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece
J Med Virol 79:591-6. 2007..The association between HHV-8 seropositivity and endoscopic examination requires further investigation... - Transmission of Kaposi sarcoma-associated herpesvirus between mothers and children in a South African populationBabatyi I Malope
Cancer Epidemiology Research Group, National Health Laboratory Services, Johannesburg, South Africa
J Acquir Immune Defic Syndr 44:351-5. 2007..To assess whether Kaposi sarcoma-associated herpesvirus (KSHV) with or without HIV coinfection in South African mothers is associated with higher KSHV seropositivity in their children... - Risk factors for human herpesvirus 8 infection among adults in the United States and evidence for sexual transmissionEric A Engels
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD 20892, USA
J Infect Dis 196:199-207. 2007..Human herpesvirus 8 (HHV-8) causes Kaposi sarcoma. In the United States, transmission routes for HHV-8 are uncertain... - Real-time PCR assay for detection and quantification of hepatitis B virus genotypes A to GTania M Welzel
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20892, USA
J Clin Microbiol 44:3325-33. 2006.... - Associations of classic Kaposi sarcoma with common variants in genes that modulate host immunityElizabeth E Brown
National Cancer Institute, 6120 Executive Boulevard, EPS 8005 MSC 7248 Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 15:926-34. 2006..Among KSHV-seropositive Italians, CKS risk was associated with diplotypes of IL8RB and IL13, supporting laboratory evidence of immune-mediated pathogenesis... - Sexually transmissible infections and prostate cancer riskWen Yi Huang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 17:2374-81. 2008..Sexually transmissible infections (STI) have been variably associated with increased risks of prostate cancer, largely in case-control studies... - Risk factors for human herpesvirus 8 seropositivity in the AIDS Cancer Cohort StudySam M Mbulaiteye
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Blvd, Executive Plaza South Rm 8006, Mail Stop Center 7248, Rockville, MD 20852, USA
J Clin Virol 35:442-9. 2006..Cigarette smoking has been associated with a decreased risk for AIDS-related and classical KS, but whether it is associated with decreased risk of human herpesvirus 8 (HHV-8) infection is unknown... - Association of clinical progression in classic Kaposi's sarcoma with reduction of peripheral B lymphocytes and partial increase in serum immune activation markersAlexander J Stratigos
Department of Dermatology, University of Athens, Andreas Sygros Hospital, Athens, Greece
Arch Dermatol 141:1421-6. 2005..To evaluate various immunologic markers in the peripheral blood of patients with early and advanced classic Kaposi's sarcoma (CKS)... - Host immunogenetics and control of human herpesvirus-8 infectionElizabeth E Brown
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Center for Cancer Research, National Cancer Institute, Rockville 20852, Maryland, USA
J Infect Dis 193:1054-62. 2006..Host genes important for control of HHV-8 infection are not well characterized... - Human herpesvirus 8 infection within families in rural TanzaniaSam M Mbulaiteye
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
J Infect Dis 187:1780-5. 2003..2; 95% CI, 1.9-9.4). Our data are consistent with the occurrence of HHV-8 transmission within families, from mothers and other relatives to children via nonsexual routes and between spouses via sexual routes... - Prevalence of Kaposi's sarcoma-associated herpesvirus infection in sex workers and women from the general population in SpainSilvia de Sanjose
Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, L Hospitalet de Llobregat, Barcelona, Spain
Int J Cancer 98:155-8. 2002..All PBMC samples were negative. These results suggest that in low-risk countries for KSHV, oral shedding and heterosexual contacts are potential pathways for KSHV transmission... - Immunoblastic lymphoma in persons with AIDS-associated Kaposi's sarcoma: a role for Kaposi's sarcoma-associated herpesvirusEric A Engels
Viral Epidemiology Branch, Division of Cancer and Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
Mod Pathol 16:424-9. 2003..We conclude that Kaposi's sarcoma-associated herpesvirus is present in some immunoblastic lymphomas in persons with AIDS-associated Kaposi's sarcoma... - Mother-to-child transmission of human herpesvirus-8 in South AfricaMartin Dedicoat
Liverpool School of Tropical Medicine, Liverpool, and Cancer Research UK Epidemiology Unit, Oxford, United Kingdom
J Infect Dis 190:1068-75. 2004..1-6.2). The presence of HHV-8 DNA in maternal saliva was unrelated to latent antibodies in children. Saliva could be a route of transmission of HHV-8 from person to person, although other routes cannot be ruled out... - Detection of kaposi sarcoma-associated herpesvirus DNA in saliva and buffy-coat samples from children with sickle cell disease in UgandaSam M Mbulaiteye
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, Maryland, USA
J Infect Dis 190:1382-6. 2004..Detection was associated with K8.1 seropositivity, younger age, and high household density, indicating the importance of in-household person-to-person transmission, likely via saliva... - Antibody reactivity to latent and lytic antigens to human herpesvirus-8 in longitudinally followed homosexual menRobert J Biggar
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
J Infect Dis 187:12-8. 2003..Because persons with more advanced infections have higher antibody titers, they are easier to detect, which may skew our understanding of the epidemiology of HHV-8... - Kaposi's sarcoma-associated herpesvirus infection in elderly Jews and non-Jews from New York CityEric A Engels
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
Int J Epidemiol 31:946-50. 2002..Elderly Jews have relatively high KS risk, but it is unclear whether this indicates heightened prevalence of KS-associated herpesvirus (KSHV), the KS agent. We studied Jewish and non-Jewish patients at a New York City geriatrics clinic... - Changes in the immune responses against human herpesvirus-8 in the disease course of posttransplant Kaposi sarcomaPatrizia Barozzi
Department of Oncology and Hematology, University of Modena and Reggio Emilia, Azienda Ospedaliera Policlinico, Via del Pozzo 71, Modena, Italy
Transplantation 86:738-44. 2008..HHV-8-specific T-cell responses are required to achieve posttransplant KS remission, and may be restored under SRL, while maintaining effective immunosuppression... - Mouthwash as a low-cost and safe specimen transport medium for human papillomavirus DNA testing of cervicovaginal specimensPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5004, EPS MSC 7234, Bethesda, MD 20892 7234, USA
Cancer Epidemiol Biomarkers Prev 16:840-3. 2007..We suggest that mouthwash might be used as a low-cost, safe, nonflammable storage and transport medium for cervical specimens for HPV DNA testing in cervical cancer screening programs... - Combining assays for estimating prevalence of human herpesvirus 8 infection using multivariate mixture modelsRuth M Pfeiffer
Biostatistics Branch, National Cancer Institute, Bethesda, MD 20892 7244, USA
Biostatistics 9:137-51. 2008..We assess model performance in simulations and present results from applying various parameterizations of the model to the Ugandan study... - Risk factors for Kaposi's sarcoma-associated herpesvirus infection among HIV-1-infected pregnant women in the USAJames J Goedert
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20892, USA
AIDS 17:425-33. 2003..Large formal studies to evaluate whether KSHV transmission occurs via transfusion are needed to inform decisions regarding screening volunteer blood donors to protect the blood supply... - Impact of interleukin-10 polymorphisms (-1082 and -3575) on the survival of patients with lymphoid neoplasmsEva Domingo-Domenech
Department of Hematology, Institut Catala d Oncologia, Avda Gran Via s n, Km 2 7, 08907 L Hospitalet de Llobregat, Barcelona, Spain
Haematologica 92:1475-81. 2007..The aim of this study was to explore the association between polymorphisms of IL-10-(1082A>G) and IL-10-(3575T>A) with the overall survival in patients with lymphoid neoplasms... - Human herpesvirus 8 load and progression of AIDS-related Kaposi sarcoma lesionsMartin M Nsubuga
Makerere University Medical School, Kampala, Uganda
Cancer Lett 263:182-8. 2008..We investigated these relationships in persons with AIDS... - No evidence of sexual transmission of Kaposi's sarcoma herpes virus in a heterosexual South African populationBabatyi I Malope
Clinical HIV Research Unit, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa
AIDS 22:519-26. 2008..The transmission of Kaposi's sarcoma herpes virus (KSHV) in men who have sex with men is clearly associated with sexual risk factors, but evidence of heterosexual transmission of KSHV is conflicting... - Seroprevalence and risk factors for human herpesvirus 8 infection, rural EgyptSam M Mbulaiteye
National Cancer Institute, Bethesda, MD, USA
Emerg Infect Dis 14:586-91. 2008..1, 95% CI 0.3-16.4), but marginal for women (OR 1.5, 95% CI 1.0-2.5). Our findings suggest salivary and possible nosocomial HHV-8 transmission in rural Egypt... - Transmission of human herpesvirus 8 by sexual activity among adults in Lagos, NigeriaMohamed A Eltom
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics DCEG, National Cancer Institute, 6120 Executive Boulevard, EPS Room 8014, Rockville, MD 20852 MSC 7248, USA
AIDS 16:2473-8. 2002..Studies in Europe and America suggest spread through homosexual contact, but evidence of heterosexual spread is inconsistent. We examined the association between HHV-8 and markers of risky sexual activity in Nigeria... - A pilot study of cidofovir in patients with kaposi sarcomaRichard F Little
HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
J Infect Dis 187:149-53. 2003..This study does not provide proof of principle for the treatment of KS with CDV. However, it remains possible that antiherpesvirus therapy can be developed for herpes-induced tumors... - Distribution of Epstein-Barr viral load in serum of individuals from nasopharyngeal carcinoma high-risk families in TaiwanXiaohong Yang
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USA
Int J Cancer 118:780-4. 2006.... - Human herpesvirus 8 seroprevalence among children and adolescents in the United StatesLesley A Anderson
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Pediatr Infect Dis J 27:661-4. 2008..4%). K8.1 seropositivity was associated with asthma (odds ratio: 6.3; 95% confidence interval: 2.4-16.9) and hay fever (3.5; 1.1-11.0), and there were borderline associations with measures of crowding and low socioeconomic status... - Azidothymidine inhibits NF-kappaB and induces Epstein-Barr virus gene expression in Burkitt lymphomaMotoki Kurokawa
Department of Dermatology, Medical College, University of Miyazaki, Japan
Blood 106:235-40. 2005..AZT inhibits NF-kappaB and up-regulates EBV gene expression in primary EBV+ BLs. AZT with hydroxyurea may represent an inexpensive, targeted regimen for endemic BL... - Correlates of Human Herpesvirus-8 DNA detection among adults in Italy without Kaposi sarcomaElizabeth E Brown
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Rockville, MD 20852, USA
Int J Epidemiol 34:1110-7. 2005..The presence of Human Herpesvirus-8 (HHV8) DNA is predictive of Kaposi sarcoma (KS) among patients with HIV-associated or iatrogenic immunosuppression. However, correlates of HHV8-DNA detection in the general population remain undefined... - A common genetic variant in FCGR3A-V158F and risk of Kaposi sarcoma herpesvirus infection and classic Kaposi sarcomaElizabeth E Brown
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 14:633-7. 2005..05). Our findings suggest that gender differences could possibly modify the effect of FCGR3A on risk of KSHV infection and CKS. Additional studies are required to confirm these relationships and determine their etiologic significance... - Water, socioeconomic factors, and human herpesvirus 8 infection in Ugandan children and their mothersSam M Mbulaiteye
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD 20852, USA
J Acquir Immune Defic Syndr 38:474-9. 2005..Human herpesvirus 8 (HHV-8) infection is common in sub-Saharan Africa, but its distribution is uneven. Transmission occurs during childhood within families by unclear routes... - Sexual behaviour and human herpesvirus 8 infection in homosexual men in AustraliaAndrew E Grulich
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Level 2, 376 Victoria Street, Sydney, NSW 2010 Australia
Sex Health 2:13-8. 2005..Human herpesvirus 8 (HHV-8) is a common sexually transmitted agent among homosexual men, but there are few Australian data. We aimed to describe the prevalence and risk factors for seropositivity to HHV-8 in Australian homosexual men... - High levels of Epstein-Barr virus DNA in saliva and peripheral blood from Ugandan mother-child pairsSam M Mbulaiteye
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, Maryland, USA
J Infect Dis 193:422-6. 2006..Our results indicate that EBV infection persists, with virus readily detectable in saliva and buffy coats from persons without apparent symptoms in Africa... - Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph ConsortiumNathaniel Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Lancet Oncol 7:27-38. 2006..We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph)... - Molecular evidence for mother-to-child transmission of Kaposi sarcoma-associated herpesvirus in Uganda and K1 gene evolution within the hostSam Mbulaiteye
Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI, Rockville, Maryland 21701, USA
J Infect Dis 193:1250-7. 2006..CONCLUSIONS: Our findings are consistent with KSHV transmission from maternal and nonmaternal sources in KS-endemic regions. Our results also provide evidence for ongoing evolution of the K1 gene in KSHV-infected children... - Amino acid residue at position 13 in HLA-DR beta chain plays a critical role in the development of Kaposi's sarcoma in AIDS patientsAntoni Gayà
Fundació Banc de Sang i Teixits, Palma de Mallorca, Spain
AIDS 18:199-204. 2004..In 1994 human herpesvirus 8 (HHV-8) was identified as the causative agent of Kaposi's sarcoma (KS). Moreover, the crucial role of HLA molecules in determining susceptibility to several infections was recognized... - Seroprevalence of human herpesvirus 8 among injection drug users in San FranciscoJonnae Atkinson
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
J Infect Dis 187:974-81. 2003..These results are consistent with the occurrence of bloodborne transmission of HHV-8 among IDUs... - Virologic, hematologic, and immunologic risk factors for classic Kaposi sarcomaElizabeth E Brown
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA
Cancer 107:2282-90. 2006.... - Human herpesvirus 8 infection and transfusion history in children with sickle-cell disease in UgandaSam M Mbulaiteye
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
J Natl Cancer Inst 95:1330-5. 2003..We studied the association between HHV-8 seropositivity and transfusion history among children with sickle-cell disease in Uganda, where HHV-8 infection is common in blood donors... - Hepatitis C and risk of lymphoma: results of the European multicenter case-control study EPILYMPHAlexandra Nieters
German Cancer Research Center, Heidelberg, Germany
Gastroenterology 131:1879-86. 2006..However, previous epidemiologic studies were limited in size to establish an association between HCV infection and specific lymphoma subtypes. We performed a large, multicenter, case-control study to address this question... - Risk factors for human Herpesvirus 8 infection and AIDS-associated Kaposi's sarcoma among men who have sex with men in a European multicentre studyElisa Martro
Centre d Estudis Epidemiològics sobre l HIV SIDA de Catalunya, Departament de Salut, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
Int J Cancer 120:1129-35. 2007.... - Detection and quantification of Kaposi's sarcoma-associated herpesvirus to predict AIDS-associated Kaposi's sarcomaEric A Engels
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
AIDS 17:1847-51. 2003..Also, EBV viral loads were higher in cases than in controls (P = 0.07). CONCLUSIONS: Among individuals with HIV-KSHV coinfection, KSHV viremia identifies a subgroup with extremely high risk for developing KS... - One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in AustraliaKyoung Mu Lee
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd EPS 8118, Bethesda, MD 20892 7240, USA
Hum Genet 122:525-33. 2007..01). In conclusion, the results of this study suggest that genetic polymorphisms of one-carbon metabolism genes such as MTHFR and TYMS may influence susceptibility to NHL...