C Weyer

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 47:1555-61. 1998
  2. ncbi request reprint Changes in energy metabolism in response to 48 h of overfeeding and fasting in Caucasians and Pima Indians
    C Weyer
    Clinical Diabetes and Nutrition Section, NIDDK, National Institutes of Health, Phoenix, Arizona 85016, USA
    Int J Obes Relat Metab Disord 25:593-600. 2001
  3. ncbi request reprint Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 86:1930-5. 2001
  4. ncbi request reprint Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes Care 24:89-94. 2001
  5. ncbi request reprint Relationship between birth weight and body composition, energy metabolism, and sympathetic nervous system activity later in life
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 8:559-65. 2000
  6. ncbi request reprint A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 49:2094-101. 2000
  7. ncbi request reprint Ethnic differences in insulinemia and sympathetic tone as links between obesity and blood pressure
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Hypertension 36:531-7. 2000
  8. ncbi request reprint Energy metabolism after 2 y of energy restriction: the biosphere 2 experiment
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85106, USA
    Am J Clin Nutr 72:946-53. 2000
  9. ncbi request reprint Insulin action and insulinemia are closely related to the fasting complement C3, but not acylation stimulating protein concentration
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes Care 23:779-85. 2000
  10. ncbi request reprint Energy expenditure, fat oxidation, and body weight regulation: a study of metabolic adaptation to long-term weight change
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 85:1087-94. 2000

Detail Information

Publications26

  1. ncbi request reprint Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 47:1555-61. 1998
    ..This is the first study to demonstrate unequivocal metabolic effects of a highly selective beta3-adrenoceptor agonist in humans...
  2. ncbi request reprint Changes in energy metabolism in response to 48 h of overfeeding and fasting in Caucasians and Pima Indians
    C Weyer
    Clinical Diabetes and Nutrition Section, NIDDK, National Institutes of Health, Phoenix, Arizona 85016, USA
    Int J Obes Relat Metab Disord 25:593-600. 2001
    ..To further examine this hypothesis, we assessed the changes in 24 h energy metabolism in response to short-term overfeeding and fasting in Caucasians (C) and Pima Indians (I), a population with a very high propensity for obesity...
  3. ncbi request reprint Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 86:1930-5. 2001
    ....
  4. ncbi request reprint Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes Care 24:89-94. 2001
    ..We therefore assessed the predictive effect of insulin resistance and insulin secretory dysfunction separately for the progression from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) and from IGT to diabetes...
  5. ncbi request reprint Relationship between birth weight and body composition, energy metabolism, and sympathetic nervous system activity later in life
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 8:559-65. 2000
    ..Programming of metabolic, endocrine, and/or autonomic pathways during intrauterine development has been proposed to explain this association...
  6. ncbi request reprint A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 49:2094-101. 2000
    ..Whether amelioration of basal insulin hypersecretion will prevent diabetes remains to be elucidated...
  7. ncbi request reprint Ethnic differences in insulinemia and sympathetic tone as links between obesity and blood pressure
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Hypertension 36:531-7. 2000
    ..The lack of an increase in SNS activity with increasing adiposity and insulinemia in Pima Indians may contribute to the low prevalence of hypertension in this population...
  8. ncbi request reprint Energy metabolism after 2 y of energy restriction: the biosphere 2 experiment
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85106, USA
    Am J Clin Nutr 72:946-53. 2000
    ..An adaptive decrease in energy expenditure (EE) in response to 6 mo of severely restricted energy intake was shown in a classic semistarvation study-the Minnesota experiment...
  9. ncbi request reprint Insulin action and insulinemia are closely related to the fasting complement C3, but not acylation stimulating protein concentration
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes Care 23:779-85. 2000
    ..We hypothesized that an elevated C3 concentration might be linked to insulin resistance and/or hyperinsulinemia, abnormalities commonly observed in association with the above conditions...
  10. ncbi request reprint Energy expenditure, fat oxidation, and body weight regulation: a study of metabolic adaptation to long-term weight change
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 85:1087-94. 2000
    ..The metabolic responses to weight changes are highly variable among individuals, however...
  11. ncbi request reprint Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 48:2197-203. 1999
    ..More severe metabolic abnormalities are present in Pima Indians with combined IFG and IGT...
  12. ncbi request reprint Fasting and postprandial plasma concentrations of acylation-stimulation protein (ASP) in lean and obese Pima Indians compared to Caucasians
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Obes Res 7:444-52. 1999
    ..We tested whether fasting and post-prandial plasma ASP concentrations are increased in Pima Indians, a population with a very high prevalence of obesity, but a remarkably low prevalence of dyslipidemia...
  13. pmc The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Invest 104:787-94. 1999
    ..Thus, defects in insulin secretion and insulin action occur early in the pathogenesis of diabetes. Intervention to prevent diabetes should target both abnormalities...
  14. ncbi request reprint Determinants of energy expenditure and fuel utilization in man: effects of body composition, age, sex, ethnicity and glucose tolerance in 916 subjects
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Int J Obes Relat Metab Disord 23:715-22. 1999
    ..24-h energy expenditure (24-EE) and 24-h respiratory quotient (24-RQ) are important measurements in obesity research, but their accurate assessment is limited to few specialized laboratories...
  15. ncbi request reprint Metabolic factors contributing to increased resting metabolic rate and decreased insulin-induced thermogenesis during the development of type 2 diabetes
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 48:1607-14. 1999
    ....
  16. ncbi request reprint Development of beta 3-adrenoceptor agonists for the treatment of obesity and diabetes--an update
    C Weyer
    National Institutes of Health, Phoenix, AZ
    Diabetes Metab 25:11-21. 1999
    ....
  17. ncbi request reprint Energy metabolism in African Americans: potential risk factors for obesity
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Am J Clin Nutr 70:13-20. 1999
    ..Recent reports have identified a lower resting metabolic rate in African Americans than in whites, but most studies included only females and used short-term measurements with ventilated-hood systems...
  18. ncbi request reprint Exaggerated pancreatic polypeptide secretion in Pima Indians: can an increased parasympathetic drive to the pancreas contribute to hyperinsulinemia, obesity, and diabetes in humans?
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Metabolism 50:223-30. 2001
    ....
  19. ncbi request reprint Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion
    B Vozarova
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 9:414-7. 2001
    ....
  20. ncbi request reprint Low acute insulin secretory responses in adult offspring of people with early onset type 2 diabetes
    J F Gautier
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 50:1828-33. 2001
    ..1,255 [1,045-1,505] pmol/l, P < 0.02). Thus, insulin secretion is lower in normal glucose tolerant offspring of people with early onset type 2 diabetes. This impairment may be worsened by exposure to a diabetic environment in utero...
  21. ncbi request reprint Exaggerated insulin secretion in Pima Indians and African-Americans but higher insulin resistance in Pima Indians compared to African-Americans and Caucasians
    N Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Diabet Med 21:1090-5. 2004
    ....
  22. ncbi request reprint Differences in oral temperature and body shape in two populations with different propensities for obesity
    B Vozarova
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Ann N Y Acad Sci 967:516-21. 2002
    ..We hypothesized that Pima Indians, a population with a high prevalence of abdominal obesity, may have a lower surface area relative to volume, that is, lower radiating area, and therefore a higher body temperature compared to Caucasians...
  23. ncbi request reprint The role of impaired early insulin secretion in the pathogenesis of Type II diabetes mellitus
    R E Pratley
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetologia 44:929-45. 2001
    ..Strategies that enhance early insulin secretion improve glucose tolerance and represent a novel and more physiologic approach to improving glycaemic control in patients with Type II diabetes mellitus...
  24. ncbi request reprint Subcutaneous abdominal adipocyte size, a predictor of type 2 diabetes, is linked to chromosome 1q21--q23 and is associated with a common polymorphism in LMNA in Pima Indians
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street, Phoenix, Arizona 85016, USA
    Mol Genet Metab 72:231-8. 2001
    ..c. abd. AS can be attributed to familial factors and that genetic variation in LMNA might not only underlie rare cases of FPLD, but may also contribute to variation in adipocyte size in the general population...
  25. ncbi request reprint Comparison of two software versions for assessment of body-composition analysis by DXA
    B Vozarova
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 9:229-32. 2001
    ..To compare two software versions provided by Lunar CO: for assessment of body composition analysis by DXA...
  26. ncbi request reprint Effect of pramlintide on satiety and food intake in obese subjects and subjects with type 2 diabetes
    I Chapman
    Department of Medicine, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia
    Diabetologia 48:838-48. 2005
    ..While amylin reduces food intake in rodents, pramlintide's effect on satiety and food intake in humans has not yet been assessed...