Research Topics
Species | C WeyerSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humansC Weyer
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Diabetes 47:1555-61. 1998..This is the first study to demonstrate unequivocal metabolic effects of a highly selective beta3-adrenoceptor agonist in humans...- Changes in energy metabolism in response to 48 h of overfeeding and fasting in Caucasians and Pima IndiansC Weyer
Clinical Diabetes and Nutrition Section, NIDDK, National Institutes of Health, Phoenix, Arizona 85016, USA
Int J Obes Relat Metab Disord 25:593-600. 2001..To further examine this hypothesis, we assessed the changes in 24 h energy metabolism in response to short-term overfeeding and fasting in Caucasians (C) and Pima Indians (I), a population with a very high propensity for obesity... - Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemiaC Weyer
Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
J Clin Endocrinol Metab 86:1930-5. 2001.... - Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes developmentC Weyer
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Diabetes Care 24:89-94. 2001..We therefore assessed the predictive effect of insulin resistance and insulin secretory dysfunction separately for the progression from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) and from IGT to diabetes... - Relationship between birth weight and body composition, energy metabolism, and sympathetic nervous system activity later in lifeC Weyer
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Obes Res 8:559-65. 2000..Programming of metabolic, endocrine, and/or autonomic pathways during intrauterine development has been proposed to explain this association... - A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemiaC Weyer
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Diabetes 49:2094-101. 2000..Whether amelioration of basal insulin hypersecretion will prevent diabetes remains to be elucidated... - Ethnic differences in insulinemia and sympathetic tone as links between obesity and blood pressureC Weyer
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Hypertension 36:531-7. 2000..The lack of an increase in SNS activity with increasing adiposity and insulinemia in Pima Indians may contribute to the low prevalence of hypertension in this population... - Energy metabolism after 2 y of energy restriction: the biosphere 2 experimentC Weyer
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85106, USA
Am J Clin Nutr 72:946-53. 2000..An adaptive decrease in energy expenditure (EE) in response to 6 mo of severely restricted energy intake was shown in a classic semistarvation study-the Minnesota experiment... - Insulin action and insulinemia are closely related to the fasting complement C3, but not acylation stimulating protein concentrationC Weyer
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Diabetes Care 23:779-85. 2000..We hypothesized that an elevated C3 concentration might be linked to insulin resistance and/or hyperinsulinemia, abnormalities commonly observed in association with the above conditions... - Energy expenditure, fat oxidation, and body weight regulation: a study of metabolic adaptation to long-term weight changeC Weyer
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
J Clin Endocrinol Metab 85:1087-94. 2000..The metabolic responses to weight changes are highly variable among individuals, however... - Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose toleranceC Weyer
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Diabetes 48:2197-203. 1999..More severe metabolic abnormalities are present in Pima Indians with combined IFG and IGT... - Fasting and postprandial plasma concentrations of acylation-stimulation protein (ASP) in lean and obese Pima Indians compared to CaucasiansC Weyer
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
Obes Res 7:444-52. 1999..We tested whether fasting and post-prandial plasma ASP concentrations are increased in Pima Indians, a population with a very high prevalence of obesity, but a remarkably low prevalence of dyslipidemia... 
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitusC Weyer
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
J Clin Invest 104:787-94. 1999..Thus, defects in insulin secretion and insulin action occur early in the pathogenesis of diabetes. Intervention to prevent diabetes should target both abnormalities...- Determinants of energy expenditure and fuel utilization in man: effects of body composition, age, sex, ethnicity and glucose tolerance in 916 subjectsC Weyer
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
Int J Obes Relat Metab Disord 23:715-22. 1999..24-h energy expenditure (24-EE) and 24-h respiratory quotient (24-RQ) are important measurements in obesity research, but their accurate assessment is limited to few specialized laboratories... - Metabolic factors contributing to increased resting metabolic rate and decreased insulin-induced thermogenesis during the development of type 2 diabetesC Weyer
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Diabetes 48:1607-14. 1999.... - Development of beta 3-adrenoceptor agonists for the treatment of obesity and diabetes--an updateC Weyer
National Institutes of Health, Phoenix, AZ
Diabetes Metab 25:11-21. 1999.... - Energy metabolism in African Americans: potential risk factors for obesityC Weyer
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
Am J Clin Nutr 70:13-20. 1999..Recent reports have identified a lower resting metabolic rate in African Americans than in whites, but most studies included only females and used short-term measurements with ventilated-hood systems... - Exaggerated pancreatic polypeptide secretion in Pima Indians: can an increased parasympathetic drive to the pancreas contribute to hyperinsulinemia, obesity, and diabetes in humans?C Weyer
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
Metabolism 50:223-30. 2001.... - Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretionB Vozarova
Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Obes Res 9:414-7. 2001.... - Low acute insulin secretory responses in adult offspring of people with early onset type 2 diabetesJ F Gautier
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes 50:1828-33. 2001..1,255 [1,045-1,505] pmol/l, P < 0.02). Thus, insulin secretion is lower in normal glucose tolerant offspring of people with early onset type 2 diabetes. This impairment may be worsened by exposure to a diabetic environment in utero... - Exaggerated insulin secretion in Pima Indians and African-Americans but higher insulin resistance in Pima Indians compared to African-Americans and CaucasiansN Stefan
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
Diabet Med 21:1090-5. 2004.... - Differences in oral temperature and body shape in two populations with different propensities for obesityB Vozarova
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Ann N Y Acad Sci 967:516-21. 2002..We hypothesized that Pima Indians, a population with a high prevalence of abdominal obesity, may have a lower surface area relative to volume, that is, lower radiating area, and therefore a higher body temperature compared to Caucasians... - The role of impaired early insulin secretion in the pathogenesis of Type II diabetes mellitusR E Pratley
Clinical Diabetes and Nutrition Section, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetologia 44:929-45. 2001..Strategies that enhance early insulin secretion improve glucose tolerance and represent a novel and more physiologic approach to improving glycaemic control in patients with Type II diabetes mellitus... - Subcutaneous abdominal adipocyte size, a predictor of type 2 diabetes, is linked to chromosome 1q21--q23 and is associated with a common polymorphism in LMNA in Pima IndiansC Weyer
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street, Phoenix, Arizona 85016, USA
Mol Genet Metab 72:231-8. 2001..c. abd. AS can be attributed to familial factors and that genetic variation in LMNA might not only underlie rare cases of FPLD, but may also contribute to variation in adipocyte size in the general population... - Comparison of two software versions for assessment of body-composition analysis by DXAB Vozarova
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Obes Res 9:229-32. 2001..To compare two software versions provided by Lunar CO: for assessment of body composition analysis by DXA... - Effect of pramlintide on satiety and food intake in obese subjects and subjects with type 2 diabetesI Chapman
Department of Medicine, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia
Diabetologia 48:838-48. 2005..CONCLUSIONS/INTERPRETATION: The results indicate that enhanced satiety and reduced food intake may explain the weight loss observed in long-term pramlintide trials...