S E Wenzel

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. ncbi request reprint Mechanisms of severe asthma
    S Wenzel
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Clin Exp Allergy 33:1622-8. 2003
  2. ncbi request reprint Selective downregulation of prostaglandin E2-related pathways by the Th2 cytokine IL-13
    John Trudeau
    Department of Medicine, Division of Pulmonary, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 117:1446-54. 2006
  3. ncbi request reprint Function and regulation of SPLUNC1 protein in Mycoplasma infection and allergic inflammation
    Hong Wei Chu
    Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Immunol 179:3995-4002. 2007
  4. ncbi request reprint TGF-beta and IL-13 synergistically increase eotaxin-1 production in human airway fibroblasts
    Sally E Wenzel
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Immunol 169:4613-9. 2002
  5. ncbi request reprint Severe asthma in adults
    Sally Wenzel
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Crit Care Med 172:149-60. 2005
  6. ncbi request reprint Physiologic and pathologic abnormalities in severe asthma
    Sally Wenzel
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Clin Chest Med 27:29-40, v. 2006
  7. ncbi request reprint The role of leukotrienes in asthma
    Sally E Wenzel
    National Jewish Medical and Research Center, and the University of Colorado Health Sciences Center, 1400 Jackson St, Denver, CO 80206, USA
    Prostaglandins Leukot Essent Fatty Acids 69:145-55. 2003
  8. ncbi request reprint Severe/fatal asthma
    Sally Wenzel
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 123:405S-10S. 2003
  9. ncbi request reprint Severe asthma: epidemiology, pathophysiology and treatment
    Sally Wenzel
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Mt Sinai J Med 70:185-90. 2003
  10. ncbi request reprint Asthma: defining of the persistent adult phenotypes
    Sally E Wenzel
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Lancet 368:804-13. 2006

Detail Information

Publications68

  1. ncbi request reprint Mechanisms of severe asthma
    S Wenzel
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Clin Exp Allergy 33:1622-8. 2003
    ..Treatment remains problematic and likely will remain so until a better understanding of this disease develops...
  2. ncbi request reprint Selective downregulation of prostaglandin E2-related pathways by the Th2 cytokine IL-13
    John Trudeau
    Department of Medicine, Division of Pulmonary, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 117:1446-54. 2006
    ....
  3. ncbi request reprint Function and regulation of SPLUNC1 protein in Mycoplasma infection and allergic inflammation
    Hong Wei Chu
    Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Immunol 179:3995-4002. 2007
    ....
  4. ncbi request reprint TGF-beta and IL-13 synergistically increase eotaxin-1 production in human airway fibroblasts
    Sally E Wenzel
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Immunol 169:4613-9. 2002
    ..These results support the concept that interactions of innate and adaptive immune systems may be important in promoting the tissue eosinophilia of asthma, particularly in those with more severe disease...
  5. ncbi request reprint Severe asthma in adults
    Sally Wenzel
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Crit Care Med 172:149-60. 2005
    ..However, 5-lipoxygenase inhibitors, anti-IgE, and immunomodulatory drugs are also likely to have a place in treatment. Improving therapy in this disease will require a better understanding of the phenotypes involved...
  6. ncbi request reprint Physiologic and pathologic abnormalities in severe asthma
    Sally Wenzel
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Clin Chest Med 27:29-40, v. 2006
    ..Recent studies suggest that response to therapy in severe asthma may depend on the phenotype...
  7. ncbi request reprint The role of leukotrienes in asthma
    Sally E Wenzel
    National Jewish Medical and Research Center, and the University of Colorado Health Sciences Center, 1400 Jackson St, Denver, CO 80206, USA
    Prostaglandins Leukot Essent Fatty Acids 69:145-55. 2003
    ..While an anti-inflammatory effect is suggested, longer-term, earlier intervention, studies are needed to determine whether these compounds will have any effect on the natural history of the disease...
  8. ncbi request reprint Severe/fatal asthma
    Sally Wenzel
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 123:405S-10S. 2003
    ..Treatment remains problematic and likely will remain so until a better understanding of this disease develops...
  9. ncbi request reprint Severe asthma: epidemiology, pathophysiology and treatment
    Sally Wenzel
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Mt Sinai J Med 70:185-90. 2003
    ..Treatment is problematic and will probably remain so until a better understanding of this disease develops...
  10. ncbi request reprint Asthma: defining of the persistent adult phenotypes
    Sally E Wenzel
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Lancet 368:804-13. 2006
    ..This Review analyses some of the methods that have been used to define asthma phenotypes and proposes an integrated method of classification to improve our understanding of these phenotypes...
  11. ncbi request reprint Pathology of difficult asthma
    Sally Wenzel
    National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO, USA
    Paediatr Respir Rev 4:306-11. 2003
    ..Understanding the commonalities of the pathology of severe asthma should, however, lead to the development of improved therapies...
  12. ncbi request reprint Improvement in health care utilization and pulmonary function with fluticasone propionate in patients with steroid-dependent asthma at a National Asthma Referral Center
    S E Wenzel
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Asthma 38:405-12. 2001
    ..In addition, five patients were completely weaned off oral steroids...
  13. ncbi request reprint Update in asthma 2005
    Sally E Wenzel
    National Jewish Medical and Research Center for Immunology, Denver, Colorado, USA
    Am J Respir Crit Care Med 173:698-706. 2006
  14. ncbi request reprint Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
    S E Wenzel
    Departments of Medicine, Medical College of Virginia, Richmond, Virginia, USA
    Am J Respir Crit Care Med 160:1001-8. 1999
    ..These results suggest that two distinct pathologic, physiologic, and clinical subtypes of severe asthma exist, with implications for further research and treatment...
  15. ncbi request reprint Leukotriene receptor antagonists and related compounds
    S E Wenzel
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Can Respir J 6:189-93. 1999
    ..While long term studies will be helpful in determining the 'disease modifying' effects of these drugs, data suggest that these drugs are useful in the treatment of a broad range of asthmatic patients...
  16. ncbi request reprint Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids
    S E Wenzel
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 156:737-43. 1997
    ..These findings suggest that inflammation remains in severe symptomatic asthmatics despite treatment with high dose glucocorticoids which may be due to the severity of disease, glucocorticoid treatment, or other as yet undefined factors...
  17. ncbi request reprint Collagen deposition in large airways may not differentiate severe asthma from milder forms of the disease
    H W Chu
    Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 158:1936-44. 1998
    ..These results suggest that although increased collagen deposition in the SBM at the large airway level is a characteristic of asthma, it may not explain the differences in severity of asthma...
  18. ncbi request reprint Persistent wheezing in very young children is associated with lower respiratory inflammation
    M E Krawiec
    Department of Pediatrics and Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 163:1338-43. 2001
    ..05) were also increased in WC compared with NC, whereas PGD(2) and beta-tryptase were not. This study confirms that inflammation is present in the airways of very young WC and may differ from patterns seen in adults with asthma...
  19. ncbi request reprint Spectrum of prostanoid release after bronchoalveolar allergen challenge in atopic asthmatics and in control groups. An alteration in the ratio of bronchoconstrictive to bronchoprotective mediators
    S E Wenzel
    Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, CO 80206
    Am Rev Respir Dis 139:450-7. 1989
    ..001). There were no significant changes among the four groups after allergen challenge in 6-keto-PGF1 alpha or PGE2.(ABSTRACT TRUNCATED AT 250 WORDS)..
  20. ncbi request reprint Elevated levels of leukotriene C4 in bronchoalveolar lavage fluid from atopic asthmatics after endobronchial allergen challenge
    S E Wenzel
    Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206
    Am Rev Respir Dis 142:112-9. 1990
    ..After allergen challenge, the best correlation was found between the levels in BALF for the prostanoids PGD2 and TxB2 (r = 0.88).(ABSTRACT TRUNCATED AT 250 WORDS)..
  21. ncbi request reprint Use of leukotriene antagonists in childhood asthma
    M E Krawiec
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, USA
    Curr Opin Pediatr 11:540-7. 1999
    ..Further, they may be considered for primary use in patients with mild, persistent asthma, especially those who are steroid-phobic or who have compliance issues...
  22. ncbi request reprint Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition
    H W Chu
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, D104, Denver 80206, Colorado, USA
    Clin Exp Allergy 32:1558-65. 2002
    ..Although 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), a product of 15-lipoxygenase (15-LO), may be involved in mild to moderate asthma, little is known about its potential roles in severe asthma...
  23. pmc Nitric oxide and related enzymes in asthma: relation to severity, enzyme function and inflammation
    M Yamamoto
    Pulmonary, Allergy and Critical Care Medicine Division, Department of Medicine, University of Pittsburgh Asthma Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Clin Exp Allergy 42:760-8. 2012
    ..Exhaled nitric oxide (FeNO) associates with asthma and eosinophilic inflammation. However, relationships between nitric oxide synthases, arginase, FeNO, asthma severity and inflammation remain poorly understood...
  24. ncbi request reprint Bronchoalveolar lavage fluid mediator levels 5 minutes after allergen challenge in atopic subjects with asthma: relationship to the development of late asthmatic responses
    S E Wenzel
    Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colo 80206
    J Allergy Clin Immunol 87:540-8. 1991
    ..Atopic subjects with asthma and without LAR had significantly higher levels of all four mediators after challenge than atopic subjects with asthma and with LAR and atopic subjects without asthma.(ABSTRACT TRUNCATED AT 250 WORDS)..
  25. ncbi request reprint Arachidonate-induced eicosanoid synthesis in RBL-2H3 cells: stimulation with antigen or A23187 induces prolonged activation of 5-lipoxygenase
    J Y Westcott
    Department of Medicine, University of Colarado Health Sciences Center, Denver 80262, USA
    Biochim Biophys Acta 1303:74-81. 1996
    ....
  26. ncbi request reprint Transbronchial biopsy as a tool to evaluate small airways in asthma
    S Balzar
    National Jewish Medical and Research Centre, Denver, CO 80206, USA
    Eur Respir J 20:254-9. 2002
    ..This study suggests that small airway may be identified and analysed in transbronchial biopsy tissue samples and therefore transbronchial biopsy tissue samples could expand the analysis of inflammation and tissue remodelling in asthma...
  27. pmc Relationship between levels of secreted phospholipase A₂ groups IIA and X in the airways and asthma severity
    T S Hallstrand
    Department of Medicine, Divisions of Pulmonary and Critical Care, University of Washington, Seattle, WA 98195, USA
    Clin Exp Allergy 41:801-10. 2011
    ..Conclusions and Clinical Relevance These data indicate that sPLA(2) -IIA and sPLA(2) -X are the major sPLA(2) s in human airways, and suggest a link between the levels of sPLA(2) -X in the airways and several features of asthma...
  28. ncbi request reprint Inhaled nonsteroidal anti-inflammatory medications in the treatment of asthma
    M E Krawiec
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80218, USA
    Respir Care Clin N Am 5:555-74. 1999
    ..Thus, the cromione, SCG and NS, are effective prophylactic drugs recommended for use in both adults and children in the management of mild persistent asthma, EIB, and potentially as modest steroid-sparing agents...
  29. ncbi request reprint Severe asthma in adults
    S E Wenzel
    National Jewish Medical and Research Center, Denver, CO, USA
    Exp Lung Res 31:22. 2005
  30. ncbi request reprint Immunoaffinity resin for purification of urinary leukotriene E4
    J Y Westcott
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Prostaglandins Other Lipid Mediat 55:301-21. 1998
    ..Urinary LTE4 was also measured in healthy children (age 3-12) and found to be 103 +/- 9...
  31. pmc TLR4/MyD88-induced CD11b+Gr-1 int F4/80+ non-migratory myeloid cells suppress Th2 effector function in the lung
    M Arora
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Pittsburgh, Pennsylvania, USA
    Mucosal Immunol 3:578-93. 2010
    ..These data suggest that CD11b(+)Gr1(int)F4/80(+) cells contribute to the protective effects of LPS in allergic asthma by tempering Th2 effector function in the tissue...
  32. ncbi request reprint High-resolution CT features of severe asthma and bronchiolitis obliterans
    S P Jensen
    National Jewish Medical and Research Center, 1400 Jackson Street, Room A011, Denver, Colorado 80206, USA
    Clin Radiol 57:1078-85. 2002
    ..To evaluate the high-resolution CT findings of severe asthma (SA) and bronchiolitis obliterans (BO) and determine whether any reliable discriminating HRCT features exist...
  33. ncbi request reprint Tissue and BAL based biomarkers in asthma
    June Y Zhang
    Allergy Immunology Section, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Immunol Allergy Clin North Am 27:623-32; vi. 2007
    ..Efforts are to compare tissue and lavage biomarkers with less invasive measures, such as sputum, serum, or exhaled breath, to improve the treatment and management of asthma...
  34. ncbi request reprint Myofibroblast or smooth muscle: do in vitro systems adequately replicate tissue smooth muscle?
    Sally E Wenzel
    Am J Respir Crit Care Med 174:364-5. 2006
  35. ncbi request reprint Recent asthma exacerbations: a key predictor of future exacerbations
    Mary K Miller
    Genentech, Inc, South San Francisco, CA 94080, USA
    Respir Med 101:481-9. 2007
    ..The objective of this analysis was to investigate whether patients with severe or difficult-to-treat asthma who experienced recent severe asthma exacerbations are at increased risk of future asthma exacerbations...
  36. pmc Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma
    Anna Planagumà
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 178:574-82. 2008
    ..Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A(4) (LXA(4)) is an arachidonic acid-derived mediator that serves as an agonist for resolution of inflammation...
  37. pmc IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 175:570-6. 2007
    ..However, an effect on exacerbations and tissue inflammation has not been shown...
  38. ncbi request reprint Risk factors associated with persistent airflow limitation in severe or difficult-to-treat asthma: insights from the TENOR study
    June H Lee
    Genentech, Inc, 1 DNA Way, MS 453B, South San Francisco, CA 94080, USA
    Chest 132:1882-9. 2007
    ..A better understanding is needed regarding factors associated with persistent airway obstruction; this study was performed to determine demographic and clinical characteristics associated with persistent airflow limitation...
  39. pmc Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 119:405-13. 2007
    ..Severe asthma causes the majority of asthma morbidity. Understanding mechanisms that contribute to the development of severe disease is important...
  40. ncbi request reprint Severe asthma: lessons from the Severe Asthma Research Program
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 119:14-21; quiz 22-3. 2007
    ..Future studies will specifically evaluate the role of inflammatory/oxidative processes, infection, genetics, and the distal lung in the pathogenesis of severe asthma...
  41. pmc IgE expression pattern in lung: relation to systemic IgE and asthma phenotypes
    Silvana Balzar
    Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, University of Pittsburgh, UPMC Montefiore, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 119:855-62. 2007
    ..IgE-mediated responses contribute to allergy and asthma. Little is understood regarding the relationship of tissue IgE to systemic IgE, inflammation or clinical outcomes...
  42. ncbi request reprint Severe asthma in adults: what are the important questions?
    Pascal Chanez
    INSERM U454 and Clinique des Maladies Respiratoires, Montpellier, France
    J Allergy Clin Immunol 119:1337-48. 2007
    ..Inhaled corticosteroids and bronchodilators are the mainstay of treatment, but patients with SRA remain uncontrolled, indicating a need for new therapies...
  43. ncbi request reprint Mechanisms of tissue inhibitor of metalloproteinase 1 augmentation by IL-13 on TGF-beta 1-stimulated primary human fibroblasts
    XiuXia Zhou
    University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 119:1388-97. 2007
    ..Although these interactions have implications for remodeling in asthma, little is understood regarding the mechanisms controlling TIMP-1 product...
  44. ncbi request reprint Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation
    Ronald L Sorkness
    Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    J Appl Physiol 104:394-403. 2008
    ..We conclude that air trapping is a characteristic feature of the severe asthma population, suggesting that there is a pathological process associated with severe asthma that makes airways more vulnerable to this component...
  45. ncbi request reprint Phenotypes in asthma: useful guides for therapy, distinct biological processes, or both?
    Sally E Wenzel
    Am J Respir Crit Care Med 170:579-80. 2004
  46. ncbi request reprint Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids
    Meghan Cundall
    Department of Medicine, National Jewish Center and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 112:1064-71. 2003
    ..Matrix metalloproteinase (MMP)-9 levels are increased in bronchoalveolar lavage (BAL) fluid from patients with severe asthma on high doses of glucocorticoids (GCs)...
  47. ncbi request reprint Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation
    Christina Miranda
    National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Allergy Clin Immunol 113:101-8. 2004
    ..Asthma is a heterogeneous process, yet little is understood regarding phenotypes...
  48. ncbi request reprint Interleukin-13 augments transforming growth factor-beta1-induced tissue inhibitor of metalloproteinase-1 expression in primary human airway fibroblasts
    XiuXia Zhou
    National Jewish Medical and Research Center, and University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Am J Physiol Cell Physiol 288:C435-42. 2005
    ..Although IL-13 induced activation of PI3K-Akt, the activation did not contribute to the synergy observed with TGF-beta1 plus IL-13 in TIMP-1 expression and in fact may dampen it. The mechanisms behind the synergy remain to be determined...
  49. pmc Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthma
    Hong Wei Chu
    Department of Medicine, National Jewish Medical and Research Center, D104, 1400 Jackson St, Denver, CO 80206, USA
    Am J Pathol 165:1097-106. 2004
    ..These data suggest that TGF-beta2 production by asthmatic bronchial epithelial cells may increase airway mucin expression. IL-13-induced mucin expression may occur in part through TGF-beta2 up-regulation...
  50. ncbi request reprint Allergic rhinitis, asthma, airway biology, and chronic obstructive pulmonary disease in AJRCCM in 2004
    Leonardo Fabbri
    Medical, Oncological, and Radiological Sciences, University of Modena, Modena, Italy
    Am J Respir Crit Care Med 171:686-98. 2005
  51. pmc Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma
    Suzy A A Comhair
    Department of Pathology, Cleveland Clinic Foundation, OH 44195, USA
    Am J Respir Crit Care Med 172:306-13. 2005
    ....
  52. ncbi request reprint Defective apoptotic cell phagocytosis attenuates prostaglandin E2 and 15-hydroxyeicosatetraenoic acid in severe asthma alveolar macrophages
    Mai Lan N Huynh
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Am J Respir Crit Care Med 172:972-9. 2005
    ..Clearance of apoptotic cells is crucial to the resolution of inflammation and development of fibrosis, but the process is not well understood in normal or diseased human lungs...
  53. ncbi request reprint Severity assessment in asthma: An evolving concept
    Mary K Miller
    Genentech, Inc, South San Francisco, CA 94080, USA
    J Allergy Clin Immunol 116:990-5. 2005
    ..Thus, the accuracy of such assessments is essential for proper clinical management. The consistency of asthma severity assessment in patients with difficult-to-treat disease is unknown...
  54. ncbi request reprint Exhaled nitric oxide identifies the persistent eosinophilic phenotype in severe refractory asthma
    Philip E Silkoff
    National Jewish Medical and Research Center, Narbeth, PA 19072, USA
    J Allergy Clin Immunol 116:1249-55. 2005
    ..The fractional concentration of exhaled nitric oxide (FENO) is increased in asthma, correlates with eosinophilic inflammation, and decreases after steroid therapy...
  55. pmc Regional fibroblast heterogeneity in the lung: implications for remodeling
    Chakradhar Kotaru
    National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Am J Respir Crit Care Med 173:1208-15. 2006
    ..Whether differing fibrotic capacities of fibroblasts from these two regions contribute to this variability is unknown...
  56. ncbi request reprint Subtle immunodeficiency in severe asthma: IgA and IgG2 correlate with lung function and symptoms
    Silvana Balzar
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Int Arch Allergy Immunol 140:96-102. 2006
    ....
  57. ncbi request reprint Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activation
    Raweewan Hoontrakoon
    Department of Pediatrics, Division of Allergy and Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Cell Mol Biol 26:404-12. 2002
    ..Thus, our results suggest that IL-15, either alone or in combination with TNF-alpha, may perpetuate allergic inflammation by reduction of spontaneous eosinophil apoptosis through autocrine production of GM-CSF and NF-kappaB activation...
  58. ncbi request reprint Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repair
    Sally E Wenzel
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 111:1345-52. 2003
    ..Although MMP-9 is increased in lavage fluid and sputum in patients with asthma, controversy exists as to the role of tissue MMP-9...
  59. ncbi request reprint Respiratory outcomes in high-risk children 7 to 10 years after prophylaxis with respiratory syncytial virus immune globulin
    Sally E Wenzel
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Med 112:627-33. 2002
    ....
  60. ncbi request reprint Characterization of autopsy-proven fatal asthma patients in São Paulo, Brazil
    Thais Mauad
    Faculdade de Medicina da Universidade de Sao Paulo, Patologia, Sao Paulo, Brazil
    Rev Panam Salud Publica 23:418-23. 2008
    ..3%) deaths took place outside a hospital. We conclude that this population shares characteristics of severe or poorly controlled asthma, low educational and socioeconomic levels, and lack of medical care and of inhaled steroid use...
  61. pmc Alterations of the arginine metabolome in asthma
    Abigail Lara
    Department of Pathobiology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Respir Crit Care Med 178:673-81. 2008
    ..As the sole nitrogen donor in nitric oxide (NO) synthesis and key intermediate in the urea cycle, arginine and its metabolic pathways are integrally linked to cellular respiration, metabolism, and inflammation...
  62. doi request reprint The role of cytokines in chronic rhinosinusitis with nasal polyps
    Bradley A Otto
    Department of Otolaryngology Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Curr Opin Otolaryngol Head Neck Surg 16:270-4. 2008
    ..Chronic rhinosinusitis with nasal polyps is generally characterized by eosinophilic infiltration and a Th2-biased cytokine profile. However, the mechanisms that lead to nasal polyps are not clear...
  63. ncbi request reprint Ensuring quality in pharmaceutical studies
    Sally E Wenzel
    Am J Respir Crit Care Med 168:1010-1; author reply 1011-2. 2003
  64. ncbi request reprint Airway eicosanoids in acute severe respiratory syncytial virus bronchiolitis
    Yves Sznajer
    Pediatric Intensive Care Unit, Sainte Justine Hospital, University of Montreal, Quebec, Canada
    J Pediatr 145:115-8. 2004
    ..001). We conclude that eicosanoids are increased in the tracheal aspirates and urine of children with bronchiolitis...
  65. ncbi request reprint Asthma in older adults: observations from the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) study
    Raymond G Slavin
    Department of Internal Medicine, Division of Allergy and Immunology, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Ann Allergy Asthma Immunol 96:406-14. 2006
    ..More than 280 pulmonologist and allergist sites across the United States participated...
  66. ncbi request reprint Allergen-dependent solubilization of IL-13 receptor alpha2 reveals a novel mechanism to regulate allergy
    Michael O Daines
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 119:375-83. 2007
    ..Despite the critical role of allergens in the pathogenesis of these disorders, little is known about how allergens modulate the immune response. IL-13 receptor alpha2 (IL-13Ralpha2) is a decoy receptor for IL-13...
  67. ncbi request reprint Gender differences in IgE-mediated allergic asthma in the epidemiology and natural history of asthma: Outcomes and Treatment Regimens (TENOR) study
    June H Lee
    Genentech, Inc, South San Francisco, California 94080, USA
    J Asthma 43:179-84. 2006
    ....
  68. ncbi request reprint A profile of U.S. asthma centers, 2006
    Ashley F Sullivan
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Ann Allergy Asthma Immunol 99:419-23. 2007
    ..Asthma is a significant public health problem that results in 1.8 million annual emergency department (ED) visits. Many ED visits may be prevented with specialized asthma care...