Research Topics
Species | Nicolas WentzensenSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Human papillomavirus genotyping, human papillomavirus mRNA expression, and p16/Ki-67 cytology to detect anal cancer precursors in HIV-infected MSMNicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
AIDS 26:2185-92. 2012..Both approaches have limited reproducibility and sensitivity for detecting anal cancer precursors. We evaluated biomarkers for human papillomavirus (HPV)-related disease in a population of HIV-infected MSM...
Methylation of HPV18, HPV31, and HPV45 genomes and cervical intraepithelial neoplasia grade 3Nicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5024, Rockville, MD 20852 7234, USA
J Natl Cancer Inst 104:1738-49. 2012..However, the extent of methylation in other HPV types and its role in progression to cancer is poorly understood...- A comparison of human papillomavirus genotype-specific DNA and E6/E7 mRNA detection to identify anal precancer among HIV-infected men who have sex with menPhilip E Castle
Albert Einstein College of Medicine, Bronx, NY, USA
Cancer Epidemiol Biomarkers Prev 22:42-9. 2013..Human papillomavirus (HPV) RNA detection is reportedly more specific for the detection of anogenital precancer than HPV DNA but it is unknown whether this is due to detection of RNA or due to HPV genotype restriction... - Heterogeneity of high-grade cervical intraepithelial neoplasia related to HPV16: implications for natural history and managementNicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852 7234, USA
Int J Cancer 132:148-54. 2013..Lesion size seems to be an important determinant of colposcopy and biopsy performance. Genotyping for HPV16 in cervical cancer screening can improve risk stratification but may pose challenges to finding small lesions in colposcopy... - Performance of p16/Ki-67 immunostaining to detect cervical cancer precursors in a colposcopy referral populationNicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
Clin Cancer Res 18:4154-62. 2012..However, the specificity of HPV DNA testing is limited, requiring additional, more disease-specific markers for efficient screening approaches... - Human papillomavirus load measured by Linear Array correlates with quantitative PCR in cervical cytology specimensNicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
J Clin Microbiol 50:1564-70. 2012..Our findings support conducting comprehensive studies of viral load and cervical cancer precursors using quantitative LA genotyping data... - HPV16 variant lineage, clinical stage, and survival in women with invasive cervical cancerRosemary E Zuna
Department of Pathology, University of Oklahoma Health Sciences Center, 940 SL Young Blvd, Oklahoma City, Oklahoma, 73104 5042, USA
Infect Agent Cancer 6:19. 2011..abstract:.. - A population-based cross-sectional study of age-specific risk factors for high risk human papillomavirus prevalence in rural NigeriaMegan A Clarke
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
Infect Agent Cancer 6:12. 2011..abstract:.. - Grading the severity of cervical neoplasia based on combined histopathology, cytopathology, and HPV genotype distribution among 1,700 women referred to colposcopy in OklahomaNicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20854 7234, USA
Int J Cancer 124:964-9. 2009..We are now using these sharpened diagnostic categories to search for novel biomarkers predicting the risk of progression and invasion... - Genetic variation on 9p22 is associated with abnormal ovarian ultrasound results in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening TrialNicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America
PLoS ONE 6:e21731. 2011..The single nucleotide polymorphism (SNP) markers localize to the BNC2 gene, which has been associated with ovarian development... - A study of Amplicor human papillomavirus DNA detection in the atypical squamous cells of undetermined significance-low-grade squamous intraepithelial lesion triage studyNicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20854 7234, USA
Cancer Epidemiol Biomarkers Prev 18:1341-9. 2009..Amplicor at the 1.5 cutoff had comparable performance with hc2. Whereas Amplicor missed more disease related to nontargeted types, hc2 was more likely to miss disease related to targeted types... - Multiple human papillomavirus genotype infections in cervical cancer progression in the study to understand cervical cancer early endpoints and determinantsNicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
Int J Cancer 125:2151-8. 2009..The potential range of HPV genotype attribution is wide at the disease categories <CIN2 to CIN3. Genotyping from cervical lesions and analyzing viral oncogene expression can improve estimates of HPV genotype attribution... - Accuracy of cervical specimens obtained for biomarker studies in women with CIN3Nicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5014, Rockville, MD 20854 7234, USA
Gynecol Oncol 115:493-6. 2009..We developed a protocol to collect representative cervical specimens based on colposcopic evaluation from women treated with loop electrosurgical excision procedure (LEEP)... - Hierarchical clustering of human papilloma virus genotype patterns in the ASCUS-LSIL triage studyNicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852 7234, USA
Cancer Res 70:8578-86. 2010..Our novel approach to study multiple genotype infections in cervical disease with the use of unsupervised hierarchical clustering can address complex genotype distributions on a population level... - [Molecular diagnosis of HPV infections]N Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852 7234, Maryland, USA
Pathologe 32:461-6. 2011..It is important to rigorously validate HPV assays before they are implemented in screening or clinical care... - Utility of methylation markers in cervical cancer early detection: appraisal of the state-of-the-scienceNicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5012, Rockville, MD 20854 7234, USA
Gynecol Oncol 112:293-9. 2009..We wanted to identify the most promising methylation marker candidates for cervical cancer early detection... - A competitive serological assay shows naturally acquired immunity to human papillomavirus infections in the Guanacaste Natural History StudyNicolas Wentzensen
National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
J Infect Dis 204:94-102. 2011..A competitive Luminex Immunoassay (cLIA) has been developed to measure neutralizing antibodies against human papillomavirus (HPV) types 6, 11, 16 and 18... - Human papillomavirus cofactors by disease progression and human papillomavirus types in the study to understand cervical cancer early endpoints and determinantsSophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5104, Rockville, MD 20854 7234, USA
Cancer Epidemiol Biomarkers Prev 18:113-20. 2009..Investigations on the molecular distinctions along the disease continuum of cervical pathogenesis by HPV type are needed... - Switch from cytology-based to human papillomavirus test-based cervical screening: implications for colposcopyCarolina Porras
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Int J Cancer 130:1879-87. 2012..Our data support the need for a nonvisual diagnostic method to guide management and treatment of HPV-positive women... - Human papillomavirus genotype attribution and estimation of preventable fraction of anal intraepithelial neoplasia cases among HIV-infected men who have sex with menVikrant V Sahasrabuddhe
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
J Infect Dis 207:392-401. 2013.... - Human papillomavirus testing in the prevention of cervical cancerMark Schiffman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
J Natl Cancer Inst 103:368-83. 2011..The greatest potential for reduction in cervical cancer rates from HPV screening is in low-resource regions that can implement infrequent rounds of low-cost HPV testing and treatment... - Methylation of human papillomavirus type 16 genome and risk of cervical precancer in a Costa Rican populationLisa Mirabello
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd, EPS 7101, Rockville, MD 20892, USA
J Natl Cancer Inst 104:556-65. 2012.... - The role of co-factors in the progression from human papillomavirus infection to cervical cancerPatricia Luhn
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
Gynecol Oncol 128:265-70. 2013..We compared established risk factors among women with CIN2 and CIN3 to evaluate the heterogeneity of these factors in precancer and also assessed their role during cervical carcinogenesis... - Endometrial cancer risk factors by 2 main histologic subtypes: the NIH-AARP Diet and Health StudyHannah P Yang
Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, NIH, Department of Human Services, Bethesda, USA
Am J Epidemiol 177:142-51. 2013..Because of the limited number of Type II cancers, additional evaluation of risk factors will benefit from consortial efforts... - Clinical and pathological heterogeneity of cervical intraepithelial neoplasia grade 3Hannah P Yang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America
PLoS ONE 7:e29051. 2012..To improve our understanding of CIN3 natural history, we performed a detailed characterization of CIN3 heterogeneity in a large referral population in the US... - A comparison of dacron versus Flocked nylon swabs for anal cytology specimen collectionJulia C Gage
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20852, USA
Acta Cytol 55:364-7. 2011..We compared the performance of commonly used Dacron versus flocked nylon swabs for anal cytology... - Elevated methylation of HPV16 DNA is associated with the development of high grade cervical intraepithelial neoplasiaLisa Mirabello
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD
Int J Cancer 132:1412-22. 2013..Higher methylation in CIN2+ cases was not explained by higher viral load. We conclude that elevated levels of HPV16 DNA methylation may be useful to predict concurrently diagnosed as well as future CIN2+... - Is estrogen plus progestin menopausal hormone therapy safe with respect to endometrial cancer risk?Britton Trabert
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
Int J Cancer 132:417-26. 2013..Risks were highest among thin-to-normal weight women, presumably reflecting their lower endogenous estrogen levels, suggesting that menopausal hormones and obesity increase endometrial cancer through common etiologic pathways... - Effect of the number of biopsies on the subsequent acquisition of new human papillomavirus infectionsPhilip E Castle
National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Obstet Gynecol 114:1057-62. 2009..To analyze the effect of number of biopsies taken at enrollment with incident human papillomavirus (HPV) infections detected at the next 6-month visit... - Ovarian cancer risk factors by histologic subtypes in the NIH-AARP Diet and Health StudyHannah P Yang
Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Int J Cancer 131:938-48. 2012..83 (serous). Obesity was a significant risk factor only for endometrioid cancers (RR = 1.64; 95% CI: 1.00, 2.70). Our findings support a link between etiological factors and histological heterogeneity in ovarian carcinoma... - A long-term prospective study of type-specific human papillomavirus infection and risk of cervical neoplasia among 20,000 women in the Portland Kaiser Cohort StudyMark Schiffman
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 20:1398-409. 2011..Adding HPV testing to cytology is recommended for women ≥30 but long-term prospective studies of HPV testing are rare... - Human papillomavirus genotypes in cervical intraepithelial neoplasia grade 3Philip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5004, MSC 7234, Bethesda, MD 20892 7234, USA
Cancer Epidemiol Biomarkers Prev 19:1675-81. 2010..There are few large case series describing the human papillomavirus (HPV) genotypes found in women diagnosed with rigorously reviewed cervical intraepithelial neoplasia grade 3 (CIN3), cervical precancer... - Reproducibility of linear array for human papillomavirus genotypingJill Koshiol
Division of Cancer Epidemiology and Genetics, NCI NIH DHHS, Bethesda, Maryland, USA
J Clin Microbiol 51:625-8. 2013..3% overall [Kappa = 0.9] and 86.8% for carcinogenic types [Kappa = 0.92]). Discordance was highest with a low hybridization signal strength. Overall, Linear Array was highly reproducible... - Assessing disease risk in genome-wide association studies using family historyArpita Ghosh
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
Epidemiology 23:616-22. 2012.... - Non-steroidal anti-inflammatory drug use and ovarian cancer risk: findings from the NIH-AARP Diet and Health Study and systematic reviewMegan A Murphy
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Cancer Causes Control 23:1839-52. 2012..Chronic inflammation has been proposed as a risk factor for ovarian cancer. Some data suggest that anti-inflammatory medications may be protective against ovarian cancer; however, results have been inconsistent... - Impact of improved classification on the association of human papillomavirus with cervical precancerPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20892 7234, USA
Am J Epidemiol 171:155-63. 2010..Finding increasingly strong associations when both test and diagnostic misclassification are reduced is a useful sign of "true association" in molecular epidemiology... - A population-based study of visual inspection with acetic acid (VIA) for cervical screening in rural NigeriaKayode Olusegun Ajenifuja
Department of Obstetrics, Gynaecology and Perinatology, Obafemi Awolowo University, Ile Ife, Nigeria
Int J Gynecol Cancer 23:507-12. 2013..We sought to compare VIA performance among different health workers in Nigeria... - Human papillomavirus DNA methylation as a potential biomarker for cervical cancerMegan A Clarke
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA
Cancer Epidemiol Biomarkers Prev 21:2125-37. 2012..To follow the promising leads, we suggest future studies to validate the use of methylated carcinogenic HPV DNA as a predictive and/or diagnostic biomarker for risk of cervical cancer among HPV-positive women... - HPV16 Seropositivity and Subsequent HPV16 Infection Risk in a Naturally Infected Population: Comparison of Serological AssaysShih Wen Lin
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
PLoS ONE 8:e53067. 2013.... - Cervical histopathology variability among laboratories: a population-based statewide investigationJulia C Gage
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services DHHS, Bethesda, MD, USA
Am J Clin Pathol 139:330-5. 2013..In conclusion, the frequency of diagnoses requiring special staining (p16(INK4a) immunostaining) to adjudicate equivocal CIN2 will be sizable and vary between laboratories, especially if extended to a fraction of CIN1 lesions... - Direct comparison of HPV16 serological assays used to define HPV-naïve women in HPV vaccine trialsMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, NIH, Bethesda, MD, USA
Cancer Epidemiol Biomarkers Prev 21:1547-54. 2012..Some of the variation in estimated vaccine efficacies may be due to the differences in these assays used to define the HPV-naïve subgroups. To guide the interpretation of published results, we compared these assays... - Human papillomavirus and cervical cancer: biomarkers for improved prevention effortsVikrant V Sahasrabuddhe
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd EPS 5024, Rockville MD 20852, USA
Future Microbiol 6:1083-98. 2011..In this article, we will discuss the potential role of new biomarkers for primary screening, triage and diagnosis in high-resource countries and their promise for prevention efforts in resource constrained settings... - Association of serum sex steroid hormone hemodilution and body mass index among healthy postmenopausal womenHannah P Yang
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Ann Epidemiol 21:466-71. 2011..Assessing the relationship of hormone concentration to total mass varies by body mass index (BMI) is etiologically important because obesity is related to hormone metabolism and cancer risk... - Frequency of mismatch repair deficiency in ovarian cancer: a systematic review This article is a US Government work and, as such, is in the public domain of the United States of AmericaMegan A Murphy
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
Int J Cancer 129:1914-22. 2011.... - 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursorsL Stewart Massad
Washington University School of Medicine, St Louis, Missouri Albert Einstein College of Medicine, New York, New York University of Alabama School of Medicine, Birmingham, Alabama Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland The Permanente Medical Group, Sacramento, California and Emory University School of Medicine, Atlanta, Georgia
Obstet Gynecol 121:829-46. 2013.... - 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursorsL Stewart Massad
Division of Gynecologic Oncology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, St Louis, MO, USA
J Low Genit Tract Dis 17:S1-S27. 2013.... - Effectiveness of a simple rapid human papillomavirus DNA test in rural NigeriaJulia C Gage
Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
Int J Cancer 131:2903-9. 2012..In a challenging low-resource setting with minimal intervention, the careHPV test performed adequately with high specificity but possibly lower sensitivity than HPV DNA tests currently used in controlled situations... - Alcohol and endometrial cancer risk in the NIH-AARP diet and health studyHannah P Yang
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
Int J Cancer 128:2953-61. 2011..Our results do not support that alcohol is a strong contributor to endometrial cancer risk, but slight risk increases may prevail among some users or for selected tumor characteristics... - Human papillomavirus infection and the multistage carcinogenesis of cervical cancerMark Schiffman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 7012, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 22:553-60. 2013..The stages of cervical carcinogenesis are better understood than for most other major cancers, providing a successful cancer etiology and prevention model... - From differences in means between cases and controls to risk stratification: a business plan for biomarker developmentNicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852 7234, USA
Cancer Discov 3:148-57. 2013..Furthermore, we provide an interactive spreadsheet that links biomarker performance with specific disease characteristics to evaluate the promise of biomarker candidates at an early stage... - Detectable clonal mosaicism and its relationship to aging and cancerKevin B Jacobs
Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
Nat Genet 44:651-8. 2012..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases... - Challenges related to developing serum-based biomarkers for early ovarian cancer detectionPhuong L Mai
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
Cancer Prev Res (Phila) 4:303-6. 2011.... - Human papillomavirus and rising oropharyngeal cancer incidence in the United StatesAnil K Chaturvedi
National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7072, Rockville, MD 20852, USA
J Clin Oncol 29:4294-301. 2011..Recent increases in incidence and survival of oropharyngeal cancers in the United States have been attributed to human papillomavirus (HPV) infection, but empirical evidence is lacking...