Nicolas Wentzensen

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Performance of p16/Ki-67 immunostaining to detect cervical cancer precursors in a colposcopy referral population
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Clin Cancer Res 18:4154-62. 2012
  2. doi request reprint Human papillomavirus genotyping, human papillomavirus mRNA expression, and p16/Ki-67 cytology to detect anal cancer precursors in HIV-infected MSM
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    AIDS 26:2185-92. 2012
  3. pmc Methylation of HPV18, HPV31, and HPV45 genomes and cervical intraepithelial neoplasia grade 3
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5024, Rockville, MD 20852 7234, USA
    J Natl Cancer Inst 104:1738-49. 2012
  4. pmc A comparison of human papillomavirus genotype-specific DNA and E6/E7 mRNA detection to identify anal precancer among HIV-infected men who have sex with men
    Philip E Castle
    Albert Einstein College of Medicine, Bronx, NY, USA
    Cancer Epidemiol Biomarkers Prev 22:42-9. 2013
  5. pmc Heterogeneity of high-grade cervical intraepithelial neoplasia related to HPV16: implications for natural history and management
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852 7234, USA
    Int J Cancer 132:148-54. 2013
  6. pmc Human papillomavirus load measured by Linear Array correlates with quantitative PCR in cervical cytology specimens
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    J Clin Microbiol 50:1564-70. 2012
  7. pmc HPV16 variant lineage, clinical stage, and survival in women with invasive cervical cancer
    Rosemary E Zuna
    Department of Pathology, University of Oklahoma Health Sciences Center, 940 SL Young Blvd, Oklahoma City, Oklahoma, 73104 5042, USA
    Infect Agent Cancer 6:19. 2011
  8. pmc A population-based cross-sectional study of age-specific risk factors for high risk human papillomavirus prevalence in rural Nigeria
    Megan A Clarke
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    Infect Agent Cancer 6:12. 2011
  9. pmc Multiple human papillomavirus genotype infections in cervical cancer progression in the study to understand cervical cancer early endpoints and determinants
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
    Int J Cancer 125:2151-8. 2009
  10. pmc Grading the severity of cervical neoplasia based on combined histopathology, cytopathology, and HPV genotype distribution among 1,700 women referred to colposcopy in Oklahoma
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20854 7234, USA
    Int J Cancer 124:964-9. 2009

Detail Information

Publications64

  1. doi request reprint Performance of p16/Ki-67 immunostaining to detect cervical cancer precursors in a colposcopy referral population
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Clin Cancer Res 18:4154-62. 2012
    ..However, the specificity of HPV DNA testing is limited, requiring additional, more disease-specific markers for efficient screening approaches...
  2. doi request reprint Human papillomavirus genotyping, human papillomavirus mRNA expression, and p16/Ki-67 cytology to detect anal cancer precursors in HIV-infected MSM
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    AIDS 26:2185-92. 2012
    ..Both approaches have limited reproducibility and sensitivity for detecting anal cancer precursors. We evaluated biomarkers for human papillomavirus (HPV)-related disease in a population of HIV-infected MSM...
  3. pmc Methylation of HPV18, HPV31, and HPV45 genomes and cervical intraepithelial neoplasia grade 3
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5024, Rockville, MD 20852 7234, USA
    J Natl Cancer Inst 104:1738-49. 2012
    ..However, the extent of methylation in other HPV types and its role in progression to cancer is poorly understood...
  4. pmc A comparison of human papillomavirus genotype-specific DNA and E6/E7 mRNA detection to identify anal precancer among HIV-infected men who have sex with men
    Philip E Castle
    Albert Einstein College of Medicine, Bronx, NY, USA
    Cancer Epidemiol Biomarkers Prev 22:42-9. 2013
    ..Human papillomavirus (HPV) RNA detection is reportedly more specific for the detection of anogenital precancer than HPV DNA but it is unknown whether this is due to detection of RNA or due to HPV genotype restriction...
  5. pmc Heterogeneity of high-grade cervical intraepithelial neoplasia related to HPV16: implications for natural history and management
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852 7234, USA
    Int J Cancer 132:148-54. 2013
    ..Lesion size seems to be an important determinant of colposcopy and biopsy performance. Genotyping for HPV16 in cervical cancer screening can improve risk stratification but may pose challenges to finding small lesions in colposcopy...
  6. pmc Human papillomavirus load measured by Linear Array correlates with quantitative PCR in cervical cytology specimens
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    J Clin Microbiol 50:1564-70. 2012
    ..Our findings support conducting comprehensive studies of viral load and cervical cancer precursors using quantitative LA genotyping data...
  7. pmc HPV16 variant lineage, clinical stage, and survival in women with invasive cervical cancer
    Rosemary E Zuna
    Department of Pathology, University of Oklahoma Health Sciences Center, 940 SL Young Blvd, Oklahoma City, Oklahoma, 73104 5042, USA
    Infect Agent Cancer 6:19. 2011
    ..abstract:..
  8. pmc A population-based cross-sectional study of age-specific risk factors for high risk human papillomavirus prevalence in rural Nigeria
    Megan A Clarke
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    Infect Agent Cancer 6:12. 2011
    ..abstract:..
  9. pmc Multiple human papillomavirus genotype infections in cervical cancer progression in the study to understand cervical cancer early endpoints and determinants
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
    Int J Cancer 125:2151-8. 2009
    ..The potential range of HPV genotype attribution is wide at the disease categories <CIN2 to CIN3. Genotyping from cervical lesions and analyzing viral oncogene expression can improve estimates of HPV genotype attribution...
  10. pmc Grading the severity of cervical neoplasia based on combined histopathology, cytopathology, and HPV genotype distribution among 1,700 women referred to colposcopy in Oklahoma
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20854 7234, USA
    Int J Cancer 124:964-9. 2009
    ..We are now using these sharpened diagnostic categories to search for novel biomarkers predicting the risk of progression and invasion...
  11. pmc Hierarchical clustering of human papilloma virus genotype patterns in the ASCUS-LSIL triage study
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852 7234, USA
    Cancer Res 70:8578-86. 2010
    ..Our novel approach to study multiple genotype infections in cervical disease with the use of unsupervised hierarchical clustering can address complex genotype distributions on a population level...
  12. pmc Accuracy of cervical specimens obtained for biomarker studies in women with CIN3
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5014, Rockville, MD 20854 7234, USA
    Gynecol Oncol 115:493-6. 2009
    ..We developed a protocol to collect representative cervical specimens based on colposcopic evaluation from women treated with loop electrosurgical excision procedure (LEEP)...
  13. pmc Utility of methylation markers in cervical cancer early detection: appraisal of the state-of-the-science
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5012, Rockville, MD 20854 7234, USA
    Gynecol Oncol 112:293-9. 2009
    ..We wanted to identify the most promising methylation marker candidates for cervical cancer early detection...
  14. doi request reprint [Molecular diagnosis of HPV infections]
    N Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852 7234, Maryland, USA
    Pathologe 32:461-6. 2011
    ..It is important to rigorously validate HPV assays before they are implemented in screening or clinical care...
  15. pmc Genetic variation on 9p22 is associated with abnormal ovarian ultrasound results in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America
    PLoS ONE 6:e21731. 2011
    ..The single nucleotide polymorphism (SNP) markers localize to the BNC2 gene, which has been associated with ovarian development...
  16. pmc A study of Amplicor human papillomavirus DNA detection in the atypical squamous cells of undetermined significance-low-grade squamous intraepithelial lesion triage study
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20854 7234, USA
    Cancer Epidemiol Biomarkers Prev 18:1341-9. 2009
    ..Amplicor at the 1.5 cutoff had comparable performance with hc2. Whereas Amplicor missed more disease related to nontargeted types, hc2 was more likely to miss disease related to targeted types...
  17. pmc A competitive serological assay shows naturally acquired immunity to human papillomavirus infections in the Guanacaste Natural History Study
    Nicolas Wentzensen
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    J Infect Dis 204:94-102. 2011
    ..A competitive Luminex Immunoassay (cLIA) has been developed to measure neutralizing antibodies against human papillomavirus (HPV) types 6, 11, 16 and 18...
  18. pmc Risk factors for anal HPV infection and anal precancer in HIV-infected men who have sex with men
    Lauren M Schwartz
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville
    J Infect Dis 208:1768-75. 2013
    ..We evaluated risk factors for HPV infection and anal precancer in a population of HIV-infected MSM...
  19. pmc Human papillomavirus cofactors by disease progression and human papillomavirus types in the study to understand cervical cancer early endpoints and determinants
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5104, Rockville, MD 20854 7234, USA
    Cancer Epidemiol Biomarkers Prev 18:113-20. 2009
    ..Investigations on the molecular distinctions along the disease continuum of cervical pathogenesis by HPV type are needed...
  20. pmc Risk of precancer determined by HPV genotype combinations in women with minor cytologic abnormalities
    Julia C Gage
    Divisions of Cancer Epidemiology and Genetics and Cancer Prevention National Cancer Institute, Department of Health and Human Services, NIH, Bethesda, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 22:1095-101. 2013
    ..We evaluated genotyping for HPV16, HPV16/18, and HPV16/18/45 in carcinogenic HPV-positive women with atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesion (LSIL) cytology...
  21. pmc Switch from cytology-based to human papillomavirus test-based cervical screening: implications for colposcopy
    Carolina Porras
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Int J Cancer 130:1879-87. 2012
    ..Our data support the need for a nonvisual diagnostic method to guide management and treatment of HPV-positive women...
  22. doi request reprint Evaluation of a multiplex panel of immune-related markers in cervical secretions: a methodologic study
    Jill Koshiol
    Division of Cancer Epidemiology and Genetics, NCI NIH DHHS, Bethesda, MD
    Int J Cancer 134:411-25. 2014
    ..g., MIP-1delta, OR: 4.48, 95% CI: 0.87-23.04 versus <CIN1/HPV-positive). More than 70% of markers were reliably measured. This assay may be used to evaluate associations of immune-related markers with CIN and HPV status. ..
  23. pmc Human papillomavirus genotype attribution and estimation of preventable fraction of anal intraepithelial neoplasia cases among HIV-infected men who have sex with men
    Vikrant V Sahasrabuddhe
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    J Infect Dis 207:392-401. 2013
    ....
  24. pmc Human papillomavirus testing in the prevention of cervical cancer
    Mark Schiffman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 103:368-83. 2011
    ..The greatest potential for reduction in cervical cancer rates from HPV screening is in low-resource regions that can implement infrequent rounds of low-cost HPV testing and treatment...
  25. pmc Methylation of human papillomavirus type 16 genome and risk of cervical precancer in a Costa Rican population
    Lisa Mirabello
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd, EPS 7101, Rockville, MD 20892, USA
    J Natl Cancer Inst 104:556-65. 2012
    ....
  26. pmc Chromosomal gains measured in cytology samples from women with abnormal cervical cancer screening results
    Patricia Luhn
    Division of Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Gynecol Oncol 130:595-600. 2013
    ..We evaluated a novel fluorescence in situ hybridization (FISH) assay that detects gains at these three loci simultaneously as a possible biomarker for detecting cervical precancer...
  27. pmc Non-steroidal anti-inflammatory drug use and ovarian cancer risk: findings from the NIH-AARP Diet and Health Study and systematic review
    Megan A Murphy
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cancer Causes Control 23:1839-52. 2012
    ..Chronic inflammation has been proposed as a risk factor for ovarian cancer. Some data suggest that anti-inflammatory medications may be protective against ovarian cancer; however, results have been inconsistent...
  28. doi request reprint The role of co-factors in the progression from human papillomavirus infection to cervical cancer
    Patricia Luhn
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
    Gynecol Oncol 128:265-70. 2013
    ..We compared established risk factors among women with CIN2 and CIN3 to evaluate the heterogeneity of these factors in precancer and also assessed their role during cervical carcinogenesis...
  29. pmc Endometrial cancer risk factors by 2 main histologic subtypes: the NIH-AARP Diet and Health Study
    Hannah P Yang
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, NIH, Department of Human Services, Bethesda, USA
    Am J Epidemiol 177:142-51. 2013
    ..Because of the limited number of Type II cancers, additional evaluation of risk factors will benefit from consortial efforts...
  30. pmc Clinical and pathological heterogeneity of cervical intraepithelial neoplasia grade 3
    Hannah P Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America
    PLoS ONE 7:e29051. 2012
    ..To improve our understanding of CIN3 natural history, we performed a detailed characterization of CIN3 heterogeneity in a large referral population in the US...
  31. pmc HPV16 seropositivity and subsequent HPV16 infection risk in a naturally infected population: comparison of serological assays
    Shih Wen Lin
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 8:e53067. 2013
    ....
  32. pmc Reproducibility of linear array for human papillomavirus genotyping
    Jill Koshiol
    Division of Cancer Epidemiology and Genetics, NCI NIH DHHS, Bethesda, Maryland, USA
    J Clin Microbiol 51:625-8. 2013
    ..3% overall [Kappa = 0.9] and 86.8% for carcinogenic types [Kappa = 0.92]). Discordance was highest with a low hybridization signal strength. Overall, Linear Array was highly reproducible...
  33. pmc A comparison of dacron versus Flocked nylon swabs for anal cytology specimen collection
    Julia C Gage
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20852, USA
    Acta Cytol 55:364-7. 2011
    ..We compared the performance of commonly used Dacron versus flocked nylon swabs for anal cytology...
  34. pmc Elevated methylation of HPV16 DNA is associated with the development of high grade cervical intraepithelial neoplasia
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    Int J Cancer 132:1412-22. 2013
    ..Higher methylation in CIN2+ cases was not explained by higher viral load. We conclude that elevated levels of HPV16 DNA methylation may be useful to predict concurrently diagnosed as well as future CIN2+...
  35. pmc Is estrogen plus progestin menopausal hormone therapy safe with respect to endometrial cancer risk?
    Britton Trabert
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Int J Cancer 132:417-26. 2013
    ..Risks were highest among thin-to-normal weight women, presumably reflecting their lower endogenous estrogen levels, suggesting that menopausal hormones and obesity increase endometrial cancer through common etiologic pathways...
  36. doi request reprint Effect of the number of biopsies on the subsequent acquisition of new human papillomavirus infections
    Philip E Castle
    National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Obstet Gynecol 114:1057-62. 2009
    ..To analyze the effect of number of biopsies taken at enrollment with incident human papillomavirus (HPV) infections detected at the next 6-month visit...
  37. pmc Circulating adipokine levels and endometrial cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial
    Patricia Luhn
    Division of Cancer Epidemiology and Genetics, Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 22:1304-12. 2013
    ..Circulating adipokine levels may be associated with endometrial cancer risk, yet few studies have evaluated these markers prospectively...
  38. pmc Human papillomavirus DNA methylation as a potential biomarker for cervical cancer
    Megan A Clarke
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 21:2125-37. 2012
    ..To follow the promising leads, we suggest future studies to validate the use of methylated carcinogenic HPV DNA as a predictive and/or diagnostic biomarker for risk of cervical cancer among HPV-positive women...
  39. pmc Ovarian cancer risk factors by histologic subtypes in the NIH-AARP Diet and Health Study
    Hannah P Yang
    Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 131:938-48. 2012
    ..83 (serous). Obesity was a significant risk factor only for endometrioid cancers (RR = 1.64; 95% CI: 1.00, 2.70). Our findings support a link between etiological factors and histological heterogeneity in ovarian carcinoma...
  40. pmc A long-term prospective study of type-specific human papillomavirus infection and risk of cervical neoplasia among 20,000 women in the Portland Kaiser Cohort Study
    Mark Schiffman
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 20:1398-409. 2011
    ..Adding HPV testing to cytology is recommended for women ≥30 but long-term prospective studies of HPV testing are rare...
  41. pmc Human papillomavirus genotypes in cervical intraepithelial neoplasia grade 3
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5004, MSC 7234, Bethesda, MD 20892 7234, USA
    Cancer Epidemiol Biomarkers Prev 19:1675-81. 2010
    ..There are few large case series describing the human papillomavirus (HPV) genotypes found in women diagnosed with rigorously reviewed cervical intraepithelial neoplasia grade 3 (CIN3), cervical precancer...
  42. pmc Ovarian cancer incidence trends in relation to changing patterns of menopausal hormone therapy use in the United States
    Hannah P Yang
    National Cancer Institute, Bethesda, MD, MD 20852, USA
    J Clin Oncol 31:2146-51. 2013
    ..Given that MHT use is also associated with increased ovarian cancer risk, we tested whether ovarian cancer incidence rates changed after 2002...
  43. pmc Assessing disease risk in genome-wide association studies using family history
    Arpita Ghosh
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Epidemiology 23:616-22. 2012
    ....
  44. pmc Impact of improved classification on the association of human papillomavirus with cervical precancer
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20892 7234, USA
    Am J Epidemiol 171:155-63. 2010
    ..Finding increasingly strong associations when both test and diagnostic misclassification are reduced is a useful sign of "true association" in molecular epidemiology...
  45. doi request reprint Aspirin, nonaspirin nonsteroidal anti-inflammatory drug, and acetaminophen use and risk of invasive epithelial ovarian cancer: a pooled analysis in the Ovarian Cancer Association Consortium
    Britton Trabert
    Affiliations of authors Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD BT, Lab, NW University of Texas School of Public Health, Houston, TX RBN Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA WL Channing Division of Network Medicine MAM, EMP and Obstetrics and Gynecology Epidemiology Center DWC, KLT, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Department of Epidemiology, Harvard School of Public Health, Boston, MA MAM, EMP, DWC, KLT Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN ELG Queensland Institute of Medical Research, Brisbane, Australia PMW, CMN, SJJ, Australian Ovarian Cancer Study Group, the Australian Cancer Study Ovarian Cancer Peter MacCallum Cancer Centre, East Melbourne, Australia Australian Ovarian Cancer Study Group Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT HAR Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA MAR, Brazil
    J Natl Cancer Inst 106:djt431. 2014
    ..Epidemiologic studies analyzing aspirin, nonaspirin nonsteroidal anti-inflammatory drug (NSAID), and acetaminophen use and ovarian cancer risk have been inconclusive...
  46. doi request reprint Natural immune responses against eight oncogenic human papillomaviruses in the ASCUS-LSIL Triage Study
    Lauren E Wilson
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 133:2172-81. 2013
    ....
  47. pmc A population-based study of visual inspection with acetic acid (VIA) for cervical screening in rural Nigeria
    Kayode Olusegun Ajenifuja
    Department of Obstetrics, Gynaecology and Perinatology, Obafemi Awolowo University, Ile Ife, Nigeria
    Int J Gynecol Cancer 23:507-12. 2013
    ..We sought to compare VIA performance among different health workers in Nigeria...
  48. doi request reprint Comparison of human papillomavirus detections in urine, vulvar, and cervical samples from women attending a colposcopy clinic
    Vikrant V Sahasrabuddhe
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
    J Clin Microbiol 52:187-92. 2014
    ....
  49. doi request reprint Cervical histopathology variability among laboratories: a population-based statewide investigation
    Julia C Gage
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services DHHS, Bethesda, MD, USA
    Am J Clin Pathol 139:330-5. 2013
    ..In conclusion, the frequency of diagnoses requiring special staining (p16(INK4a) immunostaining) to adjudicate equivocal CIN2 will be sizable and vary between laboratories, especially if extended to a fraction of CIN1 lesions...
  50. doi request reprint Direct comparison of HPV16 serological assays used to define HPV-naïve women in HPV vaccine trials
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, NIH, Bethesda, MD, USA
    Cancer Epidemiol Biomarkers Prev 21:1547-54. 2012
    ..Some of the variation in estimated vaccine efficacies may be due to the differences in these assays used to define the HPV-naïve subgroups. To guide the interpretation of published results, we compared these assays...
  51. pmc Human papillomavirus infection and the multistage carcinogenesis of cervical cancer
    Mark Schiffman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 7012, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 22:553-60. 2013
    ..The stages of cervical carcinogenesis are better understood than for most other major cancers, providing a successful cancer etiology and prevention model...
  52. pmc From differences in means between cases and controls to risk stratification: a business plan for biomarker development
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852 7234, USA
    Cancer Discov 3:148-57. 2013
    ..The methods described here apply to any method that aims to estimate risk of disease based on biomarkers, clinical tests, genetics, environment, or behavior...
  53. pmc Human papillomavirus and cervical cancer: biomarkers for improved prevention efforts
    Vikrant V Sahasrabuddhe
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd EPS 5024, Rockville MD 20852, USA
    Future Microbiol 6:1083-98. 2011
    ..In this article, we will discuss the potential role of new biomarkers for primary screening, triage and diagnosis in high-resource countries and their promise for prevention efforts in resource constrained settings...
  54. pmc Association of serum sex steroid hormone hemodilution and body mass index among healthy postmenopausal women
    Hannah P Yang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Ann Epidemiol 21:466-71. 2011
    ..Assessing the relationship of hormone concentration to total mass varies by body mass index (BMI) is etiologically important because obesity is related to hormone metabolism and cancer risk...
  55. doi request reprint No evidence for synergy between human papillomavirus genotypes for the risk of high-grade squamous intraepithelial lesions in a large population-based study
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute
    J Infect Dis 209:855-64. 2014
    ..We evaluated the risk of HSIL in women concomitantly infected with multiple HPV genotypes...
  56. pmc Frequency of mismatch repair deficiency in ovarian cancer: a systematic review This article is a US Government work and, as such, is in the public domain of the United States of America
    Megan A Murphy
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
    Int J Cancer 129:1914-22. 2011
    ....
  57. pmc Physical activity in different periods of life, sedentary behavior, and the risk of ovarian cancer in the NIH-AARP diet and health study
    Qian Xiao
    Authors Affiliations Nutritional Epidemiology Branch, Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland and AARP, Washington, District of Columbia
    Cancer Epidemiol Biomarkers Prev 22:2000-8. 2013
    ..Physical activity and sedentary behavior may influence ovarian cancer risk, but clear evidence is lacking...
  58. doi request reprint 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors
    L Stewart Massad
    Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Obstet Gynecol 121:829-46. 2013
    ....
  59. doi request reprint 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors
    L Stewart Massad
    Division of Gynecologic Oncology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, St Louis, MO, USA
    J Low Genit Tract Dis 17:S1-S27. 2013
    ....
  60. pmc Effectiveness of a simple rapid human papillomavirus DNA test in rural Nigeria
    Julia C Gage
    Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    Int J Cancer 131:2903-9. 2012
    ..In a challenging low-resource setting with minimal intervention, the careHPV test performed adequately with high specificity but possibly lower sensitivity than HPV DNA tests currently used in controlled situations...
  61. pmc Alcohol and endometrial cancer risk in the NIH-AARP diet and health study
    Hannah P Yang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Int J Cancer 128:2953-61. 2011
    ..Our results do not support that alcohol is a strong contributor to endometrial cancer risk, but slight risk increases may prevail among some users or for selected tumor characteristics...
  62. pmc Detectable clonal mosaicism and its relationship to aging and cancer
    Kevin B Jacobs
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
    Nat Genet 44:651-8. 2012
    ..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...
  63. pmc Challenges related to developing serum-based biomarkers for early ovarian cancer detection
    Phuong L Mai
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Prev Res (Phila) 4:303-6. 2011
    ....
  64. pmc Human papillomavirus and rising oropharyngeal cancer incidence in the United States
    Anil K Chaturvedi
    National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7072, Rockville, MD 20852, USA
    J Clin Oncol 29:4294-301. 2011
    ..Recent increases in incidence and survival of oropharyngeal cancers in the United States have been attributed to human papillomavirus (HPV) infection, but empirical evidence is lacking...