Research Topics
Genomes and Genes | Nan Ping WengSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Analysis of telomere length and telomerase activityKaren S Hathcock
National Cancer Institute/NIH, Bethesda, MD, USA
Curr Protoc Immunol . 2004..This unit describes methods that are used for the measurement of telomere length and telomerase activity in human and murine cells...- Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and agingN P Weng
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Immunol Rev 160:43-54. 1997..The future study of telomerase and its regulation of telomere length may enhance our understanding of how the replicative lifespan is regulated in lymphocytes... - Interplay between telomere length and telomerase in human leukocyte differentiation and agingN Weng
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
J Leukoc Biol 70:861-7. 2001..In addition, I will attempt to shed new light on the roles of telomere and telomerase in leukocyte function and potential clinical interventions... - IL-15 is a growth factor and an activator of CD8 memory T cellsNan Ping Weng
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Ann N Y Acad Sci 975:46-56. 2002..These findings indicate that IL-15 is not only a growth factor but also an antigen-independent activator for CD8 memory T cells... 
IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cellsKebin Liu
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 99:6192-7. 2002..Thus, IL-15 acts not only as a crucial growth factor but also as an antigen-independent activator of effector functions for CD8(+) memory T cells...- Gene expression and generation of CD28-CD8 T cells mediated by interleukin 15Jason Godlove
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Exp Gerontol 42:412-5. 2007..Together, these findings provide the gene expression features of CD28(-)CD8 T cells that differ from their CD28(+) counterparts and suggest a possible role of IL-15 in the increase of CD28(-)CD8 T cells that occurs with aging... - IL-21 preferentially enhances IL-15-mediated homeostatic proliferation of human CD28+ CD8 memory T cells throughout the adult age spanHuy Nguyen
National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
J Leukoc Biol 87:43-9. 2010..Together, these findings suggest that IL-21 enhances IL-15-mediated proliferation of CD8 memory T cells, particularly CD28(+) memory T cells, and also serves as an antagonist to the IL-15-induced increase of CD28(-) CD8 T cells... - Telomeres in T and B cellsRichard J Hodes
National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Rev Immunol 2:699-706. 2002..This article describes our current understanding of telomere-length regulation in lymphocytes and its implications for immune function... - IL-15 activates telomerase and minimizes telomere loss and may preserve the replicative life span of memory CD8+ T cells in vitroYu Li
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
J Immunol 174:4019-24. 2005..These findings suggest that IL-15 activates stable telomerase expression and compensates telomere loss in memory phenotype CD8(+) T cells, and that telomerase may play an important role in memory CD8(+) T cell homeostasis... - Krüppel-like factor 4 regulates B cell number and activation-induced B cell proliferationJettanong Klaewsongkram
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
J Immunol 179:4679-84. 2007..These findings demonstrate that Klf4 regulates B cell number and activation-induced B cell proliferation through directly acting on the promoter of cyclin D2... - Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B)Yasuto Araki
Laboratory of Immunology and Flow Cytometry Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
J Immunol 180:8102-8. 2008..Thus, epigenetic changes mediated via histone acetylation may provide a chromatin "memory" for the rapid and robust transcriptional response of memory CD8 T cells... - Telomerase is involved in IL-7-mediated differential survival of naive and memory CD4+ T cellsYinhua Yang
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
J Immunol 180:3775-81. 2008..Together, these findings demonstrate that telomerase is involved in IL-7-mediated differential survival of naive and memory CD4(+) T cells... - Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer's disease patientsAmanda K Damjanovic
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
J Immunol 179:4249-54. 2007..These findings demonstrate that chronic stress is associated with altered T cell function and accelerated immune cell aging as suggested by excessive telomere loss... - Telomere length and the expression of natural telomeric genes in human fibroblastsYi Ning
Department of Pathology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Hum Mol Genet 12:1329-36. 2003..These results suggest that the expression of natural telomeric genes may be influenced by alteration of local heterochromatin structure... - Telomere and adaptive immunityNan Ping Weng
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, United States
Mech Ageing Dev 129:60-6. 2008..Here I will review the recent progress of the role of telomeres and telomerase in lymphocyte differentiation, function, and aging... - Aging of the immune system: how much can the adaptive immune system adapt?Nan Ping Weng
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
Immunity 24:495-9. 2006..Here I discuss the recent progress on age-associated changes in lymphocytes and their effect on the adaptive immune system... - Themis, a T cell-specific protein important for late thymocyte developmentRenaud Lesourne
Laboratory of Mammalian Genes and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
Nat Immunol 10:840-7. 2009..Our results identify Themis as a critical component of the T cell developmental program and suggest that Themis functions to sustain and/or integrate signals required for proper lineage commitment and maturation... 
The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulationNan Ping Weng
Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Nat Rev Immunol 12:306-15. 2012....- Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cellsYasuto Araki
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Immunity 30:912-25. 2009..Our findings reveal a complex regulation by histone methylation in differential gene expression and suggest that histone methylation may be responsible for memory CD8(+) T cell function... - A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78Yongquan Luo
Laboratory of Immunology, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
J Neurochem 80:354-61. 2002..Interaction of NLK with gp78 and subsequent signaling may strengthen synaptic mechanisms underlying learning and memory formation... - Telomeres and immune competencyNan Ping Weng
Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, 251 Bayview Blvd, Suite 100, Baltimore, MD 21224, USA
Curr Opin Immunol 24:470-5. 2012..Here, I review recent studies of telomere length dynamics with particular relevance to immune function... - CD28(-) T cells: their role in the age-associated decline of immune functionNan Ping Weng
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Trends Immunol 30:306-12. 2009..Here we review recent advances in our understanding of CD28(-) T cells and their role in the age-associated decline of immune function... - Rapid default transition of CD4 T cell effectors to functional memory cellsK Kai McKinstry
Trudeau Institute, Saranac Lake, NY 12983, USA
J Exp Med 204:2199-211. 2007.... - Regulation of telomerase expression in human lymphocytesNan-Ping Weng
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Box 21, Baltimore, MD 21224, USA
Springer Semin Immunopathol 24:23-33. 2002..How telomerase is regulated and its precise role in lymphocytes is not fully understood. The recent progress in characterizing regulation of telomerase expression in human lymphocytes is discussed... - Stable telomere length and telomerase expression from naïve to memory B-lymphocyte differentiationNi Huiping Son
Laboratory of Immunology, National Institute on Aging, NIH, Baltimore, MD, USA
Mech Ageing Dev 124:427-32. 2003..Together, these findings suggest that B cells are capable of maintaining telomere length during differentiation from naïve to memory B cells and this ability is maintained through age... - Kinetic assessment of general gene expression changes during human naive CD4+ T cell activationKrista Hess
Laboratory of Immunology, National Institutes on Aging, National Institute of Health, Baltimore, MD 21224, USA
Int Immunol 16:1711-21. 2004.... - Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T-cell agingMonchou Fann
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Immunol Rev 205:190-206. 2005..Our analysis provides the gene expression portraits of CD28(null) memory phenotype CD8(+) T cells and alteration from their CD28(+) counterparts and suggests potential mechanisms of T-cell aging... - Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8(+) T-cell responseMonchou Fann
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Blood 108:3363-70. 2006..Together, these findings suggest that differential gene expression mediated at least in part by histone H3K9 hyperacetylation may be responsible for the rapid and robust memory CD8(+) T-cell response... - Generation and growth of CD28nullCD8+ memory T cells mediated by IL-15 and its induced cytokinesWai Kan Chiu
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
J Immunol 177:7802-10. 2006.... - SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulationCris Kamperschroer
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 181:3994-4003. 2008..Instead, SAP is necessary for very late stages of differentiation or, most likely, for allowing Th cells to communicate during cognate T:B interactions... - CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenzaSusan L Swain
Trudeau Institute, Saranac Lake, NY 12983, USA
Immunol Rev 211:8-22. 2006....