Nan Ping Weng

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Analysis of telomere length and telomerase activity
    Karen S Hathcock
    National Cancer Institute NIH, Bethesda, MD, USA
    Curr Protoc Immunol . 2004
  2. pmc T cell aging: a review of the transcriptional changes determined from genome-wide analysis
    Guobing Chen
    Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health Baltimore, MD, USA
    Front Immunol 4:121. 2013
  3. ncbi request reprint Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging
    N P Weng
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Immunol Rev 160:43-54. 1997
  4. ncbi request reprint IL-15 is a growth factor and an activator of CD8 memory T cells
    Nan Ping Weng
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 975:46-56. 2002
  5. ncbi request reprint Interplay between telomere length and telomerase in human leukocyte differentiation and aging
    N Weng
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Leukoc Biol 70:861-7. 2001
  6. pmc IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells
    Kebin Liu
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 99:6192-7. 2002
  7. ncbi request reprint Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T-cell aging
    Monchou Fann
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Immunol Rev 205:190-206. 2005
  8. pmc Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8(+) T-cell response
    Monchou Fann
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Blood 108:3363-70. 2006
  9. ncbi request reprint Kinetic assessment of general gene expression changes during human naive CD4+ T cell activation
    Krista Hess
    Laboratory of Immunology, National Institutes on Aging, National Institute of Health, Baltimore, MD 21224, USA
    Int Immunol 16:1711-21. 2004
  10. ncbi request reprint Telomeres in T and B cells
    Richard J Hodes
    National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 2:699-706. 2002

Collaborators

Detail Information

Publications34

  1. doi request reprint Analysis of telomere length and telomerase activity
    Karen S Hathcock
    National Cancer Institute NIH, Bethesda, MD, USA
    Curr Protoc Immunol . 2004
    ..This unit describes methods that are used for the measurement of telomere length and telomerase activity in human and murine cells...
  2. pmc T cell aging: a review of the transcriptional changes determined from genome-wide analysis
    Guobing Chen
    Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health Baltimore, MD, USA
    Front Immunol 4:121. 2013
    ..We also discuss future direction for furthering the understanding of the molecular basis of gene expression alterations in aged T cells, which could potentially provide opportunities for gene-based clinical interventions...
  3. ncbi request reprint Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging
    N P Weng
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Immunol Rev 160:43-54. 1997
    ..The future study of telomerase and its regulation of telomere length may enhance our understanding of how the replicative lifespan is regulated in lymphocytes...
  4. ncbi request reprint IL-15 is a growth factor and an activator of CD8 memory T cells
    Nan Ping Weng
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 975:46-56. 2002
    ..These findings indicate that IL-15 is not only a growth factor but also an antigen-independent activator for CD8 memory T cells...
  5. ncbi request reprint Interplay between telomere length and telomerase in human leukocyte differentiation and aging
    N Weng
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Leukoc Biol 70:861-7. 2001
    ..In addition, I will attempt to shed new light on the roles of telomere and telomerase in leukocyte function and potential clinical interventions...
  6. pmc IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells
    Kebin Liu
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 99:6192-7. 2002
    ..Thus, IL-15 acts not only as a crucial growth factor but also as an antigen-independent activator of effector functions for CD8(+) memory T cells...
  7. ncbi request reprint Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T-cell aging
    Monchou Fann
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Immunol Rev 205:190-206. 2005
    ..Our analysis provides the gene expression portraits of CD28(null) memory phenotype CD8(+) T cells and alteration from their CD28(+) counterparts and suggests potential mechanisms of T-cell aging...
  8. pmc Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8(+) T-cell response
    Monchou Fann
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Blood 108:3363-70. 2006
    ..Together, these findings suggest that differential gene expression mediated at least in part by histone H3K9 hyperacetylation may be responsible for the rapid and robust memory CD8(+) T-cell response...
  9. ncbi request reprint Kinetic assessment of general gene expression changes during human naive CD4+ T cell activation
    Krista Hess
    Laboratory of Immunology, National Institutes on Aging, National Institute of Health, Baltimore, MD 21224, USA
    Int Immunol 16:1711-21. 2004
    ....
  10. ncbi request reprint Telomeres in T and B cells
    Richard J Hodes
    National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 2:699-706. 2002
    ..This article describes our current understanding of telomere-length regulation in lymphocytes and its implications for immune function...
  11. pmc IL-21 preferentially enhances IL-15-mediated homeostatic proliferation of human CD28+ CD8 memory T cells throughout the adult age span
    Huy Nguyen
    National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Leukoc Biol 87:43-9. 2010
    ..Together, these findings suggest that IL-21 enhances IL-15-mediated proliferation of CD8 memory T cells, particularly CD28(+) memory T cells, and also serves as an antagonist to the IL-15-induced increase of CD28(-) CD8 T cells...
  12. pmc Gene expression and generation of CD28-CD8 T cells mediated by interleukin 15
    Jason Godlove
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Exp Gerontol 42:412-5. 2007
    ..Together, these findings provide the gene expression features of CD28(-)CD8 T cells that differ from their CD28(+) counterparts and suggest a possible role of IL-15 in the increase of CD28(-)CD8 T cells that occurs with aging...
  13. ncbi request reprint IL-15 activates telomerase and minimizes telomere loss and may preserve the replicative life span of memory CD8+ T cells in vitro
    Yu Li
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Immunol 174:4019-24. 2005
    ..These findings suggest that IL-15 activates stable telomerase expression and compensates telomere loss in memory phenotype CD8(+) T cells, and that telomerase may play an important role in memory CD8(+) T cell homeostasis...
  14. pmc Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B)
    Yasuto Araki
    Laboratory of Immunology and Flow Cytometry Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Immunol 180:8102-8. 2008
    ..Thus, epigenetic changes mediated via histone acetylation may provide a chromatin "memory" for the rapid and robust transcriptional response of memory CD8 T cells...
  15. pmc Krüppel-like factor 4 regulates B cell number and activation-induced B cell proliferation
    Jettanong Klaewsongkram
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Immunol 179:4679-84. 2007
    ..These findings demonstrate that Klf4 regulates B cell number and activation-induced B cell proliferation through directly acting on the promoter of cyclin D2...
  16. pmc Peptide library-based evaluation of T-cell receptor breadth detects defects in global and regulatory activation in human immunologic diseases
    John S Barber
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 110:8164-9. 2013
    ..These findings provide unique insight into the pathophysiology and functional consequences of abnormal T-cell repertoires and into differentiation of human naive T-cells...
  17. pmc Telomerase is involved in IL-7-mediated differential survival of naive and memory CD4+ T cells
    Yinhua Yang
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Immunol 180:3775-81. 2008
    ..Together, these findings demonstrate that telomerase is involved in IL-7-mediated differential survival of naive and memory CD4(+) T cells...
  18. pmc Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer's disease patients
    Amanda K Damjanovic
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Immunol 179:4249-54. 2007
    ..These findings demonstrate that chronic stress is associated with altered T cell function and accelerated immune cell aging as suggested by excessive telomere loss...
  19. ncbi request reprint Regulation of telomerase expression in human lymphocytes
    Nan Ping Weng
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Box 21, Baltimore, MD 21224, USA
    Springer Semin Immunopathol 24:23-33. 2002
    ..How telomerase is regulated and its precise role in lymphocytes is not fully understood. The recent progress in characterizing regulation of telomerase expression in human lymphocytes is discussed...
  20. ncbi request reprint Stable telomere length and telomerase expression from naïve to memory B-lymphocyte differentiation
    Ni Huiping Son
    Laboratory of Immunology, National Institute on Aging, NIH, Baltimore, MD, USA
    Mech Ageing Dev 124:427-32. 2003
    ..Together, these findings suggest that B cells are capable of maintaining telomere length during differentiation from naïve to memory B cells and this ability is maintained through age...
  21. pmc Themis, a T cell-specific protein important for late thymocyte development
    Renaud Lesourne
    Laboratory of Mammalian Genes and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Nat Immunol 10:840-7. 2009
    ..Our results identify Themis as a critical component of the T cell developmental program and suggest that Themis functions to sustain and/or integrate signals required for proper lineage commitment and maturation...
  22. pmc Telomere and adaptive immunity
    Nan Ping Weng
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, United States
    Mech Ageing Dev 129:60-6. 2008
    ..Here I will review the recent progress of the role of telomeres and telomerase in lymphocyte differentiation, function, and aging...
  23. pmc Generation and growth of CD28nullCD8+ memory T cells mediated by IL-15 and its induced cytokines
    Wai Kan Chiu
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Immunol 177:7802-10. 2006
    ....
  24. ncbi request reprint Telomere length and the expression of natural telomeric genes in human fibroblasts
    Yi Ning
    Department of Pathology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Hum Mol Genet 12:1329-36. 2003
    ..These results suggest that the expression of natural telomeric genes may be influenced by alteration of local heterochromatin structure...
  25. pmc CD28(-) T cells: their role in the age-associated decline of immune function
    Nan Ping Weng
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Trends Immunol 30:306-12. 2009
    ..Here we review recent advances in our understanding of CD28(-) T cells and their role in the age-associated decline of immune function...
  26. pmc Aging of the immune system: how much can the adaptive immune system adapt?
    Nan Ping Weng
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Immunity 24:495-9. 2006
    ..Here I discuss the recent progress on age-associated changes in lymphocytes and their effect on the adaptive immune system...
  27. doi request reprint The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation
    Nan Ping Weng
    Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Nat Rev Immunol 12:306-15. 2012
    ....
  28. pmc Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells
    Yasuto Araki
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Immunity 30:912-25. 2009
    ..Our findings reveal a complex regulation by histone methylation in differential gene expression and suggest that histone methylation may be responsible for memory CD8(+) T cell function...
  29. ncbi request reprint A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78
    Yongquan Luo
    Laboratory of Immunology, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
    J Neurochem 80:354-61. 2002
    ..Interaction of NLK with gp78 and subsequent signaling may strengthen synaptic mechanisms underlying learning and memory formation...
  30. pmc Telomeres and immune competency
    Nan Ping Weng
    Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, 251 Bayview Blvd, Suite 100, Baltimore, MD 21224, USA
    Curr Opin Immunol 24:470-5. 2012
    ..Here, I review recent studies of telomere length dynamics with particular relevance to immune function...
  31. doi request reprint Analyzing the phenotypic and functional complexity of lymphocytes using CyTOF (cytometry by time-of-flight)
    Guobing Chen
    Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Cell Mol Immunol 9:322-3. 2012
  32. pmc Rapid default transition of CD4 T cell effectors to functional memory cells
    K Kai McKinstry
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 204:2199-211. 2007
    ....
  33. pmc SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulation
    Cris Kamperschroer
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 181:3994-4003. 2008
    ..Instead, SAP is necessary for very late stages of differentiation or, most likely, for allowing Th cells to communicate during cognate T:B interactions...
  34. pmc CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza
    Susan L Swain
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Rev 211:8-22. 2006
    ....