J R Wendland

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeys
    Timothy K Newman
    Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20852, USA
    Biol Psychiatry 57:167-72. 2005
  2. ncbi request reprint Differential functional variability of serotonin transporter and monoamine oxidase a genes in macaque species displaying contrasting levels of aggression-related behavior
    Jens R Wendland
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, 97080, Wurzburg, Germany
    Behav Genet 36:163-72. 2006
  3. ncbi request reprint A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder
    Jens R Wendland
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 17:717-23. 2008
  4. pmc A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder
    Jens R Wendland
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 66:408-16. 2009
  5. ncbi request reprint Structural variation of the monoamine oxidase A gene promoter repeat polymorphism in nonhuman primates
    J R Wendland
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Genes Brain Behav 5:40-5. 2006
  6. ncbi request reprint A large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder
    Jens R Wendland
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 32:2543-51. 2007
  7. pmc How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems
    Dennis L Murphy
    Laboratory of Clinical Science, NIMH Intramural Research Program, NIH, Building 10, Room 3D41, 10 Center Drive, MSC 1264, Bethesda, MD 20892, USA
    Neuropharmacology 55:932-60. 2008
  8. pmc Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice
    Pablo R Moya
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    BMC Pharmacol 11:3. 2011
  9. pmc Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1
    Francis J McMahon
    Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 42:128-31. 2010
  10. ncbi request reprint A pharmacological analysis of mice with a targeted disruption of the serotonin transporter
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Building 10, Room 3D41, Bethesda, MD 20892, USA
    Psychopharmacology (Berl) 195:147-66. 2007

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeys
    Timothy K Newman
    Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20852, USA
    Biol Psychiatry 57:167-72. 2005
    ..We tested the hypothesis that a repeat polymorphism in the rhesus macaque MAOA gene promoter region influences aggressive behavior in male subjects...
  2. ncbi request reprint Differential functional variability of serotonin transporter and monoamine oxidase a genes in macaque species displaying contrasting levels of aggression-related behavior
    Jens R Wendland
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, 97080, Wurzburg, Germany
    Behav Genet 36:163-72. 2006
    ..Taken together, these findings suggest that genetic variation of serotonergic neurotransmission may play an important role in determining inter-species differences in aggression related behavior in macaques...
  3. ncbi request reprint A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder
    Jens R Wendland
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 17:717-23. 2008
    ..Our results contribute to a better understanding of SLC6A4 expression genetics and provide a functional haplotype framework for future serotonin-related studies...
  4. pmc A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder
    Jens R Wendland
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 66:408-16. 2009
    ..Recent evidence from linkage analyses and follow-up candidate gene studies supports the involvement of SLC1A1, which encodes the neuronal glutamate transporter, in the development of obsessive-compulsive disorder (OCD)...
  5. ncbi request reprint Structural variation of the monoamine oxidase A gene promoter repeat polymorphism in nonhuman primates
    J R Wendland
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Genes Brain Behav 5:40-5. 2006
    ....
  6. ncbi request reprint A large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder
    Jens R Wendland
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 32:2543-51. 2007
    ....
  7. pmc How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems
    Dennis L Murphy
    Laboratory of Clinical Science, NIMH Intramural Research Program, NIH, Building 10, Room 3D41, 10 Center Drive, MSC 1264, Bethesda, MD 20892, USA
    Neuropharmacology 55:932-60. 2008
    ..We provide in-depth examples of gene-based discoveries primarily related to SLC6A4 that have clarified serotonin's many important homeostatic functions in humans, non-human primates, mice and other species...
  8. pmc Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice
    Pablo R Moya
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    BMC Pharmacol 11:3. 2011
    ..In this study, we determined the responsiveness of 5-HT2CR in serotonin transporter (SERT) knockout (-/-) mice, a model characterized by increased anxiety-like and stress-responsive behaviors...
  9. pmc Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1
    Francis J McMahon
    Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 42:128-31. 2010
    ..83-0.92), with supportive evidence for association observed in two out of three independent replication cohorts. These results provide an example of a shared genetic susceptibility locus for bipolar disorder and MDD...
  10. ncbi request reprint A pharmacological analysis of mice with a targeted disruption of the serotonin transporter
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Building 10, Room 3D41, Bethesda, MD 20892, USA
    Psychopharmacology (Berl) 195:147-66. 2007
    ..Partial or complete ablation of serotonin transporter (SERT) expression in mice leads to altered responses to serotonin receptor agonists and other classes of drugs...
  11. ncbi request reprint Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder
    D T Chen
    Human Genetics Branch, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Mol Psychiatry 18:195-205. 2013
    ..Further studies are needed to replicate these findings and may potentially lead to identification of functional variants. Sample size will remain a limiting factor in the discovery of common alleles associated with BD...
  12. doi request reprint SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder
    Jens R Wendland
    Laboratory of Clinical Science, Mood and Anxiety Disorders Program, NIMH, NIH, Bethesda, Maryland 20892 1264, USA
    Psychiatr Genet 18:31-9. 2008
    ....
  13. pmc Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling
    Min Huei Liang
    Molecular Neurobiology Section, National Institute of Mental Health, National Institutes of Health, 10 Center Dr MSC 1363, Bethesda, MD, USA
    Mol Cell Neurosci 37:440-53. 2008
    ..Therapeutic implications of our findings are discussed...
  14. pmc Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation
    Zoya Marinova
    Molecular Neurobiology Section, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1363, USA
    J Neurochem 111:976-87. 2009
    ....
  15. ncbi request reprint No overlap of sensitivity to capsaicin and expression of galanin in rat dorsal root ganglion neurons after axotomy
    Jens R Wendland
    Department of Physiology, University of Wurzburg, Roentgenring 9, 97070 Wurzburg, Germany
    Exp Brain Res 153:1-6. 2003
    ....