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Species | T E WellemsSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Genome projects, genetic analysis, and the changing landscape of malaria researchT E Wellems
Malaria Genetics Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, 4 Center Drive, MSC 0425, Bethesda, MD 20892 0425, USA
Curr Opin Microbiol 2:415-9. 1999..The genetic blueprint of P. falciparum will ultimately need to be understood at multiple levels of an integrated system and will provide a detailed account of the life processes of the parasite and of the devastating disease it causes...- Plasmodium chloroquine resistance and the search for a replacement antimalarial drugThomas E Wellems
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
Science 298:124-6. 2002..Drug discovery initiatives are finding new leads that have favorable pharmaceutical properties and efficacy against chloroquine-resistant malaria... - Chloroquine-resistant malariaT E Wellems
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Infect Dis 184:770-6. 2001..Investigation of the resistance mechanisms and of the role of immunity in therapeutic outcomes will support new approaches to drugs that can take the place of chloroquine or augment its efficiency... - Conservation of a novel vacuolar transporter in Plasmodium species and its central role in chloroquine resistance of P. falciparumJ M Carlton
National Center for Biotechnology Research, National Library of Medicine, National Institutes of Health, Building 45, 45 Center Drive, Bethesda, MD 20892-6510, USA
Curr Opin Microbiol 4:415-20. 2001..vivax gene. This is consistent with lines of evidence that suggest alternative mechanisms of chloroquine resistance among various malaria parasite species... - Dissecting the loci of low-level quinine resistance in malaria parasitesMichael T Ferdig
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, NIH Campus, Bethesda, MD 20892-0425, USA
Mol Microbiol 52:985-97. 2004..Dissection of the genes and modifiers involved in QN response will require experimental strategies that can evaluate multiple genes from different chromosomes in combination... 
Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquineJuliana Martha Sá
Laboratory of Malaria and Vector Research and Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:18883-9. 2009..Increasing use of AQ in Africa poses the threat of a selective sweep of highly AQ-resistant, CQ-resistant parasites with pfcrt and pfmdr1 mutations that are as advantaged and persistent as in South America...- Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRTBronwen Naudé
Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, Maryland 20892 8132, USA
J Biol Chem 280:25596-603. 2005..Transformed D. discoideum will be useful for further studies of the chloroquine resistance mechanism and may assist in the development and evaluation of new antimalarial drugs... - Two worlds of malariaThomas E Wellems
National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
N Engl J Med 349:1496-8. 2003 - Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparumRoland A Cooper
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Pharmacol 61:35-42. 2002..The various mutations that have now been documented at PfCRT position 76 (K76T, K76N, K76I) suggest that the loss of lysine is central to the CQR mechanism... - Genetic linkage and association analyses for trait mapping in Plasmodium falciparumXinzhuan Su
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike Bethesda, Maryland 20892 8132, USA
Nat Rev Genet 8:497-506. 2007..Rapidly increasing genetic and genomic information on Plasmodium parasites, mosquitoes and humans will combine as a rich resource for new advances in our understanding of malaria, its transmission and its manifestations of disease... - The impact of malaria parasitism: from corpuscles to communitiesThomas E Wellems
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 8132, USA
J Clin Invest 119:2496-505. 2009..Advances in genetics and genomics are providing fresh insights into the nature of these evolutionary adaptations, processes of parasite transmission and infection, and the difficult challenges of malaria control... - Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparumJing Yuan
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
Nat Chem Biol 5:765-71. 2009..This study identifies new leads for antimalarial drugs and demonstrates the utility of a high-throughput chemical genomic strategy for studying malaria traits... - PfCG2, a Plasmodium falciparum protein peripherally associated with the parasitophorous vacuolar membrane, is expressed in the period of maximum hemoglobin uptake and digestion by trophozoitesRoland A Cooper
Laboratory of Malaria and Vector Research, Twinbrook III, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8132, USA
Mol Biochem Parasitol 144:167-76. 2005..PfCG2 interacts with erythrocyte cytoplasm and may be associated with processes of hemoglobin uptake and digestion by erythrocytic-stage parasites... - Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugsJianbing Mu
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, Maryland, USA
Nat Genet 42:268-71. 2010..Parasite half-maximum inhibitory concentrations for seven antimalarial drugs were obtained and used in GWAS to identify genes associated with drug responses. This study provides valuable tools and insight into the P. falciparum genome... - Plasmodium biology: genomic gleaningsL Aravind
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Cell 115:771-85. 2003..Plasmodium possesses many cell surface molecules with "animal-like" adhesion modules. Potential genetic footprints of the ancestral eukaryotic algal precursor of the apicoplast are also detectable in its genome... - Malaria. Cooperative silencing elements in var genesK W Deitsch
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0425, USA
Nature 412:875-6. 2001..This finding should help to clarify the mechanisms by which parasites coordinate the silencing and activation of var genes that are responsible for antigenic variation in malaria... - Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malariaT Nomura
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
J Infect Dis 183:1653-61. 2001..vivax gene. This is evidence that the molecular events underlying P. vivax CQR differ from those in P. falciparum... - Modulation of malaria virulence by determinants of Plasmodium falciparum erythrocyte membrane protein-1 displayRick M Fairhurst
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20852-8132, USA
Curr Opin Hematol 13:124-30. 2006..Clinical interventions aimed at reducing cytoadherence and microvascular inflammation may improve disease outcome... - Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasionKaren Hayton
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 8132, USA
Cell Host Microbe 4:40-51. 2008..nancymaae erythrocytes. Our results also suggest that PfRH5 is a parasite ligand for human infection, and that amino acid substitutions can cause its binding domain to recognize different human erythrocyte surface receptors... - Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malariaRick M Fairhurst
Laboratory of Malaria and Vector Research, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 435:1117-21. 2005..Haemoglobin C might protect against malaria by reducing PfEMP-1-mediated adherence of parasitized erythrocytes, thereby mitigating the effects of their sequestration in the microvasculature... - Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin SA Agarwal
National Institute of Allergy and Infectious Diseases and the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Blood 96:2358-63. 2000..The data also suggest that the protective effect associated with HbC may be greater than that of HbS in this population... - Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobinRushina Cholera
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 105:991-6. 2008..Coinherited hemoglobin polymorphisms and naturally acquired antibodies to PfEMP-1 may influence the degree of malaria protection in AS children by further weakening cytoadherence interactions... - Disruption of a Plasmodium falciparum gene linked to male sexual development causes early arrest in gametocytogenesisTetsuya Furuya
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8132, USA
Proc Natl Acad Sci U S A 102:16813-8. 2005..Mosquito infectivity of the knockout parasites was also greatly reduced but not completely lost. The results suggest that pfmdv-1 plays a key role in gametocyte membrane formation and integrity... - Hemoglobin C modulates the surface topography of Plasmodium falciparum-infected erythrocytesTakayuki Arie
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
J Struct Biol 150:163-9. 2005..These data support a model in which large knobs and their aggregates are promoted by hemoglobin C, reducing the adherence of parasitized erythrocytes in the microvasculature and ameliorating the severity of a malaria infection... - Band 3 modifications in Plasmodium falciparum-infected AA and CC erythrocytes assayed by autocorrelation analysis using quantum dotsFuyuki Tokumasu
Biochemical and Biophysical Parasitology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8132, USA
J Cell Sci 118:1091-8. 2005..Increased band 3 clustering may enhance recognition sites for autoantibodies, which could contribute to the protective effect of hemoglobin C against malaria... - Case report: life-threatening hypoglycaemia associated with sulfadoxine-pyrimethamine, a commonly used antimalarial drugR M Fairhurst
Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Trans R Soc Trop Med Hyg 97:595-6. 2003..In this report, we present a case of hypoglycaemic coma associated with SP, an adverse reaction that is likely to be underreported and expected to occur with greater frequency as the use of SP increases... - Plasmodium falciparum var genes are regulated by two regions with separate promoters, one upstream of the coding region and a second within the intronMichael S Calderwood
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 278:34125-32. 2003..These findings suggest that interactions between the regions of these two promoters and the generation of the sterile transcripts play a significant role in regulating var gene expression... - Aberrant development of Plasmodium falciparum in hemoglobin CC red cells: implications for the malaria protective effect of the homozygous stateRick M Fairhurst
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 101:3309-15. 2003.... - A silenced Plasmodium falciparum var promoter can be activated in vivo through spontaneous deletion of a silencing element in the intronLaila Gannoun-Zaki
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8132, USA
Eukaryot Cell 4:490-2. 2005..The resulting promoter activation does not affect the transcription of chromosomal var genes... - Mechanisms underlying mutually exclusive expression of virulence genes by malaria parasitesRon Dzikowski
Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, Box 62, New York, New York 10021, USA
EMBO Rep 8:959-65. 2007.... - Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidineRoland A Cooper
Department of Biological Sciences, Old Dominion University, Norfolk, VA 23529, USA
Mol Microbiol 63:270-82. 2007..Charge-affecting mutations within these segments may affect the ability of PfCRT to bind different quinoline drugs and determine their net accumulation in the DV... - Expression and function of pvcrt-o, a Plasmodium vivax ortholog of pfcrt, in Plasmodium falciparum and Dictyostelium discoideumJuliana Martha Sá
Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Av Lineu Prestes 1374, Sao Paulo 05508 900, SP, Brazil
Mol Biochem Parasitol 150:219-28. 2006..Our data support an effect of PvCRT-o on chloroquine transport and/or accumulation by P. vivax, independent of the K76T amino acid substitution... - Decreased prevalence of the Plasmodium falciparum chloroquine resistance transporter 76T marker associated with cessation of chloroquine use against P. falciparum malaria in Hainan, People's Republic of ChinaXinhua Wang
Tropical Medicine Institute, Guangzhou University of Traditional Chinese Medicine, Guangzhou, People s Republic of China
Am J Trop Med Hyg 72:410-4. 2005..Monitoring for continued decreases will provide valuable information for future drug-use policies in China... - Clearance of drug-resistant parasites as a model for protective immunity in Plasmodium falciparum malariaAbdoulaye A Djimde
Bandiagara Malaria Project, Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali
Am J Trop Med Hyg 69:558-63. 2003..Age-adjusted comparison of subjects able to clear resistant parasites and those unable to do so provides a new phenotype for identifying host immune and genetic factors responsible for protective immunity against malaria... - Plasmodium vivax: allele variants of the mdr1 gene do not associate with chloroquine resistance among isolates from Brazil, Papua, and monkey-adapted strainsJuliana Martha Sá
Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Av Lineu Prestes 1374, Sao Paulo SP, 05508 900, Brazil
Exp Parasitol 109:256-9. 2005..Similarity and dendrogram analyses revealed that sequences could be grouped according to their geographical origin. Within each geographical group however, no correlation was found between chloroquine resistance and specific mutations... - Transporter of a malaria catastropheThomas E Wellems
Nat Med 10:1169-71. 2004 - X-linked G6PD deficiency protects hemizygous males but not heterozygous females against severe malariaAldiouma Guindo
Malaria Research and Training Center, Faculty of Medicine, Pharmacy, and Odontostomatology, University of Bamako, Mali
PLoS Med 4:e66. 2007..These proposals are paradoxical, and they are not consistent with currently hypothesized mechanisms of protection... - Malaria-protective traits at odds in Africa?Thomas E Wellems
Nat Genet 37:1160-2. 2005 - Community permission for medical research in developing countriesDapa A Diallo
Department of Hematology, Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Mali
Clin Infect Dis 41:255-9. 2005..Far from competing with the individual informed consent process, the process of obtaining community permission both initiated and facilitated the process of disclosure for individual informed consent... - A comparison of anemia in hemoglobin C and normal hemoglobin A children with Plasmodium falciparum malariaDapa A Diallo
, University of Bamako, Bamako, Mali
Acta Trop 90:295-9. 2004..By this measure, HbC, a malaria-protective polymorphism with few deleterious consequences, does not appear to be associated with more frequent anemia than normal HbA in episodes of uncomplicated P. falciparum malaria...