Daniel R Weinberger

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry: what is happening in the schizophrenic brain?
    Daniel R Weinberger
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Dr, Bldg 10, Room 3C 101, MSC 1255, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 59:553-8. 2002
  2. ncbi request reprint Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation
    Emily M Drabant
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 63:1396-406. 2006
  3. ncbi request reprint Effect of catechol-O-methyltransferase val158met genotype on attentional control
    Giuseppe Blasi
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 25:5038-45. 2005
  4. pmc Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic risk
    Roberta Rasetti
    Genes, Cognition, and Psychosis Program, IRP, NIMH, NIH, Rm 4S 235, 10 Center Dr, Bethesda, MD 20892, USA
    Am J Psychiatry 166:216-25. 2009
  5. doi request reprint Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls
    Kristin K Nicodemus
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 67:991-1001. 2010
  6. ncbi request reprint Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia
    Kristin K Nicodemus
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD 20892, USA
    Hum Genet 120:889-906. 2007
  7. pmc Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability
    Aaron L Goldman
    Neuroimaging Core Facility, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Arch Gen Psychiatry 66:467-77. 2009
  8. pmc No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expression
    Heike Tost
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1379, USA
    Biol Psychiatry 68:105-7. 2010
  9. ncbi request reprint The G72/G30 gene complex and cognitive abnormalities in schizophrenia
    Terry E Goldberg
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD, USA
    Neuropsychopharmacology 31:2022-32. 2006
  10. pmc Is gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblings
    Robyn A Honea
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1364, USA
    Biol Psychiatry 63:465-74. 2008

Detail Information

Publications117 found, 100 shown here

  1. ncbi request reprint Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry: what is happening in the schizophrenic brain?
    Daniel R Weinberger
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Dr, Bldg 10, Room 3C 101, MSC 1255, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 59:553-8. 2002
  2. ncbi request reprint Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation
    Emily M Drabant
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 63:1396-406. 2006
    ....
  3. ncbi request reprint Effect of catechol-O-methyltransferase val158met genotype on attentional control
    Giuseppe Blasi
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 25:5038-45. 2005
    ..These results indicate that met allele load and presumably enhanced dopaminergic tone improve the "efficiency" of local circuit processing within the cingulate cortex and thereby its function during AC...
  4. pmc Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic risk
    Roberta Rasetti
    Genes, Cognition, and Psychosis Program, IRP, NIMH, NIH, Rm 4S 235, 10 Center Dr, Bethesda, MD 20892, USA
    Am J Psychiatry 166:216-25. 2009
    ..The purpose of the present study was to examine amygdala response to threatening faces among healthy siblings of schizophrenia patients in whom a subtler heritable deficit might be observed...
  5. doi request reprint Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls
    Kristin K Nicodemus
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 67:991-1001. 2010
    ..NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis...
  6. ncbi request reprint Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia
    Kristin K Nicodemus
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD 20892, USA
    Hum Genet 120:889-906. 2007
    ..In addition, we were able to replicate other studies, including allelic directionality. The use of epistatic models may improve replication of psychiatric candidate gene studies...
  7. pmc Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability
    Aaron L Goldman
    Neuroimaging Core Facility, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Arch Gen Psychiatry 66:467-77. 2009
    ..To our knowledge, cortical thickness, a measure of particular interest in schizophrenia, has not previously been evaluated in terms of its heritability in relationship to risk for schizophrenia...
  8. pmc No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expression
    Heike Tost
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1379, USA
    Biol Psychiatry 68:105-7. 2010
    ..In the largest neuroimaging intermediate phenotype study reported so far, we evaluated the effect of rs7341475 on an extended array of different neuroscientific measures...
  9. ncbi request reprint The G72/G30 gene complex and cognitive abnormalities in schizophrenia
    Terry E Goldberg
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD, USA
    Neuropsychopharmacology 31:2022-32. 2006
    ..We present evidence that SNP variations in the G72 gene region increase risk of cognitive impairment in schizophrenia. SNP variations were not strongly associated with clinical diagnosis in family-based analyses...
  10. pmc Is gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblings
    Robyn A Honea
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1364, USA
    Biol Psychiatry 63:465-74. 2008
    ..We sought to discover previously unidentified gray matter volume differences in patients with schizophrenia and their siblings with optimized voxel-based morphometry...
  11. ncbi request reprint Prefrontal broadband noise, working memory, and genetic risk for schizophrenia
    Georg Winterer
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Am J Psychiatry 161:490-500. 2004
    ..In the present study, the authors explored whether this particular physiological abnormality predicts working memory performance and is related to the genetic risk for schizophrenia...
  12. pmc Age-related alterations in default mode network: impact on working memory performance
    Fabio Sambataro
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Neurobiol Aging 31:839-52. 2010
    ..These changes may be a reflection of a deficit in cognitive control associated with advancing age that results in deficient resource allocation to the task at hand...
  13. ncbi request reprint 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
    Lukas Pezawas
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
    Nat Neurosci 8:828-34. 2005
    ....
  14. pmc Genetic modulation of GABA levels in the anterior cingulate cortex by GAD1 and COMT
    Stefano Marenco
    Clinical Brain Disorders Branch, GCAP, IRP, NIMH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 35:1708-17. 2010
    ..The directionality of the effects, however, is inconsistent with earlier evidence of decreased GABA activity in schizophrenia...
  15. doi request reprint Evidence of sex-modulated association of ZNF804A with schizophrenia
    Fengyu Zhang
    Genes, Cognition and Psychosis Program and Clinical, Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 69:914-7. 2011
    ..A recent candidate gene study, which replicated the positive association with rs1344706, identified another positive SNP (rs7597593) in ZNF804A associated with schizophrenia...
  16. pmc Neural correlates of probabilistic category learning in patients with schizophrenia
    Thomas W Weickert
    Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 29:1244-54. 2009
    ....
  17. ncbi request reprint Brain regions underlying response inhibition and interference monitoring and suppression
    Giuseppe Blasi
    CBDB, GCAP, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Bethesda, MD 20982 1379, USA
    Eur J Neurosci 23:1658-64. 2006
    ..These results extend previous findings by suggesting regional functional specialization within a cortical network supporting cognitive control...
  18. ncbi request reprint Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs
    Barbara K Lipska
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Hum Mol Genet 15:1245-58. 2006
    ..Although, many other DISC1 binding partners still need to be investigated, these data implicate genetically linked abnormalities in the DISC1 molecular pathway in the pathophysiology of schizophrenia...
  19. ncbi request reprint Allelic variation in RGS4 impacts functional and structural connectivity in the human brain
    Joshua W Buckholtz
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1364, USA
    J Neurosci 27:1584-93. 2007
    ..These findings suggest mechanisms in brain for the association of RGS4 with risk for psychiatric illness...
  20. ncbi request reprint Heritability of brain morphology related to schizophrenia: a large-scale automated magnetic resonance imaging segmentation study
    Aaron L Goldman
    Neuroimaging Core Facility, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 63:475-83. 2008
    ..Currently available data on the heritability of these structural changes are inconsistent...
  21. ncbi request reprint RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activity
    Barbara K Lipska
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute for Mental Health, NIH, DHHS, Bethesda, MD 20892 1385, USA
    Hum Mol Genet 15:2804-12. 2006
    ..These data suggest that RGS4 mRNA expression is associated with cortical dopamine signaling and illustrate the importance of genetic and/or environmental background in gene expression studies in schizophrenia...
  22. pmc Age-related alterations in simple declarative memory and the effect of negative stimulus valence
    Vishnu P Murty
    National Institutes of Health, Bethesda, MD, USA
    J Cogn Neurosci 21:1920-33. 2009
    ....
  23. pmc Catechol-O-methyltransferase valine(158)methionine polymorphism modulates brain networks underlying working memory across adulthood
    Fabio Sambataro
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 66:540-8. 2009
    ....
  24. pmc Catechol-o-methyltransferase valine(158)methionine genotype and resting regional cerebral blood flow in medication-free patients with schizophrenia
    Daniel Paul Eisenberg
    Section on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland 20892 1365, USA
    Biol Psychiatry 67:287-90. 2010
    ..Task-independent effects of this polymorphism in schizophrenia have not yet been characterized...
  25. pmc Transcript-specific associations of SLC12A5 (KCC2) in human prefrontal cortex with development, schizophrenia, and affective disorders
    Ran Tao
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1385, USA
    J Neurosci 32:5216-22. 2012
    ..Alternate transcripts from KCC2 may participate in the abnormal GABA signaling in the DLPFC associated with schizophrenia...
  26. ncbi request reprint Prefrontal electrophysiologic "noise" and catechol-O-methyltransferase genotype in schizophrenia
    Georg Winterer
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 60:578-84. 2006
    ....
  27. pmc Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans
    Hao Yang Tan
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 118:2200-8. 2008
    ..These data implicate AKT1 in modulating human prefrontal-striatal structure and function and suggest that the mechanism of this effect may be coupled to dopaminergic signaling and relevant to the expression of psychosis...
  28. ncbi request reprint Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory
    Hao Yang Tan
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 27:13393-401. 2007
    ..These findings add to the integration of dopaminergic signaling in basic cortical assemblies with their roles in specific human brain networks during the orchestration of information processing in WM...
  29. ncbi request reprint Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1
    Shiny V Mathew
    Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 1385, USA
    Hum Mol Genet 16:2921-32. 2007
    ..Together, these results suggest that the molecular mechanism of the association between NRG1 risk alleles and schizophrenia may include down-regulation of nAChR alpha7 expression...
  30. ncbi request reprint Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex
    Carlo Colantuoni
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Brain Struct Funct 213:255-71. 2008
    ..All microarray data are available at NCBI's Gene Expression Omnibus: GEO Series accession number GSE11546 (http://www.ncbi.nlm.nih.gov/geo) [corrected]..
  31. pmc Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex
    Stefano Marenco
    Genes and Cognition Program, Clinical Brain Disorders Branch, Intramural Research Program, Bldg 10, Rm 4S235, 10 Center Dr, NIMH, NIH, Bethesda, MD 20892, USA
    Am J Psychiatry 163:740-2. 2006
    ....
  32. ncbi request reprint Instability of prefrontal signal processing in schizophrenia
    Georg Winterer
    Genes, Cognition and Psychosis Program, NIH, NIMH, 10 Center Dr, MSC 1379, Bethesda, MD 20892, USA
    Am J Psychiatry 163:1960-8. 2006
    ....
  33. pmc Genetic variation in CACNA1C affects brain circuitries related to mental illness
    Kristin L Bigos
    Genes, Cognition, and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 67:939-45. 2010
    ..The CACNA1C gene (alpha-1C subunit of the L-type voltage-gated calcium channel) has been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of association has not been explored...
  34. ncbi request reprint Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892 1384, USA
    J Neurosci 23:6690-4. 2003
    ..These data implicate a specific genetic mechanism for substantial normal variation in human declarative memory and suggest that the basic effects of BDNF signaling on hippocampal function in experimental animals are important in humans...
  35. ncbi request reprint Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia
    Terry E Goldberg
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 60:889-96. 2003
    ..Cognitive dysfunction in the working memory domain seems to be under genetic control and is a candidate intermediate phenotype in schizophrenia. Genes that affect working memory processing may contribute to risk for schizophrenia...
  36. ncbi request reprint The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology
    Lukas Pezawas
    Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 24:10099-102. 2004
    ....
  37. ncbi request reprint Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications
    Thomas W Weickert
    National Institutes of Health, National Institute of Mental Health, Clinical Brain Disorders Branch, Building 10, Room 4C 101, MSC 1379, Bethesda, MD 20892, USA
    Biol Psychiatry 56:677-82. 2004
    ..The present study tested the effects of several COMT polymorphisms on the cognitive response to antipsychotic medication in patients with schizophrenia...
  38. ncbi request reprint The neonatal ventral hippocampal lesion model of schizophrenia: effects on dopamine and GABA mRNA markers in the rat midbrain
    Barbara K Lipska
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bldg 10, Rm 4 N306, Bethesda, MD 20892 1385, USA
    Eur J Neurosci 18:3097-104. 2003
    ....
  39. pmc Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia
    Cynthia Shannon Weickert
    MiNDS Unit, Section on Neuropathology, GCAP, NIMH, NIH, Bethesda, MD 20892, USA
    Hum Mol Genet 17:2293-309. 2008
    ..Thus, the variation in the ESR1 gene is associated with schizophrenia and the mechanism of this association may involve alternative gene regulation and transcript processing...
  40. ncbi request reprint Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype
    Andreas Meyer-Lindenberg
    Section on Integrative Neuroimaging, National Institute for Mental Health, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, Maryland 20892 1365, USA
    Nat Neurosci 8:594-6. 2005
    ..These data implicate a dopaminergic tuning mechanism in prefrontal cortex and suggest a systems-level mechanism for cognitive and neuropsychiatric associations with COMT...
  41. ncbi request reprint Altered hippocampal-parahippocampal function during stimulus encoding: a potential indicator of genetic liability for schizophrenia
    Roberta Rasetti
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland
    JAMA Psychiatry 71:236-47. 2014
    ..To elucidate the possible role of genetic risk factors in such findings, it is necessary to study healthy relatives of patients with schizophrenia who carry risk-associated genes but not the confounding factors related to the disorder...
  42. pmc Characteristics of the cation cotransporter NKCC1 in human brain: alternate transcripts, expression in development, and potential relationships to brain function and schizophrenia
    Yukitaka Morita
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, Department of Psychiatry, Hiroshima City Hospital, Hiroshima City, Hiroshima Prefecture, 730 8518, Japan, Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland 21205, Neurodevelopmental and Neuropsychiatric Genetics Laboratory, Departments of Psychiatry and Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, and Departments of Psychiatry, Neurology, Neuroscience and the McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Neurosci 34:4929-40. 2014
    ....
  43. pmc Effect of schizophrenia risk-associated alleles in SREB2 (GPR85) on functional MRI phenotypes in healthy volunteers
    Eugenia Radulescu
    Clinical Brain Disorders Branch, GCAP, IRP, NIMH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 38:341-9. 2013
    ..The findings in females and during the emotional memory paradigm are consistent with modulation by SREB2 of brain circuitries implicated in mood regulation and may be relevant to neuropsychiatric conditions other than schizophrenia...
  44. pmc Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia
    Joseph H Callicott
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:8627-32. 2005
    ....
  45. ncbi request reprint Tolcapone improves cognition and cortical information processing in normal human subjects
    Jose A Apud
    Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20854, USA
    Neuropsychopharmacology 32:1011-20. 2007
    ..Our results are consistent with data from animal studies and from computational models of the effects of selective enhancement of DA signaling in the prefrontal cortex...
  46. doi request reprint Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging
    Kristin K Nicodemus
    Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Genet 127:441-52. 2010
    ....
  47. pmc DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms
    Kenji Nakata
    Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1385, USA
    Proc Natl Acad Sci U S A 106:15873-8. 2009
    ..Our results implicate a molecular mechanism of genetic risk associated with DISC1 involving specific alterations in gene processing...
  48. pmc Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia
    Michael F Egan
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:12604-9. 2004
    ..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia...
  49. doi request reprint Interactive effects of DAOA (G72) and catechol-O-methyltransferase on neurophysiology in prefrontal cortex
    Devon C Nixon
    Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 69:1006-8. 2011
    ....
  50. pmc Effective connectivity of AKT1-mediated dopaminergic working memory networks and pharmacogenetics of anti-dopaminergic treatment
    Hao Yang Tan
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892, USA
    Brain 135:1436-45. 2012
    ..Thus, we suggest that genetic modulation of DRD2-AKT1-related prefrontal-subcortical circuits could at least in part influence cognitive dysfunction in psychosis and its treatment...
  51. ncbi request reprint Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain
    Cynthia Shannon Weickert
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 61:544-55. 2004
    ..3) encodes a neuronal protein that binds to beta-dystrobrevin and may be part of the dystrophin protein complex. Little is known about dysbindin expression in normal or schizophrenic brain...
  52. pmc Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function
    Hao Yang Tan
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:12536-41. 2007
    ..These findings extend putative brain dopaminergic and glutamatergic relationships indexed by COMT and GRM3 to a systems-level interaction in human cortical circuits implicated in working memory dysfunction such as in schizophrenia...
  53. pmc Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models
    Yoshitatsu Sei
    Clinical Brain Disorder Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 5:e10789. 2010
    ....
  54. pmc Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls
    Catherine M Diaz-Asper
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 63:72-9. 2008
    ..Recently, other single nucleotide polymorphisms (SNPs) across the gene have emerged as additional risk factors for schizophrenia: namely rs737865, rs165599, and rs2097603. In a large sample, we examined whether these SNPs affect WM...
  55. ncbi request reprint A susceptibility gene for affective disorders and the response of the human amygdala
    Ahmad R Hariri
    Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 62:146-52. 2005
    ....
  56. doi request reprint Effect of tolcapone on brain activity during a variable attentional control task: a double-blind, placebo-controlled, counter-balanced trial in healthy volunteers
    Sophia C Magalona
    Clinical Brain Disorders Branch CBDB, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bethesda, MD, USA
    CNS Drugs 27:663-73. 2013
    ..The dorsal cingulate (dCC) and prefrontal (PFC) cortices play critical roles in attention. Evidence indicates that catechol-O-methyltransferase (COMT) modulates dopaminergic tone in the PFC and dCC...
  57. pmc Modulatory effects of modafinil on neural circuits regulating emotion and cognition
    Roberta Rasetti
    Clinical Brain Disorders Branch Genes, Cognition, and Psychosis Program, NIMH, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 35:2101-9. 2010
    ....
  58. ncbi request reprint Differentiating allocation of resources and conflict detection within attentional control processing
    Giuseppe Blasi
    National Institute of Mental Health, National Institutes of Health, Bethesda, MA, USA
    Eur J Neurosci 25:594-602. 2007
    ....
  59. pmc Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition
    Andreas Meyer-Lindenberg
    Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, and Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute for Mental Health NIMH, NIH, Bethesda, MD 20892, USA
    J Clin Invest 117:672-82. 2007
    ..Our convergent results identify a prefrontal-neostriatal system affected by variation in PPP1R1B and suggest that DARPP-32 plays a pivotal role in cognitive function and possibly in the pathogenesis of schizophrenia...
  60. pmc Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia
    Thomas M Hyde
    Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:11088-95. 2011
    ..These findings suggest that abnormalities in GABA signaling critical to brain development contribute to genetic risk for schizophrenia...
  61. pmc Investigation of anatomical thalamo-cortical connectivity and FMRI activation in schizophrenia
    Stefano Marenco
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA
    Neuropsychopharmacology 37:499-507. 2012
    ..These results suggest that thalamocortical connectivity to the LPFC is altered in schizophrenia with functional consequences on working memory processing in LPFC...
  62. doi request reprint Verbal and visual memory: characterizing the clinical and intermediate phenotype in schizophrenia
    Shayna L Skelley
    Clinical Brain Disorders Branch, 10 Center Drive, MSC 1379, National Institute of Mental Health NIH, Bethesda, MD 20892, USA
    Schizophr Res 105:78-85. 2008
    ..Schizophr Bull, 32(1), 179-194]. It remains unclear whether deficits lie in encoding or savings, and whether the deficit is heritable...
  63. pmc Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice
    Francesco Papaleo
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:8709-23. 2008
    ..Our data indicate a critical role for the COMT gene in an apparent evolutionary trade-off between cognitive and affective functions...
  64. pmc Impact of the brain-derived neurotrophic factor Val66Met polymorphism on levels of hippocampal N-acetyl-aspartate assessed by magnetic resonance spectroscopic imaging at 3 Tesla
    Alexa J Stern
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 64:856-62. 2008
    ....
  65. ncbi request reprint Neurophysiological correlates of age-related changes in working memory capacity
    Venkata S Mattay
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Neurosci Lett 392:32-7. 2006
    ..As cognitive demand increases, however, they are pushed past a threshold beyond which physiological compensation cannot be made and, a decline in performance occurs...
  66. ncbi request reprint Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down
    Joseph H Callicott
    Clinical Brain Disorders Branch, NIMH NIH, Bldg 10, Rm 4D 20, MSC 1389, Bethesda, MD 20892 1389, USA
    Am J Psychiatry 160:2209-15. 2003
    ..The authors' goal was to explore this phenomenon...
  67. ncbi request reprint Serotonin transporter genetic variation and the response of the human amygdala
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Science 297:400-3. 2002
    ....
  68. ncbi request reprint The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    Michael F Egan
    Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s 235, 10 Center Drive, Bethesda, MD 20892, USA
    Cell 112:257-69. 2003
    ..These results demonstrate a role for BDNF and its val/met polymorphism in human memory and hippocampal function and suggest val/met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF...
  69. ncbi request reprint Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specified
    Anjene M Addington
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1600, USA
    Biol Psychiatry 55:976-80. 2004
    ..Childhood-onset schizophrenia (COS), defined as onset of psychotic symptoms by age 12 years, is a rare and severe form of the disorder that seems to be clinically and neurobiologically continuous with the adult disorder...
  70. pmc Variation in dopamine genes influences responsivity of the human reward system
    Jean Claude Dreher
    Section on Integrative Neuroimaging, Genes, Cognition and Psychosis Program, National Institute of Mental Health, Bethesda, MD 20892 1365, USA
    Proc Natl Acad Sci U S A 106:617-22. 2009
    ....
  71. ncbi request reprint Dopamine modulates the response of the human amygdala: a study in Parkinson's disease
    Alessandro Tessitore
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1384, USA
    J Neurosci 22:9099-103. 2002
    ..Furthermore, consistent with findings in experimental animal paradigms, our results provide in vivo evidence of the role of dopamine in modulating the response of the amygdala to sensory information in human subjects...
  72. ncbi request reprint Imaging genomics
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Br Med Bull 65:259-70. 2003
    ....
  73. ncbi request reprint Reduced N-acetylaspartate in prefrontal cortex of adult rats with neonatal hippocampal damage
    Alessandro Bertolino
    Clinical Brain Disorders Branch, Intramural Research Programs, National Institute of Mental Health, NIH, 10 Center Drive Room 4S235 MSC 1379, Bethesda, MD 20892, USA
    Cereb Cortex 12:983-90. 2002
    ....
  74. ncbi request reprint A validated network of effective amygdala connectivity
    Jason L Stein
    Unit for Systems Neuroscience in Psychiatry, Bethesda, MD 20892 1257, USA
    Neuroimage 36:736-45. 2007
    ..This validated model can be used to study neurocognitive correlates as well as genotype or disease-related alterations of functional interactions in the limbic system...
  75. pmc Set-shifting ability and schizophrenia: a marker of clinical illness or an intermediate phenotype?
    Alan E Ceaser
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, Maryland 20892 1379, USA
    Biol Psychiatry 64:782-8. 2008
    ....
  76. ncbi request reprint Functional and effective frontotemporal connectivity and genetic risk for schizophrenia
    Georg Winterer
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 54:1181-92. 2003
    ..We sought to determine whether abnormalities of frontotemporal connectivity are trait markers of genetic risk for schizophrenia...
  77. ncbi request reprint Intra-dimensional/extra-dimensional set-shifting performance in schizophrenia: impact of distractors
    Sandra Jazbec
    Clinical Brain Disorders Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Schizophr Res 89:339-49. 2007
    ....
  78. ncbi request reprint Effects of chronic haloperidol and clozapine treatment on neurogenesis in the adult rat hippocampus
    Nader D Halim
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 1385, USA
    Neuropsychopharmacology 29:1063-9. 2004
    ..These preliminary findings suggest that clozapine may influence the number of cells which divide, but antipsychotics do not promote the survival of the newly generated neurons at 3 weeks after a BrdU injection...
  79. pmc Impact of interacting functional variants in COMT on regional gray matter volume in human brain
    Robyn Honea
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuroimage 45:44-51. 2009
    ....
  80. ncbi request reprint Factor analysis of neurocognitive tests in a large sample of schizophrenic probands, their siblings, and healthy controls
    Margo R Genderson
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, NIH, 10 Center Drive, CRC 7 5342, Bethesda, MD 20892, United States
    Schizophr Res 94:231-9. 2007
    ..Furthermore, these findings provide the first confirmation that cognitive structure is comparable in family members of schizophrenia patients, as well as in patients themselves and controls...
  81. pmc Hierarchical organization of human cortical networks in health and schizophrenia
    Danielle S Bassett
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:9239-48. 2008
    ....
  82. ncbi request reprint Psychiatric genetics--the new era: genetic research and some clinical implications
    Sridhar Prathikanti
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Br Med Bull 73:107-22. 2005
    ..Genetic research and pharmacogenomics suggest that the subcategorization of individuals based on various sets of susceptibility alleles will make the treatment of neuropsychiatric and other illnesses more predictable and effective...
  83. ncbi request reprint Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging
    Alessandro Bertolino
    Clinical Brain Disorders Branch, Intramural Research Programs, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 53:906-13. 2003
    ..The objective of this study was to assess possible NAA reductions in hippocampus and prefrontal regions in patients with bipolar disorder...
  84. pmc Risk for premenstrual dysphoric disorder is associated with genetic variation in ESR1, the estrogen receptor alpha gene
    Liang Huo
    Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 62:925-33. 2007
    ..Premenstrual dysphoric disorder (PMDD) is a heritable mood disorder that is triggered by gonadal steroids during the luteal phase in susceptible women...
  85. ncbi request reprint Neocortical modulation of the amygdala response to fearful stimuli
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 53:494-501. 2003
    ....
  86. ncbi request reprint In vivo NMR measures of NAA and the neurobiology of schizophrenia
    Stefano Marenco
    Genes, Cognition and Psychosis Program, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Adv Exp Med Biol 576:227-40; discussion 361-3. 2006
  87. pmc Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics
    Catherine M Diaz-Asper
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    NeuroRx 3:97-105. 2006
    ..Haplotype effects also may account for a modest percentage of the variance in test performance, and are an important area for future study...
  88. ncbi request reprint BDNF Val66Met polymorphism significantly affects d' in verbal recognition memory at short and long delays
    Terry E Goldberg
    Clinical Brain Disorders Branch, NIMH, Bethesda, MD 20892, USA
    Biol Psychol 77:20-4. 2008
    ..In sum, BDNF genotypes impacted "hits" in a recognition memory paradigm, findings consistent with the general notion that BDNF plays a prominent role in memory subprocesses thought to engage the medial temporal lobe...
  89. pmc Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine
    Venkata S Mattay
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Room 4s 235, Bethesda, MD 20982 1379, USA
    Proc Natl Acad Sci U S A 100:6186-91. 2003
    ..Further, individuals with the met/met catechol O-methyltransferase genotype appear to be at increased risk for an adverse response to amphetamine...
  90. ncbi request reprint Dysfunctional and compensatory prefrontal cortical systems, genes and the pathogenesis of schizophrenia
    Hao Yang Tan
    Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Cereb Cortex 17:i171-81. 2007
    ....
  91. ncbi request reprint Amygdala activation in affective priming: a magnetoencephalogram study
    Maite Garolera
    Clinical Brain Disorders Branch, IRPP NIMH NIH DHHS, Bethesda, Maryland, USA
    Neuroreport 18:1449-53. 2007
    ..This study provides evidence for theta power changes in the amygdala and demonstrates that the analysis of brain oscillations provides a powerful tool to explore mechanisms implicated in emotional processing...
  92. ncbi request reprint Working memory deficits and levels of N-acetylaspartate in patients with schizophreniform disorder
    Alessandro Bertolino
    Department of Psychiatry and Neurological Sciences, University of Bari, Italy
    Am J Psychiatry 160:483-9. 2003
    ..In addition, they assessed the relationship between N-acetylaspartate levels and working memory deficits...
  93. ncbi request reprint Variation of human amygdala response during threatening stimuli as a function of 5'HTTLPR genotype and personality style
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 57:1517-25. 2005
    ..The objective of this study was to explore the relevance of personality style for variability of amygdala response...
  94. ncbi request reprint Glycogen synthase kinase (GSK)-3beta levels and activity in a neurodevelopmental rat model of schizophrenia
    Carmit Nadri
    Stanley Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    Brain Res Dev Brain Res 141:33-7. 2003
    ....
  95. ncbi request reprint Schizophrenia, III: brain-derived neurotropic factor and genetic risk
    Michael F Egan
    Am J Psychiatry 160:1242. 2003
  96. ncbi request reprint Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation
    Andreas Heinz
    Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Germany
    Biol Psychiatry 61:1011-4. 2007
    ..However, a recent report suggested that this interaction is driven by amygdala deactivation during presentation of neutral stimuli in s carriers...
  97. ncbi request reprint The BDNF Val66Met polymorphism has a gender specific influence on planning ability in Parkinson's disease
    Thomas Foltynie
    Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    J Neurol 252:833-8. 2005
    ..We speculate that BDNF may interact with dopaminergic transmission and dopamine receptor stimulation in the frontostriatal circuitry, with subsequent consequences on cognition in Parkinson's disease...
  98. ncbi request reprint Cortical gene expression in the neonatal ventral-hippocampal lesion rat model
    Albert H C Wong
    Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Schizophr Res 77:261-70. 2005
    ..None of these genes has been extensively studied in schizophrenia, and further work with post-mortem tissue and genetic studies are ongoing...
  99. ncbi request reprint Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Psychiatry Res 147:221-6. 2006
    ..We also replicated earlier findings that the Val allele of the COMT polymorphism is associated with greater engagement of the prefrontal cortex...
  100. ncbi request reprint Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 60:1250-8. 2006
    ..This network includes the hippocampal formation (HF) as well as the ventrolateral prefrontal cortex (VLPFC). Studies in animals have suggested that the relationship between these brain regions is strongly modulated by dopamine...
  101. ncbi request reprint COMT genotype predicts BOLD signal and noise characteristics in prefrontal circuits
    Georg Winterer
    Department of Psychiatry, Heinrich Heine University, Duesseldorf, Germany
    Neuroimage 32:1722-32. 2006
    ..In the present study, we addressed the question of whether the prefrontal SNR of the BOLD response is decreased in Val carriers using a visual oddball task and an approach to analysis of fMRI data that maximizes noise characterization...