Research Topics
Genomes and Genes
| Daniel R WeinbergerSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry: what is happening in the schizophrenic brain?Daniel R Weinberger
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Dr, Bldg 10, Room 3C 101, MSC 1255, Bethesda, MD 20892, USA
Arch Gen Psychiatry 59:553-8. 2002- Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulationEmily M Drabant
Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
Arch Gen Psychiatry 63:1396-406. 2006.... - Effect of catechol-O-methyltransferase val158met genotype on attentional controlGiuseppe Blasi
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
J Neurosci 25:5038-45. 2005..These results indicate that met allele load and presumably enhanced dopaminergic tone improve the "efficiency" of local circuit processing within the cingulate cortex and thereby its function during AC... 
Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic riskRoberta Rasetti
Genes, Cognition, and Psychosis Program, IRP, NIMH, NIH, Rm 4S 235, 10 Center Dr, Bethesda, MD 20892, USA
Am J Psychiatry 166:216-25. 2009..The purpose of the present study was to examine amygdala response to threatening faces among healthy siblings of schizophrenia patients in whom a subtler heritable deficit might be observed...- Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophreniaKristin K Nicodemus
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD 20892, USA
Hum Genet 120:889-906. 2007..In addition, we were able to replicate other studies, including allelic directionality. The use of epistatic models may improve replication of psychiatric candidate gene studies... - Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritabilityAaron L Goldman
Neuroimaging Core Facility, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Arch Gen Psychiatry 66:467-77. 2009..To our knowledge, cortical thickness, a measure of particular interest in schizophrenia, has not previously been evaluated in terms of its heritability in relationship to risk for schizophrenia... 
Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controlsKristin K Nicodemus
Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 67:991-1001. 2010..NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis...- No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expressionHeike Tost
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1379, USA
Biol Psychiatry 68:105-7. 2010..In the largest neuroimaging intermediate phenotype study reported so far, we evaluated the effect of rs7341475 on an extended array of different neuroscientific measures... - The G72/G30 gene complex and cognitive abnormalities in schizophreniaTerry E Goldberg
Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD, USA
Neuropsychopharmacology 31:2022-32. 2006..We present evidence that SNP variations in the G72 gene region increase risk of cognitive impairment in schizophrenia. SNP variations were not strongly associated with clinical diagnosis in family-based analyses... - Is gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblingsRobyn A Honea
Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1364, USA
Biol Psychiatry 63:465-74. 2008..We sought to discover previously unidentified gray matter volume differences in patients with schizophrenia and their siblings with optimized voxel-based morphometry... - Prefrontal broadband noise, working memory, and genetic risk for schizophreniaGeorg Winterer
Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
Am J Psychiatry 161:490-500. 2004..In the present study, the authors explored whether this particular physiological abnormality predicts working memory performance and is related to the genetic risk for schizophrenia... - Evidence of sex-modulated association of ZNF804A with schizophreniaFengyu Zhang
Genes, Cognition and Psychosis Program and Clinical, Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 69:914-7. 2011..A recent candidate gene study, which replicated the positive association with rs1344706, identified another positive SNP (rs7597593) in ZNF804A associated with schizophrenia... - Age-related alterations in default mode network: impact on working memory performanceFabio Sambataro
Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
Neurobiol Aging 31:839-52. 2010..These changes may be a reflection of a deficit in cognitive control associated with advancing age that results in deficient resource allocation to the task at hand... - 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depressionLukas Pezawas
Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
Nat Neurosci 8:828-34. 2005.... - Genetic modulation of GABA levels in the anterior cingulate cortex by GAD1 and COMTStefano Marenco
Clinical Brain Disorders Branch, GCAP, IRP, NIMH, Bethesda, MD 20892, USA
Neuropsychopharmacology 35:1708-17. 2010..The directionality of the effects, however, is inconsistent with earlier evidence of decreased GABA activity in schizophrenia... - Age-related alterations in simple declarative memory and the effect of negative stimulus valenceVishnu P Murty
National Institutes of Health, Bethesda, MD, USA
J Cogn Neurosci 21:1920-33. 2009.... - Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPsBarbara K Lipska
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
Hum Mol Genet 15:1245-58. 2006..Although, many other DISC1 binding partners still need to be investigated, these data implicate genetically linked abnormalities in the DISC1 molecular pathway in the pathophysiology of schizophrenia... - Catechol-O-methyltransferase valine(158)methionine polymorphism modulates brain networks underlying working memory across adulthoodFabio Sambataro
Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 66:540-8. 2009.... - RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activityBarbara K Lipska
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute for Mental Health, NIH, DHHS, Bethesda, MD 20892 1385, USA
Hum Mol Genet 15:2804-12. 2006..These data suggest that RGS4 mRNA expression is associated with cortical dopamine signaling and illustrate the importance of genetic and/or environmental background in gene expression studies in schizophrenia... - Heritability of brain morphology related to schizophrenia: a large-scale automated magnetic resonance imaging segmentation studyAaron L Goldman
Neuroimaging Core Facility, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 63:475-83. 2008..Currently available data on the heritability of these structural changes are inconsistent... - Allelic variation in RGS4 impacts functional and structural connectivity in the human brainJoshua W Buckholtz
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1364, USA
J Neurosci 27:1584-93. 2007..These findings suggest mechanisms in brain for the association of RGS4 with risk for psychiatric illness... - Prefrontal electrophysiologic "noise" and catechol-O-methyltransferase genotype in schizophreniaGeorg Winterer
Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 60:578-84. 2006.... - Transcript-specific associations of SLC12A5 (KCC2) in human prefrontal cortex with development, schizophrenia, and affective disordersRan Tao
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1385, USA
J Neurosci 32:5216-22. 2012..Alternate transcripts from KCC2 may participate in the abnormal GABA signaling in the DLPFC associated with schizophrenia... - Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memoryHao Yang Tan
Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 27:13393-401. 2007..These findings add to the integration of dopaminergic signaling in basic cortical assemblies with their roles in specific human brain networks during the orchestration of information processing in WM... - Neural correlates of probabilistic category learning in patients with schizophreniaThomas W Weickert
Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 29:1244-54. 2009.... - Brain regions underlying response inhibition and interference monitoring and suppressionGiuseppe Blasi
CBDB, GCAP, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Bethesda, MD 20982-1379, USA
Eur J Neurosci 23:1658-64. 2006..These results extend previous findings by suggesting regional functional specialization within a cortical network supporting cognitive control... - Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humansHao Yang Tan
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 118:2200-8. 2008..These data implicate AKT1 in modulating human prefrontal-striatal structure and function and suggest that the mechanism of this effect may be coupled to dopaminergic signaling and relevant to the expression of psychosis... - Instability of prefrontal signal processing in schizophreniaGeorg Winterer
Genes, Cognition and Psychosis Program, NIH, NIMH, 10 Center Dr, MSC 1379, Bethesda, MD 20892, USA
Am J Psychiatry 163:1960-8. 2006..CONCLUSIONS: These findings suggest that unstable cortical signal processing underlies classic abnormal cortical activation patterns as well as psychosis in schizophrenia... - Catechol-o-methyltransferase valine(158)methionine genotype and resting regional cerebral blood flow in medication-free patients with schizophreniaDaniel Paul Eisenberg
Section on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland 20892 1365, USA
Biol Psychiatry 67:287-90. 2010..Task-independent effects of this polymorphism in schizophrenia have not yet been characterized... - Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortexStefano Marenco
Genes and Cognition Program, Clinical Brain Disorders Branch, Intramural Research Program, Bldg 10, Rm 4S235, 10 Center Dr, NIMH, NIH, Bethesda, MD 20892, USA
Am J Psychiatry 163:740-2. 2006.... - Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortexCarlo Colantuoni
Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, MD 20892, USA
Brain Struct Funct 213:255-71. 2008..All microarray data are available at NCBI's Gene Expression Omnibus: GEO Series accession number GSE11546 (http://www.ncbi.nlm.nih.gov/geo) [corrected].. - Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophreniaCynthia Shannon Weickert
MiNDS Unit, Section on Neuropathology, GCAP, NIMH, NIH, Bethesda, MD 20892, USA
Hum Mol Genet 17:2293-309. 2008..Thus, the variation in the ESR1 gene is associated with schizophrenia and the mechanism of this association may involve alternative gene regulation and transcript processing... - The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphologyLukas Pezawas
Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
J Neurosci 24:10099-102. 2004.... - Genetic variation in CACNA1C affects brain circuitries related to mental illnessKristin L Bigos
Genes, Cognition, and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 67:939-45. 2010..The CACNA1C gene (alpha-1C subunit of the L-type voltage-gated calcium channel) has been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of association has not been explored... - Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performanceAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892 1384, USA
J Neurosci 23:6690-4. 2003..These data implicate a specific genetic mechanism for substantial normal variation in human declarative memory and suggest that the basic effects of BDNF signaling on hippocampal function in experimental animals are important in humans... - The neonatal ventral hippocampal lesion model of schizophrenia: effects on dopamine and GABA mRNA markers in the rat midbrainBarbara K Lipska
Clinical Brain Disorders Branch, National Institute of Mental Health, Bldg 10, Rm 4 N306, Bethesda, MD 20892 1385, USA
Eur J Neurosci 18:3097-104. 2003.... - Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medicationsThomas W Weickert
National Institutes of Health, National Institute of Mental Health, Clinical Brain Disorders Branch, Building 10, Room 4C 101, MSC 1379, Bethesda, MD 20892, USA
Biol Psychiatry 56:677-82. 2004..The present study tested the effects of several COMT polymorphisms on the cognitive response to antipsychotic medication in patients with schizophrenia... - Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophreniaTerry E Goldberg
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 60:889-96. 2003..Cognitive dysfunction in the working memory domain seems to be under genetic control and is a candidate intermediate phenotype in schizophrenia. Genes that affect working memory processing may contribute to risk for schizophrenia... - Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotypeAndreas Meyer-Lindenberg
Section on Integrative Neuroimaging, National Institute for Mental Health, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, Maryland 20892 1365, USA
Nat Neurosci 8:594-6. 2005..These data implicate a dopaminergic tuning mechanism in prefrontal cortex and suggest a systems-level mechanism for cognitive and neuropsychiatric associations with COMT... - Interactive effects of DAOA (G72) and catechol-O-methyltransferase on neurophysiology in prefrontal cortexDevon C Nixon
Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Biol Psychiatry 69:1006-8. 2011.... - Tolcapone improves cognition and cortical information processing in normal human subjectsJose A Apud
Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20854, USA
Neuropsychopharmacology 32:1011-20. 2007..Our results are consistent with data from animal studies and from computational models of the effects of selective enhancement of DA signaling in the prefrontal cortex... - Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain functionHao Yang Tan
Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:12536-41. 2007..These findings extend putative brain dopaminergic and glutamatergic relationships indexed by COMT and GRM3 to a systems-level interaction in human cortical circuits implicated in working memory dysfunction such as in schizophrenia... - Effective connectivity of AKT1-mediated dopaminergic working memory networks and pharmacogenetics of anti-dopaminergic treatmentHao Yang Tan
Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892, USA
Brain 135:1436-45. 2012..Thus, we suggest that genetic modulation of DRD2-AKT1-related prefrontal-subcortical circuits could at least in part influence cognitive dysfunction in psychosis and its treatment... - Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimagingKristin K Nicodemus
Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Hum Genet 127:441-52. 2010.... - Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controlsCatherine M Diaz-Asper
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 63:72-9. 2008..Recently, other single nucleotide polymorphisms (SNPs) across the gene have emerged as additional risk factors for schizophrenia: namely rs737865, rs165599, and rs2097603. In a large sample, we examined whether these SNPs affect WM... - A susceptibility gene for affective disorders and the response of the human amygdalaAhmad R Hariri
Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
Arch Gen Psychiatry 62:146-52. 2005.... - Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrainCynthia Shannon Weickert
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Arch Gen Psychiatry 61:544-55. 2004..3) encodes a neuronal protein that binds to beta-dystrobrevin and may be part of the dystrophin protein complex. Little is known about dysbindin expression in normal or schizophrenic brain... - Variation in DISC1 affects hippocampal structure and function and increases risk for schizophreniaJoseph H Callicott
Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 102:8627-32. 2005.... - DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphismsKenji Nakata
Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1385, USA
Proc Natl Acad Sci U S A 106:15873-8. 2009..Our results implicate a molecular mechanism of genetic risk associated with DISC1 involving specific alterations in gene processing... - Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophreniaMichael F Egan
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:12604-9. 2004..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia... - Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1Shiny V Mathew
Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 1385, USA
Hum Mol Genet 16:2921-32. 2007..Together, these results suggest that the molecular mechanism of the association between NRG1 risk alleles and schizophrenia may include down-regulation of nAChR alpha7 expression... - Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell modelsYoshitatsu Sei
Clinical Brain Disorder Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
PLoS ONE 5:e10789. 2010.... - Impact of the brain-derived neurotrophic factor Val66Met polymorphism on levels of hippocampal N-acetyl-aspartate assessed by magnetic resonance spectroscopic imaging at 3 TeslaAlexa J Stern
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 64:856-62. 2008.... - Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognitionAndreas Meyer-Lindenberg
Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, and Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute for Mental Health NIMH, NIH, Bethesda, MD 20892, USA
J Clin Invest 117:672-82. 2007..Our convergent results identify a prefrontal-neostriatal system affected by variation in PPP1R1B and suggest that DARPP-32 plays a pivotal role in cognitive function and possibly in the pathogenesis of schizophrenia... - Differentiating allocation of resources and conflict detection within attentional control processingGiuseppe Blasi
National Institute of Mental Health, National Institutes of Health, Bethesda, MA, USA
Eur J Neurosci 25:594-602. 2007.... - Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in miceFrancesco Papaleo
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurosci 28:8709-23. 2008..Our data indicate a critical role for the COMT gene in an apparent evolutionary trade-off between cognitive and affective functions... - Verbal and visual memory: characterizing the clinical and intermediate phenotype in schizophreniaShayna L Skelley
Clinical Brain Disorders Branch, 10 Center Drive, MSC 1379, National Institute of Mental Health NIH, Bethesda, MD 20892, USA
Schizophr Res 105:78-85. 2008..Schizophr Bull, 32(1), 179-194]. It remains unclear whether deficits lie in encoding or savings, and whether the deficit is heritable... - Modulatory effects of modafinil on neural circuits regulating emotion and cognitionRoberta Rasetti
Clinical Brain Disorders Branch Genes, Cognition, and Psychosis Program, NIMH, NIH, Bethesda, MD 20892, USA
Neuropsychopharmacology 35:2101-9. 2010.... - Investigation of anatomical thalamo-cortical connectivity and FMRI activation in schizophreniaStefano Marenco
Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA
Neuropsychopharmacology 37:499-507. 2012..These results suggest that thalamocortical connectivity to the LPFC is altered in schizophrenia with functional consequences on working memory processing in LPFC... - Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophreniaThomas M Hyde
Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 31:11088-95. 2011..These findings suggest that abnormalities in GABA signaling critical to brain development contribute to genetic risk for schizophrenia... - Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or downJoseph H Callicott
Clinical Brain Disorders Branch, NIMH NIH, Bldg 10, Rm 4D 20, MSC 1389, Bethesda, MD 20892 1389, USA
Am J Psychiatry 160:2209-15. 2003..The authors' goal was to explore this phenomenon... - Neurophysiological correlates of age-related changes in working memory capacityVenkata S Mattay
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Neurosci Lett 392:32-7. 2006..As cognitive demand increases, however, they are pushed past a threshold beyond which physiological compensation cannot be made and, a decline in performance occurs... - Serotonin transporter genetic variation and the response of the human amygdalaAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Science 297:400-3. 2002.... - The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal functionMichael F Egan
Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s 235, 10 Center Drive, Bethesda, MD 20892, USA
Cell 112:257-69. 2003..These results demonstrate a role for BDNF and its val/met polymorphism in human memory and hippocampal function and suggest val/met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF... - Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specifiedAnjene M Addington
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1600, USA
Biol Psychiatry 55:976-80. 2004..Childhood-onset schizophrenia (COS), defined as onset of psychotic symptoms by age 12 years, is a rare and severe form of the disorder that seems to be clinically and neurobiologically continuous with the adult disorder... - Variation in dopamine genes influences responsivity of the human reward systemJean Claude Dreher
Section on Integrative Neuroimaging, Genes, Cognition and Psychosis Program, National Institute of Mental Health, Bethesda, MD 20892 1365, USA
Proc Natl Acad Sci U S A 106:617-22. 2009.... - Dopamine modulates the response of the human amygdala: a study in Parkinson's diseaseAlessandro Tessitore
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-1384, USA
J Neurosci 22:9099-103. 2002..Furthermore, consistent with findings in experimental animal paradigms, our results provide in vivo evidence of the role of dopamine in modulating the response of the amygdala to sensory information in human subjects... - Imaging genomicsAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Br Med Bull 65:259-70. 2003.... - Reduced N-acetylaspartate in prefrontal cortex of adult rats with neonatal hippocampal damageAlessandro Bertolino
Clinical Brain Disorders Branch, Intramural Research Programs, National Institute of Mental Health, NIH, 10 Center Drive Room 4S235 MSC 1379, Bethesda, MD 20892, USA
Cereb Cortex 12:983-90. 2002.... - Set-shifting ability and schizophrenia: a marker of clinical illness or an intermediate phenotype?Alan E Ceaser
Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, Maryland 20892 1379, USA
Biol Psychiatry 64:782-8. 2008.... - Functional and effective frontotemporal connectivity and genetic risk for schizophreniaGeorg Winterer
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 54:1181-92. 2003..The reasons why frontotemporal connectivity appears to be a poor predictor of genetic risk for schizophrenia are discussed... - Effects of chronic haloperidol and clozapine treatment on neurogenesis in the adult rat hippocampusNader D Halim
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892-1385, USA
Neuropsychopharmacology 29:1063-9. 2004..These preliminary findings suggest that clozapine may influence the number of cells which divide, but antipsychotics do not promote the survival of the newly generated neurons at 3 weeks after a BrdU injection... - Intra-dimensional/extra-dimensional set-shifting performance in schizophrenia: impact of distractorsSandra Jazbec
Clinical Brain Disorders Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
Schizophr Res 89:339-49. 2007.... - A validated network of effective amygdala connectivityJason L Stein
Unit for Systems Neuroscience in Psychiatry, Bethesda, MD 20892 1257, USA
Neuroimage 36:736-45. 2007..This validated model can be used to study neurocognitive correlates as well as genotype or disease-related alterations of functional interactions in the limbic system... - Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imagingAlessandro Bertolino
Clinical Brain Disorders Branch, Intramural Research Programs, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 53:906-13. 2003..As suggested by other studies, neuronal pathology in the hippocampus may be involved in the pathophysiology of bipolar disorder and in susceptibility to psychosis... - Psychiatric genetics--the new era: genetic research and some clinical implicationsSridhar Prathikanti
Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Br Med Bull 73:107-22. 2005..Genetic research and pharmacogenomics suggest that the subcategorization of individuals based on various sets of susceptibility alleles will make the treatment of neuropsychiatric and other illnesses more predictable and effective... - Neocortical modulation of the amygdala response to fearful stimuliAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Biol Psychiatry 53:494-501. 2003.... - In vivo NMR measures of NAA and the neurobiology of schizophreniaStefano Marenco
Genes, Cognition and Psychosis Program, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Adv Exp Med Biol 576:227-40; discussion 361-3. 2006 - BDNF Val66Met polymorphism significantly affects d' in verbal recognition memory at short and long delaysTerry E Goldberg
Clinical Brain Disorders Branch, NIMH, Bethesda, MD 20892, USA
Biol Psychol 77:20-4. 2008..In sum, BDNF genotypes impacted "hits" in a recognition memory paradigm, findings consistent with the general notion that BDNF plays a prominent role in memory subprocesses thought to engage the medial temporal lobe... - Factor analysis of neurocognitive tests in a large sample of schizophrenic probands, their siblings, and healthy controlsMargo R Genderson
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, NIH, 10 Center Drive, CRC 7 5342, Bethesda, MD 20892, United States
Schizophr Res 94:231-9. 2007..Furthermore, these findings provide the first confirmation that cognitive structure is comparable in family members of schizophrenia patients, as well as in patients themselves and controls... - Risk for premenstrual dysphoric disorder is associated with genetic variation in ESR1, the estrogen receptor alpha geneLiang Huo
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 62:925-33. 2007..Premenstrual dysphoric disorder (PMDD) is a heritable mood disorder that is triggered by gonadal steroids during the luteal phase in susceptible women... - Hierarchical organization of human cortical networks in health and schizophreniaDanielle S Bassett
Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 28:9239-48. 2008.... - Impact of interacting functional variants in COMT on regional gray matter volume in human brainRobyn Honea
Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Neuroimage 45:44-51. 2009.... - Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeuticsCatherine M Diaz-Asper
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
NeuroRx 3:97-105. 2006..Haplotype effects also may account for a modest percentage of the variance in test performance, and are an important area for future study... - Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamineVenkata S Mattay
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Room 4S-235, Bethesda, MD 20982-1379, USA
Proc Natl Acad Sci U S A 100:6186-91. 2003..Further, individuals with the met/met catechol O-methyltransferase genotype appear to be at increased risk for an adverse response to amphetamine... - Dysfunctional and compensatory prefrontal cortical systems, genes and the pathogenesis of schizophreniaHao Yang Tan
Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
Cereb Cortex 17:i171-81. 2007.... - Amygdala activation in affective priming: a magnetoencephalogram studyMaite Garolera
Clinical Brain Disorders Branch, IRPP NIMH NIH DHHS, Bethesda, Maryland, USA
Neuroreport 18:1449-53. 2007..This study provides evidence for theta power changes in the amygdala and demonstrates that the analysis of brain oscillations provides a powerful tool to explore mechanisms implicated in emotional processing... - Planning ability in Parkinson's disease is influenced by the COMT val158met polymorphismThomas Foltynie
Cambridge Centre for Brain Repair, University of Cambridge, United Kingdom
Mov Disord 19:885-91. 2004..We suggest that polymorphisms of common genes, which regulate central nervous system dopaminergic transmission, can influence some of the phenotypic manifestations of PD... - Glycogen synthase kinase (GSK)-3beta levels and activity in a neurodevelopmental rat model of schizophreniaCarmit Nadri
Stanley Research Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheva, Israel
Brain Res Dev Brain Res 141:33-7. 2003.... - Working memory deficits and levels of N-acetylaspartate in patients with schizophreniform disorderAlessandro Bertolino
Department of Psychiatry and Neurological Sciences, University of Bari, Italy
Am J Psychiatry 160:483-9. 2003..In addition, they assessed the relationship between N-acetylaspartate levels and working memory deficits... - Cortical gene expression in the neonatal ventral-hippocampal lesion rat modelAlbert H C Wong
Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Schizophr Res 77:261-70. 2005..None of these genes has been extensively studied in schizophrenia, and further work with post-mortem tissue and genetic studies are ongoing... - Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotypeAlessandro Bertolino
Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
Biol Psychiatry 60:1250-8. 2006..This network includes the hippocampal formation (HF) as well as the ventrolateral prefrontal cortex (VLPFC). Studies in animals have suggested that the relationship between these brain regions is strongly modulated by dopamine... - Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophreniaAlessandro Bertolino
Dipartimento di Scienze Neurologiche e Psichiatriche, Universita degli Studi di Bari, Piazza Giulio Cesare 9, 70124, Bari, Italy
Am J Psychiatry 161:1798-805. 2004.... - COMT genotype predicts BOLD signal and noise characteristics in prefrontal circuitsGeorg Winterer
Department of Psychiatry, Heinrich Heine University, Duesseldorf, Germany
Neuroimage 32:1722-32. 2006..In the present study, we addressed the question of whether the prefrontal SNR of the BOLD response is decreased in Val carriers using a visual oddball task and an approach to analysis of fMRI data that maximizes noise characterization... - Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the diseaseAmanda J Law
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom
Proc Natl Acad Sci U S A 103:6747-52. 2006..These data implicate variation in isoform expression as a molecular mechanism for the genetic association of NRG1 with schizophrenia... - Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in human brainAlessandro Bertolino
Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, 70124 Bari, Italy
J Neurosci 26:3918-22. 2006..These results demonstrate additive genetic effects of genes regulating dopamine signaling on specific neuronal networks subserving working memory... - Neuroimaging-genetic paradigms: a new approach to investigate the pathophysiology and treatment of cognitive deficits in schizophreniaJoshua L Roffman
Harvard Medical School and Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02129, USA
Harv Rev Psychiatry 14:78-91. 2006..The potential of this approach for improving patient care will depend on its ability to predict outcomes with greater accuracy and sensitivity than current clinical measures... - The BDNF Val66Met polymorphism has a gender specific influence on planning ability in Parkinson's diseaseThomas Foltynie
Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
J Neurol 252:833-8. 2005..We speculate that BDNF may interact with dopaminergic transmission and dopamine receptor stimulation in the frontostriatal circuitry, with subsequent consequences on cognition in Parkinson's disease... - Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processingAhmad R Hariri
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213-2593, USA
Biol Psychiatry 59:888-97. 2006.... - Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performanceAlessandro Bertolino
Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
Psychiatry Res 147:221-6. 2006..We also replicated earlier findings that the Val allele of the COMT polymorphism is associated with greater engagement of the prefrontal cortex... - [Genetic and pharmacological effects on prefrontal cortical function in schizophrenia]Andreas Heinz
Klinik fur Psychiatrie und Psychotherapie, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Berlin
Nervenarzt 75:845-56. 2004..Molecular brain imaging combines imaging techniques with the assessment of genotype effects and represents a powerful tool for the understanding of neuropsychiatric disorders...