Daniel R Weinberger

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A
    Roberta Rasetti
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institutes of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 68:1207-17. 2011
  2. ncbi request reprint Effect of catechol-O-methyltransferase val158met genotype on attentional control
    Giuseppe Blasi
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 25:5038-45. 2005
  3. pmc Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic risk
    Roberta Rasetti
    Genes, Cognition, and Psychosis Program, IRP, NIMH, NIH, Rm 4S 235, 10 Center Dr, Bethesda, MD 20892, USA
    Am J Psychiatry 166:216-25. 2009
  4. ncbi request reprint Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation
    Emily M Drabant
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 63:1396-406. 2006
  5. doi request reprint Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls
    Kristin K Nicodemus
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 67:991-1001. 2010
  6. ncbi request reprint Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia
    Kristin K Nicodemus
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD 20892, USA
    Hum Genet 120:889-906. 2007
  7. pmc Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability
    Aaron L Goldman
    Neuroimaging Core Facility, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Arch Gen Psychiatry 66:467-77. 2009
  8. ncbi request reprint 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
    Lukas Pezawas
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
    Nat Neurosci 8:828-34. 2005
  9. doi request reprint Evidence of sex-modulated association of ZNF804A with schizophrenia
    Fengyu Zhang
    Genes, Cognition and Psychosis Program and Clinical, Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 69:914-7. 2011
  10. ncbi request reprint The G72/G30 gene complex and cognitive abnormalities in schizophrenia
    Terry E Goldberg
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD, USA
    Neuropsychopharmacology 31:2022-32. 2006

Collaborators

Detail Information

Publications76

  1. doi request reprint Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A
    Roberta Rasetti
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institutes of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 68:1207-17. 2011
    ..However, whether these patterns are trait phenomena linked to genetic risk for illness is unclear...
  2. ncbi request reprint Effect of catechol-O-methyltransferase val158met genotype on attentional control
    Giuseppe Blasi
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 25:5038-45. 2005
    ..These results indicate that met allele load and presumably enhanced dopaminergic tone improve the "efficiency" of local circuit processing within the cingulate cortex and thereby its function during AC...
  3. pmc Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic risk
    Roberta Rasetti
    Genes, Cognition, and Psychosis Program, IRP, NIMH, NIH, Rm 4S 235, 10 Center Dr, Bethesda, MD 20892, USA
    Am J Psychiatry 166:216-25. 2009
    ..The purpose of the present study was to examine amygdala response to threatening faces among healthy siblings of schizophrenia patients in whom a subtler heritable deficit might be observed...
  4. ncbi request reprint Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation
    Emily M Drabant
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 63:1396-406. 2006
    ....
  5. doi request reprint Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls
    Kristin K Nicodemus
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 67:991-1001. 2010
    ..NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis...
  6. ncbi request reprint Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia
    Kristin K Nicodemus
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD 20892, USA
    Hum Genet 120:889-906. 2007
    ..In addition, we were able to replicate other studies, including allelic directionality. The use of epistatic models may improve replication of psychiatric candidate gene studies...
  7. pmc Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability
    Aaron L Goldman
    Neuroimaging Core Facility, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Arch Gen Psychiatry 66:467-77. 2009
    ..To our knowledge, cortical thickness, a measure of particular interest in schizophrenia, has not previously been evaluated in terms of its heritability in relationship to risk for schizophrenia...
  8. ncbi request reprint 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
    Lukas Pezawas
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
    Nat Neurosci 8:828-34. 2005
    ....
  9. doi request reprint Evidence of sex-modulated association of ZNF804A with schizophrenia
    Fengyu Zhang
    Genes, Cognition and Psychosis Program and Clinical, Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 69:914-7. 2011
    ..A recent candidate gene study, which replicated the positive association with rs1344706, identified another positive SNP (rs7597593) in ZNF804A associated with schizophrenia...
  10. ncbi request reprint The G72/G30 gene complex and cognitive abnormalities in schizophrenia
    Terry E Goldberg
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD, USA
    Neuropsychopharmacology 31:2022-32. 2006
    ..We present evidence that SNP variations in the G72 gene region increase risk of cognitive impairment in schizophrenia. SNP variations were not strongly associated with clinical diagnosis in family-based analyses...
  11. pmc No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expression
    Heike Tost
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1379, USA
    Biol Psychiatry 68:105-7. 2010
    ..In the largest neuroimaging intermediate phenotype study reported so far, we evaluated the effect of rs7341475 on an extended array of different neuroscientific measures...
  12. ncbi request reprint Brain regions underlying response inhibition and interference monitoring and suppression
    Giuseppe Blasi
    CBDB, GCAP, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Bethesda, MD 20982 1379, USA
    Eur J Neurosci 23:1658-64. 2006
    ..These results extend previous findings by suggesting regional functional specialization within a cortical network supporting cognitive control...
  13. pmc Age-related alterations in default mode network: impact on working memory performance
    Fabio Sambataro
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Neurobiol Aging 31:839-52. 2010
    ..These changes may be a reflection of a deficit in cognitive control associated with advancing age that results in deficient resource allocation to the task at hand...
  14. pmc Is gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblings
    Robyn A Honea
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1364, USA
    Biol Psychiatry 63:465-74. 2008
    ..We sought to discover previously unidentified gray matter volume differences in patients with schizophrenia and their siblings with optimized voxel-based morphometry...
  15. pmc Genetic modulation of GABA levels in the anterior cingulate cortex by GAD1 and COMT
    Stefano Marenco
    Clinical Brain Disorders Branch, GCAP, IRP, NIMH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 35:1708-17. 2010
    ..The directionality of the effects, however, is inconsistent with earlier evidence of decreased GABA activity in schizophrenia...
  16. ncbi request reprint Prefrontal broadband noise, working memory, and genetic risk for schizophrenia
    Georg Winterer
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Am J Psychiatry 161:490-500. 2004
    ..In the present study, the authors explored whether this particular physiological abnormality predicts working memory performance and is related to the genetic risk for schizophrenia...
  17. pmc Neural correlates of probabilistic category learning in patients with schizophrenia
    Thomas W Weickert
    Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 29:1244-54. 2009
    ....
  18. pmc Catechol-o-methyltransferase valine(158)methionine genotype and resting regional cerebral blood flow in medication-free patients with schizophrenia
    Daniel Paul Eisenberg
    Section on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland 20892 1365, USA
    Biol Psychiatry 67:287-90. 2010
    ..Task-independent effects of this polymorphism in schizophrenia have not yet been characterized...
  19. ncbi request reprint Allelic variation in RGS4 impacts functional and structural connectivity in the human brain
    Joshua W Buckholtz
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1364, USA
    J Neurosci 27:1584-93. 2007
    ..These findings suggest mechanisms in brain for the association of RGS4 with risk for psychiatric illness...
  20. ncbi request reprint Heritability of brain morphology related to schizophrenia: a large-scale automated magnetic resonance imaging segmentation study
    Aaron L Goldman
    Neuroimaging Core Facility, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 63:475-83. 2008
    ..Currently available data on the heritability of these structural changes are inconsistent...
  21. ncbi request reprint RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activity
    Barbara K Lipska
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute for Mental Health, NIH, DHHS, Bethesda, MD 20892 1385, USA
    Hum Mol Genet 15:2804-12. 2006
    ..These data suggest that RGS4 mRNA expression is associated with cortical dopamine signaling and illustrate the importance of genetic and/or environmental background in gene expression studies in schizophrenia...
  22. pmc Age-related alterations in simple declarative memory and the effect of negative stimulus valence
    Vishnu P Murty
    National Institutes of Health, Bethesda, MD, USA
    J Cogn Neurosci 21:1920-33. 2009
    ....
  23. ncbi request reprint Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs
    Barbara K Lipska
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Hum Mol Genet 15:1245-58. 2006
    ..Although, many other DISC1 binding partners still need to be investigated, these data implicate genetically linked abnormalities in the DISC1 molecular pathway in the pathophysiology of schizophrenia...
  24. pmc Catechol-O-methyltransferase valine(158)methionine polymorphism modulates brain networks underlying working memory across adulthood
    Fabio Sambataro
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 66:540-8. 2009
    ....
  25. pmc Transcript-specific associations of SLC12A5 (KCC2) in human prefrontal cortex with development, schizophrenia, and affective disorders
    Ran Tao
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1385, USA
    J Neurosci 32:5216-22. 2012
    ..Alternate transcripts from KCC2 may participate in the abnormal GABA signaling in the DLPFC associated with schizophrenia...
  26. ncbi request reprint The neonatal ventral hippocampal lesion model of schizophrenia: effects on dopamine and GABA mRNA markers in the rat midbrain
    Barbara K Lipska
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bldg 10, Rm 4 N306, Bethesda, MD 20892 1385, USA
    Eur J Neurosci 18:3097-104. 2003
    ....
  27. ncbi request reprint The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology
    Lukas Pezawas
    Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 24:10099-102. 2004
    ....
  28. ncbi request reprint Prefrontal electrophysiologic "noise" and catechol-O-methyltransferase genotype in schizophrenia
    Georg Winterer
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 60:578-84. 2006
    ....
  29. ncbi request reprint Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia
    Terry E Goldberg
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 60:889-96. 2003
    ..Cognitive dysfunction in the working memory domain seems to be under genetic control and is a candidate intermediate phenotype in schizophrenia. Genes that affect working memory processing may contribute to risk for schizophrenia...
  30. ncbi request reprint Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1
    Shiny V Mathew
    Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 1385, USA
    Hum Mol Genet 16:2921-32. 2007
    ..Together, these results suggest that the molecular mechanism of the association between NRG1 risk alleles and schizophrenia may include down-regulation of nAChR alpha7 expression...
  31. ncbi request reprint Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory
    Hao Yang Tan
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 27:13393-401. 2007
    ..These findings add to the integration of dopaminergic signaling in basic cortical assemblies with their roles in specific human brain networks during the orchestration of information processing in WM...
  32. pmc Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans
    Hao Yang Tan
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 118:2200-8. 2008
    ..These data implicate AKT1 in modulating human prefrontal-striatal structure and function and suggest that the mechanism of this effect may be coupled to dopaminergic signaling and relevant to the expression of psychosis...
  33. ncbi request reprint Instability of prefrontal signal processing in schizophrenia
    Georg Winterer
    Genes, Cognition and Psychosis Program, NIH, NIMH, 10 Center Dr, MSC 1379, Bethesda, MD 20892, USA
    Am J Psychiatry 163:1960-8. 2006
    ....
  34. doi request reprint Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex
    Carlo Colantuoni
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Brain Struct Funct 213:255-71. 2008
    ..All microarray data are available at NCBI's Gene Expression Omnibus: GEO Series accession number GSE11546 (http://www.ncbi.nlm.nih.gov/geo) [corrected]..
  35. pmc Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia
    Cynthia Shannon Weickert
    MiNDS Unit, Section on Neuropathology, GCAP, NIMH, NIH, Bethesda, MD 20892, USA
    Hum Mol Genet 17:2293-309. 2008
    ..Thus, the variation in the ESR1 gene is associated with schizophrenia and the mechanism of this association may involve alternative gene regulation and transcript processing...
  36. ncbi request reprint Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia
    Joseph H Callicott
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20982 1389, USA
    Am J Psychiatry 160:709-19. 2003
    ..Earlier family studies have suggested that deficits in executive cognition and working memory may be related to genetic susceptibility for schizophrenia, but the biological basis for this behavioral phenotype has not been identified...
  37. ncbi request reprint Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892 1384, USA
    J Neurosci 23:6690-4. 2003
    ..These data implicate a specific genetic mechanism for substantial normal variation in human declarative memory and suggest that the basic effects of BDNF signaling on hippocampal function in experimental animals are important in humans...
  38. pmc Genetic variation in CACNA1C affects brain circuitries related to mental illness
    Kristin L Bigos
    Genes, Cognition, and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 67:939-45. 2010
    ..The CACNA1C gene (alpha-1C subunit of the L-type voltage-gated calcium channel) has been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of association has not been explored...
  39. ncbi request reprint Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications
    Thomas W Weickert
    National Institutes of Health, National Institute of Mental Health, Clinical Brain Disorders Branch, Building 10, Room 4C 101, MSC 1379, Bethesda, MD 20892, USA
    Biol Psychiatry 56:677-82. 2004
    ..The present study tested the effects of several COMT polymorphisms on the cognitive response to antipsychotic medication in patients with schizophrenia...
  40. ncbi request reprint A susceptibility gene for affective disorders and the response of the human amygdala
    Ahmad R Hariri
    Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 62:146-52. 2005
    ....
  41. ncbi request reprint Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype
    Andreas Meyer-Lindenberg
    Section on Integrative Neuroimaging, National Institute for Mental Health, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, Maryland 20892 1365, USA
    Nat Neurosci 8:594-6. 2005
    ..These data implicate a dopaminergic tuning mechanism in prefrontal cortex and suggest a systems-level mechanism for cognitive and neuropsychiatric associations with COMT...
  42. pmc Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex
    Stefano Marenco
    Genes and Cognition Program, Clinical Brain Disorders Branch, Intramural Research Program, Bldg 10, Rm 4S235, 10 Center Dr, NIMH, NIH, Bethesda, MD 20892, USA
    Am J Psychiatry 163:740-2. 2006
    ....
  43. pmc Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function
    Hao Yang Tan
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:12536-41. 2007
    ..These findings extend putative brain dopaminergic and glutamatergic relationships indexed by COMT and GRM3 to a systems-level interaction in human cortical circuits implicated in working memory dysfunction such as in schizophrenia...
  44. ncbi request reprint Tolcapone improves cognition and cortical information processing in normal human subjects
    Jose A Apud
    Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20854, USA
    Neuropsychopharmacology 32:1011-20. 2007
    ..Our results are consistent with data from animal studies and from computational models of the effects of selective enhancement of DA signaling in the prefrontal cortex...
  45. pmc Effect of schizophrenia risk-associated alleles in SREB2 (GPR85) on functional MRI phenotypes in healthy volunteers
    Eugenia Radulescu
    Clinical Brain Disorders Branch, GCAP, IRP, NIMH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 38:341-9. 2013
    ..The findings in females and during the emotional memory paradigm are consistent with modulation by SREB2 of brain circuitries implicated in mood regulation and may be relevant to neuropsychiatric conditions other than schizophrenia...
  46. pmc Effective connectivity of AKT1-mediated dopaminergic working memory networks and pharmacogenetics of anti-dopaminergic treatment
    Hao Yang Tan
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892, USA
    Brain 135:1436-45. 2012
    ..Thus, we suggest that genetic modulation of DRD2-AKT1-related prefrontal-subcortical circuits could at least in part influence cognitive dysfunction in psychosis and its treatment...
  47. pmc Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls
    Catherine M Diaz-Asper
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 63:72-9. 2008
    ..Recently, other single nucleotide polymorphisms (SNPs) across the gene have emerged as additional risk factors for schizophrenia: namely rs737865, rs165599, and rs2097603. In a large sample, we examined whether these SNPs affect WM...
  48. pmc DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms
    Kenji Nakata
    Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1385, USA
    Proc Natl Acad Sci U S A 106:15873-8. 2009
    ..Our results implicate a molecular mechanism of genetic risk associated with DISC1 involving specific alterations in gene processing...
  49. pmc Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia
    Michael F Egan
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:12604-9. 2004
    ..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia...
  50. ncbi request reprint Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain
    Cynthia Shannon Weickert
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 61:544-55. 2004
    ..3) encodes a neuronal protein that binds to beta-dystrobrevin and may be part of the dystrophin protein complex. Little is known about dysbindin expression in normal or schizophrenic brain...
  51. doi request reprint Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging
    Kristin K Nicodemus
    Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Genet 127:441-52. 2010
    ....
  52. doi request reprint Interactive effects of DAOA (G72) and catechol-O-methyltransferase on neurophysiology in prefrontal cortex
    Devon C Nixon
    Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 69:1006-8. 2011
    ....
  53. pmc Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models
    Yoshitatsu Sei
    Clinical Brain Disorder Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 5:e10789. 2010
    ....
  54. pmc Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia
    Joseph H Callicott
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:8627-32. 2005
    ....
  55. pmc Investigation of anatomical thalamo-cortical connectivity and FMRI activation in schizophrenia
    Stefano Marenco
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA
    Neuropsychopharmacology 37:499-507. 2012
    ..These results suggest that thalamocortical connectivity to the LPFC is altered in schizophrenia with functional consequences on working memory processing in LPFC...
  56. pmc Modulatory effects of modafinil on neural circuits regulating emotion and cognition
    Roberta Rasetti
    Clinical Brain Disorders Branch Genes, Cognition, and Psychosis Program, NIMH, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 35:2101-9. 2010
    ....
  57. pmc Impact of the brain-derived neurotrophic factor Val66Met polymorphism on levels of hippocampal N-acetyl-aspartate assessed by magnetic resonance spectroscopic imaging at 3 Tesla
    Alexa J Stern
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 64:856-62. 2008
    ....
  58. pmc Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice
    Francesco Papaleo
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:8709-23. 2008
    ..Our data indicate a critical role for the COMT gene in an apparent evolutionary trade-off between cognitive and affective functions...
  59. pmc Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition
    Andreas Meyer-Lindenberg
    Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, and Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute for Mental Health NIMH, NIH, Bethesda, MD 20892, USA
    J Clin Invest 117:672-82. 2007
    ..Our convergent results identify a prefrontal-neostriatal system affected by variation in PPP1R1B and suggest that DARPP-32 plays a pivotal role in cognitive function and possibly in the pathogenesis of schizophrenia...
  60. ncbi request reprint Differentiating allocation of resources and conflict detection within attentional control processing
    Giuseppe Blasi
    National Institute of Mental Health, National Institutes of Health, Bethesda, MA, USA
    Eur J Neurosci 25:594-602. 2007
    ....
  61. pmc Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia
    Thomas M Hyde
    Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:11088-95. 2011
    ..These findings suggest that abnormalities in GABA signaling critical to brain development contribute to genetic risk for schizophrenia...
  62. pmc Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine
    Venkata S Mattay
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Room 4s 235, Bethesda, MD 20982 1379, USA
    Proc Natl Acad Sci U S A 100:6186-91. 2003
    ..Further, individuals with the met/met catechol O-methyltransferase genotype appear to be at increased risk for an adverse response to amphetamine...
  63. ncbi request reprint Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down
    Joseph H Callicott
    Clinical Brain Disorders Branch, NIMH NIH, Bldg 10, Rm 4D 20, MSC 1389, Bethesda, MD 20892 1389, USA
    Am J Psychiatry 160:2209-15. 2003
    ..The authors' goal was to explore this phenomenon...
  64. ncbi request reprint Neurophysiological correlates of age-related changes in working memory capacity
    Venkata S Mattay
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Neurosci Lett 392:32-7. 2006
    ..As cognitive demand increases, however, they are pushed past a threshold beyond which physiological compensation cannot be made and, a decline in performance occurs...
  65. pmc A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia
    Stephen J Huffaker
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, Maryland, USA
    Nat Med 15:509-18. 2009
    ..These results identify a previously undescribed KCNH2 channel isoform involved in cortical physiology, cognition and psychosis, providing a potential new therapeutic drug target...
  66. pmc Impact of interacting functional variants in COMT on regional gray matter volume in human brain
    Robyn Honea
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuroimage 45:44-51. 2009
    ....
  67. pmc Genetic variation in FGF20 modulates hippocampal biology
    Herve Lemaitre
    Clinical Brain Disorder Branch, Genes, Cognition, and Psychosis Program, National Institutes of Health National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:5992-7. 2010
    ..These associations, from mRNA expression to brain morphology to cognition and an interaction with aging, confirm a role of FGF20 in human brain structure and function during development and aging...
  68. doi request reprint Verbal and visual memory: characterizing the clinical and intermediate phenotype in schizophrenia
    Shayna L Skelley
    Clinical Brain Disorders Branch, 10 Center Drive, MSC 1379, National Institute of Mental Health NIH, Bethesda, MD 20892, USA
    Schizophr Res 105:78-85. 2008
    ..Schizophr Bull, 32(1), 179-194]. It remains unclear whether deficits lie in encoding or savings, and whether the deficit is heritable...
  69. ncbi request reprint Catechol-O-methyltransferase genotype and dopamine regulation in the human brain
    Mayada Akil
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 23:2008-13. 2003
    ..This indicates that COMT genotype is a heritable aspect of dopamine regulation and it further explicates the mechanism by which the COMT valine allele increases susceptibility for psychosis...
  70. ncbi request reprint Comparison of cognitive performances during a placebo period and an atypical antipsychotic treatment period in schizophrenia: critical examination of confounds
    Thomas W Weickert
    Clinical Brain Disorders Branch, National Institute of Mental Health NIH, Building 10 Room 4N202, MSC 1379, Bethesda, MD 20892, USA
    Neuropsychopharmacology 28:1491-500. 2003
    ..These findings suggest that relative to placebo withdrawal, atypicals improve cognitive performance in SC. However, this finding may not be specific to atypicals, since analogous studies of typicals have not been performed...
  71. pmc Variation in dopamine genes influences responsivity of the human reward system
    Jean Claude Dreher
    Section on Integrative Neuroimaging, Genes, Cognition and Psychosis Program, National Institute of Mental Health, Bethesda, MD 20892 1365, USA
    Proc Natl Acad Sci U S A 106:617-22. 2009
    ....
  72. pmc Relative risk of probabilistic category learning deficits in patients with schizophrenia and their siblings
    Thomas W Weickert
    Genes, Cognition and Psychosis Program, Clinical, Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 67:948-55. 2010
    ..There are also discrepant findings regarding probabilistic category learning acquisition rate and performance in patients with schizophrenia...
  73. pmc Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain
    Wee Tin Kao
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1385, USA
    Proc Natl Acad Sci U S A 107:15619-24. 2010
    ..Our observations strengthen the evidence that NRG3 is a schizophrenia susceptibility gene, provide quantitative insight into NRG3 transcription traits in the human brain, and reveal a probable mechanistic basis for disease association...
  74. ncbi request reprint A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain
    Mitsuyuki Matsumoto
    Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 138:58-69. 2005
    ..Together, these data suggest a possible link between SREB family and neural plasticity, which may explain its extremely high conservation throughout vertebrate evolution...
  75. pmc Enuresis as a premorbid developmental marker of schizophrenia
    Thomas M Hyde
    Clinical Brain Disorders Branch, NIMH DIRP NIH, Bethesda, MD 20892, USA
    Brain 131:2489-98. 2008
    ..These findings add to the evidence implicating prefrontal dysmaturation in this disorder, potentially related to genetic risk factors...
  76. pmc Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain
    Jingshan Chen
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 75:807-21. 2004
    ....