Research Topics
Genomes and Genes
| Daniel R WeinbergerSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804ARoberta Rasetti
Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institutes of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 68:1207-17. 2011..However, whether these patterns are trait phenomena linked to genetic risk for illness is unclear...
Effect of catechol-O-methyltransferase val158met genotype on attentional controlGiuseppe Blasi
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
J Neurosci 25:5038-45. 2005..These results indicate that met allele load and presumably enhanced dopaminergic tone improve the "efficiency" of local circuit processing within the cingulate cortex and thereby its function during AC...
Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic riskRoberta Rasetti
Genes, Cognition, and Psychosis Program, IRP, NIMH, NIH, Rm 4S 235, 10 Center Dr, Bethesda, MD 20892, USA
Am J Psychiatry 166:216-25. 2009..The purpose of the present study was to examine amygdala response to threatening faces among healthy siblings of schizophrenia patients in whom a subtler heritable deficit might be observed...- Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulationEmily M Drabant
Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
Arch Gen Psychiatry 63:1396-406. 2006.... - Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophreniaKristin K Nicodemus
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD 20892, USA
Hum Genet 120:889-906. 2007..In addition, we were able to replicate other studies, including allelic directionality. The use of epistatic models may improve replication of psychiatric candidate gene studies... - Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controlsKristin K Nicodemus
Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 67:991-1001. 2010..NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis... - Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritabilityAaron L Goldman
Neuroimaging Core Facility, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Arch Gen Psychiatry 66:467-77. 2009..To our knowledge, cortical thickness, a measure of particular interest in schizophrenia, has not previously been evaluated in terms of its heritability in relationship to risk for schizophrenia... - 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depressionLukas Pezawas
Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
Nat Neurosci 8:828-34. 2005.... - Evidence of sex-modulated association of ZNF804A with schizophreniaFengyu Zhang
Genes, Cognition and Psychosis Program and Clinical, Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 69:914-7. 2011..A recent candidate gene study, which replicated the positive association with rs1344706, identified another positive SNP (rs7597593) in ZNF804A associated with schizophrenia... - The G72/G30 gene complex and cognitive abnormalities in schizophreniaTerry E Goldberg
Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD, USA
Neuropsychopharmacology 31:2022-32. 2006..We present evidence that SNP variations in the G72 gene region increase risk of cognitive impairment in schizophrenia. SNP variations were not strongly associated with clinical diagnosis in family-based analyses... - No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expressionHeike Tost
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1379, USA
Biol Psychiatry 68:105-7. 2010..In the largest neuroimaging intermediate phenotype study reported so far, we evaluated the effect of rs7341475 on an extended array of different neuroscientific measures... - Genetic modulation of GABA levels in the anterior cingulate cortex by GAD1 and COMTStefano Marenco
Clinical Brain Disorders Branch, GCAP, IRP, NIMH, Bethesda, MD 20892, USA
Neuropsychopharmacology 35:1708-17. 2010..The directionality of the effects, however, is inconsistent with earlier evidence of decreased GABA activity in schizophrenia... - Age-related alterations in default mode network: impact on working memory performanceFabio Sambataro
Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
Neurobiol Aging 31:839-52. 2010..These changes may be a reflection of a deficit in cognitive control associated with advancing age that results in deficient resource allocation to the task at hand... - Is gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblingsRobyn A Honea
Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1364, USA
Biol Psychiatry 63:465-74. 2008..We sought to discover previously unidentified gray matter volume differences in patients with schizophrenia and their siblings with optimized voxel-based morphometry... - Prefrontal broadband noise, working memory, and genetic risk for schizophreniaGeorg Winterer
Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
Am J Psychiatry 161:490-500. 2004..In the present study, the authors explored whether this particular physiological abnormality predicts working memory performance and is related to the genetic risk for schizophrenia... - RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activityBarbara K Lipska
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute for Mental Health, NIH, DHHS, Bethesda, MD 20892 1385, USA
Hum Mol Genet 15:2804-12. 2006..These data suggest that RGS4 mRNA expression is associated with cortical dopamine signaling and illustrate the importance of genetic and/or environmental background in gene expression studies in schizophrenia... - Age-related alterations in simple declarative memory and the effect of negative stimulus valenceVishnu P Murty
National Institutes of Health, Bethesda, MD, USA
J Cogn Neurosci 21:1920-33. 2009.... - Catechol-O-methyltransferase valine(158)methionine polymorphism modulates brain networks underlying working memory across adulthoodFabio Sambataro
Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 66:540-8. 2009.... - Heritability of brain morphology related to schizophrenia: a large-scale automated magnetic resonance imaging segmentation studyAaron L Goldman
Neuroimaging Core Facility, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 63:475-83. 2008..Currently available data on the heritability of these structural changes are inconsistent... - Brain regions underlying response inhibition and interference monitoring and suppressionGiuseppe Blasi
CBDB, GCAP, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Bethesda, MD 20982-1379, USA
Eur J Neurosci 23:1658-64. 2006..These results extend previous findings by suggesting regional functional specialization within a cortical network supporting cognitive control... - Allelic variation in RGS4 impacts functional and structural connectivity in the human brainJoshua W Buckholtz
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1364, USA
J Neurosci 27:1584-93. 2007..These findings suggest mechanisms in brain for the association of RGS4 with risk for psychiatric illness... - Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPsBarbara K Lipska
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
Hum Mol Genet 15:1245-58. 2006..Although, many other DISC1 binding partners still need to be investigated, these data implicate genetically linked abnormalities in the DISC1 molecular pathway in the pathophysiology of schizophrenia... - Transcript-specific associations of SLC12A5 (KCC2) in human prefrontal cortex with development, schizophrenia, and affective disordersRan Tao
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1385, USA
J Neurosci 32:5216-22. 2012..Alternate transcripts from KCC2 may participate in the abnormal GABA signaling in the DLPFC associated with schizophrenia... - The neonatal ventral hippocampal lesion model of schizophrenia: effects on dopamine and GABA mRNA markers in the rat midbrainBarbara K Lipska
Clinical Brain Disorders Branch, National Institute of Mental Health, Bldg 10, Rm 4 N306, Bethesda, MD 20892 1385, USA
Eur J Neurosci 18:3097-104. 2003.... - Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophreniaTerry E Goldberg
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 60:889-96. 2003..Cognitive dysfunction in the working memory domain seems to be under genetic control and is a candidate intermediate phenotype in schizophrenia. Genes that affect working memory processing may contribute to risk for schizophrenia... - Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memoryHao Yang Tan
Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 27:13393-401. 2007..These findings add to the integration of dopaminergic signaling in basic cortical assemblies with their roles in specific human brain networks during the orchestration of information processing in WM... - Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humansHao Yang Tan
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 118:2200-8. 2008..These data implicate AKT1 in modulating human prefrontal-striatal structure and function and suggest that the mechanism of this effect may be coupled to dopaminergic signaling and relevant to the expression of psychosis... - Catechol-o-methyltransferase valine(158)methionine genotype and resting regional cerebral blood flow in medication-free patients with schizophreniaDaniel Paul Eisenberg
Section on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland 20892 1365, USA
Biol Psychiatry 67:287-90. 2010..Task-independent effects of this polymorphism in schizophrenia have not yet been characterized... - The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphologyLukas Pezawas
Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
J Neurosci 24:10099-102. 2004.... - Neural correlates of probabilistic category learning in patients with schizophreniaThomas W Weickert
Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 29:1244-54. 2009.... - Prefrontal electrophysiologic "noise" and catechol-O-methyltransferase genotype in schizophreniaGeorg Winterer
Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 60:578-84. 2006.... - Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortexStefano Marenco
Genes and Cognition Program, Clinical Brain Disorders Branch, Intramural Research Program, Bldg 10, Rm 4S235, 10 Center Dr, NIMH, NIH, Bethesda, MD 20892, USA
Am J Psychiatry 163:740-2. 2006.... - Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophreniaCynthia Shannon Weickert
MiNDS Unit, Section on Neuropathology, GCAP, NIMH, NIH, Bethesda, MD 20892, USA
Hum Mol Genet 17:2293-309. 2008..Thus, the variation in the ESR1 gene is associated with schizophrenia and the mechanism of this association may involve alternative gene regulation and transcript processing... - Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophreniaJoseph H Callicott
Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20982 1389, USA
Am J Psychiatry 160:709-19. 2003..Earlier family studies have suggested that deficits in executive cognition and working memory may be related to genetic susceptibility for schizophrenia, but the biological basis for this behavioral phenotype has not been identified... - Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performanceAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892 1384, USA
J Neurosci 23:6690-4. 2003..These data implicate a specific genetic mechanism for substantial normal variation in human declarative memory and suggest that the basic effects of BDNF signaling on hippocampal function in experimental animals are important in humans... - Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortexCarlo Colantuoni
Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, MD 20892, USA
Brain Struct Funct 213:255-71. 2008..All microarray data are available at NCBI's Gene Expression Omnibus: GEO Series accession number GSE11546 (http://www.ncbi.nlm.nih.gov/geo) [corrected].. - Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain functionHao Yang Tan
Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:12536-41. 2007..These findings extend putative brain dopaminergic and glutamatergic relationships indexed by COMT and GRM3 to a systems-level interaction in human cortical circuits implicated in working memory dysfunction such as in schizophrenia... - Genetic variation in CACNA1C affects brain circuitries related to mental illnessKristin L Bigos
Genes, Cognition, and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 67:939-45. 2010..The CACNA1C gene (alpha-1C subunit of the L-type voltage-gated calcium channel) has been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of association has not been explored... - Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotypeAndreas Meyer-Lindenberg
Section on Integrative Neuroimaging, National Institute for Mental Health, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, Maryland 20892 1365, USA
Nat Neurosci 8:594-6. 2005..These data implicate a dopaminergic tuning mechanism in prefrontal cortex and suggest a systems-level mechanism for cognitive and neuropsychiatric associations with COMT... - A susceptibility gene for affective disorders and the response of the human amygdalaAhmad R Hariri
Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
Arch Gen Psychiatry 62:146-52. 2005.... - Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medicationsThomas W Weickert
National Institutes of Health, National Institute of Mental Health, Clinical Brain Disorders Branch, Building 10, Room 4C 101, MSC 1379, Bethesda, MD 20892, USA
Biol Psychiatry 56:677-82. 2004..The present study tested the effects of several COMT polymorphisms on the cognitive response to antipsychotic medication in patients with schizophrenia... - Instability of prefrontal signal processing in schizophreniaGeorg Winterer
Genes, Cognition and Psychosis Program, NIH, NIMH, 10 Center Dr, MSC 1379, Bethesda, MD 20892, USA
Am J Psychiatry 163:1960-8. 2006..CONCLUSIONS: These findings suggest that unstable cortical signal processing underlies classic abnormal cortical activation patterns as well as psychosis in schizophrenia... - Tolcapone improves cognition and cortical information processing in normal human subjectsJose A Apud
Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20854, USA
Neuropsychopharmacology 32:1011-20. 2007..Our results are consistent with data from animal studies and from computational models of the effects of selective enhancement of DA signaling in the prefrontal cortex... - Effective connectivity of AKT1-mediated dopaminergic working memory networks and pharmacogenetics of anti-dopaminergic treatmentHao Yang Tan
Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892, USA
Brain 135:1436-45. 2012..Thus, we suggest that genetic modulation of DRD2-AKT1-related prefrontal-subcortical circuits could at least in part influence cognitive dysfunction in psychosis and its treatment... - DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphismsKenji Nakata
Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1385, USA
Proc Natl Acad Sci U S A 106:15873-8. 2009..Our results implicate a molecular mechanism of genetic risk associated with DISC1 involving specific alterations in gene processing... - Interactive effects of DAOA (G72) and catechol-O-methyltransferase on neurophysiology in prefrontal cortexDevon C Nixon
Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Biol Psychiatry 69:1006-8. 2011.... - Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimagingKristin K Nicodemus
Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Hum Genet 127:441-52. 2010.... - Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell modelsYoshitatsu Sei
Clinical Brain Disorder Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
PLoS ONE 5:e10789. 2010.... - Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrainCynthia Shannon Weickert
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Arch Gen Psychiatry 61:544-55. 2004..3) encodes a neuronal protein that binds to beta-dystrobrevin and may be part of the dystrophin protein complex. Little is known about dysbindin expression in normal or schizophrenic brain... - Variation in DISC1 affects hippocampal structure and function and increases risk for schizophreniaJoseph H Callicott
Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 102:8627-32. 2005.... - Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophreniaMichael F Egan
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:12604-9. 2004..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia... - Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controlsCatherine M Diaz-Asper
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 63:72-9. 2008..Recently, other single nucleotide polymorphisms (SNPs) across the gene have emerged as additional risk factors for schizophrenia: namely rs737865, rs165599, and rs2097603. In a large sample, we examined whether these SNPs affect WM... - Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1Shiny V Mathew
Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 1385, USA
Hum Mol Genet 16:2921-32. 2007..Together, these results suggest that the molecular mechanism of the association between NRG1 risk alleles and schizophrenia may include down-regulation of nAChR alpha7 expression... - Investigation of anatomical thalamo-cortical connectivity and FMRI activation in schizophreniaStefano Marenco
Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA
Neuropsychopharmacology 37:499-507. 2012..These results suggest that thalamocortical connectivity to the LPFC is altered in schizophrenia with functional consequences on working memory processing in LPFC... - Differentiating allocation of resources and conflict detection within attentional control processingGiuseppe Blasi
National Institute of Mental Health, National Institutes of Health, Bethesda, MA, USA
Eur J Neurosci 25:594-602. 2007.... - Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognitionAndreas Meyer-Lindenberg
Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, and Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute for Mental Health NIMH, NIH, Bethesda, MD 20892, USA
J Clin Invest 117:672-82. 2007..Our convergent results identify a prefrontal-neostriatal system affected by variation in PPP1R1B and suggest that DARPP-32 plays a pivotal role in cognitive function and possibly in the pathogenesis of schizophrenia... - Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in miceFrancesco Papaleo
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurosci 28:8709-23. 2008..Our data indicate a critical role for the COMT gene in an apparent evolutionary trade-off between cognitive and affective functions... - Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophreniaThomas M Hyde
Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 31:11088-95. 2011..These findings suggest that abnormalities in GABA signaling critical to brain development contribute to genetic risk for schizophrenia... - Impact of the brain-derived neurotrophic factor Val66Met polymorphism on levels of hippocampal N-acetyl-aspartate assessed by magnetic resonance spectroscopic imaging at 3 TeslaAlexa J Stern
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 64:856-62. 2008.... - Modulatory effects of modafinil on neural circuits regulating emotion and cognitionRoberta Rasetti
Clinical Brain Disorders Branch Genes, Cognition, and Psychosis Program, NIMH, NIH, Bethesda, MD 20892, USA
Neuropsychopharmacology 35:2101-9. 2010.... - A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophreniaStephen J Huffaker
Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, Maryland, USA
Nat Med 15:509-18. 2009..These results identify a previously undescribed KCNH2 channel isoform involved in cortical physiology, cognition and psychosis, providing a potential new therapeutic drug target... - Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or downJoseph H Callicott
Clinical Brain Disorders Branch, NIMH NIH, Bldg 10, Rm 4D 20, MSC 1389, Bethesda, MD 20892 1389, USA
Am J Psychiatry 160:2209-15. 2003..The authors' goal was to explore this phenomenon... - Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamineVenkata S Mattay
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Room 4S-235, Bethesda, MD 20982-1379, USA
Proc Natl Acad Sci U S A 100:6186-91. 2003..Further, individuals with the met/met catechol O-methyltransferase genotype appear to be at increased risk for an adverse response to amphetamine... - Neurophysiological correlates of age-related changes in working memory capacityVenkata S Mattay
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Neurosci Lett 392:32-7. 2006..As cognitive demand increases, however, they are pushed past a threshold beyond which physiological compensation cannot be made and, a decline in performance occurs... - Impact of interacting functional variants in COMT on regional gray matter volume in human brainRobyn Honea
Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Neuroimage 45:44-51. 2009.... - Genetic variation in FGF20 modulates hippocampal biologyHerve Lemaitre
Clinical Brain Disorder Branch, Genes, Cognition, and Psychosis Program, National Institutes of Health National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurosci 30:5992-7. 2010..These associations, from mRNA expression to brain morphology to cognition and an interaction with aging, confirm a role of FGF20 in human brain structure and function during development and aging... - Verbal and visual memory: characterizing the clinical and intermediate phenotype in schizophreniaShayna L Skelley
Clinical Brain Disorders Branch, 10 Center Drive, MSC 1379, National Institute of Mental Health NIH, Bethesda, MD 20892, USA
Schizophr Res 105:78-85. 2008..Schizophr Bull, 32(1), 179-194]. It remains unclear whether deficits lie in encoding or savings, and whether the deficit is heritable... - Variation in dopamine genes influences responsivity of the human reward systemJean Claude Dreher
Section on Integrative Neuroimaging, Genes, Cognition and Psychosis Program, National Institute of Mental Health, Bethesda, MD 20892 1365, USA
Proc Natl Acad Sci U S A 106:617-22. 2009.... - Comparison of cognitive performances during a placebo period and an atypical antipsychotic treatment period in schizophrenia: critical examination of confoundsThomas W Weickert
Clinical Brain Disorders Branch, National Institute of Mental Health NIH, Building 10 Room 4N202, MSC 1379, Bethesda, MD 20892, USA
Neuropsychopharmacology 28:1491-500. 2003..These findings suggest that relative to placebo withdrawal, atypicals improve cognitive performance in SC. However, this finding may not be specific to atypicals, since analogous studies of typicals have not been performed... - Catechol-O-methyltransferase genotype and dopamine regulation in the human brainMayada Akil
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 23:2008-13. 2003..This indicates that COMT genotype is a heritable aspect of dopamine regulation and it further explicates the mechanism by which the COMT valine allele increases susceptibility for psychosis... - Relative risk of probabilistic category learning deficits in patients with schizophrenia and their siblingsThomas W Weickert
Genes, Cognition and Psychosis Program, Clinical, Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 67:948-55. 2010..There are also discrepant findings regarding probabilistic category learning acquisition rate and performance in patients with schizophrenia... - Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brainWee Tin Kao
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1385, USA
Proc Natl Acad Sci U S A 107:15619-24. 2010..Our observations strengthen the evidence that NRG3 is a schizophrenia susceptibility gene, provide quantitative insight into NRG3 transcription traits in the human brain, and reveal a probable mechanistic basis for disease association... - Enuresis as a premorbid developmental marker of schizophreniaThomas M Hyde
Clinical Brain Disorders Branch, NIMH DIRP NIH, Bethesda, MD 20892, USA
Brain 131:2489-98. 2008..These findings add to the evidence implicating prefrontal dysmaturation in this disorder, potentially related to genetic risk factors... - A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrainMitsuyuki Matsumoto
Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, MD 20892, USA
Brain Res Mol Brain Res 138:58-69. 2005..Together, these data suggest a possible link between SREB family and neural plasticity, which may explain its extremely high conservation throughout vertebrate evolution... - Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brainJingshan Chen
Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Am J Hum Genet 75:807-21. 2004....