C R Weinberg

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Fertility drugs and young-onset breast cancer: results from the Two Sister Study
    Chunyuan Fei
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Natl Cancer Inst 104:1021-7. 2012
  2. pmc Interaction and exposure modification: are we asking the right questions?
    Clarice R Weinberg
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 175:602-5. 2012
  3. pmc Can DAGs clarify effect modification?
    Clarice R Weinberg
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Epidemiology 18:569-72. 2007
  4. pmc Less is more, except when less is less: Studying joint effects
    C R Weinberg
    National Institute of Environmental Health Sciences, MD A3 03, P O Box 12233, Research Triangle Park, NC 27709, USA
    Genomics 93:10-2. 2009
  5. pmc A hybrid design for studying genetic influences on risk of diseases with onset early in life
    C R Weinberg
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Hum Genet 77:627-36. 2005
  6. pmc The genetics of preterm birth: using what we know to design better association studies
    Clarice R Weinberg
    Biostatistics Branch, Mail Drop A3 03, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 170:1373-81. 2009
  7. pmc A sibling-augmented case-only approach for assessing multiplicative gene-environment interactions
    Clarice R Weinberg
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 174:1183-9. 2011
  8. ncbi request reprint A method for identifying genes related to a quantitative trait, incorporating multiple siblings and missing parents
    Emily O Kistner
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Genet Epidemiol 29:155-65. 2005
  9. pmc Making the most of case-mother/control-mother studies
    M Shi
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 168:541-7. 2008
  10. ncbi request reprint Accounting for unreported and missing intercourse in human fertility studies
    D B Dunson
    Biostatistics Branch, MD A3 03, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709, USA
    Stat Med 19:665-79. 2000

Detail Information

Publications73

  1. pmc Fertility drugs and young-onset breast cancer: results from the Two Sister Study
    Chunyuan Fei
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Natl Cancer Inst 104:1021-7. 2012
    ..We examined the association between use of fertility drugs (clomiphene citrate [CC] and follicle-stimulating hormone [FSH]) and subsequent risk of young-onset (<50 years at diagnosis) breast cancer...
  2. pmc Interaction and exposure modification: are we asking the right questions?
    Clarice R Weinberg
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 175:602-5. 2012
    ..Openness to parsimonious joint models and the insights they can provide is key to advancing our understanding of etiology...
  3. pmc Can DAGs clarify effect modification?
    Clarice R Weinberg
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Epidemiology 18:569-72. 2007
    ..Examples are given, some of which depend on scale and some of which do not. An example illustrates possible biologic implications for such an effect modification DAG...
  4. pmc Less is more, except when less is less: Studying joint effects
    C R Weinberg
    National Institute of Environmental Health Sciences, MD A3 03, P O Box 12233, Research Triangle Park, NC 27709, USA
    Genomics 93:10-2. 2009
    ..Through genotyping of parents of population-based controls and assuming Mendelian transmission, power is markedly enhanced. One can also estimate main effects for exposures and now flexibly assess models for joint effects...
  5. pmc A hybrid design for studying genetic influences on risk of diseases with onset early in life
    C R Weinberg
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Hum Genet 77:627-36. 2005
    ....
  6. pmc The genetics of preterm birth: using what we know to design better association studies
    Clarice R Weinberg
    Biostatistics Branch, Mail Drop A3 03, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 170:1373-81. 2009
    ..Both designs offer important advantages over the commonly applied case-mother/control-mother design...
  7. pmc A sibling-augmented case-only approach for assessing multiplicative gene-environment interactions
    Clarice R Weinberg
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 174:1183-9. 2011
    ..They also show that robust analyses of interactions using tetrads or disease-discordant sibling pairs are equivalent to analyses using the SACO design...
  8. ncbi request reprint A method for identifying genes related to a quantitative trait, incorporating multiple siblings and missing parents
    Emily O Kistner
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Genet Epidemiol 29:155-65. 2005
    ..We use simulations based on a population with admixture to compare our method to a popular non-parametric family-based association test (FBAT), testing the null of no association in the presence of linkage...
  9. pmc Making the most of case-mother/control-mother studies
    M Shi
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 168:541-7. 2008
    ..Benefits are even more marked if, as is typical, information on genotype is missing for some individuals...
  10. ncbi request reprint Accounting for unreported and missing intercourse in human fertility studies
    D B Dunson
    Biostatistics Branch, MD A3 03, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709, USA
    Stat Med 19:665-79. 2000
    ..We illustrate the methods by application to two prospective fertility studies. Published in 2000 by John Wiley & Sons, Ltd...
  11. ncbi request reprint A method for using incomplete triads to test maternally mediated genetic effects and parent-of-origin effects in relation to a quantitative trait
    Emily O Kistner
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Am J Epidemiol 163:255-61. 2006
    ..Methods are illustrated with birth weight and gestational length, two quantitative outcomes for which data were collected in a Montreal, Canada, study of intrauterine growth restriction between May 1998 and June 2000...
  12. ncbi request reprint Using pooled exposure assessment to improve efficiency in case-control studies
    C R Weinberg
    Biostatistics Branch, MD A3 03, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biometrics 55:718-26. 1999
    ..In settings where high assay costs constrain the number of people an investigator can afford to study, specimen pooling can make it possible to study more people and hence improve the study's statistical power with no increase in cost...
  13. pmc Allowing for missing parents in genetic studies of case-parent triads
    C R Weinberg
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Hum Genet 64:1186-93. 1999
    ..Information from siblings also can be incorporated to further improve the statistical power when genetic data from parents or probands are missing...
  14. ncbi request reprint Use of missing-data methods to correct bias and improve precision in case-control studies in which cases are subtyped but subtype information is incomplete
    J C Schroeder
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC27709, USA
    Am J Epidemiol 154:954-62. 2001
    ..Under the same assumptions, empirical confidence interval coverage is consistent with the nominal 95%...
  15. ncbi request reprint Choosing a retrospective design to assess joint genetic and environmental contributions to risk
    C R Weinberg
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 152:197-203. 2000
    ..The investigator must also consider certain practical issues, such as the availability of parents or sibling controls...
  16. pmc Methods for detection of parent-of-origin effects in genetic studies of case-parents triads
    C R Weinberg
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Am J Hum Genet 65:229-35. 1999
    ..Simulations based on an admixed population demonstrate good operating characteristics for these procedures, under diverse scenarios...
  17. pmc The use of case-parent triads to study joint effects of genotype and exposure
    D M Umbach
    Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709 2233, USA
    Am J Hum Genet 66:251-61. 2000
    ..Because the needed assumptions likely hold in many situations, the likelihood-based approach should be broadly applicable for diseases in which probands commonly have living parents...
  18. pmc Ultraviolet radiation intensity predicts the relative distribution of dermatomyositis and anti-Mi-2 autoantibodies in women
    Lori A Love
    Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA
    Arthritis Rheum 60:2499-504. 2009
    ....
  19. pmc A log-linear approach to case-parent-triad data: assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting
    C R Weinberg
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Hum Genet 62:969-78. 1998
    ..When a single allele is under study, the proposed method can yield powerful tests for detection of linkage disequilibrium and is applicable to a broader array of causal scenarios than is the TDT...
  20. ncbi request reprint Modeling human fertility in the presence of measurement error
    D B Dunson
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biometrics 56:288-92. 2000
    ..Thus, the results of studies relating the timing of intercourse to the probability of conception should be interpreted cautiously...
  21. pmc The association of maternal factors with delayed implantation and the initial rise of urinary human chorionic gonadotrophin
    A M Z Jukic
    Epidemiology Branch, National Institute of Environmental Health Sciences, PO Box 12233, MD A3 05, Durham, NC 27709, USA
    Hum Reprod 26:920-6. 2011
    ..002). CONCLUSIONS Although limited by small numbers and infrequent exposures, our analyses suggest that a woman's exposures both early in life and at the time of pregnancy may influence early development of the conceptus...
  22. ncbi request reprint Likelihood of conception with a single act of intercourse: providing benchmark rates for assessment of post-coital contraceptives
    A J Wilcox
    Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA
    Contraception 63:211-5. 2001
    ..We find that the possibility of late ovulation produces a persistent risk of pregnancy even into the sixth week of the cycle. Post-coital contraceptives may be indicated even when intercourse has occurred late in the cycle...
  23. ncbi request reprint Evaluating effects of exposures on embryo viability and uterine receptivity in in vitro fertilization
    H Zhou
    Department of Biostatistics, University of North Carolina, Chapel Hill 27599, USA
    Stat Med 17:1601-12. 1998
    ..We illustrate by applying the method to a recent study of in vitro fertilization carried out in North Carolina. The number of cells at transfer is evidently a marker for embryo viability...
  24. ncbi request reprint Natural limits of pregnancy testing in relation to the expected menstrual period
    A J Wilcox
    Epidemiology Branch, MD A3 05, National Institute of Environmental Health Sciences, Durham, NC 27709, USA
    JAMA 286:1759-61. 2001
    ..quot; However, a pregnancy cannot be detected before the blastocyst implants. Due to natural variability in the timing of ovulation, implantation does not necessarily occur before the expected onset of next menses...
  25. pmc Bleeding following pregnancy loss before 6 weeks' gestation
    J H E Promislow
    Social and Scientific Systems, National Institute of Environmental Health Sciences, Durham, NC 27703, USA
    Hum Reprod 22:853-7. 2007
    ..Pregnancy loss before 6 weeks' gestation is common, but little has been reported about the associated bleeding. We compared women's bleeding following a pregnancy loss before 6 weeks' gestation with their typical menstruation...
  26. doi request reprint Within-person variability in urinary phthalate metabolite concentrations: measurements from specimens after long-term frozen storage
    Donna Day Baird
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Expo Sci Environ Epidemiol 20:169-75. 2010
    ..These findings support the use of stored urine specimens collected during the relevant stage of human pregnancy to investigate the influence of phthalate exposures on later outcomes...
  27. ncbi request reprint Indoor radon and lung cancer risk in connecticut and utah
    Dale P Sandler
    Epidemiology Branch, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Toxicol Environ Health A 69:633-54. 2006
    ..While results were consistent with the estimates from studies of miners, this study provides no evidence of an increased risk for lung cancer at the exposure levels observed...
  28. ncbi request reprint Birth weight and mortality: causality or confounding?
    Olga Basso
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 164:303-11. 2006
    ..If such rare factors underlie the association of birth weight with mortality, it would have broad implications for the study of fetal growth restriction and birth weight, and for the prevention of infant mortality...
  29. ncbi request reprint Trends in fetal and infant survival following preeclampsia
    Olga Basso
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    JAMA 296:1357-62. 2006
    ..This practice has increased in recent decades, but its net effect on fetal and infant survival has not been assessed...
  30. pmc Using risk-based sampling to enrich cohorts for endpoints, genes, and exposures
    Clarice R Weinberg
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 166:447-55. 2007
    ....
  31. pmc Identification of risk-related haplotypes with the use of multiple SNPs from nuclear families
    Min Shi
    Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Am J Hum Genet 81:53-66. 2007
    ..As an illustration, we reanalyze data from a previously reported orofacial cleft study, to now investigate both fetal and maternal effects of the IRF6 gene...
  32. pmc Lifestyle and reproductive factors associated with follicular phase length
    Anne Marie Zaura Jukic
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Womens Health (Larchmt) 16:1340-7. 2007
    ..We sought to identify characteristics associated with follicular phase length...
  33. pmc Effects of early pregnancy loss on hormone levels in the subsequent menstrual cycle
    Anne Marie Z Jukic
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Gynecol Endocrinol 26:897-901. 2010
    ..Very early pregnancy losses do not appear to influence subsequent menstrual cycles to the same degree as spontaneous miscarriages...
  34. pmc Pesticide exposure and hypertensive disorders during pregnancy
    Tina M Saldana
    Social and Scientific Systems, Inc, 1009 Slater Road, Durham, NC 27703, USA
    Environ Health Perspect 117:1393-6. 2009
    ..Hypertensive disorders of pregnancy, including pregnancy-induced hypertension (PIH) and preeclampsia (PE), complicate 2-8% of pregnancies. Few studies have examined environmental risk factors in relation to these conditions...
  35. pmc Using case-parent triads to estimate relative risks associated with a candidate haplotype
    Min Shi
    Biostatistics Branch, NIEHS, NIH, DHHS, Research Triangle Park, NC 27709, USA
    Ann Hum Genet 73:346-59. 2009
    ..To illustrate, we reanalyze data from a study of orofacial clefts to investigate a 9-SNP candidate haplotype of the IRF6 gene...
  36. pmc Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study
    Abee L Boyles
    Epidemiology Branch, NIEHS NIH, Durham, North Carolina 27709, USA
    Genet Epidemiol 33:247-55. 2009
    ..Despite strong evidence for genetic causes of oral facial clefts and the protective effects of maternal vitamins, we found no convincing indication that polymorphisms in these vitamin metabolism genes play an etiologic role...
  37. pmc Measuring menstrual discomfort: a comparison of interview and diary data
    Anne Marie Zaura Jukic
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Epidemiology 19:846-50. 2008
    ..Menstrual discomfort is common among women of reproductive age and can be debilitating. The accuracy of self-report of menstrual discomfort is unknown...
  38. ncbi request reprint Invited commentary: Testing for Hardy-Weinberg disequilibrium using a genome single-nucleotide polymorphism scan based on cases only
    Clarice R Weinberg
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 158:401-3; discussion 404-5. 2003
  39. ncbi request reprint Gene selection and clustering for time-course and dose-response microarray experiments using order-restricted inference
    Shyamal D Peddada
    Biostatistics Branch, Laboratory of Molecular Carcinogenesis, Research Triangle Park, NC 27709, USA
    Bioinformatics 19:834-41. 2003
    ..In this example, our method was able to identify several biologically interesting genes that previous analyses failed to reveal...
  40. ncbi request reprint Rescue of the corpus luteum in human pregnancy
    Donna Day Baird
    Epidemiology Branch Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 68:448-56. 2003
    ..Delineating the functional importance of an abrupt progesterone rise at the time of implantation may provide new strategies for promoting successful implantation in assisted reproduction...
  41. ncbi request reprint Misclassification of gestational age in the study of spontaneous abortion
    Penelope P Howards
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Bethesda, MD, USA
    Am J Epidemiol 164:1126-36. 2006
    ..Bias was greatest when the magnitude of error for pregnancies at higher risk was much larger than that for pregnancies at lower risk...
  42. ncbi request reprint Method for using complete and incomplete trios to identify genes related to a quantitative trait
    Emily O Kistner
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Genet Epidemiol 27:33-42. 2004
    ..In addition, missing parental genotype data can be accommodated through an expectation-maximization (EM) algorithm approach. The EM approach allows recovery of most of the lost power due to incomplete trios...
  43. pmc Studying parents and grandparents to assess genetic contributions to early-onset disease
    Clarice R Weinberg
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Am J Hum Genet 72:438-47. 2003
    ..Conditioning on both the grandparents' and the affected grandchild's genotypes, a third log-linear model captures the remaining information, in an independent LRT for maternal effects...
  44. ncbi request reprint On the frequency of intercourse around ovulation: evidence for biological influences
    A J Wilcox
    National Institute of Environment Health Sciences, Durham, NC, USA
    Hum Reprod 19:1539-43. 2004
    ..Such coordination has not been established in humans. We explored this possibility by examining patterns of sexual intercourse in relation to ovulation...
  45. ncbi request reprint Invited commentary: analysis of gestational-age-specific mortality--on what biologic foundations?
    Allen J Wilcox
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC 27709, USA
    Am J Epidemiol 160:213-4; discussion 215-6. 2004
  46. ncbi request reprint Seasonal influence on the onset of idiopathic inflammatory myopathies in serologically defined groups
    Kakali Sarkar
    National Institute of Environmental Health Sciences, NIH, DHHS, Bethesda, MD 20892, USA
    Arthritis Rheum 52:2433-8. 2005
    ..To assess possible seasonal patterns in the onset of polymyositis (PM) and dermatomyositis (DM)...
  47. pmc Accuracy of reporting of menstrual cycle length
    Anne Marie Zaura Jukic
    Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC 27709, USA
    Am J Epidemiol 167:25-33. 2008
    ..Studies that rely on self-reported cycle length could be prone to artifactual findings because of systematic covariate effects on reporting...
  48. ncbi request reprint Assessing human fertility using several markers of ovulation
    D B Dunson
    Biostatistics Branch, National Institute of Environmental Health Sciences, National Insitites of Health, Research Triangle Park, NC 27709, USA
    Stat Med 20:965-78. 2001
    ..Published in 2001 by John Wiley & Sons, Ltd...
  49. ncbi request reprint A geometric approach to determine association and coherence of the activation times of cell-cycling genes under differing experimental conditions
    Delong Liu
    Biostatistics Branch, MD A3 03, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Bioinformatics 20:2521-8. 2004
    ..Our proposed methodology is illustrated by applying it to a HeLa cell-cycle gene-expression data...
  50. ncbi request reprint Agricultural risk factors for t(14;18) subtypes of non-Hodgkin's lymphoma
    J C Schroeder
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Epidemiology 12:701-9. 2001
    ..Results suggest that non-Hodgkin's lymphoma classification based on the t(14;18) translocation is of value in etiologic research...
  51. ncbi request reprint Summarizing the motion of self-propelled cells: applications to sperm motility
    D B Dunson
    Biostatistics Branch, NIEHS, Research Triangle Park, North Carolina 27709, USA
    Biometrics 55:537-43. 1999
    ..We apply the method to a set of rat sperm tracks representative of both normal and abnormal motion characteristics...
  52. ncbi request reprint Urinary hCG patterns during the week following implantation
    P A Nepomnaschy
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA
    Hum Reprod 23:271-7. 2008
    ..Therefore the aim of this study was to describe the average profile of hCG and its variability during the 7 days following estimated implantation in a population of naturally conceived pregnancies...
  53. ncbi request reprint A case-control study of tobacco use and other non-occupational risk factors for t(14;18) subtypes of non-Hodgkin's lymphoma (United States)
    J C Schroeder
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cancer Causes Control 13:159-68. 2002
    ..In a new approach we evaluated associations with subtypes defined by the t(14;18) translocation, reasoning that cases within these subtypes would have more common risk factors than all NHL combined...
  54. ncbi request reprint Has human fertility declined over time?: why we may never know
    Markku Sallmen
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institute of Health, Department of Health and Human Services, Research Triangle Park, NC, USA
    Epidemiology 16:494-9. 2005
    ..Studies of couple fertility have produced conflicting results. We evaluate how changes in the availability and use of effective contraception and induced abortion might bias the direct study of time trends in couple fertility...
  55. pmc Seasonal birth patterns in myositis subgroups suggest an etiologic role of early environmental exposures
    Leora J Vegosen
    Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    Arthritis Rheum 56:2719-28. 2007
    ..To evaluate whether seasonal early environmental exposures might influence later development of autoimmune disease, by assessing distributions of birth dates in groups of patients with idiopathic inflammatory myopathies (IIMs)...
  56. pmc Phase analysis of circadian-related genes in two tissues
    Delong Liu
    Biostatistics Branch, National Institute of Environmental Health Sciences, MD A3 03, 111 TW Alexander Dr, Research Triangle Park, NC 27709, USA
    BMC Bioinformatics 7:87. 2006
    ..These interesting biological observations prompt a statistical question regarding how to distinguish the synchronized genes from genes that are systematically lagged in phase/peak expression time across two tissues...
  57. ncbi request reprint Invited commentary: Barker meets Simpson
    C R Weinberg
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 161:33-5; discussion 36-7. 2005
  58. ncbi request reprint Gene selection for sample classification based on gene expression data: study of sensitivity to choice of parameters of the GA/KNN method
    L Li
    Biostatistics Branch Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Bioinformatics 17:1131-42. 2001
    ..As an extension to our earlier work, we systematically examine the sensitivity, reproducibility and stability of gene selection/sample classification to the choice of parameters of the algorithm...
  59. ncbi request reprint A prospective study of the onset of symptoms of pregnancy
    Amy E Sayle
    Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA
    J Clin Epidemiol 55:676-80. 2002
    ..The earliest symptoms do not begin until after key stages of embryogenesis, reinforcing the need for women to initiate sound health behaviors before pregnancy is apparent. Published by Elsevier Science Inc...
  60. pmc Within-person variability in urinary bisphenol A concentrations: measurements from specimens after long-term frozen storage
    Pablo A Nepomnaschy
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Environ Res 109:734-7. 2009
    ..Our aims were to evaluate the stability of BPA in specimens after 22-24 years of storage and to measure within-person temporal variability in urinary BPA...
  61. ncbi request reprint Reduced fertility among women employed as dental assistants exposed to high levels of nitrous oxide
    A S Rowland
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
    N Engl J Med 327:993-7. 1992
    ..Epidemiologic studies have suggested an association between exposure to mixed anesthetic gases and impaired fertility. We investigated the effects of occupational exposure to nitrous oxide on the fertility of female dental assistants...
  62. pmc A random-periods model for expression of cell-cycle genes
    Delong Liu
    Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 101:7240-5. 2004
    ..The model permits estimation of and hypothesis testing about biologically meaningful parameters that characterize cycling genes...
  63. pmc Testing haplotype-environment interactions using case-parent triads
    Min Shi
    Biostatistics Branch, NIEHS, NIH, DHHS, Research Triangle Park, NC 27709, USA
    Hum Hered 70:23-33. 2010
    ..We propose a procedure that uses case-parent triad data and, though not fully robust, resists bias from population structure...
  64. ncbi request reprint Subfecundity as a correlate of preeclampsia: a study within the Danish National Birth Cohort
    Olga Basso
    Danish Epidemiology Science Centre, Aarhus University, Aarhus, Denmark
    Am J Epidemiol 157:195-202. 2003
    ..30, 4.69). The authors found that a long TTP was associated with preeclampsia, supporting the hypothesis that some factors delaying clinically recognized conception may also be in a causal pathway for preeclampsia...
  65. ncbi request reprint Parent-of-origin transmission of thrombophilic alleles to intrauterine growth-restricted newborns and transmission-ratio distortion in unaffected newborns
    Claire Infante-Rivard
    Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    Am J Epidemiol 162:891-7. 2005
    ..Affected newborns also inherited the prothrombin G20210A variant significantly less often than expected. These results suggest that these three genes exhibit segregation distortion or reduce gestational survival...
  66. ncbi request reprint Xenobiotic-metabolizing genes and small-for-gestational-age births: interaction with maternal smoking
    Claire Infante-Rivard
    Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    Epidemiology 17:38-46. 2006
    ..Little is known about the role of xenobiotic-metabolizing gene variants as risk factors for small-for-gestational-age (SGA) births or as modifiers for the effects of exposures such as maternal smoking...
  67. ncbi request reprint Intact HCG, free HCG beta subunit and HCG beta core fragment: longitudinal patterns in urine during early pregnancy
    Ruth McChesney
    Brooklyn College, The City University of New York, New York, NY, USA
    Hum Reprod 20:928-35. 2005
    ..Detecting and monitoring early pregnancy depend on the measurement of HCG. Little is known about how production of various forms of HCG may evolve over the earliest weeks of pregnancy, particularly in naturally conceived pregnancies...
  68. pmc Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants
    Min Shi
    Department of Biology, University of Iowa, Iowa City, IA, 52242, USA
    Am J Hum Genet 80:76-90. 2007
    ..This study benefited from two large samples, involving independent populations, that provided substantial power and a framework for future studies that could identify a susceptible population for preventive health care...
  69. pmc Excess transmission of the NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism in families of children with acute lymphoblastic leukemia
    Claire Infante-Rivard
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada
    Am J Epidemiol 165:1248-54. 2007
    ....
  70. ncbi request reprint Height and risk of severe pre-eclampsia. A study within the Danish National Birth Cohort
    Olga Basso
    Department of Epidemiology and Social Medicine, Danish Epidemiology Science Centre, Aarhus University, Vennelyst Boulevard 6, 8000 Aarhus C, Denmark
    Int J Epidemiol 33:858-63. 2004
    ..Women with recurrent pre-eclampsia or pre-eclampsia early in pregnancy reportedly have an increased long-term risk of CVD. Short stature is a risk factor for CVD but has rarely been examined in relation to pre-eclampsia...
  71. pmc Regarding "parental genotypes in the risk of a complex disease"
    Clarice R Weinberg
    Am J Hum Genet 71:1239-40; author reply 1240-2. 2002
  72. ncbi request reprint Evaluation of offspring and maternal genetic effects on disease risk using a family-based approach: the "pent" design
    Laura E Mitchell
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas AandM University System Health Sciences Center, Houston, TX 77030, USA
    Am J Epidemiol 162:676-85. 2005
    ..In addition, the power of the pent-1 approach is comparable with that of the approach based on data using all four grandparents...
  73. ncbi request reprint Analysis of clustered binary outcomes using within-cluster paired resampling
    Randall H Rieger
    Department of Mathematics, West Chester University, Pennsylvania 19383 2136, USA
    Biometrics 58:332-41. 2002
    ..When CLR is invalid, WCPR continues to have good operating characteristics. For illustration, we apply both WCPR and CLR to a periodontal data set where there is heterogeneity in response to exposure across clusters...