Sung Jen Wei

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Neuroinflammation 5:21. 2008
  2. ncbi request reprint Identification of Dss1 as a 12-O-tetradecanoylphorbol-13-acetate-responsive gene expressed in keratinocyte progenitor cells, with possible involvement in early skin tumorigenesis
    Sung Jen Wei
    National Center for Toxicogenomics and the Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 278:1758-68. 2003
  3. doi request reprint Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation
    Sung Jen Wei
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Mol Biol 383:693-712. 2008
  4. ncbi request reprint 12-O-tetradecanoylphorbol-13-acetate and UV radiation-induced nucleoside diphosphate protein kinase B mediates neoplastic transformation of epidermal cells
    Sung Jen Wei
    National Center for Toxicogenomics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 279:5993-6004. 2004
  5. ncbi request reprint 3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, P O Box 12233, NC, USA
    FASEB J 19:395-7. 2005
  6. pmc A novel role for the T-box transcription factor Tbx1 as a negative regulator of tumor cell growth in mice
    Carol S Trempus
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Carcinog 50:981-91. 2011
  7. ncbi request reprint NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, NIEHS, NIH, Research Triangle Park, NC 27709, USA
    J Biol Chem 279:1415-21. 2004
  8. pmc The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase
    Xun Qian
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHSS, Research Triangle Park, PO Box 12233, NC 27709, USA
    Biochem J 389:389-95. 2005
  9. ncbi request reprint Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage
    Guorong Li
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 19:489-96. 2005
  10. ncbi request reprint Interleukin-10 protects lipopolysaccharide-induced neurotoxicity in primary midbrain cultures by inhibiting the function of NADPH oxidase
    Li Qian
    The Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    J Pharmacol Exp Ther 319:44-52. 2006

Collaborators

Detail Information

Publications15

  1. pmc Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Neuroinflammation 5:21. 2008
    ..Hence, prevention of microglial over-activation has been shown to be a prime target for the development of therapeutic agents for inflammation-mediated neurodegenerative diseases...
  2. ncbi request reprint Identification of Dss1 as a 12-O-tetradecanoylphorbol-13-acetate-responsive gene expressed in keratinocyte progenitor cells, with possible involvement in early skin tumorigenesis
    Sung Jen Wei
    National Center for Toxicogenomics and the Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 278:1758-68. 2003
    ..These results strongly suggest that Dss1 is a TPA-inducible gene that may play an important role in the early stages of skin carcinogenesis...
  3. doi request reprint Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation
    Sung Jen Wei
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Mol Biol 383:693-712. 2008
    ....
  4. ncbi request reprint 12-O-tetradecanoylphorbol-13-acetate and UV radiation-induced nucleoside diphosphate protein kinase B mediates neoplastic transformation of epidermal cells
    Sung Jen Wei
    National Center for Toxicogenomics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 279:5993-6004. 2004
    ....
  5. ncbi request reprint 3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, P O Box 12233, NC, USA
    FASEB J 19:395-7. 2005
    ..In view of the well-documented very low toxicity of DM and its analogs, this report may provide an important new direction for the development of therapeutic interventions for inflammation-related diseases such as PD...
  6. pmc A novel role for the T-box transcription factor Tbx1 as a negative regulator of tumor cell growth in mice
    Carol S Trempus
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Carcinog 50:981-91. 2011
    ..2011 Wiley Periodicals, Inc...
  7. ncbi request reprint NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, NIEHS, NIH, Research Triangle Park, NC 27709, USA
    J Biol Chem 279:1415-21. 2004
    ....
  8. pmc The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase
    Xun Qian
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHSS, Research Triangle Park, PO Box 12233, NC 27709, USA
    Biochem J 389:389-95. 2005
    ..Cell 15, 689-701]...
  9. ncbi request reprint Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage
    Guorong Li
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 19:489-96. 2005
    ..These findings suggest a novel therapeutic concept of using "ultra-low" drug concentrations for the intervention of inflammation-related neurodegenerative diseases...
  10. ncbi request reprint Interleukin-10 protects lipopolysaccharide-induced neurotoxicity in primary midbrain cultures by inhibiting the function of NADPH oxidase
    Li Qian
    The Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    J Pharmacol Exp Ther 319:44-52. 2006
    ..Together, our results suggest that IL-10 inhibits LPS-induced DA neurotoxicity through the inhibition of PHOX activity in a JAK1-dependent mechanism...
  11. ncbi request reprint Comprehensive microarray transcriptome profiling of CD34-enriched mouse keratinocyte stem cells
    Carol S Trempus
    J Invest Dermatol 127:2904-7. 2007
  12. ncbi request reprint Microglia-mediated neurotoxicity is inhibited by morphine through an opioid receptor-independent reduction of NADPH oxidase activity
    Li Qian
    Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 179:1198-209. 2007
    ..Furthermore, our study reveals that inhibition of PHOX is a novel site of action for the mu-opioid receptor-independent effect of morphine...
  13. ncbi request reprint IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines
    Shin Hun Juang
    Cancer Research Cooperative Laboratory, NHRI, Taipei 100, ROC
    J Interferon Cytokine Res 24:231-43. 2004
    ....
  14. pmc Potent anti-inflammatory and neuroprotective effects of TGF-beta1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microglia
    Li Qian
    Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    J Immunol 181:660-8. 2008
    ....
  15. ncbi request reprint Identification of genes and gene ontology processes critical to skin papilloma development in Tg.AC transgenic mice
    Hong Dang
    Alpha Gamma Technologies, Inc, Raleigh, North Carolina, USA
    Mol Carcinog 45:126-40. 2006
    ..Additional analyses presented here yield novel insights into the genes and processes involved in papilloma development in Tg.AC mice...