Research Topics
| Alan S WayneSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
Financial analysis of chronic transfusion for stroke prevention in sickle cell diseaseA S Wayne
Department of Pediatrics, Division of Pediatric Hematology Oncology, Sickle Cell Center, and Pediatric Pharmacy Department, University of Miami School of Medicine, Jackson Memorial Medical Center, Miami, FL, USA
Blood 96:2369-72. 2000..These data should be considered in reference to cost and efficacy analyses of alternative therapies for sickle cell disease, such as allogeneic bone marrow transplantation...- Allogeneic hematopoietic stem cell transplantation for myeloproliferative disorders and myelodysplastic syndromesAlan S Wayne
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room 13N240, 10 Center Drive, MSC 1928, Bethesda, MD 20892 1928, USA
Hematol Oncol Clin North Am 17:1243-60. 2003..Efforts to improve outcome for older patients and for patients with alternative donors have led to decreased treatment-associated complications with associated better long-term DFS... 
Immunotherapy of childhood cancer: from biologic understanding to clinical applicationAlan S Wayne
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room 1 3750, 9000 Rockville Pike, MSC 1104, Bethesda, MD 20892 1104, USA
Curr Opin Pediatr 22:2-11. 2010..This review summarizes the biologic basis of cancer immunotherapy and highlights recent examples of progress in the application of novel humoral and cellular immunotherapies to children and adolescents with malignancy...- Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: preclinical studies and phase I clinical trialAlan S Wayne
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 1104, USA
Clin Cancer Res 16:1894-903. 2010..We conducted the first preclinical and phase I clinical studies of BL22 in that setting... - Hematopoietic stem cell transplantation for leukemiaAlan S Wayne
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room 1 3750, 9000 Rockville Pike, MSC 1104, Bethesda, MD 20892 1104, USA
Pediatr Clin North Am 57:1-25. 2010..The characteristics of these high-risk subgroups and the role of HSCT in childhood leukemias are discussed... 
Application of immunotherapy in pediatric leukemiaAlan S Wayne
Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room 1W 3750, 9000 Rockville Pike, MSC 1104, Bethesda, MD 20892, USA
Curr Hematol Malig Rep 4:159-66. 2009..Efforts to apply new immunotherapy approaches to the treatment of leukemia in pediatrics have recently begun. The optimal reagents, methods, and regimens have yet to be fully defined. Ongoing clinical trials offer promise in that regard...- Immune-based therapeutics for pediatric cancerChristian M Capitini
National Cancer Institute, National Institutes of Health, Center for Cancer Research, Pediatric Oncology Branch, 10 Center Drive, MSC 1104, Bethesda, MD 20892, USA
Expert Opin Biol Ther 10:163-78. 2010..Elucidation of the principles of tumor biology and the development of novel laboratory technologies over the last decade have led to substantial progress in bringing immunotherapies to the bedside... - Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United StatesJeffrey I Cohen
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
Blood 117:5835-49. 2011..These studies are registered at http://www.clinicaltrials.gov as NCT00032513 for CAEBV, NCT00062868 and NCT00058812 for EBV-specific T-cell studies, and NCT00578539 for the hematopoietic stem cell transplantation protocol... - Multicentric dermatofibrosarcoma protuberans in patients with adenosine deaminase-deficient severe combined immune deficiencyChimene Kesserwan
Genetics and Molecular Biology Branch and the Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 4442, USA
J Allergy Clin Immunol 129:762-769.e1. 2012..This malignancy is rarely diagnosed in childhood... - Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugatesDavid J FitzGerald
Laboratory of Molecular Biology, National Cancer Institute, NIH, Bethesda, Maryland 20892 4264, USA
Cancer Res 71:6300-9. 2011..Thus, highly toxic compounds are delivered to the interior of cancer cells based on antibody specificity for cell-surface target antigens... - Bone marrow homing and engraftment of human hematopoietic stem and progenitor cells is mediated by a polarized membrane domainAndre Larochelle
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Blood 119:1848-55. 2012.... - Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategyHui Wei
Laboratory of Molecular Biology and Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 109:6898-903. 2012..Incubation of sensitive cells with the methylation inhibitor 5-azacytidine prevented the emergence of resistant cells, suggesting that this agent in combination with HA22 may be useful in the treatment of some cases of ALL... - Cytotoxicity of the anti-CD22 immunotoxin HA22 (CAT-8015) against paediatric acute lymphoblastic leukaemiaFrancis Mussai
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4264, USA
Br J Haematol 150:352-8. 2010..These results provide a strong rationale for clinical testing of this agent in children with drug-resistant ALL and offers the potential to reduce morbidities of treatment while improving outcome... - Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemiaWaleed Haso
Pediatric Oncology Branch, Center for Cancer Research CCR, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD 20892, USA
Blood 121:1165-74. 2013..We conclude that second-generation m971 mAb-derived anti-CD22 CARs are promising novel therapeutics that should be tested in BCP-ALL... - Variables affecting the quantitation of CD22 in neoplastic B cellsGregory A Jasper
Flow Cytometry Unit, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Cytometry B Clin Cytom 80:83-90. 2011.... - Blastic plasmacytoid dendritic cell neoplasm in children: diagnostic features and clinical implicationsArmin G Jegalian
Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Haematologica 95:1873-9. 2010..Blastic plasmacytoid dendritic cell neoplasm is a rare malignancy that typically follows a highly aggressive clinical course in adults, whereas experience in children with this disease is very limited... - Juvenile xanthogranuloma in a child with previously unsuspected neurofibromatosis type 1 and juvenile myelomonocytic leukemiaMargarita Raygada
Eunice Kennedy Shriver National Institute of Child Health and Human Development, Section on Developmental Genetics, Bethesda, MD 20892 1831, USA
Pediatr Blood Cancer 54:173-5. 2010..The patient underwent bone marrow transplantation and is currently in remission. Children with concurrent cutaneous café-au-lait and JXG lesions should be evaluated and monitored closely for the possible development of JMML... - Topical corticosteroid therapy for cicatricial conjunctivitis associated with chronic graft-versus-host diseaseM R Robinson
National Eye Institute NIH, 10 10S229, 110 Center Drive, MSC 1863, Bethesda, MD 20892 1863, USA
Bone Marrow Transplant 33:1031-5. 2004..Additional studies are required to determine the long-term safety and efficacy of topical corticosteroids for cicatricial conjunctivitis associated with ocular GVHD in the context of a randomized, prospective clinical trial... - Reduced-intensity allogeneic stem cell transplantation in children and young adults with ultrahigh-risk pediatric sarcomasKristin Baird
Pediatric Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Blood Marrow Transplant 18:698-707. 2012..Enhanced chemo- and radiosensitivity of tumors and normal tissues was observed posttransplantation... - Extracorporeal photo-apheresis for the treatment of steroid-resistant graft versus host diseaseKristin Baird
Pediatric Oncology Branch, Center for Cancer Research CCR, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD, USA
Transfus Apher Sci 41:209-16. 2009..Here we review the experience of extracorporeal photo-apheresis for the treatment of steroid refractory acute and chronic graft versus host disease based on the current literature... - National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committeeMichael R Bishop
Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
Biol Blood Marrow Transplant 17:443-54. 2011..These recommendations, in coordination with ongoing research initiatives and transplantation organizations, provide a research framework to rapidly and efficiently address the significant problem of relapse after allo-HSCT... - Vulvovaginal chronic graft-versus-host disease with allogeneic hematopoietic stem cell transplantationPamela Stratton
Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892 1109, USA
Obstet Gynecol 110:1041-9. 2007..To describe the diagnosis and management of female genital chronic graft-versus-host (GVH) disease, a complication of hematopoietic stem cell transplantation... - The role of tumor histogenesis, FDG-PET, and short-course EPOCH with dose-dense rituximab (SC-EPOCH-RR) in HIV-associated diffuse large B-cell lymphomaKieron Dunleavy
Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Blood 115:3017-24. 2010..However, new therapeutic advances are needed for non-GCB DLBCL, which remains the important cause of lymphoma-specific death. This trial was registered at www.clinicaltrials.gov as NCT000019253... - Thromboembolic events in children and young adults with pediatric sarcomaIdo Paz-Priel
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA
J Clin Oncol 25:1519-24. 2007..Adults with malignancy are at increased risk for venous thromboembolic events (TEs). However, data in children and young adults with cancer are limited... - Unique abnormalities of CD4(+) and CD8(+) central memory cells associated with chronic graft-versus-host disease improve after extracorporeal photopheresisKouhei Yamashita
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Blood Marrow Transplant 12:22-30. 2006..The contrasting change in central memory cells (CD8(+) increased versus CD4(+) decreased) in cGVHD provide support for recent reports suggesting unique differences in the differentiation pathways for CD8(+) versus CD4(+) T cells... - Triad of severe abdominal pain, inappropriate antidiuretic hormone secretion, and disseminated varicella-zoster virus infection preceding cutaneous manifestations after hematopoietic stem cell transplantation: utility of PCR for early recognition and therRachel Rau
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1104, USA
Pediatr Infect Dis J 27:265-8. 2008..She was treated with acyclovir and subsequently developed VZV antigen-positive zoster. Detection of VZV DNA in blood may be useful for early diagnosis in immunocompromised hosts who present with zoster without skin lesions... - Myeloid dysplasia and bone marrow hypocellularity in adenosine deaminase-deficient severe combined immune deficiencyRobert Sokolic
Disorders of Immunity Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
Blood 118:2688-94. 2011..These trials were registered at www.clinicaltrials.gov as #NCT00018018 and #NCT00006319... - Activating signals dominate inhibitory signals in CD137L/IL-15 activated natural killer cellsHua Zhang
Pediatric Oncology Branch, NCI, NIH Clinical Center, Bethesda, MD, USA
J Immunother 34:187-95. 2011..We conclude that KIR mismatch is not a prerequisite for tumor killing by CD137L/IL15 NK cells and that NCR expression provides a biomarker for predicting potency of CD137L/IL15 NK cells in studies of NK cell-based immunotherapy... - Hematopoietic stem cell donation in children: a review of the sibling donor experienceLori S Wiener
Pediatric Psychosocial Support and Research Program, National Cancer Institute, 9000 Rockville Pike Bldg 10, Bethesda, MD 20892, USA
J Psychosoc Oncol 25:45-66. 2007.... - Pediatric melanoma: risk factor and survival analysis of the surveillance, epidemiology and end results databaseJohn J Strouse
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Clin Oncol 23:4735-41. 2005..To evaluate risk factors for the development of and factors influencing survival in pediatric melanoma... - Psychotropic medication use in pediatric patients with cancerMaryland Pao
Office of the Clinical Director, National Institute of Mental Health, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Md. 20892, USA
Arch Pediatr Adolesc Med 160:818-22. 2006..Clinical safety and efficacy trials are needed in medically ill children at high risk for mood and anxiety symptoms... - Ancillary therapy and supportive care of chronic graft-versus-host disease: national institutes of health consensus development project on criteria for clinical trials in chronic Graft-versus-host disease: V. Ancillary Therapy and Supportive Care Working Daniel Couriel
University of Texas MD Anderson Cancer Center, Houston, 77030, USA
Biol Blood Marrow Transplant 12:375-96. 2006..Optimal care of patients with chronic GVHD often requires a multidisciplinary approach... - Autologous hematopoietic stem-cell transplantation for children with acute myeloid leukemia in first or second complete remission: a prognostic factor analysisKamar Godder
Autologous Blood and Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA
J Clin Oncol 22:3798-804. 2004..Results in children who experience treatment failure with conventional chemotherapy support the use of autologous transplantation as salvage therapy if such patients achieve a subsequent CR... - Progress in the curative treatment of childhood hematologic malignanciesAlan S Wayne
J Natl Cancer Inst 100:1271-3. 2008