Wendy T Watford

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii
    Wendy T Watford
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 205:2803-12. 2008
  2. pmc Cytohesin binder and regulator (cybr) is not essential for T- and dendritic-cell activation and differentiation
    Wendy T Watford
    LCBS MIIB NIAMS NIH, Bldg 10, Room 9N256, MSC 1820, 10 Center Dr, Bethesda, MD 20892 1820, USA
    Mol Cell Biol 26:6623-32. 2006
  3. pmc Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis
    Lydia Durant
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    Immunity 32:605-15. 2010
  4. pmc Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22
    Hiroaki Takatori
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    J Exp Med 206:35-41. 2009
  5. pmc Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice
    Wendy T Watford
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:105-13. 2010
  6. pmc Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 467:967-71. 2010
  7. pmc Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation
    Lai Wei
    Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda MD 20892, USA
    Immunity 32:840-51. 2010
  8. pmc Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production
    Lisa A Mielke
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health Bethesda, MD 20892, USA
    J Immunol 183:7984-93. 2009
  9. pmc Nonredundant roles for Stat5a/b in directly regulating Foxp3
    Zhengju Yao
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1820, USA
    Blood 109:4368-75. 2007
  10. pmc Stat5a/b are essential for normal lymphoid development and differentiation
    Zhengju Yao
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:1000-5. 2006

Detail Information

Publications25

  1. pmc Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii
    Wendy T Watford
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 205:2803-12. 2008
    ..These data underscore the role of Tpl2 as a regulator of T helper cell lineage decisions and demonstrate that Tpl2 has an important functional role in the regulation of Th1 responses...
  2. pmc Cytohesin binder and regulator (cybr) is not essential for T- and dendritic-cell activation and differentiation
    Wendy T Watford
    LCBS MIIB NIAMS NIH, Bldg 10, Room 9N256, MSC 1820, 10 Center Dr, Bethesda, MD 20892 1820, USA
    Mol Cell Biol 26:6623-32. 2006
    ..Previous in vitro studies using overexpression or short interfering RNA inhibition of the levels of Cybr protein appear to have overestimated its immunological role...
  3. pmc Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis
    Lydia Durant
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    Immunity 32:605-15. 2010
    ..Thus, STAT3 orchestrates multiple critical aspects of T cell function in inflammation and homeostasis...
  4. pmc Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22
    Hiroaki Takatori
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    J Exp Med 206:35-41. 2009
    ..Thus, it appears that splenic LTi-like cells are a rapid source of IL-17 and IL-22, which might contribute to dynamic organization of secondary lymphoid organ structure or host defense...
  5. pmc Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice
    Wendy T Watford
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:105-13. 2010
    ....
  6. pmc Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 467:967-71. 2010
    ..These data indicate an alternative mode for T(H)17 differentiation. Consistent with genetic data linking IL23R with autoimmunity, our findings re-emphasize the importance of IL-23 and therefore may have therapeutic implications...
  7. pmc Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation
    Lai Wei
    Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda MD 20892, USA
    Immunity 32:840-51. 2010
    ..Clusters of genes negatively regulated by STATs were also identified, highlighting previously unappreciated repressive roles of STATs. Therefore, STAT4 and STAT6 play wide regulatory roles in T helper cell specification...
  8. pmc Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production
    Lisa A Mielke
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health Bethesda, MD 20892, USA
    J Immunol 183:7984-93. 2009
    ..These studies implicate Tpl2 as an important mediator for collaboration of pattern recognition receptors with danger-associated molecular patterns to induce TNF and IL-1beta production and optimal host defense...
  9. pmc Nonredundant roles for Stat5a/b in directly regulating Foxp3
    Zhengju Yao
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1820, USA
    Blood 109:4368-75. 2007
    ..Therefore, we conclude that Stat5a/b have an essential, nonredundant role in regulating Treg cells, and that Stat3 and Stat5a/b appear to have opposing roles in the regulation of Foxp3...
  10. pmc Stat5a/b are essential for normal lymphoid development and differentiation
    Zhengju Yao
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:1000-5. 2006
    ..Thus, deficiency of Stat5 results in severe combined immunodeficiency, similar in many respects to deficiency of IL-7R, gammac, and Jak3...
  11. pmc Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
    Gang Wei
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:155-67. 2009
    ..Our data suggest an epigenetic mechanism underlying the specificity and plasticity of effector and regulatory T cells and also provide a framework for understanding complexity of CD4(+) T helper cell differentiation...
  12. pmc Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity
    Pingtao Tang
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:2625-9. 2002
    ..Because the binding protein modified activation of ADP ribosylation factor by cytohesin-1, we designate this cytokine-inducible protein Cybr (cytohesin binder and regulator)...
  13. ncbi request reprint Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4
    Wendy T Watford
    Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, MD 20892 1820, USA
    Immunol Rev 202:139-56. 2004
    ..In contrast, IL-23 promotes end-stage inflammation. Targeting IL-12, IL-23, and their downstream signaling elements would therefore be logical strategies for the treatment of immune-mediated diseases...
  14. pmc The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death
    Carl G Feng
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:1279-87. 2008
    ..Our studies identify a feedback mechanism in the T helper type 1 response that limits the detrimental effects of IFN-gamma on effector T lymphocyte survival while promoting the antimicrobial functions of IFN-gamma...
  15. pmc Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation
    Nicolas Charles
    Laboratory of Immune Cell Signaling, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:533-43. 2009
    ..Our findings demonstrate that basophil-expressed Lyn kinase exerts regulatory control on Th2 cell differentiation and function...
  16. pmc Signal transduction and Th17 cell differentiation
    JOHN J O'SHEA
    Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Microbes Infect 11:599-611. 2009
    ..Here we review our current understanding of the signaling pathways, molecular interactions and transcriptional events that lead to Th17 differentiation and effector function, as well as the epigenetic modifications that accompany them...
  17. pmc Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity
    Susannah D Brydges
    Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:875-87. 2009
    ..These data suggest that CAPS are true inflammasome-mediated diseases and provide insight for more common inflammatory disorders...
  18. pmc STAT5 isoforms: controversies and clarifications
    Haydee L Ramos
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem J 404:e1-2. 2007
    ..This new evidence calls into question the physiological significance of this putative isoform and forces the general re-examination of proteolytically generated STAT isoforms...
  19. ncbi request reprint De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases
    Ivona Aksentijevich
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 46:3340-8. 2002
    ....
  20. pmc T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance
    Marko Pesu
    Molecular Immunology and Inflammation Branch, National Institute for Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 455:246-50. 2008
    ..Targeting furin has emerged as a strategy in malignant and infectious disease. Our results suggest that inhibiting furin might activate immune responses, but may result in a breakdown in peripheral tolerance...
  21. ncbi request reprint IFN-gamma mediates the death of Th1 cells in a paracrine manner
    Kathryn E Foulds
    Cellular Immunology Section, Human Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 180:842-9. 2008
    ..Collectively, these data show the multiple mechanisms by which Th1 effector cells are efficiently eliminated in vivo...
  22. ncbi request reprint The biology of IL-12: coordinating innate and adaptive immune responses
    Wendy T Watford
    Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Cytokine Growth Factor Rev 14:361-8. 2003
    ..IL-12 and the recently identified cytokines, IL-23 and IL-27, define a family of related cytokines that induce IFN-gamma production and promote T cell expansion and proliferation...
  23. ncbi request reprint Human tyk2 kinase deficiency: another primary immunodeficiency syndrome
    Wendy T Watford
    Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 25:695-7. 2006
    ..Janus kinases are critical for cytokine signaling. Mutations of Jak3 cause primary immunodeficiency, but Minegishi et al. (2006) now show that mutation of another Jak, tyrosine kinase 2, underlies another human immunodeficiency syndrome...
  24. ncbi request reprint Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection
    Khuong B Nguyen
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Science 297:2063-6. 2002
    ..Thus, type 1 IFNs, in addition to interleukin-12, provide pathways for innate regulation of adaptive immunity, and their immunoregulatory functions are controlled by modulating the activity of individual STATs...
  25. ncbi request reprint Autoimmunity: A case of mistaken identity
    Wendy T Watford
    Nature 421:706-8. 2003