Affiliation: National Institutes of Health
- The impact of new technologies on human population studiesMichael D Waters
National Center for Toxicogenomics, 111 Alexander Drive, P O Box 12233, MD F1 05, Research Triangle Park, NC 27709 2233, USA
Mutat Res 544:349-60. 2003..This knowledge can be used to protect susceptible individuals from disease and to reduce adverse exposure and environmentally induced disease...
- Toxicogenomics and systems toxicology: aims and prospectsMichael D Waters
National Center for Toxicogenomics, National Institute of Environmental Health Sciences, PO Box 12233, MD F1 05, 111 Alexander Drive, Research Triangle Park, North Carolina 27709 2233, USA
Nat Rev Genet 5:936-48. 2004....
- Systems toxicology and the Chemical Effects in Biological Systems (CEBS) knowledge baseMichael Waters
National Center for Toxicogenomics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
EHP Toxicogenomics 111:15-28. 2003..The CEBS development effort will span a decade or more...
- Toxicogenomic approach for assessing toxicant-related diseaseMichael D Waters
National Center for Toxigenomics, National Institute of Environmental Health Sciences, P O Box 12233, MD F1 05, 111 Alexander Drive, Research Triangle Park, NC 27709 2233, USA
Mutat Res 544:415-24. 2003....
- CEBS--Chemical Effects in Biological Systems: a public data repository integrating study design and toxicity data with microarray and proteomics dataMichael Waters
NIEHS, National Center for Toxicogenomics, PO Box 12233, Research Triangle Park, NC 27709, USA
Nucleic Acids Res 36:D892-900. 2008..niehs.nih.gov. BID can be accessed via the user interface from https://dir-apps.niehs.nih.gov/arc/. Requests for a copy of BID and for depositing data into CEBS or BID are available at http://www.niehs.nih.gov/cebs-df/...
- Toward a checklist for exchange and interpretation of data from a toxicology studyJennifer M Fostel
NIEHS, LMIT ITSS Contract, Research Triangle Park, North Carolina 27709 2233, USA
Toxicol Sci 99:26-34. 2007..It is anticipated that once a toxicology checklist is accepted and put into use, then toxicology databases can be configured to require and output these fields, making it straightforward to annotate data for interpretation by others...
- Databases applicable to quantitative hazard/risk assessment--towards a predictive systems toxicologyMichael Waters
ILS, Inc, P O Box 13501, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 233:34-44. 2008..Each of the public databases has been discussed in prior publications. They will be briefly described in the present report from the perspective of aggregating datasets to augment the data and information contained within them...
- Quality review procedures necessary for rodent pathology databases and toxicogenomic studies: the National Toxicology Program experienceGary A Boorman
Laboratory for Experimental Pathology, Environmental Toxicology Program, National Center for Toxicogenomics, NIEHS, Research Triangle Park, NC 27709, USA
Toxicol Pathol 30:88-92. 2002..The lessons learned in assuring data quality in standard rodent studies also applies to the emerging field of toxicogenomics...
- Chemical effects in biological systems--data dictionary (CEBS-DD): a compendium of terms for the capture and integration of biological study design description, conventional phenotypes, and 'omics dataJennifer Fostel
LIMT Lockheed Martin Information Technology LMIT, Research Triangle Park, NC 27709, USA
Toxicol Sci 88:585-601. 2005..To illustrate the utility of the CEBS-DD, we present an example of integrating data from two proteomics and transcriptomics studies of the response to acute acetaminophen toxicity (A. N. Heinloth et al., 2004, Toxicol. Sci. 80, 193-202)...
- Consensus recommendations to promote and advance predictive systems toxicology and toxicogenomicsMichael Waters
Integrated Laboratory Systems, Research Triangle Park, North Carolina 27709, USA
Environ Mol Mutagen 48:400-3. 2007....
- Chemical effects in biological systems (CEBS) object model for toxicology data, SysTox-OM: design and applicationSandhya Xirasagar
Science Applications International Corporation, 20201 Century Boulevard, 3rd Floor, Germantown, MD 20874, USA
Bioinformatics 22:874-82. 2006..All of these data types can be integrated in a seamless fashion to enable data query and analysis in a biologically meaningful manner...
- CEBS object model for systems biology data, SysBio-OMSandhya Xirasagar
Science Applications International Corporation, 20201 Century Building, 3rd Floor, Germantown, MD 20874, USA
Bioinformatics 20:2004-15. 2004..Data streams include, but are not limited to, gene expression analysis (transcriptomics), protein expression and protein-protein interaction analysis (proteomics) and changes in low molecular weight metabolite levels (metabolomics)...
- Database development in toxicogenomics: issues and effortsWilliam B Mattes
Pfizer Inc, Groton, Connecticut, USA
Environ Health Perspect 112:495-505. 2004....