Jerrold M Ward

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Immunohistochemical markers for the rodent immune system
    Jerrold M Ward
    Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892 8135, USA
    Toxicol Pathol 34:616-30. 2006
  2. ncbi Progressive glomerulonephritis and histiocytic sarcoma associated with macrophage functional defects in CYP1B1-deficient mice
    Jerrold M Ward
    The National Institute of Allergy and Infectious Diseases, NIH and SoBran, Inc, Twinbrook 3, Room 2W 01A, Bethesda, Maryland 20892 8135, USA
    Toxicol Pathol 32:710-8. 2004
  3. ncbi Lymphomas and leukemias in mice
    Jerrold M Ward
    Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook 3, MSC 8135, Bethesda, MD 20892 8135, USA
    Exp Toxicol Pathol 57:377-81. 2006
  4. ncbi Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice
    Kimihiko Matsusue
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Endocrinol 18:2751-64. 2004
  5. pmc Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge
    Alexander Bukreyev
    National Institute of Allergy and Infectious Diseases, Building 50, Room 6505, NIAID, National Institutes of Health, 50 South Dr MSC 8007, Bethesda, MD 20892 8007, USA
    Virology 383:348-61. 2009
  6. pmc Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
    Insook Kim
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 28:940-6. 2007
  7. pmc Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation
    Joshua D Milner
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, Bethesda, MD 20892, USA
    Blood 116:2476-83. 2010
  8. pmc Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice
    Miranda S Oakley
    Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics and Evaluation Research, Food and Drug Administration, Bethesda, MD, USA
    PLoS ONE 4:e6793. 2009
  9. ncbi Enhanced acetaminophen toxicity by activation of the pregnane X receptor
    Grace L Guo
    Laboratory of Metabolism, CCR, NCI, NIH, Bethesda, Maryland 20892, USA
    Toxicol Sci 82:374-80. 2004
  10. ncbi Impaired glucose homeostasis, neutrophil trafficking and function in mice lacking the glucose-6-phosphate transporter
    Li Yuan Chen
    Section on Cellular Differentiation, Heritable Disorders Branch, Natioanl Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1830, USA
    Hum Mol Genet 12:2547-58. 2003

Collaborators

Detail Information

Publications90

  1. ncbi Immunohistochemical markers for the rodent immune system
    Jerrold M Ward
    Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892 8135, USA
    Toxicol Pathol 34:616-30. 2006
    ....
  2. ncbi Progressive glomerulonephritis and histiocytic sarcoma associated with macrophage functional defects in CYP1B1-deficient mice
    Jerrold M Ward
    The National Institute of Allergy and Infectious Diseases, NIH and SoBran, Inc, Twinbrook 3, Room 2W 01A, Bethesda, Maryland 20892 8135, USA
    Toxicol Pathol 32:710-8. 2004
    ..The function of CYP1B1 in histiocytes and macrophages may involve both self-tolerance and tumor suppression...
  3. ncbi Lymphomas and leukemias in mice
    Jerrold M Ward
    Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook 3, MSC 8135, Bethesda, MD 20892 8135, USA
    Exp Toxicol Pathol 57:377-81. 2006
    ..This classification follows closely the more detailed human WHO classification and can be used for mouse models of lymphoma and leukemia...
  4. ncbi Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice
    Kimihiko Matsusue
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Endocrinol 18:2751-64. 2004
    ..Taken together, these results indicate that hepatic C/EBP alpha plays a critical role in the acceleration of lipogenesis in ob/ob mice and in glucose homeostasis by the indirect regulation of insulin secretion...
  5. pmc Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge
    Alexander Bukreyev
    National Institute of Allergy and Infectious Diseases, Building 50, Room 6505, NIAID, National Institutes of Health, 50 South Dr MSC 8007, Bethesda, MD 20892 8007, USA
    Virology 383:348-61. 2009
    ..Despite the attenuation, the virus was highly immunogenic, and a single IN dose completely protected the animals against a highly lethal intraperitoneal challenge of guinea pig-adapted EBOV...
  6. pmc Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
    Insook Kim
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 28:940-6. 2007
    ..They also had increased cell proliferation as revealed by increased PCNA mRNA and BrdU incorporation. These studies reveal a potential role for FXR and BAs in hepatocarcinogenesis...
  7. pmc Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation
    Joshua D Milner
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, Bethesda, MD 20892, USA
    Blood 116:2476-83. 2010
    ..These data describe a novel pathophysiologic pathway for erythrophagocytosis in the context of tissue macrophage accumulation and inflammation involving elevations in IL-4 and alternative macrophage activation...
  8. pmc Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice
    Miranda S Oakley
    Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics and Evaluation Research, Food and Drug Administration, Bethesda, MD, USA
    PLoS ONE 4:e6793. 2009
    ..We find that OX40, a marker of both T cell activation and memory, is selectively upregulated in the brain during ECM and its distribution among CD4(+) and CD8(+) T cells accumulated in the brain vasculature is approximately equal...
  9. ncbi Enhanced acetaminophen toxicity by activation of the pregnane X receptor
    Grace L Guo
    Laboratory of Metabolism, CCR, NCI, NIH, Bethesda, Maryland 20892, USA
    Toxicol Sci 82:374-80. 2004
    ..Thus, these results suggest that PXR plays a critical role in APAP-induced hepatic toxicity, probably by inducing CYP3A11 expression and hence increasing bioactivation...
  10. ncbi Impaired glucose homeostasis, neutrophil trafficking and function in mice lacking the glucose-6-phosphate transporter
    Li Yuan Chen
    Section on Cellular Differentiation, Heritable Disorders Branch, Natioanl Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1830, USA
    Hum Mol Genet 12:2547-58. 2003
    ..These findings demonstrate that G6PT is not just a G6P transport protein but also an important immunomodulatory protein whose activities need to be addressed in treating the myeloid complications in GSD-Ib patients...
  11. ncbi Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1
    Peter C Scacheri
    National Human Genome Research Institute, National Institutes of Health, Bldg 31, Room 4B09, 31 Center Drive, Bethesda, Maryland 20892, USA
    Mamm Genome 15:872-7. 2004
    ..These results argue against certain hypotheses previously proposed for the tissue specificity of tumor suppressor genes and provide insights to the mechanism of tissue specificity in MEN1...
  12. pmc Delivery to the lower respiratory tract is required for effective immunization with Newcastle disease virus-vectored vaccines intended for humans
    Joshua M DiNapoli
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8007, USA
    Vaccine 27:1530-9. 2009
    ....
  13. pmc Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice
    Ya Hui Chi
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 124:1483-9. 2009
    ..The findings here provide evidence for a cooperative role of Mad1/Mad2 and p53 genes in preventing tumor development...
  14. ncbi Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism
    Steven K Libutti
    Surgery Branch, Center for Cancer Research, National Cancer Institute NIH, 10 Center Drive, Room 2B07, Bethesda, MD 20892, USA
    Cancer Res 63:8022-8. 2003
    ..This model provides a means for dissecting the molecular basis of this familial cancer syndrome and may allow for the development of new strategies to treat related forms of hypercalcemia...
  15. ncbi Pathology of immunodeficient mice with naturally occurring murine norovirus infection
    Jerrold M Ward
    Infectious Disease Pathogenesis Section, Comparative Medicine Branch, Division of Intramural Research, NIAID, NIH, Twinbrook III, Bethesda, Maryland 20892 8135, USA
    Toxicol Pathol 34:708-15. 2006
    ..Further studies are needed to determine whether MNV presents a confounding variable in immunological, toxicological and pathological studies in mice naturally infected with MNV...
  16. pmc Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development
    Shihui Liu
    Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 26:3835-41. 2006
    ..These results attest to the physiological importance of Dph3 in development. The biological roles of Dph3 are also discussed...
  17. pmc The secreted form of respiratory syncytial virus G glycoprotein helps the virus evade antibody-mediated restriction of replication by acting as an antigen decoy and through effects on Fc receptor-bearing leukocytes
    Alexander Bukreyev
    LID, NIAID, NIH, 50 South Drive, Room 6505, Bethesda, MD 20892 8007, USA
    J Virol 82:12191-204. 2008
    ..Thus, sG helps RSV escape the antibody-dependent restriction of replication via effects as an antigen decoy and as a modulator of leukocytes bearing Fc gamma receptors...
  18. ncbi Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity
    Grace L Guo
    Laboratory of Metabolism, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:45062-71. 2003
    ..Furthermore, FXR, PXR, and CAR protect against hepatic bile acid toxicity in a complementary manner, suggesting that they serve as redundant but distinct layers of defense to prevent overt hepatic damage by bile acids during cholestasis...
  19. pmc Cellular inflammatory response to flaviviruses in the central nervous system of a primate host
    Olga A Maximova
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892 3203, USA
    J Histochem Cytochem 57:973-89. 2009
    ....
  20. ncbi Sand fly salivary proteins induce strong cellular immunity in a natural reservoir of visceral leishmaniasis with adverse consequences for leishmania
    Nicolas Collin
    Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 5:e1000441. 2009
    ..Their inclusion in an anti-Leishmania vaccine would exploit anti-saliva immunity following an infective sand fly bite and set the stage for a protective anti-Leishmania immune response...
  21. pmc Deficiency of CCAAT/enhancer binding protein family DNA binding prevents malignant conversion of adenoma to carcinoma in NNK-induced lung carcinogenesis in the mouse
    Shioko Kimura
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cancer 11:90. 2012
    ..Since multiple C/EBPs are expressed in lung, the combinatorial expression of these C/EBPs on lung carcinogenesis is not known...
  22. ncbi The Heart Is an Early Target of Anthrax Lethal Toxin in Mice: A Protective Role for Neuronal Nitric Oxide Synthase (nNOS)
    Mahtab Moayeri
    Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 5:e1000456. 2009
    ..We report the heart as an early target of LT in mice and discuss a protective role for nNOS against LT-mediated cardiac damage...
  23. ncbi The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity
    Connie Cheung
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Building 37, Room 3106, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Drug Metab Dispos 33:449-57. 2005
    ..They will also function as an important in vivo tool for predicting drug metabolism and disposition and drug-drug interactions of chemicals that are substrates for human CYP2E1...
  24. pmc Immunogenicity and protective efficacy in mice and hamsters of a β-propiolactone inactivated whole virus SARS-CoV vaccine
    Anjeanette Roberts
    Laboratory of Infectious Diseases, NIAID, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Viral Immunol 23:509-19. 2010
    ..Enhanced disease was not observed in the lungs or liver of hamsters following SARS-CoV challenge, regardless of the level of serum neutralizing antibodies...
  25. ncbi Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha
    Connie Cheung
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Res 64:3849-54. 2004
    ..The PPARalpha-humanized mice should serve as models for use in drug development and human risk assessment and to determine the mechanism of hepatocarcinogenesis of peroxisome proliferators...
  26. pmc Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation
    Reiko Kurotani
    Laboratory of Metabolism, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:19682-92. 2011
    ..This study suggests the potential utility of SCGB3A2 for targeting TGFβ signaling in the treatment of pulmonary fibrosis...
  27. pmc Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis
    Keiichirou Morimura
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 27:1074-80. 2006
    ..This mouse model will be useful for human cancer risk assessment of PPARalpha ligands...
  28. ncbi Naturally occurring murine norovirus infection in a large research institution
    Kathy A Perdue
    Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Am Assoc Lab Anim Sci 46:39-45. 2007
    ..Histopathologic lesions consisted only of a few hepatic inflammatory foci in each liver section, some of which were immunoreactive with antibodies to MNV. MNV viral antigens also were present in the mesenteric lymph nodes...
  29. pmc Role of NKX2-1 in N-bis(2-hydroxypropyl)-nitrosamine-induced thyroid adenoma in mice
    Sayuri Hoshi
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 30:1614-9. 2009
    ..Thus, NKX2-1 may function to control the proliferation of thyroid follicular cells following damage by a genotoxic carcinogen...
  30. pmc Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice
    Sun Hee Yim
    Laboratory of Metabolism, National Cancer Institute, Bethesda, MD 20892, USA
    Hepatology 44:550-60. 2006
    ..Adult ArntDeltaEC mice carrying embryonic hepatic defects developed what was possibly an early stage of cirrhosis with consequences of limited oxygen availability and altered lipid metabolism...
  31. pmc Deletion of nonstructural proteins NS1 and NS2 from pneumonia virus of mice attenuates viral replication and reduces pulmonary cytokine expression and disease
    Ursula J Buchholz
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Virol 83:1969-80. 2009
    ..In contrast, in the absence of NS2, there was an early, transient innate response involving moderate levels of IFN, IL-6, and CXCL10 that restricted virus replication and prevented disease...
  32. pmc Visceral and neural larva migrans in rhesus macaques
    Alfonso S Gozalo
    Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Am Assoc Lab Anim Sci 47:64-7. 2008
    ..These cases are similar to the low-level or covert cases of Baylisascaris infection described to occur in humans and provide further evidence of the existence of this parasite in the southeastern United States...
  33. pmc Sand fly salivary proteins induce strong cellular immunity in a natural reservoir of visceral leishmaniasis with adverse consequences for Leishmania
    Nicolas Collin
    Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 5:e1000441. 2009
    ..Their inclusion in an anti-Leishmania vaccine would exploit anti-saliva immunity following an infective sand fly bite and set the stage for a protective anti-Leishmania immune response...
  34. pmc Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA
    Ya Hui Chi
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Development 136:965-73. 2009
    ..These findings raise a heretofore unrecognized role of Sun1 in the selective gene expression of coding and non-coding RNAs needed for gametogenesis...
  35. pmc Of mice and MEN1: Insulinomas in a conditional mouse knockout
    Judy S Crabtree
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 23:6075-85. 2003
    ..Comparative genomic hybridization of beta cell tumor DNA from these mice reveals duplication of chromosome 11, potentially revealing regions of interest with respect to tumorigenesis...
  36. pmc Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease
    Joshua D Milner
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:576-81. 2007
    ..Limited repertoire complexity of Tregs may lead to a failure to control induction of immunopathologic responses, and limitation in repertoire complexity of conventional cells may be responsible for the Th2 phenotype...
  37. pmc Diversity of murine norovirus strains isolated from asymptomatic mice of different genetic backgrounds within a single U.S. research institute
    Elyssa L Barron
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 6:e21435. 2011
    ..Our study indicates that the murine noroviruses are widespread in these animal facilities, despite rigorous guidelines for animal care and maintenance...
  38. pmc TGF-beta-induced Foxp3+ regulatory T cells rescue scurfy mice
    Eva N Huter
    Laboratory of Immunology, Cellular Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Eur J Immunol 38:1814-21. 2008
    ..Thus, TGF-beta-differentiated Foxp3+ Treg appear to possess all of the functional properties of thymic-derived nTreg and represent a potent population for the cellular immunotherapy of autoimmune and inflammatory diseases...
  39. pmc Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells
    Georg H Stummvoll
    Laboratory of Immunology, Cellular Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:1908-16. 2008
    ....
  40. pmc Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice
    Miranda S Oakley
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Infect Immun 76:4518-29. 2008
    ..Our studies greatly enhance the repertoire of host molecules for use as diagnostics and novel therapeutics in CM...
  41. ncbi Gene expression profiling identifies a unique androgen-mediated inflammatory/immune signature and a PTEN (phosphatase and tensin homolog deleted on chromosome 10)-mediated apoptotic response specific to the rat ventral prostate
    Kartiki V Desai
    Laboratory of Cell Regulation and Carcinogenesis, 41 Medlar s Drive, Room C619, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Endocrinol 18:2895-907. 2004
    ..The VP castration model exhibits immune cell infiltration and loss of PTEN that is often observed in progressive PCa, thereby making this model useful for further delineation of androgen-regulated gene expression with relevance to PCa...
  42. pmc Expression of infectious murine leukemia viruses by RAW264.7 cells, a potential complication for studies with a widely used mouse macrophage cell line
    Janet W Hartley
    Laboratory of Immunopathology, NIAID, NIH, Bethesda, MD 20892, USA
    Retrovirology 5:1. 2008
    ....
  43. pmc p47phox deficiency induces macrophage dysfunction resulting in progressive crystalline macrophage pneumonia
    Qi Liu
    Monocyte Trafficking Unit, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1456, USA
    Am J Pathol 174:153-63. 2009
    ..These results suggest that p47(phox-/-) macrophages are extremely pliable, due in part to an intrinsic dysfunction of macrophage activation pathways that allows for distinct classical or alternative activation phenotypes...
  44. pmc Suboptimal ability of dirty-bedding sentinels to detect Spironucleus muris in a colony of mice with genetic manipulations of the adaptive immune system
    Kathy A Perdue
    Comparative Medicine Research, Division of Intramural Research, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, USA
    J Am Assoc Lab Anim Sci 47:10-7. 2008
    ..In light of the study results and an extensive literature review, we revised our health surveillance plan so that the age and duration of exposure to dirty bedding among sentinel mice is varied at the time of testing...
  45. ncbi PPARgamma influences susceptibility to DMBA-induced mammary, ovarian and skin carcinogenesis
    Christopher J Nicol
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Carcinogenesis 25:1747-55. 2004
    ..The data also support evidence suggesting a beneficial role for PPARgamma-specific ligands in the chemoprevention of mammary, ovarian and skin carcinogenesis...
  46. pmc The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS)
    Mahtab Moayeri
    Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    PLoS Pathog 5:e1000456. 2009
    ..We report the heart as an early target of LT in mice and discuss a protective role for nNOS against LT-mediated cardiac damage...
  47. pmc Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene
    Sergey V Ivanov
    Basic Research Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute at Frederick, Frederick, Maryland, USA
    Am J Pathol 165:1007-18. 2004
    ....
  48. ncbi Histologic and molecular characterizations of megakaryocytic leukemia in mice
    Xingpei Hao
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, MD 20852, USA
    Leuk Res 30:397-406. 2006
    ..This is the first report of spontaneous MKL in mice, defining VWF as a biomarker for diagnosis and suggesting possible involvement of a series of genes in disease pathogenesis...
  49. ncbi Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice
    Yoichi Iwanaga
    Molecular Virology Section, Laboratory of Molecular Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Cancer Res 67:160-6. 2007
    ..Our results indicate an essential MAD1 function in mouse development and correlate Mad1 haploinsufficiency with increased constitutive tumors...
  50. ncbi Microarray analysis using amplified mRNA from laser capture microdissection of microscopic hepatocellular precancerous lesions and frozen hepatocellular carcinomas reveals unique and consistent gene expression profiles
    Sun Hee Yim
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Toxicol Pathol 31:295-303. 2003
    ..Thus, amplified aRNA harvested from homogeneous cell types using LCM can be applied to study gene expression profiles by use of microarray analysis...
  51. pmc Vaccinia virus encodes I5, a small hydrophobic virion membrane protein that enhances replication and virulence in mice
    Cindy L Sood
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Drive, MSC 3210, Bethesda, MD 20892 3210, USA
    J Virol 82:10071-8. 2008
    ..We suggest that I5 is involved in an aspect of host defense that is evolutionarily conserved although a role in cell tropism should also be considered...
  52. pmc La Crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys
    Richard S Bennett
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Virol J 5:25. 2008
    ..As an initial step in the establishment of useful animal models to support vaccine development, we examined LACV infectivity, pathogenesis, and immunogenicity in both weanling mice and rhesus monkeys...
  53. pmc Secretoglobin 3A2/uteroglobin-related protein 1 is a novel marker for pulmonary carcinoma in mice and humans
    Reiko Kurotani
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA
    Lung Cancer 71:42-8. 2011
    ..The results demonstrate that SCGB3A2 is a useful marker for diagnosis of pulmonary tumors both in mice and humans...
  54. pmc Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    PLoS Pathog 5:e1000321. 2009
    ..0001). Together, these data identify OAS1 SNP rs10774671 as a host genetic risk factor for initial infection with WNV in humans...
  55. ncbi Severe acute respiratory syndrome coronavirus infection in vaccinated ferrets
    Miriam E R Darnell
    Laboratory of Hepatitis and Related Emerging Agents, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, CBER FDA, Bethesda, MD 20892, USA
    J Infect Dis 196:1329-38. 2007
    ..Previous vaccine reports have noted robust neutralizing antibody and inflammatory responses in ferrets, resulting in enhanced hepatitis...
  56. ncbi Mechanisms underlying arsenic carcinogenesis: hypersensitivity of mice exposed to inorganic arsenic during gestation
    Michael P Waalkes
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, 111 Alexander Drive, P O Box 12233, MD F0 09, Research Triangle Park, NC 27709, USA
    Toxicology 198:31-8. 2004
    ..In addition, it appears gestational arsenic can act as a tumor initiator in the female mouse liver, inducing liver lesions that can be promoted by TPA...
  57. ncbi Animal models for arsenic carcinogenesis: inorganic arsenic is a transplacental carcinogen in mice
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 198:377-84. 2004
    ..The development of these animal models should advance our understanding of the mechanisms of inorganic arsenic carcinogenesis...
  58. pmc Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, North Carolina27709, USA
    Cancer Res 68:8278-85. 2008
    ....
  59. ncbi Toxicogenomic analysis of aberrant gene expression in liver tumors and nontumorous livers of adult mice exposed in utero to inorganic arsenic
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Sci 77:249-57. 2004
    ..Some of these aberrantly expressed genes could play a role in the development of arsenic-induced tumors, at least in the liver...
  60. ncbi Induction of tumors of the liver, lung, ovary and adrenal in adult mice after brief maternal gestational exposure to inorganic arsenic: promotional effects of postnatal phorbol ester exposure on hepatic and pulmonary, but not dermal cancers
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 25:133-41. 2004
    ..Skin tumors were not initiated by arsenic in mouse fetuses possibly indicating tissue-specific mechanisms of action. This study indicates that gestation is a period of high sensitivity to arsenic carcinogenesis...
  61. ncbi Urogenital carcinogenesis in female CD1 mice induced by in utero arsenic exposure is exacerbated by postnatal diethylstilbestrol treatment
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, PO Box 12233, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Cancer Res 66:1337-45. 2006
    ..Thus, arsenic acts with estrogens to enhance production of female mouse urogenital cancers...
  62. ncbi Mouse models of human familial cancer syndromes
    Jerrold M Ward
    Veterinary and Tumor Pathology Section, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702 1201, USA
    Toxicol Pathol 32:90-8. 2004
    ..We will review these mouse models, examine their usefulness in medical research, and furnish sources of animals and references...
  63. ncbi Enhanced urinary bladder and liver carcinogenesis in male CD1 mice exposed to transplacental inorganic arsenic and postnatal diethylstilbestrol or tamoxifen
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 215:295-305. 2006
    ..In utero arsenic also initiated urinary bladder tumor formation when followed by postnatal TAM and uroepithelial proliferative lesions when followed by TAM or DES...
  64. ncbi Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in mice
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 186:7-17. 2003
    ..The development of this rodent model of inorganic arsenic carcinogenesis has important implications in defining the mechanism of action for this common environmental carcinogen...
  65. pmc Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
    Kimihiko Matsusue
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Frederick, Maryland 20892, USA
    J Clin Invest 111:737-47. 2003
    ..These data indicate that hepatic PPARgamma plays a critical role in the regulation of TG content and in the homeostasis of blood glucose and insulin resistance in steatotic diabetic mice...
  66. pmc A paramyxovirus-vectored intranasal vaccine against Ebola virus is immunogenic in vector-immune animals
    Lijuan Yang
    Laboratory of Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Rm 6505, Bethesda, Maryland 20892 8007, USA
    Virology 377:255-64. 2008
    ....
  67. pmc Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFα
    Mohamed E Moustafa
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e57389. 2013
    ..4 and 2.25 versus 0.1 ppm of selenium. Thus, selenium and selenoprotein deficiencies led to widespread pyogranuloma formation, while high selenium levels inhibited the size of TGFα-induced liver tumors...
  68. pmc Differentiation of rodent immune and hematopoietic system reactive lesions from neoplasias
    Jerrold M Ward
    Global VetPathology and Laboratory of Immunopathology, NIAID, NIH, Bethesda, Maryland 20892, USA
    Toxicol Pathol 40:425-34. 2012
    ..Proliferative lesions may be difficult to differentiate from lymphomas and leukemias. The use of immunohistochemistry, compartmental pathology, and methods for the evaluation of clonality will make interpretation easier...
  69. ncbi Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2
    Shioko Kimura
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Carcinogenesis 24:583-7. 2003
    ..In fact, CYP1A2 may even be protective against all transformation, especially in females...
  70. ncbi Molecular pathology of the MEN1 gene
    Sunita K Agarwal
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 1014:189-98. 2004
    ..The Men1+/- mouse has robust MEN1; its most important difference from human MEN1 is marked hyperplasia of pancreatic islets, a tumor precursor stage...
  71. pmc Pathology of captive moustached tamarins (Saguinus mystax)
    Alfonso S Gozalo
    Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Comp Med 58:188-95. 2008
    ..This species may be a spontaneous animal model for pathogenesis and experimental therapy studies of the analogous human diseases...
  72. ncbi Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis
    Kenichi Sakurai
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 4B36, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Neuroimmunol 129:186-96. 2002
    ..These results suggest that IDO may contribute to the regulation of T cell activity associated with the different phases of this animal model of multiple sclerosis (MS)...
  73. pmc IL-6 transgenic mouse model for extraosseous plasmacytoma
    Alexander L Kovalchuk
    Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:1509-14. 2002
    ..These findings provide a unique model of extramedullary PCT for studies on pathogenesis and treatment and suggest a previously unappreciated role for IL-6 in the genesis of germinal center-derived lymphomas...
  74. ncbi Endocrine expression of the active form of TGF-beta1 in the TGF-beta1 null mice fails to ameliorate lethal phenotype
    Glenn Longenecker
    Functional Genomics Unit and Gene Targeting Facility, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    Cytokine 18:43-50. 2002
    ....
  75. ncbi Bethesda proposals for classification of lymphoid neoplasms in mice
    Herbert C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0760, USA
    Blood 100:246-58. 2002
    ..The classification should facilitate communications about mouse models of human lymphoid diseases...
  76. ncbi Antibodies that label paraffin-embedded mouse tissues: a collaborative endeavor
    Igor Mikaelian
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Toxicol Pathol 32:181-91. 2004
    ..Regularly updated information on immunohistochemistry of normal and neoplastic mouse tissues is accessible online at (http://tumor.informatics.jax.org); links to antibody suppliers' web sites are provided...
  77. ncbi Mouse models of human cancers (part 3)
    Alexander D Borowsky
    Center for Comparative Medicine, University of California Davis, 95615, USA
    Comp Med 54:258-70. 2004
  78. ncbi Prostate pathology of genetically engineered mice: definitions and classification. The consensus report from the Bar Harbor meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee
    Scott B Shappell
    Department of Pathology and Vanderbilt Prostate Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37210, USA
    Cancer Res 64:2270-305. 2004
    ....
  79. ncbi Precancer in mice: animal models used to understand, prevent, and treat human precancers
    Robert D Cardiff
    The UCD Center for Comparative Medicine, University of California, Davis, Davis, California 95616, USA
    Toxicol Pathol 34:699-707. 2006
    ..These studies suggest that genetically engineered mice are very useful preclinical models for chemoprevention and therapy...
  80. pmc Critical role of hypoxia and A2A adenosine receptors in liver tissue-protecting physiological anti-inflammatory pathway
    Alexander Chouker
    Department of Anesthesiology Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Mol Med 14:116-23. 2008
    ..The presented data demonstrate that total body hypoxia-triggered pathway provides protection in acute hepatitis and that hypoxia (upstream) and A2AR (downstream) function in the same immunosuppressive and liver tissue-protecting pathway...
  81. pmc Hematopoietic, angiogenic and eye defects in Meis1 mutant animals
    Tomoyuki Hisa
    Center for Cancer Research, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, USA
    EMBO J 23:450-9. 2004
    ..These and other studies showing that Meis1 is expressed at high levels in hematopoietic stem cells (HSCs) suggest that Meis1 may also be required for the proliferation/self-renewal of the HSC...
  82. doi Fibro-osseous (FOL) and degenerative joint lesions in female outbred NIH Black Swiss mice
    Lyn M Wancket
    College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA
    Toxicol Pathol 36:362-5. 2008
    ....
  83. pmc Comparative neuropathogenesis and neurovirulence of attenuated flaviviruses in nonhuman primates
    Olga A Maximova
    Center for Biologics Evaluation and Research, U S Food and Drug Administration, Rockville, Maryland 20852, USA
    J Virol 82:5255-68. 2008
    ..These results provide insight into the neuropathogenesis associated with attenuated flaviviruses that may guide the design of safe vaccines...
  84. ncbi Peroxisome proliferator-activated receptor-beta/delta protects against chemically induced liver toxicity in mice
    Weiwei Shan
    Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Huck Institute of Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Hepatology 47:225-35. 2008
    ....
  85. pmc Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza
    Cameron P Simmons
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
    PLoS Med 4:e178. 2007
    ..We generated neutralizing anti-H5N1 human monoclonal antibodies (mAbs) and tested their efficacy for prophylaxis and therapy in a murine model of infection...
  86. ncbi Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis
    Thomas Hays
    Department of Veterinary Science and Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA
    Carcinogenesis 26:219-27. 2005
    ..Results from these studies demonstrate that the PPARalpha is required to mediate hepatocarcinogenesis induced by bezafibrate, and that PPARalpha protects against potential cholestasis...
  87. pmc Ras-GRF1 signaling is required for normal beta-cell development and glucose homeostasis
    Jaime Font de Mora
    Centro de Investigacion del Cancer, IBMCC, Universidad de Salamanca CSIC, Spain
    EMBO J 22:3039-49. 2003
    ..Thus, our observations demonstrate a novel and specific role for Ras-GRF1 pathways in the development and maintenance of normal beta-cell number and function...
  88. ncbi Comment on the muromics "garden path"
    Jerrold M Ward
    Comp Med 52:302. 2002
  89. pmc Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation
    Jonathan A Deane
    Laboratory of Immunogenetics, NIAID NIH, Rockville, MD 20852, USA
    Immunity 27:801-10. 2007
    ..These results underscore the importance of tightly regulating expression of TLR7 to prevent spontaneous triggering of harmful autoreactive and inflammatory responses...
  90. ncbi Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium
    Alexander Yu Nikitin
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853 6401, USA
    Cancer Res 64:2307-16. 2004
    ....