Yue Wang

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA Electronic address
    Neurobiol Aging 35:88-95. 2014
  2. ncbi request reprint Impaired long-term depression in P2X3 deficient mice is not associated with a spatial learning deficit
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging, Baltimore, MD 21224, USA
    J Neurochem 99:1425-34. 2006
  3. pmc Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Gerontology Research Center, Baltimore, MD 21224, USA
    Neurobiol Aging 30:1061-8. 2009
  4. doi request reprint DJ-1 is essential for long-term depression at hippocampal CA1 synapses
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Neuromolecular Med 10:40-5. 2008
  5. ncbi request reprint Evidence that caspase-1 is a negative regulator of AMPA receptor-mediated long-term potentiation at hippocampal synapses
    Chengbiao Lu
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    J Neurochem 97:1104-10. 2006
  6. pmc Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors
    David Wheeler
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Neurochem 109:1237-49. 2009
  7. ncbi request reprint Dual effects of ATP on rat hippocampal synaptic plasticity
    Yue Wang
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroreport 15:633-6. 2004
  8. pmc Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent
    Nigel H Greig
    Laboratory of Neurosciences and Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 102:17213-8. 2005
  9. pmc Involvement of Notch signaling in hippocampal synaptic plasticity
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 101:9458-62. 2004
  10. ncbi request reprint Plasma membrane ion permeability induced by mutant alpha-synuclein contributes to the degeneration of neural cells
    Katsutoshi Furukawa
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    J Neurochem 97:1071-7. 2006

Collaborators

Detail Information

Publications73

  1. pmc L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA Electronic address
    Neurobiol Aging 35:88-95. 2014
    ..These findings suggest a potential contribution of altered L-VGCC to the selective vulnerability of CA1 neurons to tau pathology in the 3xTgAD mice and to their degeneration in AD patients. ..
  2. ncbi request reprint Impaired long-term depression in P2X3 deficient mice is not associated with a spatial learning deficit
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging, Baltimore, MD 21224, USA
    J Neurochem 99:1425-34. 2006
    ....
  3. pmc Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Gerontology Research Center, Baltimore, MD 21224, USA
    Neurobiol Aging 30:1061-8. 2009
    ....
  4. doi request reprint DJ-1 is essential for long-term depression at hippocampal CA1 synapses
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Neuromolecular Med 10:40-5. 2008
    ..The dopamine receptor D2/3 agonist quinpirole rescued LTD in DJ-1-/- mice, suggesting a role for impaired dopaminergic signaling in the hippocampal LTD deficit...
  5. ncbi request reprint Evidence that caspase-1 is a negative regulator of AMPA receptor-mediated long-term potentiation at hippocampal synapses
    Chengbiao Lu
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    J Neurochem 97:1104-10. 2006
    ..These findings suggest that, by selectively reducing AMPA currents and calcium influx, caspase-1 functions as a negative regulator of LTP at hippocampal synapses...
  6. pmc Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors
    David Wheeler
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Neurochem 109:1237-49. 2009
    ....
  7. ncbi request reprint Dual effects of ATP on rat hippocampal synaptic plasticity
    Yue Wang
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroreport 15:633-6. 2004
    ..We conclude that ATP modulates synaptic plasticity via dual effects on pre- and post-synaptic mechanisms...
  8. pmc Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent
    Nigel H Greig
    Laboratory of Neurosciences and Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 102:17213-8. 2005
    ..Selective, reversible inhibition of brain BChE may represent a treatment for Alzheimer's disease, improving cognition and modulating neuropathological markers of the disease...
  9. pmc Involvement of Notch signaling in hippocampal synaptic plasticity
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 101:9458-62. 2004
    ..These findings suggest an important role for Notch signaling in a form of synaptic plasticity known to be associated with learning and memory processes...
  10. ncbi request reprint Plasma membrane ion permeability induced by mutant alpha-synuclein contributes to the degeneration of neural cells
    Katsutoshi Furukawa
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    J Neurochem 97:1071-7. 2006
    ..These findings suggest that the high membrane ion permeability caused by mutant alpha-synuclein may contribute to the degeneration of neurons in PD...
  11. pmc Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms
    ERIC NORMAN
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, NIH Biomedical Research Center, Baltimore, Maryland 21224, USA
    J Neurochem 114:430-9. 2010
    ..Moreover, direct intracellular application of S1P to CA1 neurons increased action potential firing. Our findings suggest roles for sphingomyelin metabolism and S1P in the positive regulation of the excitability of hippocampal neurons...
  12. ncbi request reprint The PTEN phosphatase is essential for long-term depression of hippocampal synapses
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuromolecular Med 8:329-36. 2006
    ..These findings demonstrate a pivotal role for PTEN in LTD, and suggest that alterations in PTEN could have an impact on learning and memory processes...
  13. ncbi request reprint Alteration in calcium channel properties is responsible for the neurotoxic action of a familial frontotemporal dementia tau mutation
    Katsutoshi Furukawa
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurochem 87:427-36. 2003
    ..Our results indicate that a tau mutation which decreases its microtubule-binding ability augments calcium influx by depolymerizing microtubules and activating adenylyl cyclase and PKA...
  14. doi request reprint AISAIC: a software suite for accurate identification of significant aberrations in cancers
    Bai Zhang
    Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, USA, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA, School of Computer Science and Technology, Xidian University, Xi an 710126, China, Department of Oncology and Department of Gynecology Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA Department of Oncology and Department of Physiology and Biophysics, Georgetown University, Washington, DC 20057, USA and Department of Electrical Engineering and Computer Science, University of Michigan, An Arbor, MI 48109, USA
    Bioinformatics 30:431-3. 2014
    ..Availability and implementation: AISAIC is available as a Java application, with a user's guide and source code, at https://code.google.com/p/aisaic/...
  15. ncbi request reprint Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy
    Garrick D Lee
    Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, Baltimore, Maryland 21224, USA
    Clin Cancer Res 12:198-205. 2006
    ..To control these factors, we conducted cognitive studies in female rats receiving cyclophosphamide or 5-fluorouracil (5FU)...
  16. ncbi request reprint Synaptic distribution of the endocytic accessory proteins AP180 and CALM
    Pamela J Yao
    Laboratory of Neurosciences, National Institute on Aging National Institutes of Health, Baltimore, Maryland 21224, USA
    J Comp Neurol 481:58-69. 2005
    ..We propose that both AP180 and CALM function as endocytic accessory proteins at synapses, but each may regulate distinct clathrin pathways...
  17. pmc Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks
    Lavinia Alberi
    Institute for Cell Engineering, Neuroregeneration Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 69:437-44. 2011
    ..Thus, Notch signaling is dynamically regulated in response to neuronal activity, Arc/Arg3.1 is a context-dependent Notch regulator, and Notch1 is required for the synaptic plasticity that contributes to memory formation...
  18. pmc The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior
    Jianmin Zhang
    Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 145:284-99. 2011
    ..This study identifies an AAA+ ATPase that plays a critical role in regulating the surface expression of AMPAR and thereby regulates synaptic plasticity and learning and memory...
  19. ncbi request reprint Endoplasmic reticulum calcium release is modulated by actin polymerization
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
    J Neurochem 82:945-52. 2002
    ..Our data show that the actin cytoskeleton regulates ER calcium release, suggesting roles for actin in the various physiological and pathological processes that involve calcium release...
  20. pmc MMP-7 cleaves the NR1 NMDA receptor subunit and modifies NMDA receptor function
    Arek Szklarczyk
    Johns Hopkins University, Department of Neurology, Pathology Bldg Rm 625, 600 N Wolfe St, Baltimore, MD 21287, USA
    FASEB J 22:3757-67. 2008
    ..In addition, the AMPA/NMDA ratio is increased by MMP-7 pretreatment. These data suggest that synaptic function may be altered in neurological conditions associated with increased levels of MMP-7...
  21. ncbi request reprint Birthweight differences among infants of North African immigrants and Belgians in Belgium
    Anjel Vahratian
    Department of Maternal and Child Health, School of Public Health, University of North Carolina at Chapel Hill, North Carolina, USA
    Eur J Public Health 14:381-3. 2004
    ..Infants of North African immigrants are reported to have higher birthweights than their Belgian counterparts. It is unclear what mechanism contributes to this difference...
  22. pmc Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses
    Elisabetta Kuhn
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    J Natl Cancer Inst 104:1503-13. 2012
    ..However, the molecular pathogenesis of uterine serous carcinoma is largely unknown. We analyzed the genomes of uterine serous carcinoma samples to better understand the molecular genetic characteristics of this cancer...
  23. pmc DNA copy numbers profiles in affinity-purified ovarian clear cell carcinoma
    Kuan Ting Kuo
    Division of Gynecological Pathology, Departments of Pathology, Gynecology Obstetrics, and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 16:1997-2008. 2010
    ..The purpose of this study is to comprehensively define the genomic changes in CCC based on DNA copy number alterations...
  24. pmc Multi-profile Bayesian alignment model for LC-MS data analysis with integration of internal standards
    Tsung Heng Tsai
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA, Bradley Department of Electrical and Computer Engineering, Virginia Tech, Arlington, VA 22203, USA, Department of Mathematics and Statistics, Georgetown University, Washington, DC 20057, USA, Proteomics and Mass Spectrometry Research Facility, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA and Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA
    Bioinformatics 29:2774-80. 2013
    ..Current alignment approaches estimate RT variability using either single chromatograms or detected peaks, but do not simultaneously take into account the complementary information embedded in the entire LC-MS data...
  25. ncbi request reprint A focused microarray to assess dopaminergic and glial cell differentiation from fetal tissue or embryonic stem cells
    Yongquan Luo
    Gerontology Research Center, Stem Cell Biology Unit, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    Stem Cells 24:865-75. 2006
    ..We suggest that this focused array will serve as a useful complement to other large-scale arrays in routine assessment of cell properties prior to their therapeutic use...
  26. ncbi request reprint Endocannabinoids facilitate the induction of LTP in the hippocampus
    Gregory Carlson
    Department of Physiology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, Maryland 21201, USA
    Nat Neurosci 5:723-4. 2002
    ....
  27. ncbi request reprint Inferring regulatory networks
    Huai Li
    Bioinformatics Unit, Branch of Research Resources, National Institute on Aging, NIH, Baltimore, MD, USA
    Front Biosci 13:263-75. 2008
    ..Popular solutions to each of these problems and their relative merits are discussed...
  28. ncbi request reprint Inferring network interactions using recurrent neural networks and swarm intelligence
    Habtom W Ressom
    Dept of Biostat, Bioinf, and Biomath, Georgetown Univ, Washington, DC 20057, USA
    Conf Proc IEEE Eng Med Biol Soc 1:4241-4. 2006
    ..The results indicate that the algorithm has a promising potential to infer complex interactions such as gene regulatory networks from time-series gene expression data...
  29. ncbi request reprint 2D affine-invariant contour matching using B-spline model
    Yue Wang
    School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore
    IEEE Trans Pattern Anal Mach Intell 29:1853-8. 2007
    ..The proposed algorithm has been tested by matching similar shapes from a prototype database. The experimental results showed the robustness and accuracy of the proposed method in B-Spline curve matching...
  30. pmc Transcription factor and microRNA regulation in androgen-dependent and -independent prostate cancer cells
    Guohua Wang
    School of Computer Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, PR China
    BMC Genomics 9:S22. 2008
    ....
  31. ncbi request reprint Phenotypic-specific gene module discovery using a diagnostic tree and caBIG VISDA
    Yitan Zhu
    Dept of Electr and Comput Eng, Virginia Polytech Inst and State Univ, Arlington, VA, USA
    Conf Proc IEEE Eng Med Biol Soc 1:5767-70. 2006
    ..We then superimpose existing knowledge of gene regulation and gene function (ingenuity pathway analysis) to analyze the clustering results and generate novel hypotheses for further research on muscular dystrophies...
  32. ncbi request reprint Latent variable and nICA modeling of pathway gene module composite
    Ting Gong
    Dept of ECE, Virginia Polytech Inst and State Univ, Arlington, VA, USA
    Conf Proc IEEE Eng Med Biol Soc 1:5872-5. 2006
    ..The experimental results show that significant enrichment of gene annotations within clusters can be obtained...
  33. ncbi request reprint Emergent unsupervised clustering paradigms with potential application to bioinformatics
    David J Miller
    Dept of Electrical Engineering, Pennsylvania State University, University Park, PA 16802, USA
    Front Biosci 13:677-90. 2008
    ..We review recent methods which address these problems and take the position that these methods are well-suited to addressing some common scenarios that occur in bioinformatics...
  34. pmc The properties of high-dimensional data spaces: implications for exploring gene and protein expression data
    Robert Clarke
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, 3970 Reservoir Road NW, Washington, DC 20057, USA
    Nat Rev Cancer 8:37-49. 2008
    ..From the perspective of translational science, this Review discusses the properties of high-dimensional data spaces that arise in genomic and proteomic studies and the challenges they can pose for data analysis and interpretation...
  35. pmc Motif-directed network component analysis for regulatory network inference
    Chen Wang
    Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA
    BMC Bioinformatics 9:S21. 2008
    ..We propose a new approach, motif-directed NCA (mNCA), to integrate motif information and gene expression data to infer regulatory networks...
  36. ncbi request reprint A ground truth based comparative study on clustering of gene expression data
    Yitan Zhu
    Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Arlington, VA 22203, USA
    Front Biosci 13:3839-49. 2008
    ....
  37. doi request reprint Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3
    Yue Wang
    Department of Pathophysiology, Key Laboratory of Neurological Disease of National Education Committee, Tongji Medical College, Huazhong University of Science and Technical, Wuhan, China
    J Neurochem 106:2364-74. 2008
    ..Our data provide direct evidence demonstrating that activation of GSK-3 by WT/GFX may cause memory deficit through tau hyperphosphorylation and suppression of ACh in hippocampus...
  38. ncbi request reprint Evaluation of gene expression profile of keratinocytes in response to JP-8 jet fuel
    Luis A Espinoza
    Department of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Toxicol Appl Pharmacol 200:93-102. 2004
    ..Gene expression data from these studies can be used to build accurate predictive models that separate different molecular profiles. The data establish the use and effectiveness of these approaches for future prospective studies...
  39. ncbi request reprint VISDA: an open-source caBIG analytical tool for data clustering and beyond
    Jiajing Wang
    Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, USA
    Bioinformatics 23:2024-7. 2007
    ..The distinctive features of VISDA are particularly useful for users across the cancer research and broader research communities to analyze complex biological data. AVAILABILITY: http://gforge.nci.nih.gov/projects/visda/..
  40. pmc Distinguishing lung tumours from normal lung based on a small set of genes
    Tatiana Dracheva
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Lung Cancer 55:157-64. 2007
    ....
  41. pmc Conserved regulation of the lymphocyte-specific expression of lck in the Fugu and mammals
    Sydney Brenner
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, USA
    Proc Natl Acad Sci U S A 99:2936-41. 2002
    ..The short promoter of the Fugu lck isolated by us offers a powerful tool for labeling T cells, targeting expression, and manipulating T cell activity in fishes as well as in mammals...
  42. ncbi request reprint Development and validation of a method for using breast core needle biopsies for gene expression microarray analyses
    Matthew Ellis
    Department of Oncology, Georgetown University School of Medicine, Washington, DC 20007, USA
    Clin Cancer Res 8:1155-66. 2002
    ..We wished to develop optimal tissue acquisition, processing, and analysis procedures for exploring the gene expression profiles of breast core needle biopsies representing cancer and noncancer tissues...
  43. ncbi request reprint Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780)
    Zhiping Gu
    Vincent T Lombardi Cancer Center and Department of Oncology, Georgetown University School of Medicine, Washington, DC 20007, USA
    Cancer Res 62:3428-37. 2002
    ..Thus, some breast cancer cells may survive antiestrogen treatment by bypassing specific growth inhibitory signals induced by antagonist-occupied estrogen receptors...
  44. ncbi request reprint Serine protease inhibitor 2A is a protective factor for memory T cell development
    Ni Liu
    Committees on Immunology and Developmental Biology, Department of Pathology, Ben May Institute for Cancer Research and Gwen Knapp Center for Lupus and Immunology Research, The University of Chicago, 924 East 57th Street, Chicago, Illinois 60637, USA
    Nat Immunol 5:919-26. 2004
    ..These findings suggest a model in which commitment to the memory lineage is facilitated by the upregulation of protective genes...
  45. pmc Global transcriptome analysis of the heat shock response of Shewanella oneidensis
    Haichun Gao
    Environmental Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
    J Bacteriol 186:7796-803. 2004
    ..Finally, a putative regulatory site with high conservation to the Escherichia coli sigma32-binding consensus sequence was identified upstream of a number of heat-inducible genes...
  46. ncbi request reprint Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins
    Weijia Kong
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, 100050, China
    Nat Med 10:1344-51. 2004
    ..These findings show BBR as a new hypolipidemic drug with a mechanism of action different from that of statin drugs...
  47. ncbi request reprint Evidence for the involvement of the cyclooxygenase-metabolic pathway in diclofenac-induced inhibition of spontaneous contraction of rat portal vein smooth muscle cells
    Keiichi Shimamura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan
    J Smooth Muscle Res 41:195-206. 2005
    ..These results indicate that diclofenac inhibits the amplitude of spontaneous contractions of the rat portal vein through inhibition of electrical activity, which may be related to an inhibition of the cyclooxygenase pathway...
  48. ncbi request reprint Nuclear envelope dystrophies show a transcriptional fingerprint suggesting disruption of Rb-MyoD pathways in muscle regeneration
    Marina Bakay
    Research Center for Genetic Medicine, Children s National Medical Center, Washington DC 20010, USA
    Brain 129:996-1013. 2006
    ..Our data is consistent with mutations of nuclear lamina components leading to destabilization of the transcriptome in differentiated cells...
  49. ncbi request reprint [Duration of tau hyperphosphorylation and spatial memory deficit induced by single injection of Forskolin into lateral ventricle of rat]
    Jun Xia Zhang
    Department of Pathophysiology, Tongji Medical College, Huazhong Science and Technical University, Wuhan 430030, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 28:355-9. 2006
    ....
  50. ncbi request reprint Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules
    Manling Zhang
    Department of Pathology, The University of Chicago, 924 East 57th Street, Illinois 60637, USA
    Immunity 24:451-61. 2006
    ..Spi6 KO CTLs revealed a breakdown in the integrity of cytotoxic granules, increased cytoplasmic GrB, and ensuing apoptosis. We conclude that Spi6 protects CTLs from suicide caused by GrB-mediated breakdown of cytotoxic granules...
  51. pmc Mechanisms of sex differences in TNFR2-mediated cardioprotection
    Meijing Wang
    Departments of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Circulation 118:S38-45. 2008
    ....
  52. ncbi request reprint Infusion of epidermal growth factor and basic fibroblast growth factor into the striatum of parkinsonian rats leads to in vitro proliferation and differentiation of adult neural progenitor cells
    Kun Wang
    Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, PR China
    Neurosci Lett 364:154-8. 2004
    ..We conclude that our data supports the notion that endogenous cell replacement therapies may be useful for the future treatment of Parkinson's disease (PD)...
  53. ncbi request reprint Why don't they listen? Adherence to recommendations of infectious disease consultations
    Evelyn Lo
    John H Stroger Jr Hospital of Cook County, Rush PresbyterianSt Luke s Medical Center, and Rush Medical College, Chicago, Illinois, USA
    Clin Infect Dis 38:1212-8. 2004
    ..Whether modification of consultant practice will lead to improved recommendation compliance and patient outcomes warrants further study...
  54. ncbi request reprint Targeting LFA-1 synergizes with CD40/CD40L blockade for suppression of both CD4-dependent and CD8-dependent rejection
    Yue Wang
    Department of Surgery, The Ohio State University Medical Center, Columbus, OH, USA
    Am J Transplant 3:1251-8. 2003
    ....
  55. ncbi request reprint Double blockade of cell cycle at g(1)-s transition and m phase by 3-iodoacetamido benzoyl ethyl ester, a new type of tubulin ligand
    Jian Dong Jiang
    Division of Medical Oncology, Mount Sinai School of Medicine New York University, New York 10029, USA
    Cancer Res 62:6080-8. 2002
    ..Besides being a novel lead for the design of new anticancer tubulin ligands, the activity of 3-IAABE in the cell cycle may also help us to understand the molecular pharmacology of microtubule-active drugs...
  56. ncbi request reprint The physiologic role of CD19 cytoplasmic tyrosines
    Yue Wang
    Department of Microbiology, University of Alabama at Birmingham, 35294, USA
    Immunity 17:501-14. 2002
    ..Thus, Y482 and Y513 are essential for all functions of CD19 in vivo. Mutation of these reduces proliferation in germinal center B cells, providing a potential mechanism for the failure of maturation, which abrogates antibody responses...
  57. pmc Impact of adherence with positive airway pressure therapy on hypercapnia in obstructive sleep apnea
    Babak Mokhlesi
    Division of Pulmonary and Critical Care Medicine, Cook County Hospital and Rush University Medical Center, 1901 West Harrison Street, Clinic T, Suite 2818 B, Chicago, IL 60612, USA
    J Clin Sleep Med 2:57-62. 2006
    ..Our objective was to quantify the effect of adherence with positive airway pressure on hypercapnia and hypoxia in these patients...
  58. ncbi request reprint Isolation of streptonigrin and its novel derivative from Micromonospora as inducing agents of p53-dependent cell apoptosis
    Haishan Wang
    Medicinal and Combinatorial Chemistry Laboratory, Lead Discovery Group, Microbial Collection, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore
    J Nat Prod 65:721-4. 2002
    ..6 cells that overexpress a dominant negative mutant of p53, thus suggesting that they induce apoptosis through a p53-dependent pathway...
  59. ncbi request reprint Estrogen receptor alpha positive breast tumors and breast cancer cell lines share similarities in their transcriptome data structures
    Yuelin Zhu
    Lombardi Comprehensive Cancer Center and Departments of Oncology, Georgetown University School of Medicine, Washington, DC, USA
    Int J Oncol 29:1581-9. 2006
    ....
  60. ncbi request reprint Iterative normalization of cDNA microarray data
    Yue Wang
    Department of Electrical Engineering and Computer Science, The Catholic University of America, Washington, DC 20064, USA
    IEEE Trans Inf Technol Biomed 6:29-37. 2002
    ..In this way, the two processes bootstrap one another. We evaluate the technique on real microarray data from breast cancer cell lines and complement the experiment with a data cluster visualization study...
  61. ncbi request reprint Distinct efficacy of pre-differentiated versus intact fetal mesencephalon-derived human neural progenitor cells in alleviating rat model of Parkinson's disease
    Xuan Wang
    Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, PR China
    Int J Dev Neurosci 22:175-83. 2004
    ..These data demonstrates the importance of pre-differentiation of human progenitor cells before transplantation in enhancing therapeutic potency for Parkinson's disease...
  62. ncbi request reprint [Inhibition of sodium channels in acutely isolated hippocampal neurons by scorpion venom heat resistant protein]
    Xiao Yun Zhang
    Department of Physiology, Institute of Brain Disorder, Dalian Medical University, Dalian 116027, China
    Sheng Li Xue Bao 59:278-84. 2007
    ..These results suggest that SVHRP blocks the voltage-dependent sodium currents and alters the sodium channel kinetics to decrease the excitability of neurons. This might be an interpretation for the antiepileptic effects of SVHRP...
  63. ncbi request reprint Defective alloreactive CD8 T cell function and memory response in allograft recipients in the absence of CD4 help
    Yuan Zhai
    Division of Liver and Pancreas Transplantation, Department of Surgery, Dumont University of California Los Angeles Transplant Center, Los Angeles, CA 90095, USA
    J Immunol 179:4529-34. 2007
    ..Thus, CD4 help is critical for alloreactive CD8 activation, function, and memory formation...
  64. ncbi request reprint Counterfactual links to the proportion of treatment effect explained by a surrogate marker
    Jeremy M G Taylor
    Department of Biostatistics, University of Michigan, Ann Arbor, 48109, USA
    Biometrics 61:1102-11. 2005
    ..We found that observable constraints had very little impact on the agreement between the statistic and the counterfactual model proportions, whereas unobservable constraints could lead to more agreement...
  65. ncbi request reprint Generation of chimeric HBc proteins with epitopes in E.coli: formation of virus-like particles and a potent inducer of antigen-specific cytotoxic immune response and anti-tumor effect in vivo
    Yan Zhang
    Department of Molecular Biology, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang 050017, PR China
    Cell Immunol 247:18-27. 2007
    ..Thus, the results of the current study have demonstrated the principal possibility of using VLP on the basis of HBcAg for creation of a new type of HCC-specific immunogen...
  66. ncbi request reprint Sensory neurons from Nf1 haploinsufficient mice exhibit increased excitability
    Yue Wang
    Departments of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, 46202, USA
    J Neurophysiol 94:3670-6. 2005
    ..These data clearly suggest that GAPs, such as neurofibromin, can play a key role in the excitability of nociceptive sensory neurons. This increased excitability may explain the painful conditions experienced by people with NF1...
  67. ncbi request reprint Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver
    Fu Yang
    Department of Medical Genetics, Second Military Medical University, Shanghai, PR China
    J Hepatol 48:12-9. 2008
    ....
  68. ncbi request reprint Mycobacteria inhibition of IFN-gamma induced HLA-DR gene expression by up-regulating histone deacetylation at the promoter region in human THP-1 monocytic cells
    Yue Wang
    Department of Molecular Virology, Ohio State University, Columbus, OH 43210, USA
    J Immunol 174:5687-94. 2005
    ..Thus, mycobacterial infection of human THP-1 cells specifically inhibits HLA-DR gene expression by a novel pathway that involves HDAC complex formation at the HLA-DR promoter, resulting in histone deacetylation and gene silencing...
  69. ncbi request reprint Corticotropin-releasing hormone contributes to the peripheral inflammatory response in experimental autoimmune encephalomyelitis
    Christina Benou
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:5407-13. 2005
    ..We conclude that peripheral CRH exerts a proinflammatory effect in EAE with a selective increase in Th1-type responses. These findings have implications for the treatment of Th1-mediated diseases such as multiple sclerosis...
  70. ncbi request reprint Wound repair and proliferation of bronchial epithelial cells regulated by CTNNAL1
    Yang Xiang
    Xiangya School of Medicine, Central South University, Changsha 410078, Hunan, PR China
    J Cell Biochem 103:920-30. 2008
    ..Furthermore, it may serve to Fn mediated cell-extracellular adhesion and its signal transduction...
  71. ncbi request reprint CaSPA2 is important for polarity establishment and maintenance in Candida albicans
    Xin De Zheng
    Microbial Collection and Screening Laboratory, Institute of Molecular and Cell Biology, Singapore 117609
    Mol Microbiol 49:1391-405. 2003
    ..Because of the existence of distinct growth forms and the easy control of the switch between them in vitro, C. albicans may serve as a useful model in cell polarity research...
  72. doi request reprint Anti-inflammatory drugs ameliorate opposite enzymatic changes in ileal 5-hydroxytryptamine metabolism in the delayed phase after cisplatin administration to rats
    Chuanxia Ju
    Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari Tobetsu, Hokkaido, Japan
    Eur J Pharmacol 589:281-7. 2008
    ....
  73. pmc PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells
    Yu Rong Tan
    Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410078, Hunan, China
    Biochem J 405:131-7. 2007
    ..Our data suggest that AP-2alpha and PPARalpha may be especially involved in this ozone-inducible up-regulation mechanism of BRS-3 expression...