Research Topics
Genomes and Genes
| W WangSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
The 3p21 candidate tumor suppressor gene BAF180 is normally expressed in human lung cancerIkuo Sekine
Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390 8593, USA
Oncogene 24:2735-8. 2005..We conclude that abnormalities of BAF180 are not frequently involved in the pathogenesis of lung cancer...- Fanconi anemia is associated with a defect in the BRCA2 partner PALB2Bing Xia
Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
Nat Genet 39:159-61. 2007..PALB2-deficient cells showed hypersensitivity to cross-linking agents and lacked chromatin-bound BRCA2; these defects were corrected upon ectopic expression of PALB2 or by spontaneous reversion... - The SWI/SNF family of ATP-dependent chromatin remodelers: similar mechanisms for diverse functionsW Wang
Laboratory of Genetics, National Institute on Aging, National Institute of Health, 333 Cassell Drive, TRIAD Center Room 4000, Baltimore, MD 21224, USA
Curr Top Microbiol Immunol 274:143-69. 2003..The availability of distinct types of remodelers can allow cells to regulate expression of a specific group of genes by modulating the activity of corresponding remodelers... - Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteinsWeidong Wang
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21093, USA
Nat Rev Genet 8:735-48. 2007..Now that the gene that is defective in the thirteenth and last assigned FA complementation group (FANCI) has been identified, I discuss what is known about FA proteins and their interactive network, and what remains to be discovered... 
The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomesY Xue
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, 333 Cassell Drive, TRIAD Center Room 4000, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 97:13015-20. 2000..Our data suggest that SWI/SNF-B and Rsc represent a novel subfamily of chromatin-remodeling complexes conserved from yeast to human, and could participate in cell division at kinetochores of mitotic chromosomes...- A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complexZ Nie
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Mol Cell Biol 20:8879-88. 2000..Our data suggest that BAF250 confers specificity to the human BAF complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions... - Purification and preliminary characterization of the zonula occludens toxin receptor from human (CaCo2) and murine (IEC6) intestinal cell linesS Uzzau
Division of Pediatric Gastroenterology, Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
FEMS Microbiol Lett 194:1-5. 2001..Our results suggest that Zot binding to its cellular membrane receptor requires a sequence that spans between amino acids 118 and 299... - NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activitiesY Xue
Laboratory of Genetics, National Institute on Aging, National Institute of Health, Gerontology Research Center, Baltimore, Maryland 21224, USA
Mol Cell 2:851-61. 1998..These results suggest that ATP-dependent chromatin remodeling can participate in transcriptional repression by assisting repressors in gaining access to chromatin... - Loss of HuR is linked to reduced expression of proliferative genes during replicative senescenceW Wang
Laboratory of Cellular and Molecular Biology, National Institute on Aging-Intramural Research Program, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Mol Cell Biol 21:5889-98. 2001..Our studies highlight a critical role for HuR during the process of replicative senescence... - Characterization of the 5' flanking region of the rat D(3) dopamine receptor geneW Wang
Genetic Pharmacology Unit, Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurochem 76:1736-44. 2001..The D(3) promoter is inactive in C6 and COS7 cells. We conclude that the D(3) gene, similar to the closely related D(2) gene, is transcribed from a tissue specific promoter which is under intense negative control... - Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domainM Di Pierro
Division of Pediatric Gastroenterology and Nutrition and Gastrointestinal Pathophysiology Section, Center for Vaccine Development, Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Biol Chem 276:19160-5. 2001..Amino acid comparison between the Zot active fragment and zonulin, combined with site-directed mutagenesis experiments, confirmed the presence of an octapeptide receptor-binding domain toward the amino terminus of the processed Zot... - HuR regulates p21 mRNA stabilization by UV lightW Wang
Laboratory of Biological Chemistry, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Mol Cell Biol 20:760-9. 2000..Our findings indicate that HuR plays a major role in regulating stress-induced p21 expression by enhancing p21 mRNA stability and that these effects are coupled to HuR's elevated presence in the cytoplasm... - FANCL replaces BRCA1 as the likely ubiquitin ligase responsible for FANCD2 monoubiquitinationAmom R Meetei
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Cell Cycle 3:179-81. 2004..Our data support the notion that FANCL, but not BRCA1, is the likely ligase for FANCD2 monoubiquitination... - RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stabilityDongyi Xu
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, Baltimore, Maryland 21224, USA
Genes Dev 22:2843-55. 2008..Our data suggest that multi-OB-fold complexes mediate two modes of BLM action: via RPA-mediated protein-DNA interaction, and via RMI-mediated protein-protein interactions... - Identification and analysis of new proteins involved in the DNA damage response network of Fanconi anemia and Bloom syndromeRong Guo
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, Baltimore, MD 21224, USA
Methods 48:72-9. 2009..Here, we discuss our experience in using co-IP and other techniques to isolate and characterize new FA and BS-related proteins... - New advances in the DNA damage response network of Fanconi anemia and BRCA proteins. FAAP95 replaces BRCA2 as the true FANCB proteinPeiwen Fei
Laboratory of Genetics, National Institute on Aging, Nation Institutes of Health, Baltimore, Maryland, USA
Cell Cycle 4:80-6. 2005..The presence of a single active copy of FANCB and its essentiality for a functional FA-BRCA pathway make it a potentially vulnerable component of the cellular machinery that maintains genomic integrity... - Cloning of Trp1beta isoform from rat brain: immunodetection and localization of the endogenous Trp1 proteinW Wang
Secretory Physiology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Am J Physiol 276:C969-79. 1999..The data demonstrate for the first time the presence of Trp1 protein in a nonexcitable cell... - Synergistic activity of STAT3 and c-Jun at a specific array of DNA elements in the alpha 2-macroglobulin promoterJ Y Yoo
Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Biol Chem 276:26421-9. 2001.... - A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stabilityZhijiang Yan
Laboratory of Genetics, National Institute of Aging, National Institutes of Health, Baltimore, MD 21224, USA
Mol Cell 37:865-78. 2010..Thus, FANCM-MHF is an essential DNA-remodeling complex that protects replication forks from yeast to human... - Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivoManuela Pellegrini
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1360, USA
Nature 443:222-5. 2006..These results suggest an alternative mode for stimulation of Atm by DSBs in which Atm autophosphorylation at Ser 1987, like trans-phosphorylation of downstream substrates, is a consequence rather than a cause of Atm activation... - Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replicationDongyi Xu
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
EMBO J 29:3140-55. 2010..Our data suggest that Rif1 provides a new DNA-binding interface for the BLM complex to restart stalled replication forks... - FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathwayChen Ling
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
EMBO J 26:2104-14. 2007..Our study identifies FAAP100 as a new critical component of the FA-BRCA DNA damage response network... - Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partnerZuqin Nie
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Mol Cell Biol 23:2942-52. 2003..Our data suggest that human SWI/SNF complexes show considerable heterogeneity, and one or more may be involved in the etiology of leukemia by cooperating with MLL fusion proteins... - A multiprotein nuclear complex connects Fanconi anemia and Bloom syndromeAmom Ruhikanta Meetei
Laboratory of Genetics Mass Spectrometry Unit, National Institute on Aging NIH, TRIAD Center Room 3000, 333 Cassell Drive, Baltimore, MD 21224, USA
Mol Cell Biol 23:3417-26. 2003..The findings that FA proteins are part of a DNA-unwinding complex imply that FA proteins may participate in DNA repair... - A novel ubiquitin ligase is deficient in Fanconi anemiaAmom Ruhikanta Meetei
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, 333 Cassell Drive, TRIAD Center Room 3000, Baltimore, Maryland 21224, USA
Nat Genet 35:165-70. 2003..Our data suggest that PHF9 has a crucial role in the Fanconi anemia pathway as the likely catalytic subunit required for monoubiquitination of FANCD2... - FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repairYutong Xue
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, 333 Cassell Drive, TRIAD Center Room 3000, Baltimore, MD 21224, USA
Hum Mol Genet 17:1641-52. 2008..These data are consistent with participation of FANCM and its associated FA core complex in the FA pathway at both signaling through monoubiquitination and the ensuing DNA repair... - HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage responseYongjiang Li
Laboratory of Genetics, NIA, National Institutes of Health, NIH Biomedical Research Center, Baltimore, Maryland 21224, USA
J Biol Chem 284:23525-31. 2009..Thus, our data demonstrate that hSSB1 and hSSB2 form two separate complexes with similar structures, and both are required for efficient HR-dependent repair of DSBs and ATM-dependent signaling pathways... - Use of body mass index to identify obesity-related metabolic disorders in the Chinese populationX Weng
1Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Eur J Clin Nutr 60:931-7. 2006..SPONSORSHIP: Center of a Livable Future, John Hopkins Bloomberg School of Public Health... - X-linked inheritance of Fanconi anemia complementation group BAmom Ruhikanta Meetei
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, 333 Cassell Drive, TRIAD Center Room 3000, Baltimore, Maryland 21224, USA
Nat Genet 36:1219-24. 2004..Its presence as a single active copy and essentiality for a functional Fanconi anemia-BRCA pathway make FANCB a potentially vulnerable component of the cellular machinery that maintains genomic integrity... - The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodiesYutong Xue
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 100:10635-40. 2003..Taken together, the results suggest that ATRX functions in conjunction with Daxx in a novel chromatin-remodeling complex. The defects in ATRX syndrome may result from inappropriate expression of genes controlled by this complex... - BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivationPei Wen Hsiao
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Mol Cell Biol 23:6210-20. 2003..Thus, in addition to previously identified BAF250, BAF60a may provide another critical and direct link between nuclear receptors and the BRG1 complex that is required for promoter recruitment and subsequent chromatin remodeling... - BAF250B-associated SWI/SNF chromatin-remodeling complex is required to maintain undifferentiated mouse embryonic stem cellsZhijiang Yan
Genome Instability and Chromatin Remodeling Section, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
Stem Cells 26:1155-65. 2008..The work presented here underscores the importance of SWI/SNF chromatin remodeling complexes in pluripotent stem cells... - BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrityJinhu Yin
Laboratory of Genetics, National Institute on Aging, National Institute of Health, Baltimore, MD 21224, USA
EMBO J 24:1465-76. 2005..Thus, BLAP75 is an essential component of the BLM-associated cellular machinery that maintains genome integrity... - RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathwayJinhu Yin
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, 333 Cassell Drive, TRIAD Center Room 3000, Baltimore, MD 21224, USA
Hum Mol Genet 13:2421-30. 2004..We discuss ramifications of these results, possible functions of RECQL4, and the involvement of the N-end rule pathway... - Role of the mammalian SWI/SNF chromatin remodeling complex in the cellular response to UV damageFeng Gong
Biochemistry and Biophysics, School of Molecular Biosciences, Washington State University, Pullman, Washington, USA
Cell Cycle 7:1067-74. 2008..These results also indicate that Swi/Snf may modulate checkpoint activation after UV damage via regulation of the two PCNA-binding proteins Gadd45a and p21... - Identification of a polymorphic, neuron-specific chromatin remodeling complexIvan Olave
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
Genes Dev 16:2509-17. 2002..We speculate that bBAF complexes create neuronal-specific patterns of chromatin accessibility, thereby imparting new regulatory characteristics to ubiquitous sequence-specific transcription factors in neurons... - Purification and functional analysis of the mammalian SWI/SNF-family of chromatin-remodeling complexesTianhuai Chi
Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
Methods Enzymol 377:299-316. 2004 - Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCMAlberto Ciccia
Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts, UK
Mol Cell 25:331-43. 2007..Our data indicate that the FANCM/FAAP24 complex may play a key role in recruitment of the FA core complex to damaged DNA... - Loss of the INI1 tumor suppressor does not impair the expression of multiple BRG1-dependent genes or the assembly of SWI/SNF enzymesDiem N Doan
Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Oncogene 23:3462-73. 2004..Unlike yeast deleted for the INI1 homologue, SWI/SNF enzymes in INI1-deficient cells were largely intact. Thus in human cells, SWI/SNF enzyme complex formation and the expression of many BRG1-dependent genes are independent of INI1... - PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genesZhijiang Yan
Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA
Genes Dev 19:1662-7. 2005..Our study provides in vivo evidence that PBAF and BAF regulate expression of distinct genes, and suggests that BAF200 plays a key role in PBAF function... - Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila HmxWeidong Wang
Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Dev Cell 7:439-53. 2004.... - Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaksAlexandra Sobeck
Division of Biochemistry and Molecular Biology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, Oregon 97239, USA
Mol Cell Biol 26:425-37. 2006.... - A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group MAmom Ruhikanta Meetei
Division of Experimental Hematology, Cincinnati Children s Hospital Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Nat Genet 37:958-63. 2005..Our data suggest an evolutionary link between Fanconi anemia-associated proteins and DNA repair; FANCM may act as an engine that translocates the Fanconi anemia core complex along DNA... - Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repressionJiwen Li
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Genes Dev 16:687-92. 2002..These results suggest that HDAC complexes can contribute to gene repression by two distinct mechanisms as follows: (1) specific targeting by repressors and (2) constitutive association with chromatin... - Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosisDavid N Reisman
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599 7295, USA
Cancer Res 63:560-6. 2003..This report provides supportive evidence that BRG1 and BRM act as tumor suppressor proteins and implicates a role for their loss in the development of non-small cell lung cancers... - Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in DrosophilaWeidong Wang
Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA
Development 132:2883-94. 2005..These results support and extend our previous proposal that mono-ubiquitination of DSL ligands allows them to gain access to a select, Epsin-dependent, endocytic pathway that they must normally enter to activate Notch... - Evidence for subcomplexes in the Fanconi anemia pathwayAnnette L Medhurst
Department of Clinical Genetics and Human Genetics, Vrije Universiteit University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Blood 108:2072-80. 2006.... - Altered expression of urea transporters in response to ureteral obstructionChunling Li
The Water and Salt Research Center/Institute of Experimental Clinical Research, Aarhus Univ. Hospital-Skejby, DK-8200 Aarhus, Denmark
Am J Physiol Renal Physiol 286:F1154-62. 2004..In conclusion, reduced expression of UT-A1, UT-A3, and UT-B levels in both BUO and UUO rats suggests that urea transporters play important roles in the impaired urinary concentrating capacity in response to urinary tract obstruction... - Hyperosmolality in vivo upregulates aquaporin 2 water channel and Na-K-2Cl co-transporter in Brattleboro ratsChunling Li
Department of Medicine, University of Colorado School of Medicine, 4200 East 9th Avenue, Box B173, Denver, CO 80262, USA
J Am Soc Nephrol 17:1657-64. 2006..05), and cortex plus outer stripe of outer medulla NKCC2 (142+/-16 versus 100+/-9%; P<0.05). In conclusion, hyperosmolality, secondary to either glucose or NaCl, upregulated renal AQP2 and NKCC2 in vivo in BB rats... - Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complexKeping Hu
Nat Genet 38:962-4; author reply 964-7. 2006