Sophia S Wang

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Relationship between interferon regulatory factor 4 genetic polymorphisms, measures of sun sensitivity and risk for non-Hodgkin lymphoma
    Allison H Gathany
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, Rockville, MD 20852, USA
    Cancer Causes Control 20:1291-302. 2009
  2. ncbi request reprint Common genetic variants in proinflammatory and other immunoregulatory genes and risk for non-Hodgkin lymphoma
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20892 7234, USA
    Cancer Res 66:9771-80. 2006
  3. ncbi request reprint Medication use, medical conditions, and the risk of human papillomavirus infection and subsequent cervical intraepithelial neoplasia 3 among women with mild cytologic abnormalities
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 14:542-5. 2005
  4. doi request reprint Common genetic variants and risk for non-Hodgkin lymphoma and adult T-cell lymphoma/leukemia in Jamaica
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
    Int J Cancer 125:1479-82. 2009
  5. ncbi request reprint Towards improved biomarker studies of cervical neoplasia: effects of precolposcopic procedures on gene expression patterns
    Sophia S Wang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7234, USA
    Diagn Mol Pathol 14:59-64. 2005
  6. ncbi request reprint Cervical tissue collection methods for RNA preservation: comparison of snap-frozen, ethanol-fixed, and RNAlater-fixation
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Diagn Mol Pathol 15:144-8. 2006
  7. ncbi request reprint Early diagnosis of cystic fibrosis in the newborn period and risk of Pseudomonas aeruginosa acquisition in the first 10 years of life: A registry-based longitudinal study
    S S Wang
    Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Pediatrics 107:274-9. 2001
  8. pmc Human papillomavirus cofactors by disease progression and human papillomavirus types in the study to understand cervical cancer early endpoints and determinants
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5104, Rockville, MD 20854 7234, USA
    Cancer Epidemiol Biomarkers Prev 18:113-20. 2009
  9. ncbi request reprint Cyclin D1 splice variant and risk for non-Hodgkin lymphoma
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, EPS MSC 7234, Bethesda, Rockville, MD 20892 7234, USA
    Hum Genet 120:297-300. 2006
  10. pmc Common gene variants in the tumor necrosis factor (TNF) and TNF receptor superfamilies and NF-kB transcription factors and non-Hodgkin lymphoma risk
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America
    PLoS ONE 4:e5360. 2009

Detail Information

Publications96

  1. pmc Relationship between interferon regulatory factor 4 genetic polymorphisms, measures of sun sensitivity and risk for non-Hodgkin lymphoma
    Allison H Gathany
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, Rockville, MD 20852, USA
    Cancer Causes Control 20:1291-302. 2009
    ..We evaluated the independent roles of these IRF4 polymorphisms and sun sensitivity in mediating NHL risk and explored whether they are confounded or modified by each other...
  2. ncbi request reprint Common genetic variants in proinflammatory and other immunoregulatory genes and risk for non-Hodgkin lymphoma
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20892 7234, USA
    Cancer Res 66:9771-80. 2006
    ..Our results require replication but potentially provide important clues for investigating common genetic variants as susceptibility factors and in disease outcomes, treatment responses, and immunotherapy targets...
  3. ncbi request reprint Medication use, medical conditions, and the risk of human papillomavirus infection and subsequent cervical intraepithelial neoplasia 3 among women with mild cytologic abnormalities
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 14:542-5. 2005
  4. doi request reprint Common genetic variants and risk for non-Hodgkin lymphoma and adult T-cell lymphoma/leukemia in Jamaica
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
    Int J Cancer 125:1479-82. 2009
    ..54, 95% CI = 0.36-0.84, p = 0.005; VCAM1 OR(CT) = 0.65, 95% CI = 0.42-1.01, OR(CC) = 0.20, 95% CI = 0.08-0.54, p-trend = 0.001). Confirmation of these results in Caribbean and other populations is needed...
  5. ncbi request reprint Towards improved biomarker studies of cervical neoplasia: effects of precolposcopic procedures on gene expression patterns
    Sophia S Wang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7234, USA
    Diagn Mol Pathol 14:59-64. 2005
    ....
  6. ncbi request reprint Cervical tissue collection methods for RNA preservation: comparison of snap-frozen, ethanol-fixed, and RNAlater-fixation
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Diagn Mol Pathol 15:144-8. 2006
    ....
  7. ncbi request reprint Early diagnosis of cystic fibrosis in the newborn period and risk of Pseudomonas aeruginosa acquisition in the first 10 years of life: A registry-based longitudinal study
    S S Wang
    Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Pediatrics 107:274-9. 2001
    ..The authors therefore investigated the association between early CF diagnosis and acquisition of Pseudomonas aeruginosa, the major bronchial pathogen, in the first decade of life...
  8. pmc Human papillomavirus cofactors by disease progression and human papillomavirus types in the study to understand cervical cancer early endpoints and determinants
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5104, Rockville, MD 20854 7234, USA
    Cancer Epidemiol Biomarkers Prev 18:113-20. 2009
    ..Investigations on the molecular distinctions along the disease continuum of cervical pathogenesis by HPV type are needed...
  9. ncbi request reprint Cyclin D1 splice variant and risk for non-Hodgkin lymphoma
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, EPS MSC 7234, Bethesda, Rockville, MD 20892 7234, USA
    Hum Genet 120:297-300. 2006
    ..4, 95% CI = 1.1-1.8, P-trend = 0.021), which was consistent for four B-cell subtypes. As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival...
  10. pmc Common gene variants in the tumor necrosis factor (TNF) and TNF receptor superfamilies and NF-kB transcription factors and non-Hodgkin lymphoma risk
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America
    PLoS ONE 4:e5360. 2009
    ..We hypothesized that the TNF and NF-kappaB pathways are important for NHL and that gene variations across the pathways may alter NHL risk...
  11. ncbi request reprint Evaluating the risk of cervical precancer with a combination of cytologic, virologic, and visual methods
    Sophia S Wang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, 6120 Executive Boulevard, EPS MSC 7234, Bethesda, MD 20892 7234, USA
    Cancer Epidemiol Biomarkers Prev 14:2665-8. 2005
    ..We conclude that the clear discrimination of cervical cancer risk provided by multiple test modalities is consistent with our understanding of cervical etiology related to HPV natural history...
  12. ncbi request reprint Pathological characteristics of cervical adenocarcinoma in a multi-center US-based study
    Sophia S Wang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Bethesda, MD 20852 7234, USA
    Gynecol Oncol 103:541-6. 2006
    ..We report a detailed pathology review of cervical adenocarcinoma subtypes, comparing growth patterns and appearance of non-neoplastic epithelium to inform possible clues for disease progression and early detection...
  13. pmc Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer
    Sophia S Wang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 5104, Rockville, MD 20852 7234, USA
    J Infect Dis 199:20-30. 2009
    ..We examined host genetic factors to identify those more common in individuals whose human papillomavirus (HPV) infections were most likely to persist and progress to cervical intraepithelial neoplasia grade 3 (CIN3) and cancer...
  14. ncbi request reprint Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica
    Sophia S Wang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS MSC 7234, Bethesda, MD 20892 7234, USA
    Cancer Epidemiol Biomarkers Prev 13:1355-60. 2004
    ..Whereas our data support the diagnostic potential for p16INK4a, further prospective studies with detailed follow-up determining the prognostic capacity of this marker are needed...
  15. pmc Determinants of human papillomavirus 16 serological conversion and persistence in a population-based cohort of 10 000 women in Costa Rica
    S S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7234, USA
    Br J Cancer 91:1269-74. 2004
    ..Higher HPV-16 viral load at enrollment was associated with seroconversion, and higher antibody titres at enrollment were associated with seropersistence...
  16. ncbi request reprint Human leukocyte antigen class I and II alleles and risk of cervical neoplasia: results from a population-based study in Costa Rica
    S S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7234, USA
    J Infect Dis 184:1310-4. 2001
    ..2-23.7). These results support the hypothesis that multiple risk alleles are needed in order to increase risk for cervical neoplasia, but a single protective allele may be sufficient for protection...
  17. ncbi request reprint Publishing on genes and lymphoma in the era of "big science"
    Sophia Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, USA
    Leuk Lymphoma 48:2091-2. 2007
  18. ncbi request reprint Human leukocyte antigen class I alleles and cervical neoplasia: no heterozygote advantage
    Sophia S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 11:419-20. 2002
  19. ncbi request reprint Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies
    Sophia S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892 7234, USA
    J Infect Dis 186:598-605. 2002
    ..Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia...
  20. doi request reprint Identification of novel methylation markers in cervical cancer using restriction landmark genomic scanning
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
    Cancer Res 68:2489-97. 2008
    ..Inclusion of NOL4 and LHFPL4 in evaluating methylation panels for early detection, risk prediction, and etiologic research on cervical cancer is warranted...
  21. ncbi request reprint Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976-2000
    Sophia S Wang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7234, USA
    Cancer 100:1035-44. 2004
    ..Therefore, the authors assessed the differential incidence rates of squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the cervix by race and disease stage for the past 25 years...
  22. ncbi request reprint Immune mechanisms in non-Hodgkin lymphoma: joint effects of the TNF G308A and IL10 T3575A polymorphisms with non-Hodgkin lymphoma risk factors
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892 7234, USA
    Cancer Res 67:5042-54. 2007
    ....
  23. ncbi request reprint Genetic variation in catechol-O-methyltransferase (COMT) and obesity in the prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 5104, MSC 7234, Rockville, MD 20852, USA
    Hum Genet 122:41-9. 2007
    ..Our results support a need for comprehensive evaluation of COMT variations and their functional relevance as COMT may be an important molecular target to evaluate for new treatments regarding obesity...
  24. pmc Seroprevalence of human papillomavirus-16, -18, -31, and -45 in a population-based cohort of 10000 women in Costa Rica
    S S Wang
    National Cancer Institute, Bethesda, MD 20892 7234, USA
    Br J Cancer 89:1248-54. 2003
    ..DNA- and sero-positive women showed the highest risk for concurrent CIN3/cancer, followed by DNA-positive, sero-negative women...
  25. pmc Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph)
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Blood 109:3479-88. 2007
    ..0; 95% CI = 1.6-5.6). The pattern of NHL heritability appeared to be uniform across NHL subtypes, but risk patterns differed by specific hematopoietic malignancies and the sex of the relative, revealing critical clues to disease etiology...
  26. ncbi request reprint Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    Carcinogenesis 27:1828-34. 2006
    ....
  27. ncbi request reprint Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, EPS 8109, Bethesda, MD 20892 7240, USA
    Hum Genet 121:161-8. 2007
    ..013), but was also associated with non-significant increased risks for each of the common B-cell histologies. These results suggest that SNPs in genes related to the oxidative stress pathway may be associated with increased risk of NHL...
  28. pmc Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 18:1259-70. 2009
    ..Replication of our findings and further study to identify functional SNPs are warranted...
  29. pmc Common genetic variation in TP53 and risk of human papillomavirus persistence and progression to CIN3/cancer revisited
    Jill Koshiol
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7248, USA
    Cancer Epidemiol Biomarkers Prev 18:1631-7. 2009
    ..Although genetic variation in TP53 might affect the natural history of HPV and cervical cancer, further work is needed to elucidate the possible mechanism...
  30. ncbi request reprint Sun exposure, vitamin D receptor gene polymorphisms and risk of non-Hodgkin lymphoma
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8009, Rockville, MD 20892, USA
    Cancer Causes Control 18:989-99. 2007
    ....
  31. pmc Grading the severity of cervical neoplasia based on combined histopathology, cytopathology, and HPV genotype distribution among 1,700 women referred to colposcopy in Oklahoma
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20854 7234, USA
    Int J Cancer 124:964-9. 2009
    ..We are now using these sharpened diagnostic categories to search for novel biomarkers predicting the risk of progression and invasion...
  32. ncbi request reprint Genotype frequency and F ST analysis of polymorphisms in immunoregulatory genes in Chinese and Caucasian populations
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Immunogenetics 59:839-52. 2007
    ..25). These results suggest that there is substantial genetic diversity in immune genes and exploration of SNP associations with immune-related diseases that vary in incidence across these two populations may be warranted...
  33. ncbi request reprint Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Lancet Oncol 7:27-38. 2006
    ..We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph)...
  34. pmc Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Br J Haematol 151:239-44. 2010
    ..These results support the hypothesis that common genetic polymorphisms in human DNA repair genes may modify the risk of NHL...
  35. pmc Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
    Carcinogenesis 28:1759-64. 2007
    ..Several previous studies have found non-Hodgkin lymphoma (NHL) risk to be associated with hair dye use, particularly use of permanent, dark colors and use before 1980, when hair dye formulations changed...
  36. pmc Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma
    Joanne S Colt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
    Blood 113:1899-905. 2009
    ..This shows that the relation between organochlorine exposure and NHL risk may be modified by particular variants in immune genes and provides one of the first examples of a potential gene-environment interaction for NHL...
  37. pmc Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut
    Kyoung Mu Lee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Am J Hematol 85:560-3. 2010
    ..Additional studies are needed to replicate these findings and, more generally, to explore the manner in which genes and receptors may influence the pathogenesis of this poorly understood malignancy...
  38. ncbi request reprint DRD2 genetic variation in relation to smoking and obesity in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
    Pharmacogenet Genomics 16:901-10. 2006
    ..To assess the specificity of genetic effects, we also investigated other reward-motivated characteristics (obesity, alcohol consumption)...
  39. pmc Heterogeneity of high-grade cervical intraepithelial neoplasia related to HPV16: implications for natural history and management
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852 7234, USA
    Int J Cancer 132:148-54. 2013
    ..Lesion size seems to be an important determinant of colposcopy and biopsy performance. Genotyping for HPV16 in cervical cancer screening can improve risk stratification but may pose challenges to finding small lesions in colposcopy...
  40. pmc Single nucleotide polymorphisms in the PRDX3 and RPS19 and risk of HPV persistence and cervical precancer/cancer
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e33619. 2012
    ..Host genetic factors might affect the risk of progression from infection with carcinogenic human papillomavirus (HPV), the etiologic agent for cervical cancer, to persistent HPV infection, and hence to cervical precancer and cancer...
  41. pmc SLC6A3 and body mass index in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
    Elizabeth M Azzato
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland, USA
    BMC Med Genet 10:9. 2009
    ....
  42. ncbi request reprint Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, DHHS, Bethesda, MD 20892 7240, USA
    Carcinogenesis 28:823-7. 2007
    ..The striking protective associations observed for polymorphisms in all four genes for NHL and/or one or more subtypes suggest that genetic variation in CASP genes may play an important role in the etiology of NHL...
  43. pmc Etiologic heterogeneity among non-Hodgkin lymphoma subtypes
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Rockville, MD, USA
    Blood 112:5150-60. 2008
    ....
  44. pmc Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Blood 114:264-7. 2009
    ..It is noteworthy that genetic variants in CASP8 were associated with risk of all major NHL subtypes. Our findings suggest that genetic variation in caspases may play an important role in lymphomagenesis...
  45. pmc Genetic variation in Th1/Th2 pathway genes and risk of non-Hodgkin lymphoma: a pooled analysis of three population-based case-control studies
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, USA
    Br J Haematol 153:341-50. 2011
    ..This SNP was also associated specifically with risk of follicular lymphoma (allele risk OR= 1·26; P(trend)= 0·0012). These findings suggest that genetic variation in Th1/Th2 cytokine genes may contribute to lymphomagenesis...
  46. ncbi request reprint Determinants of human papillomavirus load among women with histological cervical intraepithelial neoplasia 3: dominant impact of surrounding low-grade lesions
    Mark E Sherman
    Department of Health and Human Services, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland 20892 7374, USA
    Cancer Epidemiol Biomarkers Prev 12:1038-44. 2003
    ..These factors severely limit the clinical use of load measurements irrespective of HPV testing methodology...
  47. pmc Accuracy of cervical specimens obtained for biomarker studies in women with CIN3
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5014, Rockville, MD 20854 7234, USA
    Gynecol Oncol 115:493-6. 2009
    ..We developed a protocol to collect representative cervical specimens based on colposcopic evaluation from women treated with loop electrosurgical excision procedure (LEEP)...
  48. ncbi request reprint Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Hum Genet 119:659-68. 2006
    ..Further work is needed to extend these findings by carrying out extended haplotype analyses of these and related genes and to replicate the observations in other studies...
  49. pmc Common variation in genes related to innate immunity and risk of adult glioma
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 18:1651-8. 2009
    ..We have identified a promising set of innate immunity-related genetic regions for further investigation...
  50. ncbi request reprint Common variants in genes that mediate immunity and risk of multiple myeloma
    Elizabeth E Brown
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Int J Cancer 120:2715-22. 2007
    ..Our findings provide preliminary evidence that common genetic variants in specific immune-mediated pathways could influence the risk of MM...
  51. pmc Multiple human papillomavirus genotype infections in cervical cancer progression in the study to understand cervical cancer early endpoints and determinants
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
    Int J Cancer 125:2151-8. 2009
    ..The potential range of HPV genotype attribution is wide at the disease categories <CIN2 to CIN3. Genotyping from cervical lesions and analyzing viral oncogene expression can improve estimates of HPV genotype attribution...
  52. ncbi request reprint Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan
    Allan Hildesheim
    Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rm 7062, Rockville, MD 20852, USA
    J Natl Cancer Inst 94:1780-9. 2002
    ..We used high-resolution HLA genotyping in a case-control study in Taiwan to systematically evaluate the association between various HLA alleles and NPC...
  53. pmc A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
    Carcinogenesis 30:275-81. 2009
    ..No associations with TLR4 variants were observed. This pooled analysis provides strong evidence that variation in the TLR10-TLR1-TLR6 region is associated with NHL risk and suggests that TLR2 variants may influence susceptibility to MZL...
  54. pmc Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Bethesda, Maryland, USA
    Nat Genet 45:868-76. 2013
    ..3 (ODF1, P=5.40×10(-8)) and 5p15.33 (TERT, P=1.92×10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism...
  55. pmc Evaluation of a multiplex panel of immune-related markers in cervical secretions: a methodologic study
    Jill Koshiol
    Division of Cancer Epidemiology and Genetics, NCI NIH DHHS, Bethesda, MD
    Int J Cancer 134:411-25. 2014
    ..g., MIP-1delta, OR: 4.48, 95% CI: 0.87-23.04 versus <CIN1/HPV-positive). More than 70% of markers were reliably measured. This assay may be used to evaluate associations of immune-related markers with CIN and HPV status. ..
  56. pmc Incidence of lymphoid neoplasms by subtype among six Asian ethnic groups in the United States, 1996-2004
    J Daniel Carreon
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
    Cancer Causes Control 19:1171-81. 2008
    ..To establish baseline data for lymphoid neoplasm incidence by subtype for six Asian-American ethnic groups...
  57. pmc Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, MSC 7240, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Blood 107:4101-8. 2006
    ..84; 95% CI = 1.79-8.22; P < .001). Further, the IL10 and IL4 SNP associations remained significant after adjusting for multiple comparisons. These results suggest that SNPs in Th2 cytokine genes may be associated with risk of NHL...
  58. pmc Reproducibility of linear array for human papillomavirus genotyping
    Jill Koshiol
    Division of Cancer Epidemiology and Genetics, NCI NIH DHHS, Bethesda, Maryland, USA
    J Clin Microbiol 51:625-8. 2013
    ..3% overall [Kappa = 0.9] and 86.8% for carcinogenic types [Kappa = 0.92]). Discordance was highest with a low hybridization signal strength. Overall, Linear Array was highly reproducible...
  59. pmc Human papillomavirus load measured by Linear Array correlates with quantitative PCR in cervical cytology specimens
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    J Clin Microbiol 50:1564-70. 2012
    ..Our findings support conducting comprehensive studies of viral load and cervical cancer precursors using quantitative LA genotyping data...
  60. pmc Clinical and pathological heterogeneity of cervical intraepithelial neoplasia grade 3
    Hannah P Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America
    PLoS ONE 7:e29051. 2012
    ..To improve our understanding of CIN3 natural history, we performed a detailed characterization of CIN3 heterogeneity in a large referral population in the US...
  61. doi request reprint Seroprevalence and correlates of human papillomavirus 16/18 seropositivity among young women in Costa Rica
    Sarah Coseo
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS, Room 7079, Rockville, MD 20852, USA
    Sex Transm Dis 37:706-14. 2010
    ..We investigated HPV16 and 18 seroepidemiology among young, unvaccinated women aged between 18 and 25...
  62. pmc A pooled analysis of three studies evaluating genetic variation in innate immunity genes and non-Hodgkin lymphoma risk
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, USA
    Br J Haematol 152:721-6. 2011
    ....
  63. pmc Risk of meningioma and common variation in genes related to innate immunity
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, Neuro Oncology Branch, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS Room 7058, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 19:1356-61. 2010
    ..The etiology of meningioma, the second most common type of adult brain tumor in the United States, is largely unknown. Prior studies indicate that history of immune-related conditions may affect the risk of meningioma...
  64. pmc Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphoma
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    Pharmacogenet Genomics 16:537-45. 2006
    ..15-5.20, P = 0.02). Our data provide evidence that NAT1 and NAT2 genotypes are associated with NHL risk and support a contributory role for carcinogenic aromatic and/or heterocyclic amines in the multi-factorial etiology of NHL...
  65. ncbi request reprint Mortality trends for cervical squamous and adenocarcinoma in the United States. Relation to incidence and survival
    Mark E Sherman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892 7374, USA
    Cancer 103:1258-64. 2005
    ..To make inferences about the effectiveness of screening, the authors assessed mortality trends for squamous and adenocarcinoma in relation to incidence of these tumors, incidence of their precursors and survival...
  66. pmc Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control study
    Unhee Lim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Rockville, MD 20852, USA
    Blood 109:3050-9. 2007
    ..04-0.39), and MTRR Ex5+136T>CTT (OR = 0.67; 95% CI = 0.47-0.97) genotypes. Warranting replication, our finding of gene-nutrient interactions in one-carbon metabolism supports their etiologic involvement in lymphomagenesis...
  67. ncbi request reprint A case-control study of risk factors for invasive cervical cancer among U.S. women exposed to oncogenic types of human papillomavirus
    Tammy S Shields
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, MSC 7234, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 13:1574-82. 2004
    ..It is particularly worth considering further why studies of different designs are inconsistent regarding the effect of oral contraceptive use...
  68. pmc Utility of methylation markers in cervical cancer early detection: appraisal of the state-of-the-science
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5012, Rockville, MD 20854 7234, USA
    Gynecol Oncol 112:293-9. 2009
    ..We wanted to identify the most promising methylation marker candidates for cervical cancer early detection...
  69. ncbi request reprint Host and viral genetics and risk of cervical cancer: a review
    Allan Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 7062, EPS MSC 7234, Rockville, MD 20852, USA
    Virus Res 89:229-40. 2002
    ..A consistent association between HPV16 non-European variants and risk of disease is also evident from published work. These findings are discussed. Gaps in our understanding and future research needs are also discussed...
  70. ncbi request reprint Human leukocyte antigen class I and II haplotypes and risk of cervical cancer
    J D Carreon
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Tissue Antigens 66:321-4. 2005
    ..No HLA haplotype was significantly associated with cervical neoplasia, suggesting that individual allele associations reported to date (e.g. HLA-DR*13) are not likely explained by underlying haplotypes...
  71. ncbi request reprint "Sip volume" as a quality indicator in liquid-based cervical cytology
    Mark E Sherman
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892 7374, USA
    Cancer 108:462-7. 2006
    ..It was hypothesized that the volumes required to prepare ThinPreps ("sip volumes") represent indicators of specimen quality...
  72. pmc Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001
    Lindsay M Morton
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 7055, Rockville, MD 20852, USA
    Blood 107:265-76. 2006
    ..We conclude that the striking differences in incidence patterns by histologic subtype strongly suggest that there is etiologic heterogeneity among lymphoid neoplasms and support the pursuit of epidemiologic analysis by subtype...
  73. ncbi request reprint Histopathologic extent of cervical intraepithelial neoplasia 3 lesions in the atypical squamous cells of undetermined significance low-grade squamous intraepithelial lesion triage study: implications for subject safety and lead-time bias
    Mark E Sherman
    The National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 12:372-9. 2003
    ....
  74. ncbi request reprint Genetic variation and willingness to participate in epidemiologic research: data from three studies
    Parveen Bhatti
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7091, MSC 7238, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 14:2449-53. 2005
    ..To the extent possible, investigators should evaluate their own genetic data for bias in response categories...
  75. pmc Reproductive factors, exogenous hormone use and risk of lymphoid neoplasms among women in the National Institutes of Health-AARP Diet and Health Study Cohort
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
    Int J Cancer 124:2737-43. 2009
    ..These data do not support an important role for reproductive factors or exogenous hormones in modulating lymphomagenesis...
  76. pmc Risk factors for non-Hodgkin lymphoma subtypes defined by histology and t(14;18) in a population-based case-control study
    Cindy M Chang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892, USA
    Int J Cancer 129:938-47. 2011
    ..Future efforts should focus on pooling data to confirm and extend previous research on risk factors for t(14;18)-NHL subtypes...
  77. ncbi request reprint Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS Room 7085, 6120 Executive Boulevard, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 16:1655-61. 2007
    ..Our results suggest that common variants in the CASP8, CCND1, CCNH, and MDM2 genes may influence brain tumor risk. Future research in this area should include more detailed coverage of genes in the apoptosis/cell cycle control pathways...
  78. ncbi request reprint Socioeconomic status and the risk of cervical intraepithelial neoplasia grade 3 among oncogenic human papillomavirus DNA-positive women with equivocal or mildly abnormal cytology
    Michelle J Khan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville Maryland, USA
    Cancer 104:61-70. 2005
    ....
  79. ncbi request reprint Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma
    A V Brenner
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7238, USA
    Carcinogenesis 28:2543-7. 2007
    ..07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma...
  80. ncbi request reprint The C242T CYBA polymorphism as a major determinant of NADPH oxidase activity in patients with cardiovascular disease
    P Mehranpour
    Emory University School of Medicine, Division of Cardiology, Atlanta, GA 30322, USA
    Cardiovasc Hematol Agents Med Chem 7:251-9. 2009
    ..By reducing the influence of confounding environmental factors, lymphoblastoid cell lines could serve as a tool to assess direct genotype/phenotype interactions of candidate genes known to affect atherosclerosis...
  81. ncbi request reprint Determinants of human papillomavirus-negative, low-grade squamous intraepithelial lesions in the atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesions triage study (ALTS)
    Rosemary E Zuna
    Pathology Department, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Cancer 105:253-62. 2005
    ..Using the Atypical Squamous Cells of Undetermined Significance/LSIL Triage Study (ALTS) population, the authors evaluated the significance of HPV-negative LSIL...
  82. ncbi request reprint Impact of interleukin-10 polymorphisms (-1082 and -3575) on the survival of patients with lymphoid neoplasms
    Eva Domingo-Domenech
    Department of Hematology, Institut Catala d Oncologia, Avda Gran Via s n, Km 2 7, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Haematologica 92:1475-81. 2007
    ..The aim of this study was to explore the association between polymorphisms of IL-10-(1082A>G) and IL-10-(3575T>A) with the overall survival in patients with lymphoid neoplasms...
  83. pmc Vegetables- and antioxidant-related nutrients, genetic susceptibility, and non-Hodgkin lymphoma risk
    Linda E Kelemen
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA
    Cancer Causes Control 19:491-503. 2008
    ..Although most associations have not been examined previously with NHL, our results suggest the examined polymorphisms are not modifiers of the association between vegetable and zinc intakes and NHL risk...
  84. pmc Re: Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma, author response
    Shelia Hoar Zahm
    Carcinogenesis 29:1084-5. 2008
  85. pmc Evaluation of candidate methylation markers to detect cervical neoplasia
    Narayan Shivapurkar
    Hamon Center for Therapeutic Oncology Research, Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75930, USA
    Gynecol Oncol 107:549-53. 2007
    ..We used quantitative PCR assays to evaluate methylation in five candidate genes (TNFRSF10C, DAPK1, SOCS3, HS3ST2 and CDH1) previously demonstrated as methylated in cervical cancer...
  86. pmc Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era
    Thomas M Habermann
    Mayo Clinic College of Medicine, Rochester, MN, USA
    Blood 112:2694-702. 2008
    ..These data support a role for germ line variation in immune genes, particularly genes associated with a proinflammatory state, as predictors of late survival in DLBCL...
  87. pmc Human papillomavirus (HPV) genotyping using paired exfoliated cervicovaginal cells and paraffin-embedded tissues to highlight difficulties in attributing HPV types to specific lesions
    Patti E Gravitt
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room E6535, Baltimore, MD 21205, USA
    J Clin Microbiol 45:3245-50. 2007
    ....
  88. ncbi request reprint Comparison of human papillomavirus distribution in cytologic subgroups of low-grade squamous intraepithelial lesion
    Rosemary E Zuna
    Pathology Department, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Cancer 108:288-97. 2006
    ..In this study, the objective was to determine whether these 2 morphologic subcategories are characterized by differences in risk for CIN3 and/or HPV type distribution...
  89. ncbi request reprint Interleukin-6-related genotypes, body mass index, and risk of multiple myeloma and plasmacytoma
    Wendy Cozen
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, MC 9175, Los Angeles, CA 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 15:2285-91. 2006
    ..These results suggest that IL-6 promoter genotypes may be associated with increased risk of plasma cell neoplasms...
  90. ncbi request reprint Predicting absolute risk of CIN3 during post-colposcopic follow-up: results from the ASCUS-LSIL Triage Study (ALTS)
    Joan L Walker
    Department of Obstetrics and Gynecology, University of Oklahoma, Oklahoma City, OK, USA
    Am J Obstet Gynecol 195:341-8. 2006
    ..Using data from the ASCUS-LSIL Triage Study (ALTS) to inform clinical management, we calculated the absolute risk for developing CIN3 within 2 years of referral to an enrollment colposcopy...
  91. ncbi request reprint A putative exonic splicing polymorphism in the BCL6 gene and the risk of non-Hodgkin lymphoma
    Yawei Zhang
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
    J Natl Cancer Inst 97:1616-8. 2005
    ..2, 95% CI = 2.0 to 13.3). Our results support the hypothesis that a genetic variant that could alter mRNA transcripts of BCL6 may contribute to the etiology of NHL and suggest that this variant warrants further investigation...
  92. pmc Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes
    Deirdre A Hill
    Cancer Center and Department of Internal Medicine, UNM School of Medicine, 1 University of New Mexico, MSC 10 5550, Albuquerque, NM 87131 0001, USA
    Blood 108:3161-7. 2006
    ..03) in the nonhomologous end joining (NHEJ)/V(D)J pathway. These NHEJ/V(D)J-related gene variants represent promising candidates for further studies of NHL etiology and require replication in other studies...
  93. ncbi request reprint The impact of early cystic fibrosis diagnosis on pulmonary function in children
    Sophia S Wang
    Office of Genetics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Pediatr 141:804-10. 2002
    ..To investigate the impact of early diagnosis on pulmonary function in a large cohort of children with cystic fibrosis (CF)...
  94. pmc Lack of evidence for human-to-human transmission of avian influenza A (H9N2) viruses in Hong Kong, China 1999
    Timothy M Uyeki
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 8:154-9. 2002
    ..No serologic evidence of H9N2 infection was found in family members or health-care workers who had close contact with the H9N2-infected children, suggesting that these H9N2 viruses were not easily transmitted from person to person...
  95. pmc The role of genetic polymorphisms in environmental health
    Samir N Kelada
    Department of Environmental Health, University of Washington School of Public Health and Community Medicine, Seattle, WA, USA
    Environ Health Perspect 111:1055-64. 2003
    ..Both offer opportunities for developing new methods of disease prevention. Finally, we describe a basic framework for researchers interested in pursuing health effects research that incorporates genetic polymorphisms...