Affiliation: National Institutes of Health
- Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowdingHuanchen Wang
Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
Nat Chem Biol 8:111-6. 2012..We describe the enzyme's conformational dynamics, its unprecedented topological presentation of nucleotide and inositol phosphate, and the charge balance that facilitates partly associative in-line phosphoryl transfer...
- Structural insight into inositol pyrophosphate turnoverStephen B Shears
Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, PO Box 12233, NC 27709, USA
Adv Biol Regul 53:19-27. 2013..This work includes the analysis of crystal complexes with substrates, products, transition state analogs, and a novel phosphonoacetate substrate analog...