Huanchen Wang

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
    Huanchen Wang
    Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Nat Chem Biol 8:111-6. 2012
  2. doi request reprint The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment
    Jeremy D Weaver
    Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, P O Box 12233, NC 27709, U S A
    Biosci Rep 33:e00022. 2013
  3. pmc Structural insight into inositol pyrophosphate turnover
    Stephen B Shears
    Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, PO Box 12233, NC 27709, USA
    Adv Biol Regul 53:19-27. 2013

Collaborators

Detail Information

Publications3

  1. doi request reprint Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
    Huanchen Wang
    Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Nat Chem Biol 8:111-6. 2012
    ..We describe the enzyme's conformational dynamics, its unprecedented topological presentation of nucleotide and inositol phosphate, and the charge balance that facilitates partly associative in-line phosphoryl transfer...
  2. doi request reprint The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment
    Jeremy D Weaver
    Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, P O Box 12233, NC 27709, U S A
    Biosci Rep 33:e00022. 2013
    ..Finally, the specificity constants for PPIP5K2 revise upwards by one-to-two orders of magnitude the inherent catalytic activities of this enzyme, and we show its equilibrium point favours 80-90% depletion of InsP₆/₅-InsP₇...
  3. pmc Structural insight into inositol pyrophosphate turnover
    Stephen B Shears
    Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, PO Box 12233, NC 27709, USA
    Adv Biol Regul 53:19-27. 2013
    ..This work includes the analysis of crystal complexes with substrates, products, transition state analogs, and a novel phosphonoacetate substrate analog...