Hongsheng Wang

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Association of the pre-B cell receptor (BCR) expression level with the quality of pre-BII cell differentiation reveals hierarchical pre-BCR function
    Hongsheng Wang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Disease, National Institutes of Health, 5640 Fishers Lane, Rockville, MD 20852, USA
    Mol Immunol 44:1765-74. 2007
  2. pmc IRF8 regulates B-cell lineage specification, commitment, and differentiation
    Hongsheng Wang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 112:4028-38. 2008
  3. pmc An ENU-induced mutation in the lymphotoxin alpha gene impairs organogenesis of lymphoid tissues in C57BL/6 mice
    Hongsheng Wang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers LN, TB1, Rm 1518, Rockville, MD 20852, USA
    Biochem Biophys Res Commun 370:461-7. 2008
  4. ncbi request reprint Transitional B cells lose their ability to receptor edit but retain their potential for positive and negative selection
    Hongsheng Wang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 179:7544-52. 2007
  5. pmc IRF8 regulates myeloid and B lymphoid lineage diversification
    Hongsheng Wang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook 1, Rm 1518, 5640 Fishers Lane, Rockville, MD 20852, USA
    Immunol Res 43:109-17. 2009
  6. pmc Expression of plasma cell alloantigen 1 defines layered development of B-1a B-cell subsets with distinct innate-like functions
    Hongsheng Wang
    Virology and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 109:20077-82. 2012
  7. pmc Anaplastic plasmacytomas: relationships to normal memory B cells and plasma cell neoplasms of immunodeficient and autoimmune mice
    Chen Feng Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    J Pathol 221:106-16. 2010
  8. pmc IFN regulatory factor 8 regulates MDM2 in germinal center B cells
    Jeff X Zhou
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 183:3188-94. 2009
  9. pmc Functional deficiency in IL-7 caused by an N-ethyl-N-nitrosourea-induced point mutation
    Jianxun Feng
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Genetics 175:545-51. 2007
  10. pmc Differential expression of IRF8 in subsets of macrophages and dendritic cells and effects of IRF8 deficiency on splenic B cell and macrophage compartments
    Chen Feng Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Twinbrook I, Room 1528, Rockville, MD 20852, USA
    Immunol Res 45:62-74. 2009

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Association of the pre-B cell receptor (BCR) expression level with the quality of pre-BII cell differentiation reveals hierarchical pre-BCR function
    Hongsheng Wang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Disease, National Institutes of Health, 5640 Fishers Lane, Rockville, MD 20852, USA
    Mol Immunol 44:1765-74. 2007
    ..These data reveal a hierarchy of pre-BCR function that determines the development and plasticity of early B cells...
  2. pmc IRF8 regulates B-cell lineage specification, commitment, and differentiation
    Hongsheng Wang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 112:4028-38. 2008
    ..Together, these results indicate that IRF8 modulates lineage choice by HSCs and is part of the transcriptional network governing B-cell lineage specification, commitment, and differentiation...
  3. pmc An ENU-induced mutation in the lymphotoxin alpha gene impairs organogenesis of lymphoid tissues in C57BL/6 mice
    Hongsheng Wang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers LN, TB1, Rm 1518, Rockville, MD 20852, USA
    Biochem Biophys Res Commun 370:461-7. 2008
    ..This new strain provides opportunities for understanding the full range of Lta gene function on a pure C57BL/6 background...
  4. ncbi request reprint Transitional B cells lose their ability to receptor edit but retain their potential for positive and negative selection
    Hongsheng Wang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 179:7544-52. 2007
    ..Our results support the idea that transitional B cells lose the capacity to edit, but are sensitive to positive and negative selection...
  5. pmc IRF8 regulates myeloid and B lymphoid lineage diversification
    Hongsheng Wang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook 1, Rm 1518, 5640 Fishers Lane, Rockville, MD 20852, USA
    Immunol Res 43:109-17. 2009
    ..Here we review the contributions of IRF8 to B cell development from hematopoietic stem cells in the bone marrow and its place in the hierarchical regulatory network governing specification and commitment to the B cell fate...
  6. pmc Expression of plasma cell alloantigen 1 defines layered development of B-1a B-cell subsets with distinct innate-like functions
    Hongsheng Wang
    Virology and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 109:20077-82. 2012
    ..We conclude that identification of B-1a.PC1(lo) and B-1a.PC1(hi) cells extends the concept of a layered immune system with important implications for developing effective vaccines and promoting the generation of immunoregulatory B cells...
  7. pmc Anaplastic plasmacytomas: relationships to normal memory B cells and plasma cell neoplasms of immunodeficient and autoimmune mice
    Chen Feng Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    J Pathol 221:106-16. 2010
    ..Published in 2010 by John Wiley & Sons, Ltd...
  8. pmc IFN regulatory factor 8 regulates MDM2 in germinal center B cells
    Jeff X Zhou
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 183:3188-94. 2009
    ..These results suggest that by regulating MDM2, IRF8 might allow GC B cells to tolerate physiological DNA breaks that otherwise would trigger apoptosis...
  9. pmc Functional deficiency in IL-7 caused by an N-ethyl-N-nitrosourea-induced point mutation
    Jianxun Feng
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Genetics 175:545-51. 2007
    ..This new strain thus provides a new model for studying the functions of IL-7 on a pure C57BL/6 background...
  10. pmc Differential expression of IRF8 in subsets of macrophages and dendritic cells and effects of IRF8 deficiency on splenic B cell and macrophage compartments
    Chen Feng Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Twinbrook I, Room 1528, Rockville, MD 20852, USA
    Immunol Res 45:62-74. 2009
    ..These findings demonstrate differential requirements for IRF8 among distinct subsets of B cells, DC, and macrophages...
  11. pmc The CXCR7 chemokine receptor promotes B-cell retention in the splenic marginal zone and serves as a sink for CXCL12
    Hongsheng Wang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA
    Blood 119:465-8. 2012
    ..CXCR7 thus appears to function as a scavenger receptor for CXCL12 on MZ B cells...
  12. pmc Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts
    Ryusuke Yoshimi
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    J Immunol 182:7527-38. 2009
    ....
  13. pmc Mouse IgM Fc receptor, FCMR, promotes B cell development and modulates antigen-driven immune responses
    Seung Chul Choi
    Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 190:987-96. 2013
    ..Our studies demonstrate that FCMR is required for B cell differentiation and homeostasis, the prevention of autoreactive B cells, and responsiveness to antigenic challenge...
  14. pmc Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma
    Zhaoyang Li
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Blood 114:4158-68. 2009
    ..These results suggest that, in addition to constitutive activation of BCL10 in MZ B cells, other genetic factors or environmental influences are required for short latency oncogenic transformation...
  15. pmc IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools
    Jianxun Feng
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 186:1458-66. 2011
    ..Functional studies showed that IRF8-CKO mice generated normal Ab responses to T-independent and T-dependent Ags. Thus, IRF8 controls the expansion and maturation of MZ and FO B cells but has little effect on B cell function...
  16. pmc Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein
    Chang Hoon Lee
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:63-72. 2006
    ..These results suggest previously unappreciated roles for IRF8 in the transcriptional regulation of B cell GC reactions that include direct regulation of AICDA and BCL6...
  17. pmc Characterization of monoclonal antibodies to the plasma cell alloantigen ENPP1
    Sadia Abbasi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, MD 20850, USA
    Hybridoma (Larchmt) 30:11-7. 2011
    ..Here, we characterize a novel anti-ENPP1 monoclonal antibody that recognizes both alleles and can be used for flow cytometry...
  18. pmc NOTCH is part of the transcriptional network regulating cell growth and survival in mouse plasmacytomas
    Dong Mi Shin
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, NIH, Rockville, Maryland 20852, USA
    Cancer Res 68:9202-11. 2008
    ....
  19. ncbi request reprint Evidence for a ligand-mediated positive selection signal in differentiation to a mature B cell
    Hongsheng Wang
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 171:6381-8. 2003
    ..These data are consistent with a requirement for a ligand-mediated BCR signal for differentiation to a mature B-2 cell...
  20. ncbi request reprint EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity
    Hongsheng Wang
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 177:2793-802. 2006
    ..These data further implicate TLRs in the etiology of SLE and suggest a mechanistic link between EBV infection and SLE...
  21. ncbi request reprint Regulation of B-cell development by antibody specificity
    Hongsheng Wang
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7290, USA
    Curr Opin Immunol 16:246-50. 2004
    ..Instead, evidence suggests that entry into a mature subset involves active B-cell receptor signaling and self-antigen-mediated positive selection...
  22. ncbi request reprint Impaired clearance of apoptotic cells induces the activation of autoreactive anti-Sm marginal zone and B-1 B cells
    Ye Qian
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599
    J Immunol 172:625-35. 2004
    ..Since marginal zone and B-1 cells are positively selected, these data suggest a loss of ignorance rather than a loss of tolerance...
  23. ncbi request reprint IHH and FGF8 coregulate elongation of digit primordia
    Jian Zhou
    Bio X Center, Shanghai Jiao Tong University, Shanghai, China
    Biochem Biophys Res Commun 363:513-8. 2007
    ..IHH and FGF8 maybe play different roles and act synergistically to promote chondrogenesis during digit primordia elongation...