Research Topics
Genomes and Genes
| Sharon M WahlSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
Secretory leukocyte protease inhibitor suppresses the inflammation and joint damage of bacterial cell wall-induced arthritisX Y Song
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4352, USA
J Exp Med 190:535-42. 1999....- Requirement for transforming growth factor beta1 in controlling T cell apoptosisW Chen
Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
J Exp Med 194:439-53. 2001..These findings may have broad implications not only for T cell selection and death in immune responses and in the generation of tolerance, but also for defining the mechanisms of programmed cell death in general... 
HIV accomplices and adversaries in macrophage infectionSharon M Wahl
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Rm 320, 30 Convent Dr, MSC 4352, Bethesda, MD 20892 4352, USA
J Leukoc Biol 80:973-83. 2006..These and other manipulatable pathways may give the macrophage a fighting chance in its battle against the virus...- The kiss of death: interrupted by NK-cell close encounters of another kindSharon M Wahl
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
Trends Immunol 27:161-4. 2006..Through a contact-dependent mechanism involving transforming growth factor-beta, regulatory T cells provide an escape mechanism from NK-cell-mediated tumor surveillance... - Nitric oxide in experimental joint inflammation. Benefit or detriment?S M Wahl
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
Cells Tissues Organs 174:26-33. 2003..Collectively, these data implicate discrete roles for the NOS isoforms in the emergence of local tissue pathology and underscore the need to define the specific pathways that are being targeted for interventional strategies... - Transforming growth factor-beta-induced regulatory T cells referee inflammatory and autoimmune diseasesSharon M Wahl
Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Disease, National Institutes of Health, Bethesda, Maryland, USA
Arthritis Res Ther 7:62-8. 2005.... - TGF-beta: the perpetrator of immune suppression by regulatory T cells and suicidal T cellsSharon M Wahl
NIDCR, NIH, Building 30, Rm 320, 30 Convent Drive, MSC4352, Bethesda, MD 20892 4352, USA
J Leukoc Biol 76:15-24. 2004.... - TGF-beta: how tolerant can it be?Sharon M Wahl
Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
Immunol Res 28:167-79. 2003..Central to several of these pathways is transforming growth factor-beta (TGF-beta), a potent immunoregulatory cytokine that contributes to the function and generation of regulatory T cells... - Viral and host cofactors facilitate HIV-1 replication in macrophagesSharon M Wahl
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institute of Health, Bethesda, MD 20892 4352, USA
J Leukoc Biol 74:726-35. 2003..Inroads into understanding how HIV-1 co-opts host factors to generate a permissive environment for viral replication and transmission to new viral hosts may provide opportunities for targeted interruption of this lethal process... - Permissive factors for HIV-1 infection of macrophagesS M Wahl
National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4352, USA
J Leukoc Biol 68:303-10. 2000..avium and HIV-1 paralleled these in vitro findings. Furthermore, reduction in viral burden is associated with treatment of infected or inflamed tissues, underscoring the link between immune activation and viral replication... - Regulatory T cells and transcription factors: gatekeepers in allergic inflammationSharon M Wahl
Building 30, Room 320, 30 Convent Drive, MSC 4352, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4352, USA
Curr Opin Immunol 16:768-74. 2004..Continued unraveling of the pathways underlying the development of deleterious immune responses and their control will guide new avenues of investigation and intervention... - TGF-beta: a mobile purveyor of immune privilegeSharon M Wahl
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
Immunol Rev 213:213-27. 2006.... - Transforming growth factor-beta: innately bipolarSharon M Wahl
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research NIDCR, National Institutes of Health NIH, Bethesda, MD 20892 4352, USA
Curr Opin Immunol 19:55-62. 2007..Disruption of the tenuous balance between these opposing actions of TGF-beta underlies immunopathogenicity... 
Systemic and mucosal differences in HIV burden, immune, and therapeutic responsesSharon M Wahl
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
J Acquir Immune Defic Syndr 56:401-11. 2011..Mucosal tissues represent major targets for HIV transmission but differ in susceptibility and reservoir function by unknown mechanisms...- Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferonTeresa Greenwell-Wild
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
Blood 114:1864-74. 2009..In addition to macrophages, the IL-27-IFN-alpha connection is operative in CD4(+) T cells, consistent with an IFN-alpha-dependent pathway underlying host cell defense to HIV... - Aberrant Toll receptor expression and endotoxin hypersensitivity in mice lacking a functional TGF-beta 1 signaling pathwayNancy McCartney-Francis
Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 172:3814-21. 2004..Constitutive and/or environmental activation of TLR4 and downstream elements, in the absence of TGF-beta suppression, may impact on innate and adaptive immunity and contribute to massive uncontrolled inflammation... - Secretory leukocyte protease inhibitor binds to annexin II, a cofactor for macrophage HIV-1 infectionGe Ma
Oral Infection and Immunity Branch, NIDCR, NIH, 30 Convent Dr, MSC4352, Building 30, Room 320, Bethesda, MD 20892, USA
J Exp Med 200:1337-46. 2004..Moreover, this HIV-1 PS interaction with annexin II can be disrupted by SLPI or other annexin II-specific inhibitors. The PS-annexin II connection may represent a new target to prevent HIV-1 infection... - Rapid myeloid cell transcriptional and proteomic responses to periodontopathogenic Porphyromonas gingivalisSalvador Nares
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892 4352, USA
Am J Pathol 174:1400-14. 2009..The shared, unique, and/or complementary transcriptional and proteomic profiles may frame the context of the host response to P. gingivalis, contributing to the destructive nature of periodontal inflammation... - Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3Wanjun Chen
Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 198:1875-86. 2003..Finally, in a murine asthma model, coadministration of these TGF-beta-induced suppressor T cells prevented house dust mite-induced allergic pathogenesis in lungs... - Mycobacterium avium-induced SOCS contributes to resistance to IFN-gamma-mediated mycobactericidal activity in human macrophagesNancy Vazquez
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892 4352, USA
J Leukoc Biol 80:1136-44. 2006..Our data provide new insights into the manipulation of the host response by this opportunistic pathogen and the potential for modulating SOCS to influence the outcome of M. avium infection in immunocompromised hosts... - Secretory leukocyte protease inhibitor (SLPI) expression and tumor invasion in oral squamous cell carcinomaJie Wen
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, USA
Am J Pathol 178:2866-78. 2011.... - Myeloid differentiation and susceptibility to HIV-1 are linked to APOBEC3 expressionGang Peng
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
Blood 110:393-400. 2007..Differences in promiscuity of monocytes, macrophages, and DCs can be defined, at least partly, by disparities in APOBEC expression, with implications for enhancing cellular defenses against HIV-1... - Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activityGang Peng
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 203:41-6. 2006..Our data provide a new dimension by which IFN-alpha mediates its antiviral activity and suggest a means to render the host nonpermissive for viral replication... - Human immunodeficiency virus type 1-induced macrophage gene expression includes the p21 gene, a target for viral regulationNancy Vazquez
National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Virol 79:4479-91. 2005..These data implicate p21 as a pivotal macrophage facilitator of the viral life cycle. Moreover, regulators of p21, such as CDDO, may provide an interventional approach to modulate HIV-1 replication... - Tonsil epithelial factors may influence oropharyngeal human immunodeficiency virus transmissionNiki M Moutsopoulos
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda 20892, USA
Am J Pathol 171:571-9. 2007..Collectively, our data suggest that increased expression of molecules associated with HIV binding and entry coupled with decreased innate antiviral factors may render the tonsil a potential site for oral transmission... - TGF-beta: receptors, signaling pathways and autoimmunityWanjun Chen
National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
Curr Dir Autoimmun 5:62-91. 2002 - Modulation of innate host factors by Mycobacterium avium complex in human macrophages includes interleukin 17Nancy Vazquez
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892 4352, USA
J Infect Dis 206:1206-17. 2012..Our study examines the ability of MAC to regulate interleukin 17 (IL-17), a proinflammatory cytokine involved in host cell recruitment... - Dysregulation of IFN-gamma signaling pathways in the absence of TGF-beta 1Nancy L McCartney-Francis
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 326, 30 Convent Drive, Bethesda, MD 20892, USA
J Immunol 169:5941-7. 2002..The global nature of immune dysregulation in TGF-beta1 null mice documents TGF-beta1 as an essential immunoregulatory molecule... - Regulation of the tonsil cytokine milieu favors HIV susceptibilityNiki M Moutsopoulos
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Dr, MSC 4352, Bethesda, MD 20892, USA
J Leukoc Biol 80:1145-55. 2006..These and other local environmental factors may render tonsil cells increasingly susceptible to HIV infection... - Mycobacterium avium infection and modulation of human macrophage gene expressionTeresa Greenwell-Wild
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 169:6286-97. 2002.... - Structural variants of IFNα preferentially promote antiviral functionsNancy Vazquez
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
Blood 118:2567-77. 2011..Defining IFN structure and function relative to APOBEC and other antiviral genes may enable design of novel IFN-related molecules preserving beneficial antiviral roles while minimizing negative effects... - Tumor necrosis factor-alpha (TNF-α) is a therapeutic target for impaired cutaneous wound healingGillian S Ashcroft
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Wound Repair Regen 20:38-49. 2012.... - Aberrant mucosal wound repair in the absence of secretory leukocyte protease inhibitorNikola Angelov
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Thromb Haemost 92:288-97. 2004..In addition, our model provides a unique opportunity to delineate the cellular and molecular mechanisms underlying the differences between dermal scarring and oral scar-free healing... - Transcriptional events in a clinical model of oral mucosal tissue injury and repairGary Warburton
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
Wound Repair Regen 13:19-26. 2005..Here we identify genes constitutively expressed in normal oral mucosa and transcriptional events following mucosal tissue injury, which may be useful in identifying new therapeutic targets... - Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesisGikas E Katsifis
Oral Infection and Immunity Branch and Sjögren s Syndrome Clinic, National Institute of Dental and Craniofacial Research NIH, 30 Convent Drive, Bethesda, MD 20892, USA
Am J Pathol 175:1167-77. 2009.... - Cytomegalovirus production by infected astrocytes correlates with transforming growth factor-beta releaseThomas Kossmann
Oral Infection and Immunity Branch, National Institute of Dental and Crainofacial Research, National Institutes of Health, Bethesda, Maryland, USA
J Infect Dis 187:534-41. 2003..These findings suggest that CMV infection of astrocytes induces the production of TGF-beta, which in turn enhances productive CMV expression... - Mycobacterium avium complex promotes recruitment of monocyte hosts for HIV-1 and bacteriaHollie Hale-Donze
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, and Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 169:3854-62. 2002..In vivo, opportunistic infection may act as a recruitment mechanism in which newly arrived monocytes serve as naive hosts for both MAC and HIV-1, thus perpetuating both infections... - TGF-beta can leave you breathlessBi Feng Qian
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, United States
Curr Opin Pharmacol 9:454-61. 2009.... - Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory painXiao Min Wang
NINR NIH, Bethesda, MD 20892, USA
Pain 128:136-47. 2007..These findings may also suggest an alternative hypothesis for the adverse effects attributed to selective inhibition of COX-2... - Chitinases in the salivary glands and circulation of patients with Sjögren's syndrome: macrophage harbingers of disease severityTeresa Greenwell-Wild
National Institute of Dental and Craniofacial Research, Oral Infection and Immunity Branch, NIH, Bethesda, Maryland
Arthritis Rheum 63:3103-15. 2011.... - TGF-beta and tumors--an ill-fated allianceNiki M Moutsopoulos
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, United States
Curr Opin Immunol 20:234-40. 2008..Collectively, the ability of the tumor to hijack these host defense pathways can tip the balance in favor of the tumor... - Inflammatory joint disease: clinical, histological, and molecular parameters of acute and chronic inflammation and tissue destructionNancy L McCartney-Francis
NIDCR, NIH, Bethesda, MD, USA
Methods Mol Biol 225:147-59. 2003 - Intraarticular gene transfer of TNFR:Fc suppresses experimental arthritis with reduced systemic distribution of the gene productJames M K Chan
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Ther 6:727-36. 2002..Hence, the use of rAAV as the delivery vector for TNFR:Fc effectively suppressed SCW-induced arthritis and may provide an approach for local delivery of antiarthritic therapy... - Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrenceMasaki Terabe
Molecular Immunogenetics and Vaccine Research Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 198:1741-52. 2003.... - Porphyromonas gingivalis promotes Th17 inducing pathways in chronic periodontitisNiki M Moutsopoulos
National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, United States Electronic address
J Autoimmun 39:294-303. 2012..gingivalis, whereas IL-1β was more resistant to proteolysis. Our data unveil multiple pathways by which P. gingivalis may orchestrate chronic inflammation, providing insights into interventional strategies... - Host gene expression changes correlating with anti-HIV-1 effects in human subjects after treatment with peginterferon Alfa-2aJONATHAN J HUBBARD
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Infect Dis 205:1443-7. 2012..87, p = .003). This study links HIV virological response to a specific IFIG subset, a potential prognostic indicator in peginterferon alfa-2a-treated patients with HIV infection... - Clinical evaluation of patients with temporomandibular joint implantsLauren E Ta
Postdoctoral Fellow, Pain and Neurosensory Mechanisms Branch, National Institutes of Health, Bethesda, MD 20892, USA
J Oral Maxillofac Surg 60:1389-99. 2002..We examined the possible relationship between TMJ implants and persistent pain, responses to sensory stimuli, quality of life, and systemic immune dysfunction... - Isolation of human monocyte populationsLarry M Wahl
National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
Curr Protoc Immunol . 2006..This latter procedure can be used to isolate large numbers of purified, nonactivated monocytes... - TGF-beta: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppressionWanjun Chen
Cellular Immunology Section, Oral Infection and Immunity Branch, NIDCR, NIH, Room 332, Building 30, Bethesda, MD 20892-4352, USA
Cytokine Growth Factor Rev 14:85-9. 2003..Collectively, multiple previously unconnected puzzle pieces are beginning to be linked into a more coherent, albeit incomplete picture of CD4(+)CD25(+) T cell-mediated suppression... - Inhibition of acute peritoneal inflammation in rats by a cytokine-induced neutrophil chemoattractant receptor antagonistJ Zagorski
Oral Infection and Immunity Branch, National Institute of Dental Research, Bethesda, MD 20892, USA
J Immunol 159:1059-62. 1997..When coinjected with zymosan into the peritoneal cavities of Lewis rats, 100 microg of CINCra inhibited neutrophil influx by approximately 40%, which was comparable with inhibition caused by polyclonal anti-CINC Abs... - Mycobacterium avium complex augments macrophage HIV-1 production and increases CCR5 expressionS M Wahl
Oral Infection and Immunity Branch, National Institute of Dental Research, 30 Convent Drive, MSC 4352, MD 20892, USA
Proc Natl Acad Sci U S A 95:12574-9. 1998..Consequently, treating OI may inhibit not only the OI-induced pathology, but also limit the viral burden... - Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory responseG S Ashcroft
Laboratory of Cell Regulation and Carcinogenesis, NCI, Bethesda, Maryland 20892 5055, USA
Nat Cell Biol 1:260-6. 1999..These data are, to our knowledge, the first to implicate Smad3 in specific pathways of tissue repair and in the modulation of keratinocyte and monocyte function in vivo... - Co-infection with opportunistic pathogens promotes human immunodeficiency virus type 1 infection in macrophagesS M Wahl
Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
J Infect Dis 179:S457-60. 1999..The opportunistic infections promote macrophage susceptibility to HIV-1 through cytokine modulation and altered chemokine co-receptors, potential targets for intervention... - TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieuW Chen
Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 14:715-25. 2001..These findings broaden the potential mechanisms whereby induction of immune tolerance or deficiency occurs through T cell deletion... - Cytokine regulation of schistosome-induced granuloma and fibrosisS M Wahl
Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA
Kidney Int 51:1370-5. 1997..mansoni granuloma and hepatic fibrosis. In addition to the Th1/Th2 cytokine balance, modulation of TGF-beta 1 may change the outcome of chronic inflammatory fibrotic disease... - Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory responseG S Ashcroft
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Am J Pathol 155:1137-46. 1999..These data demonstrate that delays in wound healing in the elderly can be significantly diminished by topical estrogen in both male and female subjects... - T lymphocytes in Sjögren's syndrome: contributors to and regulators of pathophysiologyGikas E Katsifis
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
Clin Rev Allergy Immunol 32:252-64. 2007..Defining the contributions of participating T cells may unravel strategies for therapeutic intervention... - Synthetic fibronectin peptides interrupt inflammatory cell infiltration in transforming growth factor beta 1 knockout miceK L Hines
Cellular Immunology Section, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892
Proc Natl Acad Sci U S A 91:5187-91. 1994..Peptide treatment initiated on day 8, coincident with the first evidence of increased leukocyte-endothelial cell interactions, not only blocked tissue infiltration but also moderated the lethal wasting syndrome... - Selective inhibition of inducible nitric oxide synthase exacerbates erosive joint diseaseN L McCartney-Francis
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 166:2734-40. 2001..These studies uncover a contribution of the constitutive isoforms of NOS to the evolution of acute and chronic inflammation pathology which may be important in the design of therapeutic agents... - Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cellsW Chen
Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
J Exp Med 188:1849-57. 1998..CTLA-4, through TGF-beta, may serve as a counterbalance for CD28 costimulation of IL-2 and CD4(+) T cell activation... - Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasisKarin List
Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland, MD 20892, USA
Oncogene 21:3765-79. 2002..This study demonstrates that Matriptase/MT-SP1 has pleiotropic functions in the development of the epidermis, hair follicles, and cellular immune system... - Histopathological and lymphangiogenic parameters in relation to lymph node metastasis in early stage oral squamous cell carcinomaGary Warburton
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4532, USA
J Oral Maxillofac Surg 65:475-84. 2007..In this study, we assess various clinical, histopathological and lymphangiogenic parameters in early stage oral SCC and their association with DNM... - Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healingG S Ashcroft
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, Building 30, 30 Convent Drive, MSC 4352, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 6:1147-53. 2000..The altered inflammatory profile involves enhanced activation of local TGF-beta in Slpi-null mice. We propose that SLPI is a pivotal endogenous factor necessary for optimal wound healing... - Measurement of TGF-beta in biological fluidsH Hale-Donze
National Institute of Dental and Craniofacial Research, Bethesda, Maryland, USA
Curr Protoc Immunol . 2001..Two support protocols describe acid-activation and neutralization of TGF-beta... 
Lack of efficacy of etanercept in Sjögren syndrome correlates with failed suppression of tumour necrosis factor alpha and systemic immune activationN M Moutsopoulos
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Ann Rheum Dis 67:1437-43. 2008....- Lacrimal gland inflammation is responsible for ocular pathology in TGF-beta 1 null miceN L McCartney-Francis
Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA
Am J Pathol 151:1281-8. 1997..Impeding the leukocyte infiltration into the glands with synthetic fibronectin peptides, which block adhesion, not only prevents the inflammatory pathology but also prevents the persistent eye closure characteristic of these mice... - Differential mucosal susceptibility in HIV-1 transmission and infectionN M Moutsopoulos
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Rm. 320, 30 Convent Dr, MSC 4352, Bethesda, MD 20892-4352, USA
Adv Dent Res 19:52-6. 2006..Continued elucidation of the unique features of mucosal HIV immunology is essential for understanding HIV pathogenesis and for developing effective vaccines and therapeutics... - COX inhibitors downregulate PDE4D expression in a clinical model of inflammatory painX M Wang
Pain Research Section, National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland, USA
Clin Pharmacol Ther 84:39-42. 2008..They both, however, downregulated the gene and protein expression of phosphodiesterase type 4 (PDE4D), which might represent a novel mechanism contributing to their analgesic and anti-inflammatory effects... - Immunological consequences of thalidomide treatment in Sjögren's syndromeN M Moutsopoulos
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Ann Rheum Dis 65:112-4. 2006.... - Expression and cloning of migration inhibitory factor-related protein (MRP)8 and MRP14 in arthritis-susceptible ratsT Imamichi
Cellular Immunology Section, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892
Biochem Biophys Res Commun 194:819-25. 1993..These differences suggest a role for MRP8 and MRP14 in susceptibility to SCW-induced chronic disease... - Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factorGillian S Ashcroft
School of Biological Sciences, University of Manchester, Manchester, United Kingdom
J Clin Invest 111:1309-18. 2003..We suggest that estrogen inhibits the local inflammatory response by downregulating MIF, suggesting a specific target for future therapeutic intervention in impaired wound-healing states... - Transforming growth factor-beta induces development of the T(H)17 lineagePaul R Mangan
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
Nature 441:231-4. 2006..The action of TGF-beta on naive T cells is antagonized by interferon-gamma and IL-4, thus providing a mechanism for divergence of the T(H)1, T(H)2 and T(H)17 lineages... - Augmented interferon-alpha pathway activation in patients with Sjögren's syndrome treated with etanerceptClio P Mavragani
Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA
Arthritis Rheum 56:3995-4004. 2007..To address the hypothesis that tumor necrosis factor blockade can result in increased levels of interferon-alpha (IFNalpha) and BAFF, we quantified those mediators in plasma from etanercept- and placebo-treated SS patients... - Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functionsHarald Schulze
Dana Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115, USA
Blood 104:3949-57. 2004..SLPI may thus have unanticipated roles in MK and platelet functions, including regulated proteolysis after activation... - Activation and repression of interleukin-12 p40 transcription by erythroid Kruppel-like factor in macrophagesQi Luo
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 279:18451-6. 2004..The bifunctional control of IL-12 p40 by EKLF and its modulation of NFkappaB support a potential function for this factor in orchestrating IL-12 p40 production in macrophages... - Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repairJing Zhu
Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
Cell 111:867-78. 2002..Supplying PEPI corrects the wound-healing defect in SLPI null mice. Thus, SLPI/elastase act via PEPI/EPIs to operate a switch at the interface between innate immunity and wound healing... - Proinflammatory and antimicrobial nitric oxide in gingival fluid of diabetic patients with periodontal diseaseUros Skaleric
Department of Oral Medicine and Periodontology, Faculty of Medicine, Hrvatski trg 6, 1000 Ljubljana, Slovenia
Infect Immun 74:7010-3. 2006..Although increased NO reflected more-severe inflammation, it was associated with reductions in CFU of Prevotella intermedia, a major periodontopathogen, highlighting dual roles for NO...