Sharon M Wahl

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Secretory leukocyte protease inhibitor binds to annexin II, a cofactor for macrophage HIV-1 infection
    Ge Ma
    Oral Infection and Immunity Branch, NIDCR, NIH, 30 Convent Dr, MSC4352, Building 30, Room 320, Bethesda, MD 20892, USA
    J Exp Med 200:1337-46. 2004
  2. pmc Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity
    Gang Peng
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:41-6. 2006
  3. pmc Secretory leukocyte protease inhibitor suppresses the inflammation and joint damage of bacterial cell wall-induced arthritis
    X Y Song
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4352, USA
    J Exp Med 190:535-42. 1999
  4. pmc Requirement for transforming growth factor beta1 in controlling T cell apoptosis
    W Chen
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 194:439-53. 2001
  5. ncbi request reprint TGF-beta: how tolerant can it be?
    Sharon M Wahl
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
    Immunol Res 28:167-79. 2003
  6. ncbi request reprint Transforming growth factor-beta: innately bipolar
    Sharon M Wahl
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research NIDCR, National Institutes of Health NIH, Bethesda, MD 20892 4352, USA
    Curr Opin Immunol 19:55-62. 2007
  7. ncbi request reprint Viral and host cofactors facilitate HIV-1 replication in macrophages
    Sharon M Wahl
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institute of Health, Bethesda, MD 20892 4352, USA
    J Leukoc Biol 74:726-35. 2003
  8. ncbi request reprint Nitric oxide in experimental joint inflammation. Benefit or detriment?
    S M Wahl
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
    Cells Tissues Organs 174:26-33. 2003
  9. ncbi request reprint TGF-beta: a mobile purveyor of immune privilege
    Sharon M Wahl
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
    Immunol Rev 213:213-27. 2006
  10. ncbi request reprint Permissive factors for HIV-1 infection of macrophages
    S M Wahl
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4352, USA
    J Leukoc Biol 68:303-10. 2000

Collaborators

Detail Information

Publications78

  1. pmc Secretory leukocyte protease inhibitor binds to annexin II, a cofactor for macrophage HIV-1 infection
    Ge Ma
    Oral Infection and Immunity Branch, NIDCR, NIH, 30 Convent Dr, MSC4352, Building 30, Room 320, Bethesda, MD 20892, USA
    J Exp Med 200:1337-46. 2004
    ..Moreover, this HIV-1 PS interaction with annexin II can be disrupted by SLPI or other annexin II-specific inhibitors. The PS-annexin II connection may represent a new target to prevent HIV-1 infection...
  2. pmc Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity
    Gang Peng
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:41-6. 2006
    ..Our data provide a new dimension by which IFN-alpha mediates its antiviral activity and suggest a means to render the host nonpermissive for viral replication...
  3. pmc Secretory leukocyte protease inhibitor suppresses the inflammation and joint damage of bacterial cell wall-induced arthritis
    X Y Song
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4352, USA
    J Exp Med 190:535-42. 1999
    ....
  4. pmc Requirement for transforming growth factor beta1 in controlling T cell apoptosis
    W Chen
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 194:439-53. 2001
    ..These findings may have broad implications not only for T cell selection and death in immune responses and in the generation of tolerance, but also for defining the mechanisms of programmed cell death in general...
  5. ncbi request reprint TGF-beta: how tolerant can it be?
    Sharon M Wahl
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
    Immunol Res 28:167-79. 2003
    ..Central to several of these pathways is transforming growth factor-beta (TGF-beta), a potent immunoregulatory cytokine that contributes to the function and generation of regulatory T cells...
  6. ncbi request reprint Transforming growth factor-beta: innately bipolar
    Sharon M Wahl
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research NIDCR, National Institutes of Health NIH, Bethesda, MD 20892 4352, USA
    Curr Opin Immunol 19:55-62. 2007
    ..Disruption of the tenuous balance between these opposing actions of TGF-beta underlies immunopathogenicity...
  7. ncbi request reprint Viral and host cofactors facilitate HIV-1 replication in macrophages
    Sharon M Wahl
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institute of Health, Bethesda, MD 20892 4352, USA
    J Leukoc Biol 74:726-35. 2003
    ..Inroads into understanding how HIV-1 co-opts host factors to generate a permissive environment for viral replication and transmission to new viral hosts may provide opportunities for targeted interruption of this lethal process...
  8. ncbi request reprint Nitric oxide in experimental joint inflammation. Benefit or detriment?
    S M Wahl
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
    Cells Tissues Organs 174:26-33. 2003
    ..Collectively, these data implicate discrete roles for the NOS isoforms in the emergence of local tissue pathology and underscore the need to define the specific pathways that are being targeted for interventional strategies...
  9. ncbi request reprint TGF-beta: a mobile purveyor of immune privilege
    Sharon M Wahl
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
    Immunol Rev 213:213-27. 2006
    ....
  10. ncbi request reprint Permissive factors for HIV-1 infection of macrophages
    S M Wahl
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4352, USA
    J Leukoc Biol 68:303-10. 2000
    ..avium and HIV-1 paralleled these in vitro findings. Furthermore, reduction in viral burden is associated with treatment of infected or inflamed tissues, underscoring the link between immune activation and viral replication...
  11. ncbi request reprint TGF-beta: the perpetrator of immune suppression by regulatory T cells and suicidal T cells
    Sharon M Wahl
    NIDCR, NIH, Building 30, Rm 320, 30 Convent Drive, MSC4352, Bethesda, MD 20892 4352, USA
    J Leukoc Biol 76:15-24. 2004
    ....
  12. ncbi request reprint HIV accomplices and adversaries in macrophage infection
    Sharon M Wahl
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Rm 320, 30 Convent Dr, MSC 4352, Bethesda, MD 20892 4352, USA
    J Leukoc Biol 80:973-83. 2006
    ..These and other manipulatable pathways may give the macrophage a fighting chance in its battle against the virus...
  13. ncbi request reprint Regulatory T cells and transcription factors: gatekeepers in allergic inflammation
    Sharon M Wahl
    Building 30, Room 320, 30 Convent Drive, MSC 4352, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4352, USA
    Curr Opin Immunol 16:768-74. 2004
    ..Continued unraveling of the pathways underlying the development of deleterious immune responses and their control will guide new avenues of investigation and intervention...
  14. pmc Transforming growth factor-beta-induced regulatory T cells referee inflammatory and autoimmune diseases
    Sharon M Wahl
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Disease, National Institutes of Health, Bethesda, Maryland, USA
    Arthritis Res Ther 7:62-8. 2005
    ....
  15. ncbi request reprint The kiss of death: interrupted by NK-cell close encounters of another kind
    Sharon M Wahl
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
    Trends Immunol 27:161-4. 2006
    ..Through a contact-dependent mechanism involving transforming growth factor-beta, regulatory T cells provide an escape mechanism from NK-cell-mediated tumor surveillance...
  16. pmc Systemic and mucosal differences in HIV burden, immune, and therapeutic responses
    Sharon M Wahl
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
    J Acquir Immune Defic Syndr 56:401-11. 2011
    ..Mucosal tissues represent major targets for HIV transmission but differ in susceptibility and reservoir function by unknown mechanisms...
  17. pmc Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    Wanjun Chen
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1875-86. 2003
    ..Finally, in a murine asthma model, coadministration of these TGF-beta-induced suppressor T cells prevented house dust mite-induced allergic pathogenesis in lungs...
  18. pmc Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon
    Teresa Greenwell-Wild
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
    Blood 114:1864-74. 2009
    ..In addition to macrophages, the IL-27-IFN-alpha connection is operative in CD4(+) T cells, consistent with an IFN-alpha-dependent pathway underlying host cell defense to HIV...
  19. ncbi request reprint Aberrant Toll receptor expression and endotoxin hypersensitivity in mice lacking a functional TGF-beta 1 signaling pathway
    Nancy McCartney-Francis
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:3814-21. 2004
    ..Constitutive and/or environmental activation of TLR4 and downstream elements, in the absence of TGF-beta suppression, may impact on innate and adaptive immunity and contribute to massive uncontrolled inflammation...
  20. pmc Rapid myeloid cell transcriptional and proteomic responses to periodontopathogenic Porphyromonas gingivalis
    Salvador Nares
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892 4352, USA
    Am J Pathol 174:1400-14. 2009
    ..The shared, unique, and/or complementary transcriptional and proteomic profiles may frame the context of the host response to P. gingivalis, contributing to the destructive nature of periodontal inflammation...
  21. pmc Human immunodeficiency virus type 1-induced macrophage gene expression includes the p21 gene, a target for viral regulation
    Nancy Vazquez
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 79:4479-91. 2005
    ..These data implicate p21 as a pivotal macrophage facilitator of the viral life cycle. Moreover, regulators of p21, such as CDDO, may provide an interventional approach to modulate HIV-1 replication...
  22. ncbi request reprint Mycobacterium avium-induced SOCS contributes to resistance to IFN-gamma-mediated mycobactericidal activity in human macrophages
    Nancy Vazquez
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892 4352, USA
    J Leukoc Biol 80:1136-44. 2006
    ..Our data provide new insights into the manipulation of the host response by this opportunistic pathogen and the potential for modulating SOCS to influence the outcome of M. avium infection in immunocompromised hosts...
  23. pmc Secretory leukocyte protease inhibitor (SLPI) expression and tumor invasion in oral squamous cell carcinoma
    Jie Wen
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, USA
    Am J Pathol 178:2866-78. 2011
    ....
  24. pmc Myeloid differentiation and susceptibility to HIV-1 are linked to APOBEC3 expression
    Gang Peng
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
    Blood 110:393-400. 2007
    ..Differences in promiscuity of monocytes, macrophages, and DCs can be defined, at least partly, by disparities in APOBEC expression, with implications for enhancing cellular defenses against HIV-1...
  25. ncbi request reprint Mycobacterium avium infection and modulation of human macrophage gene expression
    Teresa Greenwell-Wild
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:6286-97. 2002
    ....
  26. ncbi request reprint TGF-beta: receptors, signaling pathways and autoimmunity
    Wanjun Chen
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    Curr Dir Autoimmun 5:62-91. 2002
  27. doi request reprint A link between interferon and augmented plasmin generation in exocrine gland damage in Sjögren's syndrome
    Maria Gliozzi
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, MSC 4352, Bethesda, MD 20892 4352, USA
    J Autoimmun 40:122-33. 2013
    ....
  28. pmc Tonsil epithelial factors may influence oropharyngeal human immunodeficiency virus transmission
    Niki M Moutsopoulos
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda 20892, USA
    Am J Pathol 171:571-9. 2007
    ..Collectively, our data suggest that increased expression of molecules associated with HIV binding and entry coupled with decreased innate antiviral factors may render the tonsil a potential site for oral transmission...
  29. ncbi request reprint Dysregulation of IFN-gamma signaling pathways in the absence of TGF-beta 1
    Nancy L McCartney-Francis
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 326, 30 Convent Drive, Bethesda, MD 20892, USA
    J Immunol 169:5941-7. 2002
    ..The global nature of immune dysregulation in TGF-beta1 null mice documents TGF-beta1 as an essential immunoregulatory molecule...
  30. ncbi request reprint Inflammatory joint disease: clinical, histological, and molecular parameters of acute and chronic inflammation and tissue destruction
    Nancy L McCartney-Francis
    NIDCR, NIH, Bethesda, MD, USA
    Methods Mol Biol 225:147-59. 2003
  31. ncbi request reprint Aberrant mucosal wound repair in the absence of secretory leukocyte protease inhibitor
    Nikola Angelov
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Thromb Haemost 92:288-97. 2004
    ..In addition, our model provides a unique opportunity to delineate the cellular and molecular mechanisms underlying the differences between dermal scarring and oral scar-free healing...
  32. pmc Porphyromonas gingivalis promotes Th17 inducing pathways in chronic periodontitis
    Niki M Moutsopoulos
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
    J Autoimmun 39:294-303. 2012
    ..gingivalis, whereas IL-1β was more resistant to proteolysis. Our data unveil multiple pathways by which P. gingivalis may orchestrate chronic inflammation, providing insights into interventional strategies...
  33. pmc Chitinases in the salivary glands and circulation of patients with Sjögren's syndrome: macrophage harbingers of disease severity
    Teresa Greenwell-Wild
    National Institute of Dental and Craniofacial Research, Oral Infection and Immunity Branch, NIH, Bethesda, Maryland
    Arthritis Rheum 63:3103-15. 2011
    ....
  34. pmc Modulation of innate host factors by Mycobacterium avium complex in human macrophages includes interleukin 17
    Nancy Vazquez
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892 4352, USA
    J Infect Dis 206:1206-17. 2012
    ..Our study examines the ability of MAC to regulate interleukin 17 (IL-17), a proinflammatory cytokine involved in host cell recruitment...
  35. ncbi request reprint Regulation of the tonsil cytokine milieu favors HIV susceptibility
    Niki M Moutsopoulos
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Dr, MSC 4352, Bethesda, MD 20892, USA
    J Leukoc Biol 80:1145-55. 2006
    ..These and other local environmental factors may render tonsil cells increasingly susceptible to HIV infection...
  36. pmc Structural variants of IFNα preferentially promote antiviral functions
    Nancy Vazquez
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    Blood 118:2567-77. 2011
    ..Defining IFN structure and function relative to APOBEC and other antiviral genes may enable design of novel IFN-related molecules preserving beneficial antiviral roles while minimizing negative effects...
  37. pmc Tumor necrosis factor-alpha (TNF-α) is a therapeutic target for impaired cutaneous wound healing
    Gillian S Ashcroft
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Wound Repair Regen 20:38-49. 2012
    ....
  38. ncbi request reprint Mycobacterium avium complex promotes recruitment of monocyte hosts for HIV-1 and bacteria
    Hollie Hale-Donze
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, and Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:3854-62. 2002
    ..In vivo, opportunistic infection may act as a recruitment mechanism in which newly arrived monocytes serve as naive hosts for both MAC and HIV-1, thus perpetuating both infections...
  39. pmc TGF-beta can leave you breathless
    Bi Feng Qian
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, United States
    Curr Opin Pharmacol 9:454-61. 2009
    ....
  40. pmc Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence
    Masaki Terabe
    Molecular Immunogenetics and Vaccine Research Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1741-52. 2003
    ....
  41. ncbi request reprint Intraarticular gene transfer of TNFR:Fc suppresses experimental arthritis with reduced systemic distribution of the gene product
    James M K Chan
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Ther 6:727-36. 2002
    ..Hence, the use of rAAV as the delivery vector for TNFR:Fc effectively suppressed SCW-induced arthritis and may provide an approach for local delivery of antiarthritic therapy...
  42. ncbi request reprint Transcriptional events in a clinical model of oral mucosal tissue injury and repair
    Gary Warburton
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Wound Repair Regen 13:19-26. 2005
    ..Here we identify genes constitutively expressed in normal oral mucosa and transcriptional events following mucosal tissue injury, which may be useful in identifying new therapeutic targets...
  43. pmc Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesis
    Gikas E Katsifis
    Oral Infection and Immunity Branch and Sjögren s Syndrome Clinic, National Institute of Dental and Craniofacial Research NIH, 30 Convent Drive, Bethesda, MD 20892, USA
    Am J Pathol 175:1167-77. 2009
    ....
  44. ncbi request reprint Cytomegalovirus production by infected astrocytes correlates with transforming growth factor-beta release
    Thomas Kossmann
    Oral Infection and Immunity Branch, National Institute of Dental and Crainofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 187:534-41. 2003
    ..These findings suggest that CMV infection of astrocytes induces the production of TGF-beta, which in turn enhances productive CMV expression...
  45. ncbi request reprint TGF-beta: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression
    Wanjun Chen
    Cellular Immunology Section, Oral Infection and Immunity Branch, NIDCR, NIH, Room 332, Building 30, Bethesda, MD 20892 4352, USA
    Cytokine Growth Factor Rev 14:85-9. 2003
    ..Collectively, multiple previously unconnected puzzle pieces are beginning to be linked into a more coherent, albeit incomplete picture of CD4(+)CD25(+) T cell-mediated suppression...
  46. pmc Host gene expression changes correlating with anti-HIV-1 effects in human subjects after treatment with peginterferon Alfa-2a
    JONATHAN J HUBBARD
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 205:1443-7. 2012
    ..87, p = .003). This study links HIV virological response to a specific IFIG subset, a potential prognostic indicator in peginterferon alfa-2a-treated patients with HIV infection...
  47. pmc Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain
    Xiao Min Wang
    NINR NIH, Bethesda, MD 20892, USA
    Pain 128:136-47. 2007
    ..These findings may also suggest an alternative hypothesis for the adverse effects attributed to selective inhibition of COX-2...
  48. pmc TGF-beta and tumors--an ill-fated alliance
    Niki M Moutsopoulos
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, United States
    Curr Opin Immunol 20:234-40. 2008
    ..Collectively, the ability of the tumor to hijack these host defense pathways can tip the balance in favor of the tumor...
  49. ncbi request reprint Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis
    Karin List
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland, MD 20892, USA
    Oncogene 21:3765-79. 2002
    ..This study demonstrates that Matriptase/MT-SP1 has pleiotropic functions in the development of the epidermis, hair follicles, and cellular immune system...
  50. doi request reprint Isolation of human monocyte populations
    Larry M Wahl
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Curr Protoc Immunol . 2006
    ..This latter procedure can be used to isolate large numbers of purified, nonactivated monocytes...
  51. ncbi request reprint Clinical evaluation of patients with temporomandibular joint implants
    Lauren E Ta
    Postdoctoral Fellow, Pain and Neurosensory Mechanisms Branch, National Institutes of Health, Bethesda, MD 20892, USA
    J Oral Maxillofac Surg 60:1389-99. 2002
    ..We examined the possible relationship between TMJ implants and persistent pain, responses to sensory stimuli, quality of life, and systemic immune dysfunction...
  52. ncbi request reprint TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu
    W Chen
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 14:715-25. 2001
    ..These findings broaden the potential mechanisms whereby induction of immune tolerance or deficiency occurs through T cell deletion...
  53. ncbi request reprint Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
    G S Ashcroft
    Laboratory of Cell Regulation and Carcinogenesis, NCI, Bethesda, Maryland 20892 5055, USA
    Nat Cell Biol 1:260-6. 1999
    ..These data are, to our knowledge, the first to implicate Smad3 in specific pathways of tissue repair and in the modulation of keratinocyte and monocyte function in vivo...
  54. ncbi request reprint Cytokine regulation of schistosome-induced granuloma and fibrosis
    S M Wahl
    Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA
    Kidney Int 51:1370-5. 1997
    ..mansoni granuloma and hepatic fibrosis. In addition to the Th1/Th2 cytokine balance, modulation of TGF-beta 1 may change the outcome of chronic inflammatory fibrotic disease...
  55. pmc Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response
    G S Ashcroft
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Pathol 155:1137-46. 1999
    ..These data demonstrate that delays in wound healing in the elderly can be significantly diminished by topical estrogen in both male and female subjects...
  56. ncbi request reprint Co-infection with opportunistic pathogens promotes human immunodeficiency virus type 1 infection in macrophages
    S M Wahl
    Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
    J Infect Dis 179:S457-60. 1999
    ..The opportunistic infections promote macrophage susceptibility to HIV-1 through cytokine modulation and altered chemokine co-receptors, potential targets for intervention...
  57. pmc Mycobacterium avium complex augments macrophage HIV-1 production and increases CCR5 expression
    S M Wahl
    Oral Infection and Immunity Branch, National Institute of Dental Research, 30 Convent Drive, MSC 4352, MD 20892, USA
    Proc Natl Acad Sci U S A 95:12574-9. 1998
    ..Consequently, treating OI may inhibit not only the OI-induced pathology, but also limit the viral burden...
  58. ncbi request reprint Inhibition of acute peritoneal inflammation in rats by a cytokine-induced neutrophil chemoattractant receptor antagonist
    J Zagorski
    Oral Infection and Immunity Branch, National Institute of Dental Research, Bethesda, MD 20892, USA
    J Immunol 159:1059-62. 1997
    ..When coinjected with zymosan into the peritoneal cavities of Lewis rats, 100 microg of CINCra inhibited neutrophil influx by approximately 40%, which was comparable with inhibition caused by polyclonal anti-CINC Abs...
  59. ncbi request reprint T lymphocytes in Sjögren's syndrome: contributors to and regulators of pathophysiology
    Gikas E Katsifis
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
    Clin Rev Allergy Immunol 32:252-64. 2007
    ..Defining the contributions of participating T cells may unravel strategies for therapeutic intervention...
  60. pmc Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells
    W Chen
    Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 188:1849-57. 1998
    ..CTLA-4, through TGF-beta, may serve as a counterbalance for CD28 costimulation of IL-2 and CD4(+) T cell activation...
  61. ncbi request reprint Selective inhibition of inducible nitric oxide synthase exacerbates erosive joint disease
    N L McCartney-Francis
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 166:2734-40. 2001
    ..These studies uncover a contribution of the constitutive isoforms of NOS to the evolution of acute and chronic inflammation pathology which may be important in the design of therapeutic agents...
  62. pmc Synthetic fibronectin peptides interrupt inflammatory cell infiltration in transforming growth factor beta 1 knockout mice
    K L Hines
    Cellular Immunology Section, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 91:5187-91. 1994
    ..Peptide treatment initiated on day 8, coincident with the first evidence of increased leukocyte-endothelial cell interactions, not only blocked tissue infiltration but also moderated the lethal wasting syndrome...
  63. ncbi request reprint Histopathological and lymphangiogenic parameters in relation to lymph node metastasis in early stage oral squamous cell carcinoma
    Gary Warburton
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4532, USA
    J Oral Maxillofac Surg 65:475-84. 2007
    ..In this study, we assess various clinical, histopathological and lymphangiogenic parameters in early stage oral SCC and their association with DNM...
  64. pmc Lacrimal gland inflammation is responsible for ocular pathology in TGF-beta 1 null mice
    N L McCartney-Francis
    Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA
    Am J Pathol 151:1281-8. 1997
    ..Impeding the leukocyte infiltration into the glands with synthetic fibronectin peptides, which block adhesion, not only prevents the inflammatory pathology but also prevents the persistent eye closure characteristic of these mice...
  65. ncbi request reprint Measurement of TGF-beta in biological fluids
    H Hale-Donze
    National Institute of Dental and Craniofacial Research, Bethesda, Maryland, USA
    Curr Protoc Immunol . 2001
    ..Two support protocols describe acid-activation and neutralization of TGF-beta...
  66. doi request reprint Lack of efficacy of etanercept in Sjögren syndrome correlates with failed suppression of tumour necrosis factor alpha and systemic immune activation
    N M Moutsopoulos
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann Rheum Dis 67:1437-43. 2008
    ....
  67. ncbi request reprint Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing
    G S Ashcroft
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, Building 30, 30 Convent Drive, MSC 4352, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 6:1147-53. 2000
    ..The altered inflammatory profile involves enhanced activation of local TGF-beta in Slpi-null mice. We propose that SLPI is a pivotal endogenous factor necessary for optimal wound healing...
  68. ncbi request reprint Differential mucosal susceptibility in HIV-1 transmission and infection
    N M Moutsopoulos
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Rm 320, 30 Convent Dr, MSC 4352, Bethesda, MD 20892 4352, USA
    Adv Dent Res 19:52-6. 2006
    ..Continued elucidation of the unique features of mucosal HIV immunology is essential for understanding HIV pathogenesis and for developing effective vaccines and therapeutics...
  69. pmc Immunological consequences of thalidomide treatment in Sjögren's syndrome
    N M Moutsopoulos
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Ann Rheum Dis 65:112-4. 2006
    ..To study the immunological consequences of systemic thalidomide treatment in patients with Sjögren's syndrome...
  70. doi request reprint COX inhibitors downregulate PDE4D expression in a clinical model of inflammatory pain
    X M Wang
    Pain Research Section, National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland, USA
    Clin Pharmacol Ther 84:39-42. 2008
    ..They both, however, downregulated the gene and protein expression of phosphodiesterase type 4 (PDE4D), which might represent a novel mechanism contributing to their analgesic and anti-inflammatory effects...
  71. ncbi request reprint Expression and cloning of migration inhibitory factor-related protein (MRP)8 and MRP14 in arthritis-susceptible rats
    T Imamichi
    Cellular Immunology Section, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892
    Biochem Biophys Res Commun 194:819-25. 1993
    ..These differences suggest a role for MRP8 and MRP14 in susceptibility to SCW-induced chronic disease...
  72. ncbi request reprint Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions
    Harald Schulze
    Dana Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Blood 104:3949-57. 2004
    ..SLPI may thus have unanticipated roles in MK and platelet functions, including regulated proteolysis after activation...
  73. pmc Activation and repression of interleukin-12 p40 transcription by erythroid Kruppel-like factor in macrophages
    Qi Luo
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:18451-6. 2004
    ..The bifunctional control of IL-12 p40 by EKLF and its modulation of NFkappaB support a potential function for this factor in orchestrating IL-12 p40 production in macrophages...
  74. ncbi request reprint Transforming growth factor-beta induces development of the T(H)17 lineage
    Paul R Mangan
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    Nature 441:231-4. 2006
    ..The action of TGF-beta on naive T cells is antagonized by interferon-gamma and IL-4, thus providing a mechanism for divergence of the T(H)1, T(H)2 and T(H)17 lineages...
  75. pmc Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor
    Gillian S Ashcroft
    School of Biological Sciences, University of Manchester, Manchester, United Kingdom
    J Clin Invest 111:1309-18. 2003
    ..We suggest that estrogen inhibits the local inflammatory response by downregulating MIF, suggesting a specific target for future therapeutic intervention in impaired wound-healing states...
  76. pmc Augmented interferon-alpha pathway activation in patients with Sjögren's syndrome treated with etanercept
    Clio P Mavragani
    Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA
    Arthritis Rheum 56:3995-4004. 2007
    ..To address the hypothesis that tumor necrosis factor blockade can result in increased levels of interferon-alpha (IFNalpha) and BAFF, we quantified those mediators in plasma from etanercept- and placebo-treated SS patients...
  77. ncbi request reprint Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair
    Jing Zhu
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cell 111:867-78. 2002
    ..Supplying PEPI corrects the wound-healing defect in SLPI null mice. Thus, SLPI/elastase act via PEPI/EPIs to operate a switch at the interface between innate immunity and wound healing...
  78. pmc Proinflammatory and antimicrobial nitric oxide in gingival fluid of diabetic patients with periodontal disease
    Uros Skaleric
    Department of Oral Medicine and Periodontology, Faculty of Medicine, Hrvatski trg 6, 1000 Ljubljana, Slovenia
    Infect Immun 74:7010-3. 2006
    ..Although increased NO reflected more-severe inflammation, it was associated with reductions in CFU of Prevotella intermedia, a major periodontopathogen, highlighting dual roles for NO...